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carlos-conde.bsky.social
Carlos Conde
@carlos-conde.bsky.social
140 followers 140 following 34 posts
Cell Biologist at i3S studying chromosome segregation. Assistant Professor at ICBAS-University of Porto.
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carlos-conde.bsky.social
Carlos Conde @carlos-conde.bsky.social · Apr 13
I'm happy to share our study “Proximity-based activation of AURORA A by MPS1 potentiates error correction” now published at @currentbiology.bsky.social

www.sciencedirect.com/science/arti...

It describes a new way kinetochores and centrosomes communicate to ensure accurate chromosome segregation.
Proximity-based activation of AURORA A by MPS1 potentiates error correction
Faithful cell division relies on mitotic chromosomes becoming bioriented with each pair of sister kinetochores bound to microtubules oriented toward o…
www.sciencedirect.com
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carlos-conde.bsky.social
Carlos Conde @carlos-conde.bsky.social · 5d
Muitos parabéns
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Reposted by Carlos Conde
drtanyasoliman.bsky.social
Dr Tanya Soliman @drtanyasoliman.bsky.social · 6d
Are you a future black leader in cancer? Come join @mirazrahman.bsky.social and my labs @qmbci.bsky.social @kingscollegelondon.bsky.social to work on turning defective cell cycle checkpoints into innovative cancer therapies! Get in touch for more details www.colcc.ac.uk/2026-blic-ph...
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Reposted by Carlos Conde
mcclellandlab.bsky.social
Mcclelland lab @mcclellandlab.bsky.social · 6d
We are looking for our next PhD student to join us 🤩 www.mcclellandlab.com to understand cancer radiation therapy's impact on DNA damage repair and chromosomal instability. Prestigious funding from CRUK RadNet. Please contact me informally - deadline 5th Nov! crukradnet.colcc.ac.uk/phd-students...
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carlos-conde.bsky.social
Carlos Conde @carlos-conde.bsky.social · 8d
Many thanks to the other members of the PhD viva committee @raoliveira.bsky.social , @jorgeferreira.bsky.social and Mariana Osswald for their insightful contributions. And of course, a special word of gratitude to @cesunkel.bsky.social and @polarityi3s.bsky.social for their role as co-supervisors.
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carlos-conde.bsky.social
Carlos Conde @carlos-conde.bsky.social · 8d
Good things still happen: a couple of weeks ago Nelson Leça successfully defended his PhD! 🥳 He did a fantastic job discussing his work and "wrestling" the exciting examination led by @jakedel.bsky.social and @pseudoenzyme.bsky.social.
It was a good day! 👏🎉
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Reposted by Carlos Conde
adesaurin.bsky.social
Adrian Saurin @adesaurin.bsky.social · 19d
Very excited to post our latest work showing the mitotic stopwatch monitors more than just mitotic delays - it protects against whole genome doubling and cell enlargement.

Great work by fantastic postdocs Lindsey and Reece (& student Maria)
#PostdocAppreciationWeek

www.biorxiv.org/content/10.1...
The mitotic stopwatch limits the proliferation of whole genome doubled cells
Whole genome doubling (WGD) is a frequent event in tumourigenesis that promotes chromosomal instability and tumour evolution. WGD is sensed indirectly due to the presence of extra centrosomes, which a...
www.biorxiv.org
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carlos-conde.bsky.social
Carlos Conde @carlos-conde.bsky.social · 20d
Congratulations Sachin and team! very nice!
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Reposted by Carlos Conde
spindlebehavior.bsky.social
Sachin Kotak @spindlebehavior.bsky.social · 25d
Happy to share our work in @embojournal 👉 shorturl.at/zXNyn
For decades, we’ve known cells dismantle & rebuild the nuclear envelope in sync with spindle poles. But why does this coordination matter? And how do pole material properties ensure error-free division?
Follow this thread to know more 👇
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carlos-conde.bsky.social
Carlos Conde @carlos-conde.bsky.social · 20d
Fantastic seminar by Jake @jakedel.bsky.social on the wonders of the NDC80 complex, which never ceases to amaze.
Reposted by Carlos Conde
monicamsousa.bsky.social
monicamsousa.bsky.social @monicamsousa.bsky.social · 20d
Our group [@i3suporto.bsky.social] is hiring a Senior Technician (tinyurl.com/3ehju86r) and a Bioinformatician (tinyurl.com/2xwatnpx).
Know someone who might be a good fit? Send them our way
tinyurl.com
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Reposted by Carlos Conde
suebiggins.bsky.social
Sue Biggins @suebiggins.bsky.social · 22d
Looking for your next step in fly genetics? The Rajan Lab at Fred Hutch is hiring a staff scientist + postdoc for projects on fat–brain signals, immunity, and brain aging. Stable, long-term role in a collaborative lab. Apply: careers-fhcrc.icims.com/jobs/30062/j...
Fred Hutchinson Cancer Center
Fred Hutch is dedicated to the elimination of cancer and related diseases as causes of human suffering and death.
careers-fhcrc.icims.com
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Reposted by Carlos Conde
suebiggins.bsky.social
Sue Biggins @suebiggins.bsky.social · 23d
New cell cycle meeting starts next summer!
events.faseb.org/event/c40174...
Cell Cycle Regulation in Health and Disease.
Explore breakthroughs in cell cycle regulation and its impact on disease and therapies at this new multidisciplinary scientific meeting.
events.faseb.org
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Reposted by Carlos Conde
andrea-musacchio.bsky.social
Andrea Musacchio @andrea-musacchio.bsky.social · 23d
The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona | Science Advances www.science.org/doi/10.1126/...

