Lillemeier lab
@lillemeier-lab.bsky.social
We are a research group at University of Freiburg that studies the molecular mechanisms of T cell activation and how to use them for immunotherapy.
https://lillemeier.biologie.uni-freiburg.de/
https://lillemeier.biologie.uni-freiburg.de/
Reposted by Lillemeier lab
This week on #ImmunoHub: #EXCELLAward lecture by Dr. Sharpe on the biology behind PD-1 pathway blockade.
Awarded the 2025 EXCELL Award with the support of Frontiers, she shares new insights into PD-1 regulation & CRISPR-based discovery approaches.
https://loom.ly/PpJzb68
#ImmunologyWithoutBorders
Awarded the 2025 EXCELL Award with the support of Frontiers, she shares new insights into PD-1 regulation & CRISPR-based discovery approaches.
https://loom.ly/PpJzb68
#ImmunologyWithoutBorders
November 25, 2025 at 1:02 PM
This week on #ImmunoHub: #EXCELLAward lecture by Dr. Sharpe on the biology behind PD-1 pathway blockade.
Awarded the 2025 EXCELL Award with the support of Frontiers, she shares new insights into PD-1 regulation & CRISPR-based discovery approaches.
https://loom.ly/PpJzb68
#ImmunologyWithoutBorders
Awarded the 2025 EXCELL Award with the support of Frontiers, she shares new insights into PD-1 regulation & CRISPR-based discovery approaches.
https://loom.ly/PpJzb68
#ImmunologyWithoutBorders
Reposted by Lillemeier lab
Reposted by Lillemeier lab
Uncovering structural determinants of peptide recognition by public and private T-cell receptors https://www.biorxiv.org/content/10.1101/2025.11.23.690020v1
November 25, 2025 at 2:15 AM
Uncovering structural determinants of peptide recognition by public and private T-cell receptors https://www.biorxiv.org/content/10.1101/2025.11.23.690020v1
Reposted by Lillemeier lab
We are hiring! We have a postdoc position opened @fredhutch.org to join our team to design next gen cellular therapies for cancer. Heavy focus on T cell signaling and understanding how synthetic receptors instruct T cells to fight cancer.
November 25, 2025 at 1:06 AM
We are hiring! We have a postdoc position opened @fredhutch.org to join our team to design next gen cellular therapies for cancer. Heavy focus on T cell signaling and understanding how synthetic receptors instruct T cells to fight cancer.
Reposted by Lillemeier lab
We have an amazing opportunity for Early-Career Researchers to join our Board of Directors!
We're looking for someone with experience in leading #OpenScience projects to support and lead eLife in our mission to change research communication.
🔗 buff.ly/SZgtgVv
We're looking for someone with experience in leading #OpenScience projects to support and lead eLife in our mission to change research communication.
🔗 buff.ly/SZgtgVv
November 24, 2025 at 9:02 PM
We have an amazing opportunity for Early-Career Researchers to join our Board of Directors!
We're looking for someone with experience in leading #OpenScience projects to support and lead eLife in our mission to change research communication.
🔗 buff.ly/SZgtgVv
We're looking for someone with experience in leading #OpenScience projects to support and lead eLife in our mission to change research communication.
🔗 buff.ly/SZgtgVv
Reposted by Lillemeier lab
Bispecifics and T cell engagers are transforming care for hematologic malignancies and solid tumors! Join our free webinar Dec. 17 to gain practical strategies for managing toxicities from these modalities and improve patient care. View more: https://ow.ly/gUIq50XwRuI
November 24, 2025 at 3:02 PM
Bispecifics and T cell engagers are transforming care for hematologic malignancies and solid tumors! Join our free webinar Dec. 17 to gain practical strategies for managing toxicities from these modalities and improve patient care. View more: https://ow.ly/gUIq50XwRuI
Reposted by Lillemeier lab
We are #hiring! We are looking for a #lab #technician to help us running our new Multiplex-Imaging System. It is a 50% part-time #position at our @bmc-lmu.bsky.social at @lmumuenchen.bsky.social in south of #Munich, #Germany.
More details ➡️ job-portal.lmu.de/jobposting/7...
More details ➡️ job-portal.lmu.de/jobposting/7...
November 24, 2025 at 12:31 PM
We are #hiring! We are looking for a #lab #technician to help us running our new Multiplex-Imaging System. It is a 50% part-time #position at our @bmc-lmu.bsky.social at @lmumuenchen.bsky.social in south of #Munich, #Germany.
More details ➡️ job-portal.lmu.de/jobposting/7...
More details ➡️ job-portal.lmu.de/jobposting/7...
Reposted by Lillemeier lab
Physical principles have redefined our understanding of autophagy.
In our new @cp-trendsbiochem.bsky.social review, we discuss how phase separation, avidity, and wetting shape autophagy at the molecular level.
