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Reposted by Dimitrios Davalos & Lab

Science Magazine @science.org · 9d

A “crisis” that rocked the island of Santorini may reveal a shared magma system between two volcanoes with explosive histories. https://scim.ag/428JVho

Thousands of quakes struck a major Greek volcano, mapping the plumbing beneath it

A “crisis” that rocked the island of Santorini may reveal a shared magma system between two volcanoes with explosive histories

scim.ag

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Reposted by Dimitrios Davalos & Lab

Nature @nature.com · 14d

Finding the tick-borne encephalitis cellular gateway could transform prevention and treatment

go.nature.com/3Kqp5E9

How a tick-borne virus enters human cells

Tick-borne encephalitis virus can infect the nervous system and cause life-threatening illness. Finding the cellular gateway it uses could transform prevention and treatment.

go.nature.com

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Reposted by Dimitrios Davalos & Lab

Nature Reviews Neurology @natrevneurol.nature.com · 14d

Beneficial impact of physical activity on multiple sclerosis disability progression jnnp.bmj.com/content/earl...

Beneficial impact of physical activity on multiple sclerosis disability progression

Background Physical activity has been associated with neuroprotective and immunomodulatory benefits, potentially influencing long-term disability outcomes in multiple sclerosis (MS). However, longitud...

jnnp.bmj.com

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Reposted by Dimitrios Davalos & Lab

Nima Sharifi MD @nimasharifimd.bsky.social · 14d

We are hiring and looking for exceptional faculty! If you are interested in the fundamental mechanisms of human biology, biochemistry, metabolism, or genetics, please look here! 🧪 jobs.sciencecareers.org/job/675109/f...

Faculty – Assistant, Associate and Full Professor - Miami, Florida (US) job with Miami Miller School of Medicine - Desai Sethi Urology and Sylvester Comprehensive Cancer Center | 675109

The Desai Sethi Urology Institute seeks scientists to study genitourinary cancers, offering strong support, collaboration, and a new cancer facility.

jobs.sciencecareers.org

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Reposted by Dimitrios Davalos & Lab

Hao Yin @haoyin.bsky.social · 19d

#BloodBrainBarrier

"microglia are not necessary for the maintenance of BBB structure, function, or gene expression in the healthy brain"

Evidence from >95% microglia depletion by PLX5622, a CSF1R inhibitor (1 mo) & BBB ultrastructure

@cprofaci.bsky.social #Neuron 2024
www.cell.com/neuron/fullt...

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Reposted by Dimitrios Davalos & Lab

Joe Sabatino @jsabatino37.bsky.social · 21d

2024 MS McDonald criteria now published

www.thelancet.com/journals/lan...

www.thelancet.com

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Reposted by Dimitrios Davalos & Lab

Itai Yanai @itaiyanai.bsky.social · Sep 7

Legend David Baltimore died yesterday. He understood the way things should work: "the real contribution of MIT is that it doesn't take itself too seriously. It takes ideas seriously, but the people are relatively informal. They are not self-aggrandizing the way academics can be."

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Reposted by Dimitrios Davalos & Lab

Neuron @cp-neuron.bsky.social · Sep 3

We are proud to present a Special Issue on Cancer Neuroscience, curated by editors Bennie Babayan & Ted Dobie. This issue offers a snapshot of the field through a collection of Perspectives, Reviews, and NeuroViews: cell.com/neuron/issue.... See below for details on the pieces:

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Reposted by Dimitrios Davalos & Lab

The Rockefeller University @rockefeller.edu · Jun 20

New research from the #StricklandLab suggests that amyloid-beta (Aβ) oligomers and the vascular protein fibrinogen may, when forming a complex, contribute to Alzheimer's disease. #RockefellerScience

How an Alzheimer's peptide and a blood protein may combine to drive early disease pathology - News

A new study by researchers from The Rockefeller University identifies one possible means for the drug's impact on patients.

www.rockefeller.edu

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Reposted by Dimitrios Davalos & Lab

Jaime Grutzendler @jgrutzendler.bsky.social · Jun 14

Happy to share our latest publication on subcellular myelin proteomics and structural changes in Alzheimer disease www.nature.com/articles/s41...

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Reposted by Dimitrios Davalos & Lab

Nature @nature.com · Jun 11

Massive telescope will map the Universe and provide an evolving record of the Solar System and distant stars.

https://go.nature.com/3HvKM4r

Major telescope hosts world's largest digital camera: how it will transform astronomy

Massive telescope will map the Universe and provide an evolving record of the Solar System and distant stars.

go.nature.com

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Reposted by Dimitrios Davalos & Lab

Nature @nature.com · Jun 11

A man with a severe speech disability is able to speak expressively and sing using a brain implant that translates his neural activity into words almost instantly.

https://go.nature.com/4dV6avS

World first: brain implant lets man speak with expression ― and sing

Device translates thought to speech in real time.

go.nature.com

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Dimitrios Davalos & Lab @davalos.bsky.social · May 25

That is the hope, but it remains to be seen. We share some thoughts about that in the discussion of the paper if you would like to take a look.

