Lightnews — Scholar-powered news

Lorena Benedetti @lorenabenedetti.bsky.social · 5d

Excited that our paper was featured! It was exciting to bring together advanced imaging and physiology to uncover this hidden layer of communication in brain cells.

Peter Rupprecht @ptrrupprecht.bsky.social · Aug 11

New blog post, where I review some recent interesting papers on the role of cell organelles for neuronal calcium signaling: gcamp6f.com/2025/08/11/i...
Featuring work by @lorenabenedetti.bsky.social, O'Hare et al. and Lin et al.!

Interesting papers on the role of cell organelles in neuronal dendrites for calcium signaling

Researchers utilize calcium imaging to track neuronal activity in the brain, highlighting the role of calcium as a signaling molecule. Recent studies investigate intracellular calcium dynamics, par…

gcamp6f.com

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Lorena Benedetti @lorenabenedetti.bsky.social · 5d

Thrilled to see our paper highlighted in @ptrrupprecht.bsky.social blog post!

The ER helps carry Ca2+ signals not just within dendrites but also across tiny spines, the main sites of synaptic input. This means that spines can be connected through the ER.

gcamp6f.com/2025/08/11/i...

Interesting papers on the role of cell organelles in neuronal dendrites for calcium signaling

Researchers utilize calcium imaging to track neuronal activity in the brain, highlighting the role of calcium as a signaling molecule. Recent studies investigate intracellular calcium dynamics, par…

gcamp6f.com

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Lorena Benedetti @lorenabenedetti.bsky.social · May 30

Extremely honored and humbled to be part of the 2025 Leading Edge Court. Grateful for the opportunity to join this inspiring community of scientists pushing the boundaries of discovery. Looking forward to learning, connecting, and growing together! 🌟

#LeadingEdge2025 #WomenInScience #hhmi #janelia

Leading Edge Fellows Program @leadingedgeprogram.bsky.social · May 27

We are thrilled to announce the 2025 Leading Edge Fellows! 40 outstanding postdoctoral fellows doing pioneering research in a wide range of biological and biomedical disciplines.

Learn more about these exceptional scientists:

www.leadingedgesymposium.org/fellows

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Lorena Benedetti @lorenabenedetti.bsky.social · Apr 24

Cool new #optogenetic tool developed to disassemble intermediate filaments 🤩

Andy Moore @aaandmoore.bsky.social · Apr 22

Happy to officially introduce FilaBuster - a strategy for rapid, light-mediated intermediate filament disassembly. Compatible with multiple IF types, modular in design, and precise enough to induce localized filament disassembly in live cells.

www.biorxiv.org/content/10.1...

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Reposted by Lorena Benedetti

Andy Moore @aaandmoore.bsky.social · Mar 10

What started as a brief chat with @buvansr.bsky.social and @vgelfand.bsky.social at the 2023 CellBio meeting @ascbiology.bsky.social has grown into our published collaborative work on single vimentin IF dynamics and organization in cells. Love when stuff like that happens.

Journal of Cell Biology @jcb.org · Mar 10

Renganathan, Moor, @vgelfand.bsky.social et al. use single-particle tracking to show that #vimentin intermediate filaments display active movement throughout the cell, with individual filaments within a bundle moving independently rupress.org/jcb/article/...

#Cytoskeleton #Microscopy

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Reposted by Lorena Benedetti

Austin E. Y. T. Lefebvre @austin-lefebvre.bsky.social · Feb 27

Do you LOVE organelles??
Well I am THRILLED to announce that Nellie has been published in @naturemethods.bsky.social!

Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy

🧵1/N

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Reposted by Lorena Benedetti

Janelia Research Campus @hhmijanelia.bsky.social · Feb 24

🔬 Researchers from the Shroff Lab & collaborators have developed a new method to simultaneously image the 3D orientation & position of biomolecules, giving scientists a new view into how structures are arranged inside cells.
🔗 www.janelia.org/news/new-ima...

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Lorena Benedetti @lorenabenedetti.bsky.social · Feb 10

New insights into the mysterious spine apparatus from the super talented @haniehfalahati.bsky.social

Hanieh Falahati @haniehfalahati.bsky.social · Dec 2

Our paper is out just in time for #EM_Monday! It is about a specialized neuron-specific ER, called the spine apparatus, which is found close to synapses and has a very peculiar shape. If you think neurons are special, the spine apparatus is their🦄 horn! But how does it form?!
doi.org/10.1016/j.cu...

Gif showing a spine containing spine apparatus, reconstructed from FIB-SEM images. ER: red, synapse: yellow, plasma membrane: blue

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Reposted by Lorena Benedetti

Janelia Research Campus @hhmijanelia.bsky.social · Feb 7

💪New research led by @lorenabenedetti.bsky.social in the Lippincott-Schwartz Lab shows that subcellular structures similar to those that propagate signals that make muscles contract also transmit signals in the brain that may facilitate learning & memory 🧠
🔗 https://hhmi.news/4jMHbNY

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Reposted by Lorena Benedetti

Philip Hubbard @philiphubbard.bsky.social · Jan 3

This #FluorescenceFriday video shows 89 volumes from the #HHMIJanelia FlyLight Split-GAL4 collection: premotor and related neurons from the #Drosophila fruit fly's equivalent of a spinal cord. I gave a high-level description of the video to neuVid, which drove rendering by VVD Viewer.

