Lightnews — Scholar-powered news

Brian Sheridan Lab @bsheridanlab.bsky.social · Aug 18

www.nejm.org/doi/10.1056/...

Science is pretty amazing! The amount of basic science that leads to these clinical breakthroughs is staggering and often not appreciated by the politicians that decide funding levels

Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | NEJM

The need to suppress a patient’s immune system after the transplantation of allogeneic cells is associated with wide-ranging side effects. We report the outcomes of transplantation of genetically m...

www.nejm.org

Brian Sheridan Lab @bsheridanlab.bsky.social · Jul 30

I'll take #gdTcells for $500

Priya Devarajan @priyadevarajan.bsky.social · Jul 30

Things got competitive with immunology jeopardy (slight bias towards certain topics 😉) at our @bsheridanlab.bsky.social @priyadevarajan.bsky.social joint lab meeting this week!

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Reposted by Brian Sheridan Lab

Nature @nature.com · Jul 10

A key US Senate committee has indicated that it will reject the huge budget cuts that President Donald Trump proposed for some science agencies, including the US National Science Foundation and NASA.

go.nature.com/40H0XST

US senators poised to reject Trump’s proposed massive science cuts

Committee gives first hint that policymakers might preserve, rather than slash, funding for US National Science Foundation and other agencies.

go.nature.com

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Reposted by Brian Sheridan Lab

Angie Rasmussen @angierasmussen.bsky.social · Jun 16

As NIH budget deliberations continue, prepare to hear Bhattacharya deflect substantial questions about the negative effects of his funding policies with “I’m an economist.”

He’s not a very good one if he’s unable to assess the impact of funding decisions at the agency he directs.

Ferric Fang, MD @fangferric.bsky.social · Jun 15

BHATTACHARYA'S "FORWARD FUNDING" SCHEME

In last week's Senate Appropriations hearing with the NIH Director, Bhattacharya and Sen. Baldwin clashed over the proposed scheme. Baldwin said it was "funny math," to which Bhattacharya responded, "I'm an economist."

www.politico.com/newsletters/...

NIH’s ‘forward-funding scheme’

NIH Director Jay Bhattacharya and Sen. Tammy Baldwin (D-Wis.) sparred over a proposal in the White House budget plan to give more grant recipients their money up front during a Senate Appropriations p...

www.politico.com

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Reposted by Brian Sheridan Lab

Kamal M Khanna @khannakm.bsky.social · Jun 7

Our latest review on macrophages Macrophages: sentinels, warriors, and healers url:https://academic.oup.com/hmg/article-abstract/doi/10.1093/hmg/ddaf087/8158008

academic.oup.com/hmg/advance-...

Macrophages: sentinels, warriors, and healers

Abstract. Macrophages are versatile innate immune cells that act as sentinels, warriors, and healers in virtually every tissue. This review synthesizes cur

academic.oup.com

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Brian Sheridan Lab @bsheridanlab.bsky.social · Jun 2

This is a great idea! I really enjoy the JI Pillar articles

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Brian Sheridan Lab @bsheridanlab.bsky.social · May 27

Listen to our newest Immunology faculty @priyadevarajan.bsky.social discussing her new lab @stonybrookmedicine.bsky.social and the benefit of @societymucosalimm.bsky.social mentorship program to her career development!

Mucosal Immunology @mucosalimmunol.bsky.social · May 26

Start your week off with the latest episode of the Mucosal Immunology Podcast @societymucosalimm.bsky.social featuring @priyadevarajan.bsky.social with @marionbrunck.bsky.social @ashu-mangalam.bsky.social and more: open.spotify.com/episode/3dJF...

Immunity to respiratory viruses

Mucosal Immunology Podcast · Episode

open.spotify.com

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Reposted by Brian Sheridan Lab

Carl T. Bergstrom @carlbergstrom.com · May 26

These are VERY rough estimates, but here's life expectancy after diagnosis of type-I diabetes over the past 150 years.

It was Banting and Best's discovery of how to isolate insulin in 1921 — not some fucking cooking class — that gave people including my daughter a new lease on life.

Plot of life expectancy after Type 1 diabetes diagnosis, 1850-2025.

After the discovery of insulin in 1921, life expectancies go gradually from zero to seventy years.

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Reposted by Brian Sheridan Lab

Jeremy Berg @jeremymberg.bsky.social · May 24

Proud of Harvard for pushing back, exercising some creativity, and, maybe, helping folks get some needed education.

Harvard is making many of their online government courses FREE.

I just signed up for "Citizen Politics in America".

They even asked me my Gender.

pll.harvard.edu/subject/gove...

Government | Harvard University

Browse the latest Government courses from Harvard University.

pll.harvard.edu

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Brian Sheridan Lab @bsheridanlab.bsky.social · May 14

Metabolic reprogramming of IL-17 producing gd T cells promotes de novo lipogenesis under psoriasis conditions

γδ T cell Forum @forum-gd.bsky.social · May 14

Metabolic reprogramming of interleukin-17-producing γδ T cells promotes ACC1-mediated de novo lipogenesis under psoriatic conditions

#gdTcells @natmetabolism.nature.com

Metabolic reprogramming of interleukin-17-producing γδ T cells promotes ACC1-mediated de novo lipogenesis under psoriatic conditions - Nature Metabolism

Kao et al. provide insight into the metabolic requirements of IL-17A-producing γδ T cells, offering an actionable target to treat psoriasis by inhibiting fatty acid synthesis.

www.nature.com

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Reposted by Brian Sheridan Lab

Scott Delaney @scott-delaney.bsky.social · Apr 30

NEW: We (mostly @noamross.net) launched a website to shine a brighter light on terminated NIH and NSF grants.

grant-watch.us

It links to our NIH & NSF trackers, grant info submission forms, and other info. We'll also add new analyses soon.