Great collaboration with @wilflinglab.bsky.social
www.cell.com/trends/bioch...
In our new @cp-trendsbiochem.bsky.social review, we discuss how phase separation, avidity, and wetting shape autophagy at the molecular level.
Great collaboration with @wilflinglab.bsky.social
www.cell.com/trends/bioch...
Autophagy regulation by phase separation, avidity, and wetting
Autophagy enables cells to selectively degrade a wide range of macromolecules, and
how this process achieves spatial precision within the densely packed cytosol is an
active area of investigation. Rec...
www.cell.com
November 20, 2025 at 1:34 PM
Physical principles have redefined our understanding of autophagy.
In our new @cp-trendsbiochem.bsky.social review, we discuss how phase separation, avidity, and wetting shape autophagy at the molecular level.
Great collaboration with @wilflinglab.bsky.social
www.cell.com/trends/bioch...
In our new @cp-trendsbiochem.bsky.social review, we discuss how phase separation, avidity, and wetting shape autophagy at the molecular level.
Great collaboration with @wilflinglab.bsky.social
www.cell.com/trends/bioch...
Reposted by Lillemeier lab
Job alert! 🫵 Interested in high parameter imaging? Our colleagues at the Bioimaging facility @bmc-lmu.bsky.social are hiring: job-portal.lmu.de/jobposting/7...
Technische Assistenz in einem Forschungslabor (m/w/d)
job-portal.lmu.de
November 21, 2025 at 8:02 AM
Job alert! 🫵 Interested in high parameter imaging? Our colleagues at the Bioimaging facility @bmc-lmu.bsky.social are hiring: job-portal.lmu.de/jobposting/7...
Reposted by Lillemeier lab
🚀 New bioRxiv preprint!
We used a standardized SARS-CoV-2 mRNA vaccination model to study antigen-reactive CD4⁺ T cells in their resting and stimulated states.
🔗 www.biorxiv.org/content/10.1...
(1/5)
We used a standardized SARS-CoV-2 mRNA vaccination model to study antigen-reactive CD4⁺ T cells in their resting and stimulated states.
🔗 www.biorxiv.org/content/10.1...
(1/5)
Antigen-reactive CD4+ T cells after SARS-CoV-2 vaccination show divergent phenotypic states with or without restimulation bias
Understanding antigen reactivity is crucial for characterizing CD4+ T helper (Th) cell fate, yet conventional peptide restimulation assays introduce phenotypic bias by activating cells ex vivo. Howeve...
www.biorxiv.org
November 22, 2025 at 8:39 AM
🚀 New bioRxiv preprint!
We used a standardized SARS-CoV-2 mRNA vaccination model to study antigen-reactive CD4⁺ T cells in their resting and stimulated states.
🔗 www.biorxiv.org/content/10.1...
(1/5)
We used a standardized SARS-CoV-2 mRNA vaccination model to study antigen-reactive CD4⁺ T cells in their resting and stimulated states.
🔗 www.biorxiv.org/content/10.1...
(1/5)
Reposted by Lillemeier lab
Great news for cancer research! 🔬
Congratulations to all our colleagues in OncoEscape, especially to OncoEscape Spokesperson and CIBSS PI Robert Zeiser!
Congratulations to all our colleagues in OncoEscape, especially to OncoEscape Spokesperson and CIBSS PI Robert Zeiser!
Deutsche Forschungsgemeinschaft @dfg.de fördert den Sonderforschungsbereich „OncoEscape“ an der #UniversitätFreiburg für eine weitere Förderperiode. Er erforscht Grundlagen neuer #Immuntherapien gegen Krebserkrankungen. ufr.link/sfb-oncoescape-verlaengert
@uniklinik-fr.bsky.social @cibss.bsky.social
@uniklinik-fr.bsky.social @cibss.bsky.social
November 21, 2025 at 11:35 AM
Great news for cancer research! 🔬
Congratulations to all our colleagues in OncoEscape, especially to OncoEscape Spokesperson and CIBSS PI Robert Zeiser!
Congratulations to all our colleagues in OncoEscape, especially to OncoEscape Spokesperson and CIBSS PI Robert Zeiser!
Reposted by Lillemeier lab
Are you a postdoc or assistant professor on the job market? Reminder that our department is hiring! We are a scientifically diverse department looking for a colleague that is excited about science, teaching, and potential collaborations! Please apply by 12/5/25!
November 20, 2025 at 6:52 PM
Are you a postdoc or assistant professor on the job market? Reminder that our department is hiring! We are a scientifically diverse department looking for a colleague that is excited about science, teaching, and potential collaborations! Please apply by 12/5/25!
