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Reposted by Geoff Faulkner

Miguel Branco @brancolab.bsky.social · 13d

Another neurodegenerative disease caused by an SVA insertion. Not intron retention as seen in XPD, but aberrant splicing.

Deep Intronic SVA_E Insertion Identified as the Most Common Pathogenic Variant Associated With Canavan Disease | Neurology Genetics

Background and ObjectivesCanavan disease (CD) is a neurodegenerative disorder in which biallelic pathogenic variants in ASPA result in spongiform degeneration of the cerebral white matter, leading to ...

www.neurology.org

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Geoff Faulkner @faulknerlab.bsky.social · 13d

Very interesting! It seems like there's a lot of these pathogenic SVAs out there that have been overlooked for various reasons.

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Geoff Faulkner @faulknerlab.bsky.social · 16d

Congrats Marco!

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Reposted by Geoff Faulkner

Marco Trizzino @marcotrizzino.bsky.social · 16d

Our study on the role of LTR5HS and SVAs in regulation of human neural crest migration is now published as peer-reviewed paper on @molsystbiol.org!
Congrats to first author brilliant postdoc Laura Deelen, and all the authors involved! @imperialsci.bsky.social
www.embopress.org/doi/full/10....

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Reposted by Geoff Faulkner

Transposon and Cancer Epigenetics Group @deniz-lab.bsky.social · Sep 3

Our new review is out in Trends in Cancer. We had fund writing this :) We discuss the roles of retrotransposons in immune modulation in normal and malignant
hematopoiesis. www.cell.com/trends/cance...

Reawakening retrotransposons: immune modulation in normal and malignant hematopoiesis

Retrotransposons are mobile repetitive elements that constitute around 43% of the human genome. Normally silenced through epigenetic mechanisms, retrotransposons can become reactivated in response to ...

www.cell.com

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Reposted by Geoff Faulkner

Karolinska Institutet @ki.se · Jun 25

Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential.
🔗 All positions: ki.se/en/about-ki/...

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Reposted by Geoff Faulkner

Johan Jakobsson @jakobssonlab.bsky.social · Aug 23

New paper from our lab! We found that LINE-1 transposons contribute to early human brain development.

Funded by @asapresearch.parkinsonsroadmap.org

www.cell.com/cell-genomic...

LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development

Adami et al. demonstrate that evolutionarily young L1s are expressed in human pluripotent stem cells and are dynamically regulated throughout neural differentiation. The study examines the role of L1s...

www.cell.com

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Reposted by Geoff Faulkner

Miguel Branco @brancolab.bsky.social · Aug 22

New paper from Bin Cao, showing that placenta-specific KO of ADAR1 is embryonic lethal.

ADAR1 as a Placental Innate Immune Rheostat Sustaining the Homeostatic Balance of Intrinsic Interferon Response at the Maternal‐Fetal Interface

This study reveals that ADAR1, an RNA-editing enzyme, fine-tunes immune responses in the placenta by preventing the accumulation of immunogenic double-stranded RNAs (dsRNAs) from interferon-stimulate...

advanced.onlinelibrary.wiley.com

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Reposted by Geoff Faulkner

Marco Trizzino @marcotrizzino.bsky.social · Aug 20

This preprint is now a published peer-reviewed paper! Thanks to all the co-authors involved, to the funders and to @reviewcommons.org and @embopress.org @emboreports.org for a smooth editorial process! Excited to see this in press! www.embopress.org/doi/full/10....

@imperiallifesci.bsky.social

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Reposted by Geoff Faulkner

Liana Lareau @lianafaye.bsky.social · Aug 7

At the same time, we made thousands of synonymous mutations in endogenous yeast genes and measured their growth. We used careful statistics and controls. Only 3%, 204 of 6874, had a fitness effect! This goes against a controversial recent result that most synonymous mutations had fitness effects.

Scatterplot showing fitness effect of ~7000 synonymous mutations in yeast: read count at start vs log2 fold change. Most data points are not significant but 204 points are significant outliers, either advantageous or deleterious.

