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Reposted by Jose Bengoechea

Ilyas Alav @ilyasalav.bsky.social · 16d

My nose must be riddled with S. aureus then 🫠

Nature Microbiology @natmicrobiol.nature.com · 16d

#NewResearch

Nasal colonisation by S. aureus is linked with depression in a human cohort and shown in a mouse model to cause decreased serotonin and dopamine in the brain

#MicroSky #Depression

www.nature.com/articles/s41...

Nasal Staphylococcus aureus carriage promotes depressive behaviour in mice via sex hormone degradation - Nature Microbiology

Nasal colonization by Staphylococcus aureus is linked with depression in a human cohort and shown in a mouse model to cause decreased serotonin and dopamine in the brain.

www.nature.com

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Reposted by Jose Bengoechea

ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · 17d

𝘒𝘭𝘦𝘣𝘴𝘪𝘦𝘭𝘭𝘢 𝘱𝘯𝘦𝘶𝘮𝘰𝘯𝘪𝘢𝘦 is a Gram-negative, non-motile, straight rod-shaped bacterium that can divide rapidly, with some strains having a median doubling time of < 30 min, forming biofilms that interfere with both antibiotic and immune clearance

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Reposted by Jose Bengoechea

Olaya Rendueles @olayarendueles.bsky.social · 26d

What an incredible week for @julielebris.bsky.social with one published ms in @asm.org #mBio on #capsule phenotypic heterogeneity & a preprint on the modular evolution of a highly exchangeable locus ⏩️capsule 😅
All her hard work is paying off!
#ProudPI
#microsky @klebclub.bsky.social
Check her 🧵👇🏻

Julie Le Bris @julielebris.bsky.social · 28d

How complex functions, with important physiological and evolutionary impacts get repeatedly and efficiently transferred across genomes?
That’s what we explored using one of the fastest-evolving loci in Bacteria: the capsule locus.
The paper: www.biorxiv.org/content/10.1...
Thread👇

Serotype swapping in Klebsiella spp. by plug-and-play

Understanding how complex, multi-gene systems evolve and function across genetic backgrounds is a central question in molecular evolution. While such systems often impose costs through epistatic inter...

www.biorxiv.org

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Jose Bengoechea @josebengoechea.bsky.social · 27d

Cool work Lindsay, congrats.

Hall Lab @halllab.bsky.social · 27d

Excited to share our @cp-cellhostmicrobe.bsky.social led by Magda showing how Bif has co-evolved with different animal hosts 🐒🐭🐷🐦

Key takeaways:
🔹 Host ancestry + diet shape Bif evolution
🔹 Mammals enriched for carb-busting enzymes
🔹 Untapped diversity in non-human hosts = new probiotic potential

Cell Host & Microbe @cp-cellhostmicrobe.bsky.social · 27d

Bifido adaptations across hosts

@halllab.bsky.social survey insects, reptiles, birds & mammals to uncover how Bifidobacterium adapts to hosts. Bifidobacterium & host exhibit strong co-phylogenetic associations, driven by vertical transmission & dietary selection
www.cell.com/cell-host-mi...

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Reposted by Jose Bengoechea

Nature Microbiology @natmicrobiol.nature.com · Sep 8

#NewResearch

This study uses Salmonella strains genetically engineered to express minimal effector subsets and mass cytometry to characterise infection of the spleen, revealing bottlenecks overcome by these effectors

#MicroSky

www.nature.com/articles/s41...

Single-cell analysis of genetically minimized Salmonella reveals effector gene cooperation in vivo - Nature Microbiology

A minimal effector subset enables Salmonella Typhimurium to overcome bottlenecks regulated by the early innate immune response and establish infection within a CD62L+ monocyte niche in the spleen.

www.nature.com

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Reposted by Jose Bengoechea

Jessica Blair @jessicamablair.bsky.social · Sep 1

A good way to think about institutional research culture!

Roger Kline @rogerkline.bsky.social · Sep 1

Thanks for sharing this Vijaya Nath

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Jose Bengoechea @josebengoechea.bsky.social · Aug 26

Good opportunity here to work with a super talented new PI.