Reposted by Lillemeier lab
EVOLVE platform, a trispecific T cell engager with integrated CD2 costimulation, for the treatment of solid and hematologic tumors @evolveimmune.bsky.social
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
November 21, 2025 at 2:26 AM
EVOLVE platform, a trispecific T cell engager with integrated CD2 costimulation, for the treatment of solid and hematologic tumors @evolveimmune.bsky.social
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted by Lillemeier lab
Pancreatic cancer cells express cryptic peptides shared across patients that may be therapeutic targets, according to research from earlier this year in Science.
Learn more in this #SciencePerspective on #WorldPancreaticCancerDay: https://scim.ag/4o0MslR
Learn more in this #SciencePerspective on #WorldPancreaticCancerDay: https://scim.ag/4o0MslR
The hunt for common tumor antigens
Pancreatic cancer cells express cryptic peptides shared across patients that may be therapeutic targets
scim.ag
November 20, 2025 at 4:53 PM
Pancreatic cancer cells express cryptic peptides shared across patients that may be therapeutic targets, according to research from earlier this year in Science.
Learn more in this #SciencePerspective on #WorldPancreaticCancerDay: https://scim.ag/4o0MslR
Learn more in this #SciencePerspective on #WorldPancreaticCancerDay: https://scim.ag/4o0MslR
Reposted by Lillemeier lab
We got a large Helmholtz Bioengineering grant with Oliver Daumke, Artur Yakimovich, Alina Bazarova, and Dietrich Ruess to use protein design to target cancer.
Five open postdoctoral positions in Generative AI & Protein Engineering. Share & apply!
jobrxiv.org/job/max-delb...
Five open postdoctoral positions in Generative AI & Protein Engineering. Share & apply!
jobrxiv.org/job/max-delb...
Postdoctoral Positions in Protein Engineering
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
jobrxiv.org
November 21, 2025 at 7:08 AM
We got a large Helmholtz Bioengineering grant with Oliver Daumke, Artur Yakimovich, Alina Bazarova, and Dietrich Ruess to use protein design to target cancer.
Five open postdoctoral positions in Generative AI & Protein Engineering. Share & apply!
jobrxiv.org/job/max-delb...
Five open postdoctoral positions in Generative AI & Protein Engineering. Share & apply!
jobrxiv.org/job/max-delb...
Reposted by Lillemeier lab
A new @nature.com.web.brid.gy paper by @peeperlab.bsky.social shows that T cells that cling to cancer cells are the most potent killers. These clusters, long overlooked, can be isolated directly from tumors www.nature.com/articles/s41...
Tumour-reactive heterotypic CD8 T cell clusters from clinical samples - Nature
Tumour-reactive CD8+ T cells are enriched in functional clusters with tumour cells and/or antigen-presenting cells and can be isolated and expanded from clinical samples.
www.nature.com
November 20, 2025 at 10:53 AM
A new @nature.com.web.brid.gy paper by @peeperlab.bsky.social shows that T cells that cling to cancer cells are the most potent killers. These clusters, long overlooked, can be isolated directly from tumors www.nature.com/articles/s41...
Reposted by Lillemeier lab
Our new paper is out in Nature - online today!
Huge congrats to shared first authors Sofía Ibáñez-Molero & Johanna Veldman, the whole team & all collaborators.
📄 Open-access paper: www.nature.com/articles/s41...
Huge congrats to shared first authors Sofía Ibáñez-Molero & Johanna Veldman, the whole team & all collaborators.
📄 Open-access paper: www.nature.com/articles/s41...
Tumour-reactive heterotypic CD8 T cell clusters from clinical samples - Nature
Tumour-reactive CD8+ T cells are enriched in functional clusters with tumour cells and/or antigen-presenting cells and can be isolated and expanded from clinical samples.
www.nature.com
November 19, 2025 at 9:00 PM
Our new paper is out in Nature - online today!
Huge congrats to shared first authors Sofía Ibáñez-Molero & Johanna Veldman, the whole team & all collaborators.
📄 Open-access paper: www.nature.com/articles/s41...
Huge congrats to shared first authors Sofía Ibáñez-Molero & Johanna Veldman, the whole team & all collaborators.
📄 Open-access paper: www.nature.com/articles/s41...
Reposted by Lillemeier lab
Reminder to register for the Midwinter Conference of Immunologists at the Asilomar Conference Center in Pacific Grove, CA! Join us for some great science and the opportunity to talk to junior and senior colleagues in a beautiful setting!!
www.midwconfimmunol.org
www.midwconfimmunol.org
November 18, 2025 at 8:37 PM
Reminder to register for the Midwinter Conference of Immunologists at the Asilomar Conference Center in Pacific Grove, CA! Join us for some great science and the opportunity to talk to junior and senior colleagues in a beautiful setting!!