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Reposted by Geoff Faulkner

Maxim Greenberg @maxvcg.bsky.social · Aug 9

I believe that over the past ~ two decades, since the breakthrough papers on UHRF1, this is the first reported DNA methylation phenotype of its close paralog, UHRF2 (and not for lack of trying). Congrats to Ambre Bender and Michael Weber on this fantastic study! www.nature.com/articles/s41...

UHRF2 mediates resistance to DNA methylation reprogramming in primordial germ cells - Nature Communications

DNA methylation in mouse primordial germ cells (PGCs) is restricted to transposable elements, but how this unique DNA methylome is established is poorly understood. Here, the authors identify UHRF2 as...

www.nature.com

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Geoff Faulkner @faulknerlab.bsky.social · Aug 7

Thanks for visiting!

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Reposted by Geoff Faulkner

Julius Brennecke @juliusbrennecke.bsky.social · Jul 29

last call!
submit your abstract by tonight to be selected for one of the many oral presentations at the leading European Transposon Meeting. We are very much looking forward to your contribution and attendance!

EMBL Events @events.embl.org · Jun 18

⏰ Abstract deadline for 'The mobile genome' is 29 July!

👉 https://s.embl.org/mge25-01-bl

Join us 4–7 Nov 2025 at EMBL Heidelberg (or online) to explore the impact of TEs across biology. 🧬🔍

⭐🧑🏼‍🔬 24 talks + 15 flash talks from posters – don't miss out!

#EMBOMobileGenome

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Reposted by Geoff Faulkner

Guillaume Bourque @guilbourque.bsky.social · Jul 21

Is the annotation of viruses in the human genome accurate? We think not. Take a look at our new paper and let us know if you agree! www.science.org/doi/10.1126/...

A phylogenetic approach uncovers cryptic endogenous retrovirus subfamilies in the primate lineage

A phylogenetic approach reveals cryptic LTR subfamilies and functional insights at nucleotide resolution in primates.

www.science.org

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Reposted by Geoff Faulkner

Ed Chuong @edchuong.bsky.social · Jul 17

Are you bravely deciding to do a postdoc in the US? And also interested in some combination of genomics, immunology, and transposons? If so, consider applying to my lab at the BioFrontiers Institute in Boulder, Colorado!

jobs.colorado.edu/jobs/JobDeta...

🧪🧬 #TESky #interferosky

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Reposted by Geoff Faulkner

Ryan Lister @ryanlister.bsky.social · Jul 16

We're hiring! Need a microscopy wizard to help build the world’s first synthetic plant chromosome! Bring your lights, lasers, & lens-craft to characterise new artificial chromosomes. Join our ARIA-funded project at UWA in Perth & ‪@plants4space.bsky.social‬. Apply: bit.ly/3GKSRSA

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Reposted by Geoff Faulkner

Rebecca Berrens @rberrens.bsky.social · Jul 16

Very happy to share our protocols paper for CELLO-seq. This will make single cell long read RNA-seq more accessible and provides analysis guidelines. We hope this helps the #transposon #TEsky community and folks working on #singleCell isoform and allelic #gene expression. doi.org/10.1038/s415...

Long-read RNA sequencing of transposable elements from single cells using CELLO-seq - Nature Protocols

Single-cell long-read RNA sequencing enables the high-fidelity mapping of single-cell expression data from highly sequence-similar transposable elements to unique genomic loci by correcting errors fro...

doi.org

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Reposted by Geoff Faulkner

Julius Brennecke @juliusbrennecke.bsky.social · Jul 16

Pls. share widely

Calling all transposon fans & lovers of genetic innovation

MOBILE GENOME welcomes you in Heidelberg, Nov. 4–7 2025

→ Vibrant & friendly community
→ Cutting-edge talks from mechanisms to physiology
→ Plenty of surprises (TEs never stop innovating)

submit abstract by July 29

EMBL Events @events.embl.org · Jun 18

⏰ Abstract deadline for 'The mobile genome' is 29 July!