Joe Wanford @jwanford.bsky.social · Aug 26

🚨 Job alert 🚨

I’m recruiting two postdoctoral research associates to join my lab at KCL to study how #Klebsiella pneumoniae regulates virulence factor expression during infection! #klebclub

Mol Micro: tinyurl.com/mtrwtx5e

Infection: tinyurl.com/2s3u8ca2

Deadline: 21st September.

Postdoctoral Research Associate in Molecular Microbiology

www.kcl.ac.uk

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Reposted by Jose Bengoechea

Willem van Schaik @wvschaik.bsky.social · Aug 20

Maybe I am being grumpy, but can people please stop using poorly curated databases of antibiotic resistance genes (I am looking at you, DeepARG) on shotgun metagenomic data and then present these results without any reflection on their validity, or shortcomings of databases?

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Reposted by Jose Bengoechea

ASM @asm.org · Jul 29

New in #JClinMicro! An optimized, streamlined nanopore-only workflow for epidemiologic analysis of bacterial pathogens, enabling outbreak analysis with performance comparable to that of Illumina short-read sequencing.
Get the details: asm.social/2wd

Schematic overview of benchmarking approach, highlighting the optimized pipeline.

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Reposted by Jose Bengoechea

Asaf Levy @asaflevylab.bsky.social · Oct 22

Several years of work with several great collaborators, that combined computational biology, molecular microbiology, biochemistry, structural biology and mycology assay culminated in today's publication on discovery of novel bacterial toxins:
www.nature.com/articles/s41...

Systematic discovery of antibacterial and antifungal bacterial toxins - Nature Microbiology

Genome sequence mining and computational analyses lead to the discovery and functional characterization of conserved bacterial toxins with activity against bacteria and fungi.

www.nature.com

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Reposted by Jose Bengoechea

Kate Baker @ksbakes.bsky.social · Jul 27

There are half a million cases of invasive non-Typhoidal Salmonella (iNTS) every year and while you might know S. Typhimurim and Enteritidis, you may not have heard of S. Panama 💩 🩸 🧫 💊 Check out our latest in @lancetmicrobe.bsky.social doi.org/10.1016/j.la... and the 🧵 below to find out more 1/n

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Reposted by Jose Bengoechea

London School of Hygiene & Tropical Medicine @lshtm.bsky.social · Jul 21

Are you a physician, nurse, or pharmacist looking to specialise in travel medicine?✈️🌏

Gain the knowledge, practical tools & conceptual framework needed to deliver a modern, evidence-based travel health service with our expertly designed short course.

bit.ly/3Qy7Y0O

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Reposted by Jose Bengoechea

Catrin Moore @catrinm.bsky.social · Jul 18

I provided some comments about the aid cuts in the UK that’s affecting the Fleming Fund today: microbiologysociety.org/news/society...

Microbiology Society responds to UK aid cuts affecting global AMR programme

microbiologysociety.org

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Reposted by Jose Bengoechea

Journal of Cell Science @jcellsci.bsky.social · Jul 9

Journal of Cell Science is published by a not-for-profit charitable organisation (@biologists.bsky.social)
that exists to benefit science, not shareholders. We provide Travelling Fellowships, Training Grants, support for ECRs and more.
For details, visit: journals.biologists.com/jcs/pages/re...

Image showing three covers of Journal of Cell Science

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Reposted by Jose Bengoechea

Laura Mike @lauraamike.bsky.social · Jul 3

It's seem like arginine is emerging as a major host cue. So we wrote an IAI minireview on how arginine levels vary between host tissues and affect microbial behavior.

The review is online today!
journals.asm.org/doi/epdf/10....

@brookeeryan3.bsky.social

#microsky

Known effects of arginine on Gram-positive and Gram-negative behavior

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Reposted by Jose Bengoechea

Bacteriophage Lab of Institut Pasteur @phagepasteur.bsky.social · Jul 2

🚨NEW PAPER ALERT!!!🚨 The BBH lab is proud to present the latest www.nature.com/articles/s41... from our collaboration with @joshuasweitz.bsky.social (now at UMaryland), evaluating the importance of alveolar macrophages (AM) for the efficacy of phage therapy against P. aeruginosa

Let's dig in (1/6)

Macrophage-induced reduction of bacteriophage density limits the efficacy of in vivo pulmonary phage therapy - Nature Communications

In vivo experiments and mathematical modelling in this work, show that alveolar macrophages lower phage densities and phage-bacteria contact rates, limiting the effectiveness of synergistic treatment ...

www.nature.com

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Reposted by Jose Bengoechea

Jerónimo Rodríguez-Beltrán @jerorb.bsky.social · Jul 2

🚨🚨New paper out in @natcomms.nature.com!!

