Maïwen Caudron-Herger
@maiwen-ch.bsky.social
Physicist, Group Leader @German Cancer Research Center, RNA-Protein Complexes, Cell Division #Riboregulation #RNA #RNAsky #Mitosis #Interdisciplinary #Teaching #Mentoring
www.dkfz.de/en/RNA-Protein-Komplexe-Zellproliferation/index.php
RBP2GO.dkfz.de
www.dkfz.de/en/RNA-Protein-Komplexe-Zellproliferation/index.php
RBP2GO.dkfz.de
Pinned
Our study on the #riboregulation of key mitotic factors is now published in Nature Communications
www.nature.com/articles/s41...
Additional findings include:
- RNA stimulates AURKA kinase activity
- RNA stabilises AURKA conformation
#RNA #RNAsky #mitosis #spindle
www.nature.com/articles/s41...
Additional findings include:
- RNA stimulates AURKA kinase activity
- RNA stabilises AURKA conformation
#RNA #RNAsky #mitosis #spindle
Reposted by Maïwen Caudron-Herger
Franziska Faber and I are recruiting shared postdocs, PhD students to work on Fusobacterium & new BGCs. www.helmholtz-hiri.de/fileadmin/HI...
December 12, 2025 at 3:43 PM
Franziska Faber and I are recruiting shared postdocs, PhD students to work on Fusobacterium & new BGCs. www.helmholtz-hiri.de/fileadmin/HI...
Reposted by Maïwen Caudron-Herger
RBP2GO - Version 2.0
rbp2gov2.dkfz.de
November 27, 2025 at 4:49 AM
Reposted by Maïwen Caudron-Herger
The epitranscriptome formed by the growing number of modifications occurring within mRNA transcripts.
We have been mapping mRNA modifications for over a decade.
=> Characterizing their functions -- especially on translation -- is a research frontier.
We have been mapping mRNA modifications for over a decade.
=> Characterizing their functions -- especially on translation -- is a research frontier.
November 30, 2025 at 2:36 PM
The epitranscriptome formed by the growing number of modifications occurring within mRNA transcripts.
We have been mapping mRNA modifications for over a decade.
=> Characterizing their functions -- especially on translation -- is a research frontier.
We have been mapping mRNA modifications for over a decade.
=> Characterizing their functions -- especially on translation -- is a research frontier.
Reposted by Maïwen Caudron-Herger
When people celebrate the individual genius of folks in science, they should also
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
November 7, 2025 at 11:43 PM
When people celebrate the individual genius of folks in science, they should also
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
Reposted by Maïwen Caudron-Herger
Regulation by RNAs might be even more extensive than we thought. Many enzymes and other proteins not previously considered as RNA-binding proteins do seem to fall into this class & might have their activity regulated by RNA.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Rethinking RNA-binding proteins: Riboregulation challenges prevailing views
The advent of system-wide proteomic approaches has largely expanded the number of
RNA-binding proteins (RBPs). This review discusses how recent discoveries are transforming
our understanding of biolog...
www.cell.com
September 5, 2025 at 3:49 PM
Regulation by RNAs might be even more extensive than we thought. Many enzymes and other proteins not previously considered as RNA-binding proteins do seem to fall into this class & might have their activity regulated by RNA.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Maïwen Caudron-Herger
🎉 We’re excited to share our very first preprint!! 🎉
"Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells"
👉 doi.org/10.1101/2025...
#FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience
"Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells"
👉 doi.org/10.1101/2025...
#FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience
Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells
Pluripotent stem cells (SCs) rely on metabolic rewiring to regulate self-renewal and differentiation. The hexosamine biosynthetic pathway (HBP) integrates multiple metabolic inputs to produce uridine ...
doi.org
August 24, 2025 at 11:29 AM
🎉 We’re excited to share our very first preprint!! 🎉
"Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells"
👉 doi.org/10.1101/2025...
#FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience
"Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells"
👉 doi.org/10.1101/2025...
#FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience
Reposted by Maïwen Caudron-Herger
My PhD student @leonielorenz.bsky.social (with Eva Geissen) has made this nice (free) online course to introduce mathematical modelling for biology:
www.ebi.ac.uk/training/onl...
Including both molecular and epidemiological examples
www.ebi.ac.uk/training/onl...
Including both molecular and epidemiological examples
Mathematical modelling for biologists - Modelling concepts in biological research
Mathematical modelling for biologists - Modelling concepts in biological research
www.ebi.ac.uk
August 15, 2025 at 10:39 AM
My PhD student @leonielorenz.bsky.social (with Eva Geissen) has made this nice (free) online course to introduce mathematical modelling for biology:
www.ebi.ac.uk/training/onl...
Including both molecular and epidemiological examples
www.ebi.ac.uk/training/onl...
Including both molecular and epidemiological examples
Reposted by Maïwen Caudron-Herger
My colleagues Baptise Rafanel et al. investigated how a newly invading transposon can be silenced. They found that not only antisense insertions in piRNA clusters such as flamenco, but also insertions in the 3‘UTR of genes can drive potent silencing.
