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Leo Kiss

@leokiss.bsky.social

1.1K followers 870 following 81 posts

Interested in Ubiquitin, Proteostasis and Signaling Scientist at @mpibiochem.bsky.social Alumnus of @mrclmb.bsky.social

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Leo Kiss @leokiss.bsky.social · Jul 9

Excited about #Ubiquitin and protein degradation?

Have a look at my recent talk at the @danafarber.bsky.social Targeted Protein Degradation Webinar Series now out on YouTube. Here, I talk about my recent publication (see Blue-torial below)

www.youtube.com/watch?v=Cpg0...

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Reposted by Leo Kiss

The EMBO Journal @embojournal.org · 2d

RNF114 and RNF166 exemplify a new E3 ligases family that recognizes #MARUbylation –hybrid ADP-ribose/ubiquitin modifications– and extends them with K11-linked polyubiquitin
@jnpruneda.bsky.social @michaelnadbio.bsky.social and colleagues
www.embopress.org/doi/full/10....

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Reposted by Leo Kiss

Sumo Muller lab @sumo-mullerlab.bsky.social · 5d

www.cell.com/trends/pharm...

Reprogramming SUMO-primed ubiquitylation: opportunities in oncology and neurology

Drugs that reprogram the cellular ubiquitin-proteasome system for removal of disease-causing proteins hold great promise as a new type of pharmacology. Small ubiquitin-related modifier (SUMO)-targeted...

www.cell.com

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Leo Kiss @leokiss.bsky.social · 9d

Very exciting! Congrats!

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Reposted by Leo Kiss

Kranzusch Lab @kranzuschlab.bsky.social · 13d

You’ve heard of ubiquitination, meet deazaguanylation: Doug Wassarman in our lab discovered phage defense pathways have co-opted Q nucleobase biosynthetic enzymes to catalyze a new form of protein conjugation chemistry @science.org

www.science.org/doi/10.1126/...

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Reposted by Leo Kiss

Craig A. Goodman @craigagoodman1.bsky.social · 14d

Ubiquitin precursor with C-terminal extension promotes proteostasis and longevity
www.sciencedirect.com/science/arti...

Ubiquitin precursor with C-terminal extension promotes proteostasis and longevity

Ubiquitin is a conserved modifier regulating the stability and function of numerous target proteins. In all eukaryotes, polyubiquitin precursors are g…

www.sciencedirect.com

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Reposted by Leo Kiss

Lorenz Lab @sonjalorenzlab.bsky.social · 14d

Allosteric activation of a ubiquitin ligase by an internal kinase domain! Congratulations to our team member Thornton Fokkens for this fascinating discovery in a neglected disease area with strong therapeutic need. Many thanks to all our great collaborators!
www.sciencedirect.com/science/arti...

A Leishmania virulence factor harnesses an allosteric kinase switch to regulate its ubiquitin ligase activity

Stringent control of ubiquitylation is a central requirement of signaling specificity in eukaryotes. Here, we discover a domain module integrating pro…

www.sciencedirect.com

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Reposted by Leo Kiss

Rune Busk Damgaard @rbdamgaard.bsky.social · 23d

A few months ago, our review “The Molecular Toolbox for Linkage Type-Specific Analysis of Ubiquitin Signaling” 🧬🧰🛠️ came out in ChemBioChem. Time to give it a spotlight!

chemistry-europe.onlinelibrary.wiley.com/doi/full/10....

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Reposted by Leo Kiss

Andrea Musacchio @andrea-musacchio.bsky.social · 24d

The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona | Science Advances www.science.org/doi/10.1126/...

Congratulations @vcmentowski.bsky.social for solving a remarkably challenging molecular puzzle

The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona

The kinetochore fibrous corona docks on CENP-E and a second elusive receptor identified as the checkpoint protein BUB1.

www.science.org

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Leo Kiss @leokiss.bsky.social · 28d

Very exciting to see this in prin! Congrats Cole!

Reposted by Leo Kiss

$pelletfraction.bsky.social$

Cole Sitron @pelletfraction.bsky.social · 28d

Why are α-synuclein aggregates in Parkinson’s disease (PD) toxic at the cell biological level?

Our new study shows that α-syn fibrils hijack the ESCRT membrane repair system, triggering a feedback loop that worsens aggregation.

You can find it at: authors.elsevier.com/sd/article/S...

ScienceDirect.com | Science, health and medical journals, full text articles and books.

authors.elsevier.com

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Leo Kiss @leokiss.bsky.social · Sep 2

Very cool! Congrats @sonjalorenzlab.bsky.social

Leo Kiss @leokiss.bsky.social · Aug 27

Big congrats! Goes straight on the must read list!

Reposted by Leo Kiss

Dan Grabarczyk @dangrabarczyk.bsky.social · Aug 27

Happy to share our work on the structure and function of the unusual E3 ligase ZNFX1 @cp-cell.bsky.social. It uses a nucleic acid-activated transthiolation mechanism, ubiquitinating and clustering RNA to protect cells in an immune response. @clausenlab.bsky.social
www.cell.com/cell/fulltex...