Come for the first large-scale analysis of plasmid copy number across species,
stay for one of the most intriguing results of my lab: universal scaling laws in plasmid biology! 📈🧬

👉 www.nature.com/articles/s41...

Universal rules govern plasmid copy number - Nature Communications

Plasmids exhibit a broad range of sizes and copies per cell, and these two parameters appear to be negatively correlated. Here, Ramiro-Martínez et al. analyse the copy number of thousands of diverse b...

www.nature.com

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Reposted by Jose Bengoechea

Max Gutierrez @maxgg.bsky.social · Jul 1

💥 Very excited to share this review in Nature Reviews Microbiology.
Contributing to this review with Val, Digby and Amy was an enlightening experience! Hope people in the community find it useful- we managed to cite around 200 papers...
www.nature.com/articles/s41...
www.nature.com/articles/s41...

Mycobacterium tuberculosis biology, pathogenicity and interaction with the host

Nature Reviews Microbiology - In this Review, Warner, Barczak, Gutierrez and Mizrahi explore essential aspects of Mycobacterium tuberculosis physiology and biology, present recent advances related...

www.nature.com

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Reposted by Jose Bengoechea

Willem van Schaik @wvschaik.bsky.social · Jun 23

I am delighted that our manuscript 'Staphylococcus haemolyticus is a reservoir of antibiotic resistance genes in the preterm infant gut' is now published.

www.tandfonline.com/doi/full/10....

Big thank you to all co-authors, particularly @lisalamberte.bsky.social and @halllab.bsky.social

Staphylococcus haemolyticus is a reservoir of antibiotic resistance genes in the preterm infant gut

Staphylococcus haemolyticus is an important cause of sepsis in preterm infants, with gut colonization being recognized as a risk factor for infection. To better understand the diversity of S. haemo...

www.tandfonline.com

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Reposted by Jose Bengoechea

London School of Hygiene & Tropical Medicine @lshtm.bsky.social · Jun 21

📢 Nearly 600 heat-related deaths expected in UK #heatwave

LSHTM & @granthamicl.bsky.social real-time rapid analysis estimates impact of rising UK temperatures as researchers warn risks set to increase @gasparrini.bsky.social

#PublicHeath

👉 www.lshtm.ac.uk/newsevents/n...

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Jose Bengoechea @josebengoechea.bsky.social · Jun 21

www.biorxiv.org/content/10.1.... New pre-print of the lab in which we dive deep into Klebsiella-macrophage interface. High structural resolution of the lipid A produced by Klebsiella within the Klebsiella containing vacuole governed bt TLR4 signaling. Superb job led PhD student Toby Bartholomew

www.biorxiv.org

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Reposted by Jose Bengoechea

London School of Hygiene & Tropical Medicine @lshtm.bsky.social · May 24

Want to be part of a diverse student community making a difference in #GlobalHealth?

Our #students & recent graduates tell us why they chose to study with us, from inspiring lecturers to 1st class research, a truly global network & warm welcome 🌎

Find out more👉 www.lshtm.ac.uk/study/intern...

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Reposted by Jose Bengoechea

LSHTM AMR Centre @lshtmamrcentre.bsky.social · Jun 5

Researchers at @lshtm.bsky.social, led by @josebengoechea.bsky.social, will conduct a £2.2M study funded by UK MRC to investigate how Klebsiella pneumoniae silently colonises the gut before causing deadly infections. 🔬🦠

Read more 👉 bit.ly/4mNSreh

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Reposted by Jose Bengoechea

Kat Holt @katholt.bsky.social · May 22

Excited to share the first beta release of AMRrules at #ABPHM! (Poster 42 tonight)
interpretamr.github.io/AMRrules

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Jose Bengoechea @josebengoechea.bsky.social · Apr 30

Indeed he looks the same as 15 years ago!

Feldman Lab@WashU @feldmanlab.bsky.social · Apr 30

For those who have not seen Guy Cornelis in years, here you have the pic we took today. He looks the same, its quite remarkable!!

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