Congratulations @vcmentowski.bsky.social for solving a remarkably challenging molecular puzzle
The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona
The kinetochore fibrous corona docks on CENP-E and a second elusive receptor identified as the checkpoint protein BUB1.
www.science.org
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Reposted by Carlos Conde
burkardlab.bsky.social
Burkard Lab @burkardlab.bsky.social · 24d
Measuring chromosomal instability #CIN isn’t straightforward. We compared live imaging, FISH, scDNA-seq & other assays, and found significant differences. Our take: Use mis-segregations per diploid division (MDD) as a clear standard.
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
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carlos-conde.bsky.social
Carlos Conde @carlos-conde.bsky.social · 25d
Great seminar by Viji @viji-draviam.bsky.social at @i3suporto.bsky.social and very insightful discussions. Always a pleasure to host colleagues and brainstorm!
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Reposted by Carlos Conde
pedroprocha.bsky.social
Pedro Rocha @pedroprocha.bsky.social · Sep 8
🚨🚨🚨 Please repost
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...
Job add showing the lab logo and the following text: WHAT WE OFFER Fully-funded fellowships up to five years Opportunity to start your own research program or lead ongoing projects. Large, diverse and extraordinary scientific network at the NIH/Bethesda campus. Working at NIH offers the possibility of living in a diverse, liberal and vibrant city: Washington DC Or in a calm residential area with great schools and good affordable housing: Bethesda and Rockville. WHO YOU ARE You share our enthusiasm for epigenetics, gene regulation, nuclear organization and mouse development. You have PhD-experience in one or more of the following: mouse development, mouse genetics, epigenetics, or computational biology.
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Reposted by Carlos Conde
dfachinetti.bsky.social
dfachinetti.bsky.social @dfachinetti.bsky.social · Sep 4
#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...
DNA methylation influences human centromere positioning and function - Nature Genetics
Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.
www.nature.com
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Reposted by Carlos Conde
jorgeferreira.bsky.social
Jorge Ferreira @jorgeferreira.bsky.social · Sep 3
New preprint from the lab! Please check it out. 🚨
Have you ever wondered how cells decide when it’s time to divide? So did we!
www.biorxiv.org/content/10.1...
Chromosome condensation mechanically primes the nucleus for mitosis
Timely and accurate transition into mitosis is essential to preserve genome integrity and avoid chromosome segregation errors. This transition depends on spatial and temporal activity patterns of the ...
www.biorxiv.org
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Reposted by Carlos Conde
jcb.org
Journal of Cell Biology @jcb.org · Sep 3
Abouelghar, Carrier, @mpmiller.bsky.social et al. @utah.edu show that budding yeast Stu2’s #kinetochore function is essential for cell viability. Surprisingly, this function is independent of its canonical ability to induce #microtubule assembly and disassembly. rupress.org/jcb/article/...
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Reposted by Carlos Conde
lacefieldlab.bsky.social
Soni Lacefield @lacefieldlab.bsky.social · Aug 29
Check out our new manuscript on biorxiv on the role of MOS in mammalian oocyte meiosis: www.biorxiv.org/cgi/content/...
With @schindlerlab.bsky.social @giselacairobaza.bsky.social @muhammad-haseeb.bsky.social
A persistent intracellular bridge and cell cycle misregulation enable polar body cell divisions and tumor formation in Mos-deficient eggs
Mammalian female meiosis is uniquely regulated to produce a developmentally competent egg capable of supporting embryogenesis. During meiosis I, homologous chromosomes segregate, with half extruded in...
www.biorxiv.org
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Reposted by Carlos Conde
centriolelab.bsky.social
Paul & Virginie - Centriole Lab @centriolelab.bsky.social · Aug 28
Trouble imaging actin in ExM? Meet HAK-Actin, a probe for U-ExM, cryo-ExM & iU-ExM. Enables post-expansion labeling for max signal. www.biorxiv.org/content/10.1...
Soon at @spirochrome.com
Led by O.Mercey and @lreymond.bsky.social, in collab with @dudinlab.bsky.social and @marinelap.bsky.social
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Reposted by Carlos Conde
lacefieldlab.bsky.social
Soni Lacefield @lacefieldlab.bsky.social · Aug 27
My department at Dartmouth Medical School is hiring a tenure-track Assistant Professor. We are looking broadly for a biochemist or cell biologist. Please share this add! apply.interfolio.com/171438
@dartmouthbcb.bsky.social @futurepislack.bsky.social
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
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carlos-conde.bsky.social
Carlos Conde @carlos-conde.bsky.social · Aug 21
Wow! Amazing!
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Reposted by Carlos Conde
astraight.bsky.social
Aaron Straight @astraight.bsky.social · Aug 18
@currentbiology.bsky.social has always been one of my favorite journals but I think they have now outdone themselves www.cell.com/current-biol.... And picked up by the @nytimes.com as well! www.nytimes.com/2025/08/18/s...
Periodic excretion patterns of seabirds in flight
Uesaka and Sato report on the excretion patterns of seabirds in the open ocean determined using a rear-facing video logger.
www.cell.com
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Reposted by Carlos Conde
ki.se
Karolinska Institutet @ki.se · Aug 18
Final call: Applications close September 2! KI is recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential. All positions: ki.se/en/about-ki/...
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