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Reposted by Holly Merta, PhD

Henne lab @hennelab.bsky.social · 27d

A pleasure to write this short review on lipid droplets for
@jcb.org together with Will Prinz and amazing artist Emma Reynolds!

We discuss 5 pervasive questions surrounding these remarkable little lipid organelles.

doi.org/10.1083/jcb....

Lipid droplets: Open questions and conceptual advances around a unique organelle | Journal of Cell Biology | Rockefeller University Press

Henne and Prinz discuss the lipid droplet field and pervasive questions surrounding droplets and their roles in physiology and disease.

doi.org

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Reposted by Holly Merta, PhD

Journal of Cell Biology @jcb.org · 27d

New review: Henne (@hennelab.bsky.social), Reynolds, and Prinz discuss recent discoveries and enduring mysteries in the lipid droplet field. rupress.org/jcb/article/...

#Biochemistry #CellMetabolism #LipidDroplets

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Reposted by Holly Merta, PhD

Fran Bottanelli @franbottanelli.bsky.social · Aug 13

Our protocol for gene editing is online and all plasmids are on @addgene.bsky.social! CRISPR away everybody and get in touch if you need anything 🤩

STAR Protocols @cp-starprotocols.bsky.social · Aug 7

Protocol for fast antibiotic resistance-based gene editing of mammalian cells with CRISPR-Cas9 #protocol #starprotocols #cellpress

Protocol for fast antibiotic resistance-based gene editing of mammalian cells with CRISPR-Cas9

Protein tagging with CRISPR-Cas9 enables the investigation of protein function in its native environment but is limited by low homology-directed repair (HDR) efficiency. Here, we present a protocol for fast antibiotic resistance-based gene editing with CRISPR-Cas9 (FAB-CRISPR), which streamlines N/C-terminal tagging using an antibiotic resistance cassette for rapid selection and enrichment of gene-edited cells. We describe in detail guide RNA and HDR donor plasmid cloning, transfection of editin...

dlvr.it

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Reposted by Holly Merta, PhD

Journal of Cell Biology @jcb.org · Jul 22

Nodal modulator (NOMO) is a force-bearing transmembrane protein required for muscle differentiation, say Brigitte Naughton, Christian Schlieker @schliekerlab.bsky.social and colleagues @yaleschoolofmed.bsky.social: rupress.org/jcb/article/...

#StructuralBiology #Biochemistry #Organelles #Membrane

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Reposted by Holly Merta, PhD

Journal of Cell Biology @jcb.org · Jul 15

Naughton et al. @schliekerlab.bsky.social conducted force measurements within the endoplasmic reticulum (ER) measuring forces in the piconewton range uncovering a critical role for NOMO as force-bearing transmembrane protein that is critical for myogenesis. rupress.org/jcb/article/...

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Reposted by Holly Merta, PhD

Cell Biology J-Club @cellclub.bsky.social · Jul 15

Nodal modulator (NOMO) is a force-bearing transmembrane protein required for muscle differentiation url: rupress.org/jcb/article/...

Nodal modulator (NOMO) is a force-bearing transmembrane protein required for muscle differentiation | Journal of Cell Biology | Rockefeller University Press

Naughton et al. establish that the ER experiences forces in the piconewton range across the ER lumen and identify NOMO as a force-bearing transmembrane pro

rupress.org

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Reposted by Holly Merta, PhD

Henne lab @hennelab.bsky.social · May 19

We had a great kick-off of our Lipid Metabolism & Neurodegenerative Disease Mini-symposium! Many thanks to all speakers and attendees! #UTSW_science

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Reposted by Holly Merta, PhD

Rafeeque Mavoor @rafeeque.com · May 13

🧵5 Top Free Alternatives to BioRender for Scientific Illustrations!

These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.

Save and share the post!

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Holly Merta, PhD @hollymerta.bsky.social · Apr 7

I am excited to announce that my postdoc work in @hennelab.bsky.social is now online at Cell Reports! Congrats and thanks to all who helped us on this journey!

