Lightnews — Scholar-powered news

John De Vos @jdevos.bsky.social · 2h

It is with great sadness that I learned of the passing of Professor Sir John Gurdon, founder of the Gurdon Institute and a true visionary in developmental and stem cell biology.

www.cam.ac.uk/research/new...

Nobel Laureate Professor Sir John Gurdon dies aged 92

It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the Gurdon Institute.

www.cam.ac.uk

Reposted by John De Vos

Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 1d

Will chemists be happy tomorrow 🍾, or will they say, “Here we go again with biology” 😡 for the Nobel Prize in Chemistry? #chemnobel 😬

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Reposted by John De Vos

eLife @elife.bsky.social · 2d

1/ We’re delighted to hear that our Reviewing Editor, Shimon Sakaguchi, has been awarded the 2025 Nobel Prize in Physiology and Medicine today alongside colleagues Fred Ramsdell and Mary Brunkell: www.nobelprize.org

The official website of the Nobel Prize - NobelPrize.org

The Nobel Prize rewards science, humanism and peace efforts. This is one of the central concepts in the will of Alfred Nobel, and it also permeates the outreach activities that have been developed for...

www.nobelprize.org

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Reposted by John De Vos

Albert Vilella, PhD. @albertvilella.bsky.social · 2d

@rohanpaul.bsky.social , not active on #Bluesky, on the comparisons between the AI revolution and the dot-com bubble of the 2000s.

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Reposted by John De Vos

Itai Yanai @itaiyanai.bsky.social · 2d

Congratulations to Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi for this year's Nobel Prize in Physiology or Medicine. It also demonstrates the fairness of the prize, as Mary Brunkow is a Senior Program Manager (not a professor) at the @isbscience.org
hood.isbscience.org/people/mary-...

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John De Vos @jdevos.bsky.social · 2d

Immunology is back in the spotlight! The 2025 Nobel Prize in Physiology or Medicine has been awarded to research on TReg lymphocytes.

www.nobelprize.org/prizes/medic...

#NobelPrize

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Reposted by John De Vos

🌴 Scott Zona, Ph.D. 🌴 @scottzona.bsky.social · 16d

Let’s take a look at Magnoliaceae. Named for Pierre Magnol, who gave us the modern concept of plant families. There are now just 2 genera, distributed in Asia & the Americas: Magnolia s.l. (📷2: M. cylindrica) & Liriodendron (📷3: L. tulipifera). #Magnoliaceae #Botany 🌾🧪🌱

Photo of a bust of Pierre Magnol. Photo by Scott Zona CCBYNC2.

Photo of a leafless branch bearing many large, white magnolia flowers. Photo by Scott Zona CCBYNC2.

Photo of two cut flowers from Liriodendron. They are large, with tepals that are green with a splash of orange at the base. Photo by Scott Zona CCBYNC2.

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John De Vos @jdevos.bsky.social · 6d

Regenerative cell therapy marches into corneal blindness

Human endothelial cells (CHECs) can reduce corneal edema and opacity, are approved in Japan in 2023 for bullous keratopathy and in phase III in the US.

www.nature.com/articles/s41...

Regenerative cell therapy marches into corneal blindness - Nature Biotechnology

With a newly marketed product in Japan and 10 years of clinical data, regenerative cell therapies promise new options for patients facing a choice between invasive surgery or blindness.

www.nature.com

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John De Vos @jdevos.bsky.social · 6d

Derivation of embryonic stem cells across 8 avian species including chicken.

buff.ly/ZA7QdIy
#ESCells #PSCells #Pluripotency

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John De Vos @jdevos.bsky.social · 6d

In vivo chimeric antigen receptor (CAR)-T cell therapy : a review by C. June et al. in Nature Reviews Drug Discovery.

👉🏻 buff.ly/XhyYwfe
#CARTCells

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Reposted by John De Vos

Nature Biotechnology @natbiotech.nature.com · 7d

Design of optimized epigenetic regulators for durable gene silencing with application to PCSK9 in nonhuman primates go.nature.com/46uDMyK

Design of optimized epigenetic regulators for durable gene silencing with application to PCSK9 in nonhuman primates - Nature Biotechnology

Sustained epigenetic silencing in monkeys is made more efficient with optimized regulators.

go.nature.com

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Reposted by John De Vos

Waggoner Lab @labwaggoner.bsky.social · 6d

Review @natrevdrugdiscov.nature.com
In vivo chimeric antigen receptor (#CAR)-T cell therapy
www.nature.com/articles/s41...

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John De Vos @jdevos.bsky.social · 9d

👏🏻 Successful gene therapy for hereditary ATTR with polyneuropathy was achieved in a phase I study of 36 patients using a single intravenous infusion.

nej.md/46Qhur7

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John De Vos @jdevos.bsky.social · 10d

Merci!
Île de Maïre, et j’aime la vision qu’en a Vincent Bioulès.

