banner
dwendscheck.bsky.social
Daniel Wendscheck
@dwendscheck.bsky.social
790 followers 1K following 71 posts
PhD student (close to finish!) at the University Würzburg. Likes to play with structure prediction tools, Crosslinking-MS, Native MS and bicycles. Proud of DOI:10.1073/pnas.2009502117 and DOI:10.1101/2024.04.30.591961 #TeamMassSpec #phdlife #peroxisomes
Posts Media Videos Starter Packs
Pinned
dwendscheck.bsky.social
Daniel Wendscheck @dwendscheck.bsky.social · Dec 22
Post-Doc Position WANTED⚡️
I'll finish my PhD work within the next few month and started to sort out where to continue doing exciting science. Any recommendations & suggestions are welcome🙏 More information on my scientific background and ideas for the future below 🧵 reskeet very much appreciated!
1 6 12
dwendscheck.bsky.social
Daniel Wendscheck @dwendscheck.bsky.social · 8d
"That's one small step for [a] man, one giant leap for #peroxisome research" Yesterday I finally submitted my PhD thesis @uni-wuerzburg.de ! Thanks to everyone involved from the @warscheidlab.bsky.social and others and very much looking forward to the defense 🛡⚔️ #proteomics #TeamMassSpec #PhDlife
1 8
Reposted by Daniel Wendscheck
frezzalab.bsky.social
Christian Frezza @frezzalab.bsky.social · 21d
Peroxisomal metabolism of branched fatty acids regulates energy homeostasis

www.nature.com/articles/s41...
Peroxisomal metabolism of branched fatty acids regulates energy homeostasis - Nature
A UCP1-independent mechanism of thermogenesis involving ATP-consuming metabolism of monomethyl branched-chain fatty acids in peroxisomes is described and a previously unrecognized role for peroxisomes...
www.nature.com
12 23
Reposted by Daniel Wendscheck
stephanieaw.bsky.social
Stephanie Wankowicz @stephanieaw.bsky.social · 27d
Structural bioinformatics is incredibly powerful on its own or when paired with theory or experiment. One of the PDB's superpowers isn’t from one structure, but comparing many to uncover folds, binding sites, and subtle conformational shifts. chemrxiv.org/engage/chemr...
10 Rules for a Structural Bioinformatic Analysis
The Protein Data Bank (PDB) is one of the richest open‑source repositories in biology, housing over 277,000 macromolecular structural models alongside much of the experimental data that underpins thes...
chemrxiv.org
1 15 54
Reposted by Daniel Wendscheck
matthiaswilmanns.bsky.social
Matthias Wilmanns @matthiaswilmanns.bsky.social · Sep 3
We are excited to share our latest work, where we unravel the structural and functional secrets of the once-mysterious protein Pex8 revealing how it controls the peroxisomal cargo import receptor Pex5.

Read more here: www.biorxiv.org/content/10.1101/2025.08.30.673231v1
Ensemble model of the full length Pex5 receptor (different blue color) in complex with Pex8 (green colors). Key Findings: Pex8 binds to a novel site on the mostly unfolded N-terminal region of the Pex5 receptor. This interaction is essential for peroxisomal protein import. Computational modelling reveals the formation of an assembly with the trimeric peroxisomal E3-ubiquitin ligase. We propose that this action positions the Pex5 receptor for its recycling, a step essential for the entire protein import process. Why this matters: Peroxisomes rely entirely on the import of folded proteins to function. Impaired peroxisome function is linked to severe disorders, and recent data show their crucial roles in carcinogenesis and the immune response. Our work elevates Pex8 from an enigma to a central player in this critical biological process. Read the full story and see the structures here: https://www.biorxiv.org/content/10.1101/2025.08.30.673231v1 #CellBiology #StructuralBiology #Peroxisome #ProteinImport #bioRxiv #Biochemistry
1 6 18
dwendscheck.bsky.social
Daniel Wendscheck @dwendscheck.bsky.social · Aug 7
Thanks "loading" Lorenz! 🙏
1
dwendscheck.bsky.social
Daniel Wendscheck @dwendscheck.bsky.social · Jul 31
Thank you Ralph for your warm words and this fantastic wrap-up of our work. As an ECR I can only guess that such productive and regardful colabs are an exception rather than the rule 🙏
1 2
dwendscheck.bsky.social
Daniel Wendscheck @dwendscheck.bsky.social · Jul 31
Thank you Walter for your generous words🙏
The project was really fun and fueled my interest for basic research🤩
1
dwendscheck.bsky.social
Daniel Wendscheck @dwendscheck.bsky.social · Jul 30
Major part of my PhD thesis is finally online! Thanks to everyone involved 🙏 @walterwchen.bsky.social @rjdlab.bsky.social @tmoeckli.bsky.social @hirakdas.bsky.social and the entire @warscheidlab.bsky.social #peroxisomes #Massspec #proteomics
uni-wuerzburg.de
Julius-Maximilians-Universität Würzburg @uni-wuerzburg.de · Jul 30
#Biochemistry: #PEX39, a newly discovered #peroxin protein, transports enzymes into #peroxisomes like a relay racer. New paper @natcellbio.nature.com – congratulations to @dwendscheck.bsky.social @warscheidlab.bsky.social et al!
➡️ www.uni-wuerzburg.de/en/news-and-...
Like a relay racer: The protein PEX39 (purple) carries enzymes (yellow) like a baton to the peroxisomes. There, the cargo is transported through the membrane by another PEX protein. (Image: Daniel Wendscheck / University of Würzburg)
3 3 12
Reposted by Daniel Wendscheck
kmichie.bsky.social
Kate Michie @kmichie.bsky.social · Jul 24
🧬🧶
chimerax.ucsf.edu
ChimeraX @chimerax.ucsf.edu · Jul 24
ChimeraX daily builds can predict binding affinity of small molecules using Boltz 2 on your Mac, Windows or Linux computer. www.rbvi.ucsf.edu/chimerax/dat...
6 19
Reposted by Daniel Wendscheck
oceanfilly.bsky.social
Brooke Fitzwater, PhD (she/her) 🐟🪱🏳️‍🌈♾️ @oceanfilly.bsky.social · Jul 18
As Requested - A Starter Pack of PIs in Biology (or adjacent) fields who are recruiting POSTDOCS! Please don't hesitate to reach out if you wish to be added! go.bsky.app/4gbXXR3
15 79 120
Reposted by Daniel Wendscheck
pastelbio.bsky.social
PastelBio @pastelbio.bsky.social · Jul 18
CryoEM-enabled visual proteomics reveals de novo structures of oligomeric protein complexes www.cell.com/structu...