Henne lab @hennelab.bsky.social · Apr 7

Important to celebrate trainee victories: excited to have Holly Merta's @hollymerta.bsky.social paper out!

We use TurboID sub-organelle proteomics to map the ER network.

We find calmin/CLMN, an ER-to-actin tether regulating focal adhesions & cell motility.

www.sciencedirect.com/science/arti...

Spatial proteomics of ER tubules reveals CLMN, an ER-actin tether at focal adhesions that promotes cell migration

The endoplasmic reticulum (ER) is structurally and functionally diverse, yet how its functions are organized within morphological subdomains is incomp…

www.sciencedirect.com

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Reposted by Holly Merta, PhD

Henne lab @hennelab.bsky.social · Apr 7

Important to celebrate trainee victories: excited to have Holly Merta's @hollymerta.bsky.social paper out!

We use TurboID sub-organelle proteomics to map the ER network.

We find calmin/CLMN, an ER-to-actin tether regulating focal adhesions & cell motility.

www.sciencedirect.com/science/arti...

Spatial proteomics of ER tubules reveals CLMN, an ER-actin tether at focal adhesions that promotes cell migration

The endoplasmic reticulum (ER) is structurally and functionally diverse, yet how its functions are organized within morphological subdomains is incomp…

www.sciencedirect.com

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Reposted by Holly Merta, PhD

James Manton @jamesdmanton.bsky.social · Apr 1

Following a helpful and pleasant peer-review process, our direct-view oblique plane microscopy manuscript has now been published in Optica: doi.org/10.1364/OPTI...

Special thanks to the copy editor who let us keep our cheeky little acknowledgement of the enjoyableness of drinking a cup of tea.

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Reposted by Holly Merta, PhD

Jonathan Friedman @labfriedman.bsky.social · Feb 19

Some good news (and fresh science) to break things up! Our work identifying a subpopulation of compositionally unique mitochondria that localize to filopodia and promote cell migration is now @currentbiology.bsky.social! Led by fantastic @madeleinempavey.bsky.social!

www.cell.com/current-biol...

Compositionally unique mitochondria in filopodia support cellular migration

Marlar-Pavey et al. determine that a subpopulation of compositionally unique mitochondria, METEORs, dynamically localize to filopodia. Loss of mitochondrial targeting to filopodia correlates with a re...

www.cell.com

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Reposted by Holly Merta, PhD

Rachel Zwick @rkzwick.bsky.social · Feb 6

The Zwick lab has landed in the Regenerative Medicine Institute @NYU! I’m incredibly excited to build a team to study how epithelial organs are patterned and remodeled throughout life, with a major focus on the remarkable changes that occur in the maternal body during pregnancy..1/5

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Reposted by Holly Merta, PhD

Henne lab @hennelab.bsky.social · Feb 5

Want to follow developments in the field of inter-organelle communication? Follow Contact @contactctc.bsky.social and its latest publications!

Contact: The Journal of Inter-Organelle Communication @contactctc.bsky.social · Feb 5

Contact is here at last #firstpost. 2025 also sees us adding a strapline to our title. Instead of one pithy word, we have 5 more:

Contact: The Journal of Inter-Organelle Communication

We look forward to sharing new of progress in this scientific field in general and for the journal specifically.

Landing page for Contact: The Journal of Inter-Organelle Communication

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Reposted by Holly Merta, PhD

Jonathan Friedman @labfriedman.bsky.social · Jan 16

A big congrats to Alia on a successful thesis defense! @themitotracker.bsky.social gave an excellent talk and did the lab proud! 🥳🎉🍾

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Reposted by Holly Merta, PhD

Cristina Nuevo-Tapioles @cnuevotapioles.bsky.social · Jan 13

Applications are still open for the 2025 Leading Edge cohort! Deadline is Feb 3, 2025.

Leading Edge Fellows Program @leadingedgeprogram.bsky.social · Jan 6

Leading Edge is celebrating a milestone: 100 (actually 102!) new assistant professors!!! 🎉🥳🎊

Learn more about them:
www.leadingedgesymposium.org/fellows/

Applications are now open for the 2025 Leading Edge cohort! (Deadline Feb 3).