👉 https://s.embl.org/mge25-01-bl

Join us 4–7 Nov 2025 at EMBL Heidelberg (or online) to explore the impact of TEs across biology. 🧬🔍

⭐🧑🏼‍🔬 24 talks + 15 flash talks from posters – don't miss out!

#EMBOMobileGenome

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Reposted by Geoff Faulkner

Deborah Bourc’his @deborahbourchis.bsky.social · Jul 15

Exactly two weeks left to submit your abstract to the EMBO Mobile Genome Workshop.
☝️this year we will select from abstracts 2 “long” talks to highlight last minute breakthrough from early career scientists. Apply! July 29th

EMBL Events @events.embl.org · Jun 18

⏰ Abstract deadline for 'The mobile genome' is 29 July!

👉 https://s.embl.org/mge25-01-bl

Join us 4–7 Nov 2025 at EMBL Heidelberg (or online) to explore the impact of TEs across biology. 🧬🔍

⭐🧑🏼‍🔬 24 talks + 15 flash talks from posters – don't miss out!

#EMBOMobileGenome

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Reposted by Geoff Faulkner

Gael Cristofari @retrogenomics.bsky.social · Jul 11

🦟 Bioinformatics Research Scientist position open in my lab in Nice (FR) to study Aedes mosquito retrotransposons & their interactions with arboviruses collab w/ @salehlabparis.bsky.social & @lambrechtslab.bsky.social
Apply: euraxess.ec.europa.eu/jobs/359830
Please boost! #ArboRetro #Bioinformatics

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Reposted by Geoff Faulkner

Danielle Bianchi @daaninthelab.bsky.social · Jul 4

In today’s publication in Science we introduce Zincore: a novel protein of QRICH1 and SEPHS1 and functions as a transcriptional coregulator dedicated to zinc finger transcription factors. Here’s how we found it: 🧵 www.science.org/doi/10.1126/... 1/11

Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression

Zinc finger proteins (ZNFs) are the largest family of transcription factors, yet how they activate gene expression remains unclear. In this study, we identified Zincore, a protein complex consisting o...

www.science.org

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Reposted by Geoff Faulkner

Nadia Davidson @nadia-davidson.bsky.social · Jul 1

Researchers, if you have career disruptions e.g. parental leave 👶, and would like a simple way to calculate full-time equivalent (FTE) years you might like our new calculator, eramezani.github.io/career/ - Written by @eramezani.bsky.social‬ 🙌. Feel free to share around.

NHMRC Investigator Grant Career Disruption Calculator

Free online calculator for NHMRC Investigator Grant applications. Calculate FTE years and document career disruptions.

eramezani.github.io

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Reposted by Geoff Faulkner

Tugce Aktas @aktast.bsky.social · Jun 30

We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease.
www.nature.com/articles/s41...

Transcriptional and post-transcriptional regulation of transposable elements and their roles in development and disease - Nature Reviews Molecular Cell Biology

Transposable elements (TEs) comprise nearly half of the human genome. This Review discusses transcriptional and post-transcriptional mechanisms that repress TE activity, how TEs escape this suppressio...

www.nature.com

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Reposted by Geoff Faulkner

Mathew Kiang @mathewkiang.com · Jun 25

Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages.

ki.se/en/about-ki/...

Call for 20 Assistant Professor positions

Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...

ki.se

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Reposted by Geoff Faulkner

Kasia Siudeja @ksiudeja.bsky.social · Jun 18

Happy that our preprint from early this year, uncovering the regulation a somatically "hot" endogenous retroelement locus, has now found its home in @narjournal.bsky.social.
"TEsky"
doi.org/10.1093/nar/...

An endogenous retroviral element co-opts an upstream regulatory sequence to achieve somatic expression and mobility

Abstract. Retrotransposons, multi-copy sequences that propagate via copy-and-paste mechanisms, occupy large portions of eukaryotic genomes. A great majorit

doi.org

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