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Lorena Benedetti @lorenabenedetti.bsky.social · Dec 27

Check out the stunning movie by @xianglejerry.bsky.social from @wumin-lab.bsky.social, the winner of the 2024 ASCB Video Contest! Traveling waves of FBP17-EGFP at the cortex of immune mast cells #ASCB2024 @ascbiology.bsky.social

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Lorena Benedetti @lorenabenedetti.bsky.social · Dec 25

Thank you so much, Amélie! It was nice meeting you in person at ASCB.

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Lorena Benedetti @lorenabenedetti.bsky.social · Dec 21

Thank you, Hanieh! 💕

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Reposted by Lorena Benedetti

Philip Hubbard @philiphubbard.bsky.social · Dec 21

This video was fun. I matched the #Neuroscience segmentations shown first (from the #HHMIJanelia FlyEM team) to the #CellBiology segmentations shown later (from Alyson Petruncio, @herrsaalfeld.bsky.social and the CellMap team). I described the animation with neuVid and rendered it with #Blender.

Lorena Benedetti @lorenabenedetti.bsky.social · Dec 20

5/ and in neurons of the fly brain.

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Lorena Benedetti @lorenabenedetti.bsky.social · Dec 21

Thank you, Itay!

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Lorena Benedetti @lorenabenedetti.bsky.social · Dec 21

Thank you so much, Sarah!

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Lorena Benedetti @lorenabenedetti.bsky.social · Dec 21

Thank you!

Lorena Benedetti @lorenabenedetti.bsky.social · Dec 21

Thank you, Prasanna! It was great meeting you at ASCB.

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Lorena Benedetti @lorenabenedetti.bsky.social · Dec 21

We haven’t look at the effects of disease related mutation of JPH3 on the capability to organize the Ca2+ regulatory machinery or Ca2+ signal propagation but it’s something we are definitely interested to pursue in the future.

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Lorena Benedetti @lorenabenedetti.bsky.social · Dec 21

Hi Jeff, thanks a lot! Despite JPH3 KD the ER is still organized in a ladder-like structure and can still form contacts with the plasma membrane. We think JPH4 and other ER-PM contact site protein can structurally compensate for the lack of JPH3.

Reposted by Lorena Benedetti

Prasanna Satpute-Krishnan @pskcellbio.bsky.social · Dec 21

Congratulations to @lorenabenedetti.bsky.social and colleagues @jls_lab.bsky.social for this beautiful work revealing the role for periodic ER-PM junctions in propagating long range Ca²⁺ signaling along dendrites.

Lorena Benedetti @lorenabenedetti.bsky.social · Dec 20

I am super excited to share our article addressing a longstanding question in neurobiology: how Ca²⁺ signaling cascades initiated at dendritic spines operate at a distance. Check it out here: authors.elsevier.com/sd/article/S... @cp-cell.bsky.social.

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Reposted by Lorena Benedetti

Thibaut Brunet @thibautbrunet.bsky.social · Dec 21

I was amazed to see this beautiful work at @hhmijanelia.bsky.social a few months ago - happy to see it out! The ER as an integral actor of neurotransmission 🤯

Lorena Benedetti @lorenabenedetti.bsky.social · Dec 20

I am super excited to share our article addressing a longstanding question in neurobiology: how Ca²⁺ signaling cascades initiated at dendritic spines operate at a distance. Check it out here: authors.elsevier.com/sd/article/S... @cp-cell.bsky.social.

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Reposted by Lorena Benedetti

King Cada @kingcada.bsky.social · Dec 21

First heard of this at the cell biology of the neuron #GRC. It was such a great study with beautifully executed experiments. Congrats to everyone involved!

Lorena Benedetti @lorenabenedetti.bsky.social · Dec 20

I am super excited to share our article addressing a longstanding question in neurobiology: how Ca²⁺ signaling cascades initiated at dendritic spines operate at a distance. Check it out here: authors.elsevier.com/sd/article/S... @cp-cell.bsky.social.

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Reposted by Lorena Benedetti

Nesia Zurek, PhD @docnessmonster.bsky.social · Dec 21

Very cool work on ER/PM junctions in neurons and how they regulate VGCCs. #neuroskyence

Lorena Benedetti @lorenabenedetti.bsky.social · Dec 20

I am super excited to share our article addressing a longstanding question in neurobiology: how Ca²⁺ signaling cascades initiated at dendritic spines operate at a distance. Check it out here: authors.elsevier.com/sd/article/S... @cp-cell.bsky.social.

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Lorena Benedetti @lorenabenedetti.bsky.social · Dec 20

12/ A huge shout-out to our incredible team, collaborators, and mentors who made this work possible. Science is a team effort, and I’m so grateful for all the support along the way. @herrsaalfeld.bsky.social @philiphubbard.bsky.social @aaandmoore.bsky.social @rangarajuvidhya.bsky.social

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