You do NOT need to be ready for the job market to apply.

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Reposted by Holly Merta, PhD

Uri Manor @manorlaboratory.bsky.social · Jan 7

Our collaboration with the Germain Lab is now out in its final form!

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Reposted by Holly Merta, PhD

Leading Edge Fellows Program @leadingedgeprogram.bsky.social · Jan 6

Leading Edge is celebrating a milestone: 100 (actually 102!) new assistant professors!!! 🎉🥳🎊

Learn more about them:
www.leadingedgesymposium.org/fellows/

Applications are now open for the 2025 Leading Edge cohort! (Deadline Feb 3).

You do NOT need to be ready for the job market to apply.

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Reposted by Holly Merta, PhD

Henne lab @hennelab.bsky.social · Jan 7

Happy to announce I am serving as Director of the Lipid Metabolism & Neurodegenerative Diseases (LMND) Program at UTSW. Our goal is to stimulate collaborations bridging lipid metabolism & neurological disease.
So proud of our lab & their cell biology adventures! #onward_science

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Holly Merta, PhD @hollymerta.bsky.social · Dec 16

If you are at #cellbio2024, please consider coming to the Membrane Contact Sites session tomorrow (12/16) at 5pm in room 29C! Many great talks planned! I will be presenting “Keep Calmin and Carry On: Tethering the ER to F-actin Enables Cell Migration” at 6. Hope to see you there!

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Reposted by Holly Merta, PhD

Alia Edington @themitotracker.bsky.social · Dec 15

Never found my school's 🦋, so I hope it's ok that I'm posting this myself. I'm presenting my poster today on characterizing internal mediators of mitochondrial fission at 11:15am at poster #B143! If you missed my #MitoTalks last month, please stop by! #CellBio24 #mitofission #microscopy

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Reposted by Holly Merta, PhD

Henne lab @hennelab.bsky.social · Dec 15

Beautiful day in sunny San Diego for ASCB #CellBio2024!

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Reposted by Holly Merta, PhD

Sarah Cohen @cohenlaboratory.bsky.social · Dec 11

Cohen lab will be well represented at #CellBio2024! If you love #Organelles, #MembraneContactSites, and/or #Neurons and #Astrocytes, please come say hello!

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Reposted by Holly Merta, PhD

Tim @timisstuck.bsky.social · Dec 9

A huge congratulations to the winner of JCB's Alan Hall award, Alia Edington from the Friedman lab at UTSW

And to the winner of our Norton B Gilula award, Justin Krish Williams from the Schekman lab at UC Berkeley!

rupress.org/jcb/pages/al...

Alan Hall and Norton B. Gilula Travel Awards | Journal of Cell Biology | Rockefeller University Press

Alan Hall and Norton B. Gilula Travel Awards | Journal of Cell Biology | Rockefeller University Press Alan Hall and Norton B. Gilula Awards To support the next generation of researcher...

rupress.org

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Reposted by Holly Merta, PhD

Jonathan Friedman @labfriedman.bsky.social · Dec 9

So proud of Alia Edington @themitotracker.bsky.social for winning the JCB Alan Hall Travel award to attend ASCB! Thank you @jcellbiol.bsky.social for recognizing the hard work of our trainees!

Be sure to check out Alia's talk 5pm Mon. in the organelle subgroup or at poster B143 Sun. 11:15!

Tim @timisstuck.bsky.social · Dec 9

A huge congratulations to the winner of JCB's Alan Hall award, Alia Edington from the Friedman lab at UTSW

And to the winner of our Norton B Gilula award, Justin Krish Williams from the Schekman lab at UC Berkeley!

rupress.org/jcb/pages/al...

Alan Hall and Norton B. Gilula Travel Awards | Journal of Cell Biology | Rockefeller University Press

Alan Hall and Norton B. Gilula Travel Awards | Journal of Cell Biology | Rockefeller University Press Alan Hall and Norton B. Gilula Awards To support the next generation of researcher...

rupress.org

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