---
#proteomics #prot-paper
2 5
dwendscheck.bsky.social
Daniel Wendscheck @dwendscheck.bsky.social · Jul 17
www.arte.tv/en/videos/11...

Highly recommended ☝️ so far undisclosed video material embedded in insightful interviews!
Antonov - The World's Largest Aircraft - Watch the full documentary | ARTE in English
The Antonov AN-225 Mriya, the world's largest cargo plane and the pride of Ukraine, was destroyed in a Russian attack on Hostomel airport near Kyiv at the beginning of the invasion in 2022. With exclu...
www.arte.tv
3 10
Reposted by Daniel Wendscheck
smhsci.bsky.social
Stella Hurtley @smhsci.bsky.social · Jul 10
Organelles share the load | Science www.science.org/doi/10.1126/...
Organelles share the load
Peroxisome-mitochondria contact sites manage mitochondrial oxidative stress
www.science.org
3 5
Reposted by Daniel Wendscheck
walterwchen.bsky.social
Walter W. Chen, MD, PhD @walterwchen.bsky.social · Jul 9
Excited to receive an NIH K08 Clinical Investigator Award to support my research on #mitochondria #peroxisomes 😀 The $775K will be critical in helping me transition to independence as I begin looking for a place to start my lab 🙏🏻 @the-asci.bsky.social
5 3 52
Reposted by Daniel Wendscheck
cri-utsw.bsky.social
Children's Research Institute at UT Southwestern @cri-utsw.bsky.social · Jun 27
Today in @dallasnews.com by @sodendritic.bsky.social: "Dallas researchers find cancer’s secret weapon to defeat death" ⬇️ read more www.dallasnews.com/news/2025/06...
🧪 #relentlessdiscovery @rjdlab.bsky.social
Dallas researchers find cancer’s secret weapon to defeat death
Cancers use lipids to build a shield with vitamin E. Stripping that shield could lead to new treatments.
www.dallasnews.com
6 7
Reposted by Daniel Wendscheck
sinzandrea.bsky.social
Andrea Sinz 🧪 @sinzandrea.bsky.social · Jun 25
‼️ Job alert 🚨: I have an open 3-year postdoc position in my lab to develop novel crosslinking mass spectrometry workflows. 🧪🧪 So if you want to do cool stuff in protein MS, please apply ! ⬇️ Please RT
www.verwaltung.uni-halle.de/dezern3/Auss...