A split-site E3 ligase mechanism enables ZNFX1 to ubiquitinate and cluster single-stranded RNA into ubiquitin-coated nucleoprotein particles

Grabarczyk et al. show the structure and mechanism of a non-canonical ubiquitin ligase, which is activated through nucleic-acid-induced oligomerization and is critical for cell survival during immune ...

www.cell.com

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Reposted by Leo Kiss

Nature Chemical Biology @natchembio.nature.com · Aug 21

A new paper reports direct ubiquitination of a small molecule BRD1732 in cells. BR31732 ubiquitination is E3 ligase-dependent and leads to inhibition of proteasomal degradation.

www.nature.com/articles/s41...

Highly specific intracellular ubiquitination of a small molecule - Nature Chemical Biology

Li et al. discovered that the cytotoxic synthetic small molecule BRD1732 is directly ubiquitinated in cells. Ubiquitination of BRD1732 is E3 ligase dependent and leads to inhibition of proteasomal deg...

www.nature.com

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Leo Kiss @leokiss.bsky.social · Aug 20

Very exciting! Congratulations!!

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Reposted by Leo Kiss

Sven Lange @sven-m-lange.bsky.social · Aug 20

Excited to see this work published online at @cp-cell.bsky.social today!

www.cell.com/cell/fulltex...

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Reposted by Leo Kiss

Carolin Klose @carolinklose.bsky.social · Aug 11

Super excited to share our new #preprint on #BioRxiv ✨
We reveal the structural basis of a partnership between the ER membrane complex (EMC) and the P5A-ATPase Spf1 — an insertase–dislocase duo that coordinates membrane protein biogenesis and quality control.
www.biorxiv.org/content/10.1...

Structural basis of an EMC:Spf1 insertase-dislocase complex in the eukaryotic endoplasmic reticulum

Most eukaryotic membrane proteins are inserted into the membrane at the endoplasmic reticulum (ER). This essential but error-prone process relies on molecular quality control machineries to prevent mi...

www.biorxiv.org

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Leo Kiss @leokiss.bsky.social · Aug 14

Congratulations @pyustecheca.bsky.social and team!very exciting!

Reposted by Leo Kiss

Patricia Yuste-Checa @pyustecheca.bsky.social · Aug 8

Curious about the structure and functional analysis of one of the most abundant and enigmatic extracellular #chaperones and one of the highest genetic risk factor for developing late onset #Alzheimer’s disease? Check out our paper on Clusterin/ApoJ!
#proteostasis #apolipoprotein
rdcu.be/ezRLv

Structural analyses define the molecular basis of clusterin chaperone function

Nature Structural & Molecular Biology - The authors reveal a three-domain architecture of glycoprotein clusterin and show that the hydrophobic tails are crucial for clusterin’s functions...

rdcu.be

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Reposted by Leo Kiss

Carolin Klose @carolinklose.bsky.social · Aug 5

Excited to share our latest study in @natcomms.nature.com , where we characterize the chaperone function of the ER membrane protein complex (EMC)—supporting membrane protein biogenesis beyond insertion!
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www.nature.com/articles/s41...

The EMC acts as a chaperone for membrane proteins - Nature Communications

Membrane proteins are essential for any cell but difficult to fold. Here, the authors show that the EMC acts as a chaperone for membrane proteins. They dissect client recognition and provide a molecul...

www.nature.com

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Leo Kiss @leokiss.bsky.social · Jul 25

Very exciting! Congratulations!

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Reposted by Leo Kiss

Elias Adriaenssens @elias-adriaenssens.bsky.social · Jul 25

And it's out!

I'm thrilled to share our new paper (Adriaenssens et al., Nat Cell Biol 2025).

This paper describes a new mechanism for the initiation of autophagosome biogenesis.

We found that this WIPI-ATG13-driven pathway is preferentially used by a group of transmembrane autophagy receptors.

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Leo Kiss @leokiss.bsky.social · Jul 16

Congrats Stan! Very exciting

Reposted by Leo Kiss

Hellerschmied Lab @hellerschmiedlab.bsky.social · Jul 15

Very happy to see our contribution to a better understanding of Hsp70/90 #chaperones online! Congrats and a big thank you to all co-authors, collaborators and reviewers! #proteostasis @poepsel-lab.bsky.social @crc1430.bsky.social @unidue-zmb.bsky.social

Nature Structural & Molecular Biology @natsmb.nature.com · Jul 14

New online: Conformational plasticity of a BiP–GRP94 chaperone complex

Conformational plasticity of a BiP–GRP94 chaperone complex

Nature Structural & Molecular Biology, Published online: 14 July 2025; doi:10.1038/s41594-025-01619-0BiP–glucose-regulated protein 94 chaperones are critical to the proper folding of secretory and transmembrane proteins. Brenner et al. provide biochemical and structural insight into a conserved mechanism of chaperone cooperation underlying this quality control process.

go.nature.com

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