Check it out and let us know what else you'd like to see.

Grant Watch

grant-watch.us

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Reposted by Brian Sheridan Lab

Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Apr 30

www.appropriations.senate.gov/hearings/bio...

Biomedical Research: Keeping America’s Edge in Innovation | United States Senate Committee on Appropriations

United States Senate Committee on Appropriations

www.appropriations.senate.gov

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Brian Sheridan Lab @bsheridanlab.bsky.social · Apr 30

Check out this cool new study from a colleague at @stonybrookmedicine.bsky.social. Congrats to Charles and his team! Mtb-reactive CD8a expressing NK cells in humans!

Waggoner Lab @labwaggoner.bsky.social · Apr 29

CD8α marks a Mycobacterium tuberculosis-reactive human NK cell population with high activation potential
www.nature.com/articles/s41...

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Brian Sheridan Lab @bsheridanlab.bsky.social · Apr 26

Another great study from the @khannakm.bsky.social lab! Disease tolerance to limit Pathology in mucosal tissues

Kamal M Khanna @khannakm.bsky.social · Apr 25

Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling: Immunity www.cell.com/immunity/ful... our study out now [email protected] #macrophages

Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling

The local immunoregulatory mechanisms that safeguard the host from excessive lung infection inflammation remain unclear. Yeung, Yokota et al. uncover the essential role of nerve- and airway-associated...

www.cell.com

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Brian Sheridan Lab @bsheridanlab.bsky.social · Apr 26

Check out this fantastic story from @ikinglab.bsky.social group! There's always something cool going on in the mucosa

King Lab at McGill University @ikinglab.bsky.social · Apr 22

I am very excited to share our article on IFNg, stroma and disease tolerance during intestinal helminth infection published today in Cell. This work was lead by the amazing @susanwestfall.bsky.social and supported by many international collaborators.

www.sciencedirect.com/science/arti...

A type 1 immune-stromal cell network mediates disease tolerance against intestinal infection

Type 1 immunity mediates host defense through pathogen elimination, but whether this pathway also impacts tissue function is unknown. Here, we demonst…

www.sciencedirect.com

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Reposted by Brian Sheridan Lab

Edward Nirenberg @enirenberg.bsky.social · Apr 23

I don't get how anyone can possibly be okay with ending the WHI. This study has accrued decades of data from 42000 women and it is still going. It helps to address critical research gaps that have been allowed to go unfilled because of durable misogyny and provides invaluable insight into aging.

NIH cancels its first and largest study centered on women

The Women’s Health Initiative has produced numerous influential findings

www.science.org

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Reposted by Brian Sheridan Lab

Society for Mucosal Immunology @societymucosalimm.bsky.social · Apr 18

From South America to the global stage!

Meet Dr. Eduardo Villablanca and Gustavo Monasterio Ocares as they share how SMI has supported their efforts to increase opportunities for mucosal immunologists in South America.

Watch here: www.socmucimm.org/about/smi-or...

#MucosalImmunology

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Brian Sheridan Lab @bsheridanlab.bsky.social · Apr 9

gavage with Listeria leads to rapid (within 4 hour dissemination to the liver) but feeding takes 48 hours and appears to pass through the MLN. We thought this was a technical limitation of gavage but perhaps it's different with Yersinia.

Thanks for sharing and best of luck with submission!

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Brian Sheridan Lab @bsheridanlab.bsky.social · Apr 9

Okay, that sounds great. So, how do you think this works? The ole direct access to the hepatic portal vein? Shouldn't that require pass through though? We've been struggling with these questions in the Listeria system for some time. But...

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Brian Sheridan Lab @bsheridanlab.bsky.social · Apr 9

Very cool study! Curious if you looked at foodborne infection instead of gavage using this approach to compare splenic/liver vs intestinal founders?

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Brian Sheridan Lab @bsheridanlab.bsky.social · Mar 19

Will do. Just switched over from the other place a few weeks back.

Brian Sheridan Lab @bsheridanlab.bsky.social · Mar 19

Thanks Laura 😊
Hope all is well at UConn!

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Reposted by Brian Sheridan Lab

Justin Wolfers @justinwolfers.bsky.social · Mar 11

This chart seems to suggest that something is going wrong in the United States, specifically.
(www.ft.com/content/7568... )

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Reposted by Brian Sheridan Lab

Nature @nature.com · Mar 7

Postdoctoral students, graduate students and other junior scientists in large research groups are more likely to drop out of academia than are their peers in smaller groups, says a study of more than one million early-career researchers.

https://go.nature.com/3F8sZyV

How a PhD student’s lab size affects their chance of future academic success

Trainees in big research groups tend to go on to greater academic success than their small-group counterparts ― but are more likely to quit academia altogether.

go.nature.com

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Brian Sheridan Lab @bsheridanlab.bsky.social · Mar 7

Congrats Jie and team!

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