John De Vos @jdevos.bsky.social · 13d

A first participant received randomized treatment in the pivotal Phase III clinical trial, exPDite-2, of bemdaneprocel, dopamine producing neuron precursors derived from human embryonic pluripotent stem cells.

buff.ly/Rjr3fFV

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John De Vos @jdevos.bsky.social · 13d

Bluerock (Bayer) traite le 1er patient dans son essai de phase 3 pour parkinson.

buff.ly/6kgBAUI

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Reposted by John De Vos

Vallier Lab @vallierlab.bsky.social · 15d

Tomorrow the first Berlin symposium on organoids will take place @ BCRT/BIH/Charite. Program: www.bihealth.org/en/notices/b....

I will present a summary of our work on liver organoids. : "Everything you always wanted to know about liver organoids (but you were afraid to ask)".

Berlin Organoid Symposium - News - BIH at Charité

The Berlin Organoid Symposium will highlight recent advances in the field, covering topics from fundamental organoid biology to translational applications. By uniting scientists from various instituti...

www.bihealth.org

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Reposted by John De Vos

Itai Yanai @itaiyanai.bsky.social · 15d

🔥A really interesting new episode of the Night Science Podcast came out today! Akiko Iwasaki talks about the art of creativity management & how a discovery is like a gem hidden inside a hairball. nightscience.buzzsprout.com/1744020/epis... @virusesimmunity.bsky.social @nightsciencepod.bsky.social

77 | Akiko Iwasaki and the art of creativity maintenance - Night Science

Akiko Iwasaki, a Yale professor and Howard Hughes Investigator, was named one of Time Magazine’s 100 most influential people in 2024. Together, we reflect on how diverse backgrounds enrich research, a...

nightscience.buzzsprout.com

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John De Vos @jdevos.bsky.social · 19d

✨🔬Great #StemCell research. Come, discuss, join us in Lyon Nov 17-19, 2025 at the 7th #FSSCR annual meeting. Outstanding talks, see speakers: 👉https://buff.ly/FRotkAi
📆 Regular rates available until 19 Oct 2025
@FSSCR_officiel
#FSSCR2025

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John De Vos @jdevos.bsky.social · 20d

Waouh! Early results show that in vivo #CARTCells therapy is not only feasible but also effective! 🚀 A very promising step forward! Future work will need to define the respective indications for in vivo vs. in vitro CARTCells.
buff.ly/O7ausAq

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John De Vos @jdevos.bsky.social · 20d

In vivo anti CD19 #CartCells work in systemic lupus!

NEJM.org @nejm.org · 20d

In patients with refractory systemic lupus erythematosus, in vivo generation of CD19 CAR T cells by means of lipid nanoparticles led to B-cell depletion, reduced disease activity, and no major toxic effects. Full study results: nej.md/42u4eWF

A graph showing the time course of the ratio of chimeric antigen receptor (CAR) T cells to CD8+ T cells in peripheral blood after the administration of HN2301, shown as the percentage of CAR T cells relative to CD8+ T cells.

A graph showing the percentage of CD19+ B cells relative to total lymphocytes in peripheral blood of patients receiving HN2301.

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Reposted by John De Vos

Denis Duboule @denisduboule.bsky.social · 20d

Out today. 🙏 again to everyone for this wonderful piece of work, in particular to Aurelie @aurhin.bsky.social Chase @chasebolt.bsky.social and Brent @homeobox.bsky.social. 🙏 also to the Harris lab @fish4walking.bsky.social and @neilshubin.bsky.social @biology-unige.bsky.social @college-de-france.fr

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Reposted by John De Vos

Alan Regenberg @aregenberg.bsky.social · 20d

Scientists make most authentic kidney replicas so far: Lab-grown organoids reproduce some of a kidney’s internal structure and function | Science | AAAS www.science.org/content/arti...

Scientists make most authentic kidney replicas so far

Lab-grown organoids reproduce some of a kidney’s internal structure and function

www.science.org

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John De Vos @jdevos.bsky.social · 21d

🔬 Don’t miss the 7th Annual FSSCR Meeting in Lyon!
✨ #StemCells research & future clinical applications.
📆 Register by 19 Oct 2025 for regular rates 👉 buff.ly/FRotkAi
#FSSCR2025
@fsscr.bsky.social

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Reposted by John De Vos

European Bank for iPSCs @ebisc.bsky.social · 22d

📢 Today’s the day! Thrilled to kick off the #UKSCN 2025 meeting in Manchester today.

Looking forward to a packed day of talks and discussions.

If you see our team around, come say hi! 👋

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