#Academicsky
#Chemsky
#teammassspec
www.verwaltung.uni-halle.de
27 32
Reposted by Daniel Wendscheck
edreesrashan.bsky.social
Eddie Rashan @edreesrashan.bsky.social · Jun 22
AND IT'S DONE! A 🧵 on our recent article now out in @natsmb.nature.com! Co-led with @abbybartlett.bsky.social, Pagliarini Lab, @judisimcox.bsky.social, we find ACAD10/11 are NOT like other acyl-CoA dehydrogenases and instead catabolize atypical lipids called 4-hydroxy acids 🤯 doi.org/10.1038/s415...
ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism - Nature Structural & Molecular Biology
Rashan, Bartlett and colleagues show that mammalian 4-hydroxy fatty acids are primarily catabolized by ACAD10 and ACAD11 (atypical mitochondrial and peroxisomal acyl-CoA dehydrogenases, respectively) ...
doi.org
2 18 33
Reposted by Daniel Wendscheck
luisams.bsky.social
Luisa M.S. @luisams.bsky.social · Jun 18
I am already excited for my talk later, where I have the honor to present my PhD Thesis. Are you at #EuPA2025? Then join the award session and refresh your knowledge about #muscle #proteomics!
2 4 22
Reposted by Daniel Wendscheck
legal-alien-nyc.bsky.social
Legal Alien in NYC, so far @legal-alien-nyc.bsky.social · Jun 17
Spitzenforschung wird immer mehr mit einem Leistungssport gleichgesetzt, keinem Mannschaftssport, keine Teamveranstaltung
Der Spitzenforscher wird glorifiziert, die notwendige Vorarbeit die von Dutzenden anderen Forschenden geleistet wird, wird ausgeblendet und herabgewürdigt
amreibahr.bsky.social
Amrei Bahr @amreibahr.bsky.social · Jun 17
Sie ist überall: die Rede vom #Spitzenforscher. Nur: Was soll das überhaupt sein? Über einen Begriff, der das Gros der Wissenschaftler_innen als zweitklassig degradiert & einem Geniekult zuarbeitet, der der Arbeitsrealität in der Wissenschaft weder angemessen noch zuträglich ist. ⬇️ #ArbeitInDerWiss
Keine Spitze ohne Berg: Zum Begriff des „Spitzenforschers“
Der Begriff des Spitzenforschers degradiert das Gros der Wissenschaftler_innen als zweitklassig und stützt einen Geniekult, der der Arbeitsrealität in der Wissenschaft weder angemessen noch zuträglich...
arbeitinderwissenschaft.substack.com
3 8 33
Reposted by Daniel Wendscheck
amreibahr.bsky.social
Amrei Bahr @amreibahr.bsky.social · Jun 16
📺 #IchBinHanna​-Community: Ihr werdet gesucht für 1 TV-Format! Die Anfrage:

„Für eine Dokumentation für den Öffentlich-rechtlichen Rundfunk suchen wir Wissenschaftler*innen ohne Lebenszeitprofessur, die bereit wären, mit uns über ihre Erfahrungen mit dem dt. Wissenschaftssystem zu sprechen:

(1/3)
1 56 62
Reposted by Daniel Wendscheck
maccoss.bsky.social
Michael MacCoss @maccoss.bsky.social · Jun 16
Excited to see this published! It is a good step in the process for people to assess their FDR control in proteomics experiments. Great work from @bo-wen.bsky.social and @urikeich.bsky.social in particular who drove this.
natmethods.nature.com
Nature Methods @natmethods.nature.com · Jun 16
Assessing error control is fundamental in mass spectrometry-based proteomics. @bo-wen.bsky.social @maccoss.bsky.social @urikeich.bsky.social et al introduce a theoretical foundation for entrapment along with a method for more accurate evaluation of FDR control.
www.nature.com/articles/s41...
Assessment of false discovery rate control in tandem mass spectrometry analysis using entrapment - Nature Methods
A theoretical foundation for entrapment methods is presented, along with a method that enables more accurate evaluation of false discovery rate (FDR) control in proteomics mass spectrometry analysis p...
www.nature.com
1 9 41
dwendscheck.bsky.social
Daniel Wendscheck @dwendscheck.bsky.social · Jun 12
I like your humor #microsoft Word! Preparing the list of abbreviations for my #PhD thesis #PhDlife #proteomics
MS Word suggests to use more consice language by abrreviating RING with "interesting new gene" instead of "really interesting new gene"
3
dwendscheck.bsky.social
Daniel Wendscheck @dwendscheck.bsky.social · Jun 6
en.m.wikipedia.org/wiki/Nikolai...
Nikolai Yezhov - Wikipedia
en.m.wikipedia.org
9
Reposted by Daniel Wendscheck
maccoss.bsky.social
Michael MacCoss @maccoss.bsky.social · Jun 1
New Preprint ... This was a bit different of a project than what we normally do for hardware comparisons. I think there is a lot of potential in the methods mentioned here for calibrating the instrument response to a common scale. Nice work by @chrhsu.bsky.social!

www.biorxiv.org/content/10.1...
Evaluation of an Orbitrap Astral Zoom mass spectrometer prototype for quantitative proteomics - beyond identification lists
Mass spectrometry instrumentation continues to evolve rapidly, yet quantifying these advances beyond conventional peptide and protein detections remains challenging. Here, we evaluate a modified Orbit...
www.biorxiv.org
4 15 39
Reposted by Daniel Wendscheck
ksdrew.bsky.social
Kevin Drew @ksdrew.bsky.social · May 29
Very excited that our work describing hu.MAP3.0 is published in @molsystbiol.org. Here we use machine learning to integrate >25k mass spectrometry experiments to place ~70% of human proteins into 15k protein complexes.

www.embopress.org/doi/full/10....
hu.MAP3.0: atlas of human protein complexes by integration of >25,000 proteomic experiments | Molecular Systems Biology
imageimagehu.MAP3.0 integrates mass spectrometry experiments to identify human protein complexes. Using this resource, this study characterizes covariation of complexes, identifies mutually exclusive ...
www.embopress.org
3 28 53