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Reposted by Gemma Noviello

Max Planck Institute for Molecular Genetics @molgen.mpg.de · Aug 1

🧬 New study from the Kinkley Lab! 🧬 In collaboration with the Vingron and Hnisz labs at the MPIMG the team has gained new insights how the epigenetic reader PHF13 regulates it´s affinity to bind to chromatin.
Read more: www.molgen.mpg.de/2025-07-28-o...
Congrats to first author Francesca Rossi!

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Gemma Noviello @gemnov.bsky.social · 2d

Happy to see this insightful and rigorous work published in its final form! Congrats to all authors and in particular to super hard-working first author @tschwammle.bsky.social and to @eddaschulz.bsky.social for the brilliant guidance.

Edda Schulz @eddaschulz.bsky.social · 2d

⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation.
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial

Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus - Nature Structural & Molecular Biology

Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.

www.nature.com

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Reposted by Gemma Noviello

Jamie Hackett @jamiehackett.bsky.social · 11d

❓Can a father’s environmental exposures before conception influence their offspring?

We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences

www.embopress.org/doi/full/10....

Embryonic signatures of intergenerational epigenetic inheritance across paternal environments and genetic backgrounds | The EMBO Journal

imageimagePaternal environmental exposures have been linked with modulation of phenotype and disease risk in offspring via largely unclear mechanisms. This study employs in vitro fertilization and sin...

www.embopress.org

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Gemma Noviello @gemnov.bsky.social · 11d

Pizza al taglio senza glutine. 😋 #Roma ci ama. #glutenfree #pizza

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Reposted by Gemma Noviello

Drug Monkey @drugmonkey.bsky.social · 12d

This may be the most important paper ever published about NIH funded research.

www.science.org/doi/10.1126/...

What if NIH had been 40% smaller?

Replaying history with less NIH funding shows widespread impacts on drug-linked research

www.science.org

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Reposted by Gemma Noviello

Luca Giorgetti lab @FMI @lucagiorgetti.bsky.social · 13d

Really excited to share our latest work led by @mattiaubertini.bsky.social and @nesslfy.bsky.social: we report that cohesin loop extrusion creates rare but long-lived encounters between genomic sequences which underlie efficient enhancer-promoter communication.
www.biorxiv.org/content/10.1...
A🧵👇

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Gemma Noviello @gemnov.bsky.social · 13d

Congrats to all authors! Will dive in the details soon as now I'm very curious.

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Reposted by Gemma Noviello

Granite Man @granitedhuine.bsky.social · 15d

A quick guide on "How to fall downstairs":

Step 1

Step 6

Step 8, 9, 10, 11.

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Reposted by Gemma Noviello

The Atlantic @theatlantic.com · 20d

Nobel laureate Jennifer Doudna tells Jeffrey Goldberg that vaccinations have been so successful that "there's been a collective forgetting that measles, and mumps, and rubella—these used to be diseases that would kill people in fairly large numbers." #TAF25 bit.ly/46a5DUE

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Julia Carrie Wong @joolia.bsky.social · 18d

this exists it is called thinking

Matthew McConaughey says he wants a private LLM, fed only with his books, notes, journals, and aspirations, so he can ask it questions and get answers based solely on that information, without any outside influence.

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Gemma Noviello @gemnov.bsky.social · 19d

Congrats!

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Gemma Noviello @gemnov.bsky.social · 20d

Beautiful story about chromatin modifiers orchestrating cell states by fine-tuning gene expression from @jzylicz.bsky.social lab. Congrats to all, especially 1st author Nikos Stamidis !

Jan Żylicz @jzylicz.bsky.social · 20d

Genes are not On/Off switches. In a new preprint we show that HDAC3 is key to establish correct transcriptional dose in development. Gr8 work from N. Stamidis @ucph.bsky.social and collab. @jamiehackett.bsky.social @gregersenlab.bsky.social . Huge thx to all authors! www.biorxiv.org/content/10.1...

HDAC3 prevents enhancer hyperactivation to enable developmental transitions

Dynamic gene regulation requires precise cooperation between transcription factors and chromatin modifiers at regulatory elements to achieve not only activation or repression, but also appropriate tra...

www.biorxiv.org

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Gemma Noviello @gemnov.bsky.social · 28d

A Bronx Tale, 1993

Reposted by Gemma Noviello

Elizabeth Picciuto @epicciuto.bsky.social · Sep 8

One of my kids thought I was making like a bad @theonion.com joke when I told him that their slogan used to be “don’t be evil” but then they got rid of it.