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Dimitrios Davalos & Lab @davalos.bsky.social · May 21

Thanks Kelsey! Teamwork makes the dream work! And having spent a few years thinking about the science, makes you “see” things in your head… 🤓

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Dimitrios Davalos & Lab @davalos.bsky.social · May 21

Emma Vidal brought our concept to life.
For more info about the science produced in the @chopralab.bsky.social and ours, that inspired our geeky idea, please read the paper here: www.cell.com/immunity/abs...

Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease

Why microglia stop reducing amyloid deposits from Alzheimer’s disease (AD) brains is unknown. Prakash, Manchanda, et al. show that microglia increase their lipid droplets and lose their phagocytic cap...

www.cell.com

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Dimitrios Davalos & Lab @davalos.bsky.social · May 21

But blocking or reducing DGAT2 (using a cool new drug developed by @chopralab.bsky.social ) restores microglial phagocytosis of Aβ and thereby reduces plaque load and neuronal damage in a preclinical model of #Alzheimer’sDisease

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Dimitrios Davalos & Lab @davalos.bsky.social · May 21

Microglia are the brain’s resident immune cells & natural phagocytes, but they stop reducing amyloid deposits from Alzheimer’s disease brains for unknown reasons. We found that microglia increase their lipid droplets and lose their phagocytic capacity with increasing Aβ exposure from amyloid plaques

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Dimitrios Davalos & Lab @davalos.bsky.social · May 21

Microglia: A super-heroine that had a DGAT2-blocking beverage (cans) so she could break the chains from lipid droplets holding her back (LD weights) and lift the amyloid load (beams) that trapped the neurons, thereby rescuing them in the aged Brain (City sign)! #NotTheCover @cp-immunity.bsky.social

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Dimitrios Davalos & Lab @davalos.bsky.social · May 19

It was fantastic to work with you, Palak and the rest of the Chopra group @pryprk.bsky.social !

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Reposted by Dimitrios Davalos & Lab

Priya Prakash @pryprk.bsky.social · May 19

Happy to share that our work "Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease" is out now @cp-immunity.bsky.social! ➡️ www.cell.com/immunity/ful...

Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease

Why microglia stop reducing amyloid deposits from Alzheimer’s disease (AD) brains is unknown. Prakash, Manchanda, et al. show that microglia increase their lipid droplets and lose their phagocytic cap...

www.cell.com

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Dimitrios Davalos & Lab @davalos.bsky.social · May 19

Tremendously grateful to an amazing team of lab members and collaborators including @pryprk.bsky.social , @evipaouri.bsky.social , Palak Manchanda and Gaurav Chopra and pretty much all Chopra and Davalos Lab members for the smooth teamwork @clevelandclinic.bsky.social @purdueuniversity.bsky.social

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Dimitrios Davalos & Lab @davalos.bsky.social · May 19

Why do the brain’s professional phagocytes stop clearing amyloid in Alzheimer’s disease? Can we restore microglial superpowers & rescue dying neurons in AD? YES, by stopping DGAT2-mediated lipid droplet formation! Checkout our latest manuscript @cp-immunity.bsky.social 👇🏼
www.cell.com/immunity/abs...

Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease

Why microglia stop reducing amyloid deposits from Alzheimer’s disease (AD) brains is unknown. Prakash, Manchanda, et al. show that microglia increase their lipid droplets and lose their phagocytic cap...

www.cell.com

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Reposted by Dimitrios Davalos & Lab

Immunity @cp-immunity.bsky.social · May 5

Check out our special collection on #neuroimmunology that is online now! www.cell.com/immuni/newar... #AAI2025

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Dimitrios Davalos & Lab @davalos.bsky.social · May 3

Beautiful work by @lukensjohnr.bsky.social and team out @cp-immunity.bsky.social! Congratulations to all!

John Lukens @lukensjohnr.bsky.social · May 3

Excited to share our new work demonstrating a role for astrocytic inflammasome signaling in modulating hippocampal plasticity. @cp-immunity.bsky.social
All credit to Kristine Zengeler, who was the brains🧠 and muscle💪 behind this project and is a wonderful collaborator. www.cell.com/immunity/ful...

Inflammasome signaling in astrocytes modulates hippocampal plasticity

The function of immune pathways in homeostatic neurobiology remains underexplored. Zengeler et al. find that the inflammasome complex, typically associated with immune responses, is involved in memory...

www.cell.com

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Reposted by Dimitrios Davalos & Lab

isfp-official.bsky.social @isfp-official.bsky.social · Apr 17

Also announcing our upcoming ISFP joint congress with IFRS and the Plasminogen Activation Workshop in Corfu, Sep 28, 2025! Abstract deadline has been extended! Please join the ISFP membership to ensure your registration (includes room & board) discount! ifrs-isfpcongress2025.org

IFRS-ISFP Congress 2025 in Corfu – Register Now!

Join top researchers in fibrinolysis and proteolysis. Register now for Corfu, Sept 28–Oct 2, 2025!

ifrs-isfpcongress2025.org

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