www.midwconfimmunol.org
www.midwconfimmunol.org
Reposted by Lillemeier lab
Analysis of the three-dimensional genome of exhausted CD8+ T cells reveals a critical role of IRF8 in their differentiation and functions in cancer @natimmunol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Analysis of the three-dimensional genome of exhausted CD8+ T cells reveals a critical role of IRF8 in their differentiation and functions in cancer - Nature Immunology
Dong and colleagues examine the 3D chromatin structure changes that accompany CD8⁺ T cell exhaustion. They identify a role for IRF8, which is required for recruitment of the chromatin topology organiz...
www.nature.com
November 18, 2025 at 6:09 PM
Analysis of the three-dimensional genome of exhausted CD8+ T cells reveals a critical role of IRF8 in their differentiation and functions in cancer @natimmunol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Lillemeier lab
Very happy to share our latest manuscript about TCR-epitope recognition specificity: www.biorxiv.org/content/10.1...
www.biorxiv.org
November 18, 2025 at 7:21 AM
Very happy to share our latest manuscript about TCR-epitope recognition specificity: www.biorxiv.org/content/10.1...
Reposted by Lillemeier lab
⏳ Spring School: The registration deadline has been extended to 23 November! dgfi.org/akademie-fue...
About the DGfI-Spring School on Immunology
dgfi.org/akademie-fue...
@iuis-online.bsky.social @iuisjuniorcomm.bsky.social @dgfi-yi.bsky.social @drfzberlin.bsky.social
About the DGfI-Spring School on Immunology
dgfi.org/akademie-fue...
@iuis-online.bsky.social @iuisjuniorcomm.bsky.social @dgfi-yi.bsky.social @drfzberlin.bsky.social
November 18, 2025 at 9:33 AM
⏳ Spring School: The registration deadline has been extended to 23 November! dgfi.org/akademie-fue...
About the DGfI-Spring School on Immunology
dgfi.org/akademie-fue...
@iuis-online.bsky.social @iuisjuniorcomm.bsky.social @dgfi-yi.bsky.social @drfzberlin.bsky.social
About the DGfI-Spring School on Immunology
dgfi.org/akademie-fue...
@iuis-online.bsky.social @iuisjuniorcomm.bsky.social @dgfi-yi.bsky.social @drfzberlin.bsky.social
Reposted by Lillemeier lab
FlAsH-ID: A short peptide tag for live cell photoproximity labeling https://www.biorxiv.org/content/10.1101/2025.10.24.684417v1
October 25, 2025 at 3:18 AM
FlAsH-ID: A short peptide tag for live cell photoproximity labeling https://www.biorxiv.org/content/10.1101/2025.10.24.684417v1
Reposted by Lillemeier lab
Ten days left to apply to be a @crick.ac.uk Early Career Group Leader
Closing date 27th November
www.crick.ac.uk/careers-stud...
Closing date 27th November
www.crick.ac.uk/careers-stud...
November 17, 2025 at 11:55 AM
Ten days left to apply to be a @crick.ac.uk Early Career Group Leader
Closing date 27th November
www.crick.ac.uk/careers-stud...
Closing date 27th November
www.crick.ac.uk/careers-stud...
Reposted by Lillemeier lab
Come do a joint postdoc with me and @tinakim-neuro.bsky.social, splitting your time between Princeton and Columbia. Come design new activity-dependent labeling enzymes and transcriptional reporters optimized for application in the peripheral nervous system.
hhmi.wd1.myworkdayjobs.com/en-US/Extern...
hhmi.wd1.myworkdayjobs.com/en-US/Extern...
Postdoctoral Scientist- Kim and Abdus-Saboor Lab
Primary Work Address: Dept of Molecular Biology, Princeton, NJ, 08544 Current HHMI Employees, click here to apply via your Workday account. The Kim Lab at Princeton University and Abdus-Saboor Lab at ...
hhmi.wd1.myworkdayjobs.com
November 17, 2025 at 5:34 PM
Come do a joint postdoc with me and @tinakim-neuro.bsky.social, splitting your time between Princeton and Columbia. Come design new activity-dependent labeling enzymes and transcriptional reporters optimized for application in the peripheral nervous system.
hhmi.wd1.myworkdayjobs.com/en-US/Extern...
hhmi.wd1.myworkdayjobs.com/en-US/Extern...
Reposted by Lillemeier lab
Job Alert! The Institute for Neuro- and Behavioural Biology at the Faculty of Biology @uni-muenster.de invites applications for a Full Professorship (W3) in “Systems Neuroscience” - Highly attractive research environment at the Multiscale Imaging Center. Apply by January 5th. See shorturl.at/VczFp
November 12, 2025 at 5:42 PM
Job Alert! The Institute for Neuro- and Behavioural Biology at the Faculty of Biology @uni-muenster.de invites applications for a Full Professorship (W3) in “Systems Neuroscience” - Highly attractive research environment at the Multiscale Imaging Center. Apply by January 5th. See shorturl.at/VczFp