Dave Vetter @davidrvetter.bsky.social · Sep 8

ICYMI: Google removes net zero goal from website.

Google quietly removes net-zero carbon goal from website amid rapid power-hungry AI data center buildout — industry-first sustainability pledge moved to background amidst AI energy crisis

Google's goal to be net-zero in carbon emissions by 2030 is still apparently company policy, it's just not broadcasting it anymore

www.tomshardware.com

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Gemma Noviello @gemnov.bsky.social · Sep 5

Congrats Juliane! You rock! 🎉🔥💪🏽

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Gemma Noviello @gemnov.bsky.social · Sep 4

Congrats to all winners! A quick consideration as 🇮🇹 researcher. Italians get 11,5% of all StG (55/478, 2nd top after DE): Italian scientists are top level! Italy itself gets 6.2% of all grants (30/378, jumping to 7th after DE, UK, NL, FR, CH, BE). Italy, why do you like to seed but not to harvest?

European Research Council (ERC) @erc.europa.eu · Sep 4

📣 The ERC Starting Grant call results are out!

Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!

➡️ buff.ly/IsafuFh

#FrontierResearch 🇪🇺#EUfunded #HorizonEurope

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Reposted by Gemma Noviello

EMBL @embl.org · Sep 1

📢 Recruitment for the EMBL International PhD Programme is officially open!

At EMBL, we train young scientists to become skilled and creative future leaders in academia and other sectors. Join us and get a head start on your career in life sciences!

bit.ly/47mmiFF

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Reposted by Gemma Noviello

Brent Toderian @brenttoderian.bsky.social · Aug 29

“Over the past 20 years, Paris has undergone a major physical transformation, trading automotive arteries for bike lanes, adding green spaces and eliminating 50,000 parking spaces.

Part of the payoff has been invisible — in the air itself.”

Leadership, strategy, real action, common sense. #Paris

Paris said au revoir to cars. Air pollution maps reveal a dramatic change.

Air pollution fell substantially as the city restricted car traffic and made way for parks and bike lanes.

www.washingtonpost.com

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Gautam Dey @gautamdey.bsky.social · Aug 27

Final year PhD students, I know you’re desperately trying to finish experiments/revisions/submissions/write a thesis & just survive - but please spare a few minutes to apply to your dream postdoc labs.

It easily takes A YEAR from first contact, even if everything goes to plan on both sides.

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Gemma Noviello @gemnov.bsky.social · Aug 25

Congrats Julia! That's fantastic news 🎉

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Reposted by Gemma Noviello

Elphege Nora Lab at UCSF @elphegenoralab.bsky.social · Aug 16

New preprint with @gfudenberg.bsky.social

We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding.

This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇

www.biorxiv.org/content/10.1...

NIPBL dosage shapes genome folding by tuning the rate of cohesin loop extrusion

Cohesin loop extrusion is a major driver of chromosome folding, but how its dynamics are controlled to shape the genome remains elusive. Here we disentangle the contributions of the cohesin cofactors ...

www.biorxiv.org

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Reposted by Gemma Noviello

Sean Carroll @seanmcarroll.bsky.social · Aug 12

I mean, it's nice to have a Wikipedia page. Even nicer to have a Wikipedia page devoted to something named after you. But it's hard to beat a Wikipedia page devoted to simply *listing* things that are named after you.

en.wikipedia.org/wiki/List_of...

List of things named after Enrico Fermi - Wikipedia

en.wikipedia.org

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Reposted by Gemma Noviello

Dr Sian Gramates @drglam.bsky.social · Aug 11

I just got the notice that all the FlyBase people at Harvard, including me, will be laid off on October 12. I'm devastated.

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Reposted by Gemma Noviello

Barbara Marte @barbmarte.bsky.social · Aug 8

new out in Nature www.nature.com/articles/s41...

NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers - Nature

A highly potent and selective small-molecule catalytic inhibitor of the protein lysine methyltransferase NSD2 shows therapeutic efficacy in preclinical models of KRAS-driven pancreatic cancer and...

www.nature.com

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Gemma Noviello @gemnov.bsky.social · Aug 6

Thanks! Looking forward to hear opinions. I tried to be as simple as possible. I hope it didn't became too banal.