Antisense transposon insertions into host genes trigger piRNA mediated immunity https://www.biorxiv.org/content/10.1101/2025.07.28.667215v1
August 2, 2025 at 8:36 PM
My colleagues Baptise Rafanel et al. investigated how a newly invading transposon can be silenced. They found that not only antisense insertions in piRNA clusters such as flamenco, but also insertions in the 3‘UTR of genes can drive potent silencing.
Reposted by Maïwen Caudron-Herger
EMBL Cell Biology and Biophysics department is searching for a new director. A major position to lead this field in Europe and beyond.
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Head of the Cell Biology and Biophysics Unit
The European Molecular Biology Laboratory (EMBL) is Europe’s flagship life sciences organisation, and one of the world’s leading research institutions. An intergovernmental organisation of 29 Member S...
embl.wd103.myworkdayjobs.com
July 29, 2025 at 7:50 AM
EMBL Cell Biology and Biophysics department is searching for a new director. A major position to lead this field in Europe and beyond.
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Reposted by Maïwen Caudron-Herger
Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @cp-cell.bsky.social, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. www.sciencedirect.com/science/arti...
July 26, 2025 at 7:15 PM
Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @cp-cell.bsky.social, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. www.sciencedirect.com/science/arti...
Reposted by Maïwen Caudron-Herger
Not sure who came up with "Manhattan Plot", but in 2014 I coined the alternative term "Nijmegen Plot" (inspired by the Dutch town where I live) to describe underwhelming results from our earliest genome-wide association scans of language/reading traits.
July 28, 2025 at 4:42 PM
Not sure who came up with "Manhattan Plot", but in 2014 I coined the alternative term "Nijmegen Plot" (inspired by the Dutch town where I live) to describe underwhelming results from our earliest genome-wide association scans of language/reading traits.
Reposted by Maïwen Caudron-Herger
How do chromatin remodelers use #IDRs to find TF binding partners? In our new Molecular Cell paper, we show that β-catenin is an adaptor that links SWI/SNF (cBAF) subunit ARID1A with binding partners via IDR-domain interactions.
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
July 22, 2025 at 6:42 PM
How do chromatin remodelers use #IDRs to find TF binding partners? In our new Molecular Cell paper, we show that β-catenin is an adaptor that links SWI/SNF (cBAF) subunit ARID1A with binding partners via IDR-domain interactions.
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Reposted by Maïwen Caudron-Herger
Finally out!
I’m thrilled to share our new paper (Wolin et al., Cell 2025).
This paper describes SPIDR, a high-throughput method for mapping RBP binding sites.
By combining #SPIDR with #cryoEM, we identified the exact binding site of LARP1 within the #mRNA channel of the 40S ribosomal subunit.
I’m thrilled to share our new paper (Wolin et al., Cell 2025).
This paper describes SPIDR, a high-throughput method for mapping RBP binding sites.
By combining #SPIDR with #cryoEM, we identified the exact binding site of LARP1 within the #mRNA channel of the 40S ribosomal subunit.
July 22, 2025 at 5:12 PM
Reposted by Maïwen Caudron-Herger
Recently I learnt that EMBL-EBI has a free online course about AlphaFold — how it works, strengths and limitations, how to use it — and it's very good!
There are also little quizzes and interactives.
www.ebi.ac.uk/training/onl...
There are also little quizzes and interactives.
www.ebi.ac.uk/training/onl...
AlphaFold - A practical guide
AlphaFold - A practical guide
www.ebi.ac.uk
July 21, 2025 at 3:33 PM
Recently I learnt that EMBL-EBI has a free online course about AlphaFold — how it works, strengths and limitations, how to use it — and it's very good!
There are also little quizzes and interactives.
www.ebi.ac.uk/training/onl...
There are also little quizzes and interactives.
www.ebi.ac.uk/training/onl...
Reposted by Maïwen Caudron-Herger
Opportunity alert!
Are you looking for an exciting position at the intersection of super-resolution microscopy and AI? Then check out the PhD and PostDoc position we offer for a joint project with the Group of Stephan Hell at MPI Göttingen. Please share with anyone interested, read on for links and details.
July 7, 2025 at 1:35 PM
Opportunity alert!
Reposted by Maïwen Caudron-Herger
Hello! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @cp-cellreports.bsky.social, @mardakheh.bsky.social and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit!
tinyurl.com/ydn6e3ac
tinyurl.com/ydn6e3ac
June 30, 2025 at 9:15 PM
Hello! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @cp-cellreports.bsky.social, @mardakheh.bsky.social and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit!
tinyurl.com/ydn6e3ac
tinyurl.com/ydn6e3ac
Reposted by Maïwen Caudron-Herger
Structure of the microtubule anchoring factor NEDD1 bound to the γ-tubulin ring complex. new study from Hugo Muñoz-Hernández, Yixin Xu, Michal Wieczorek @mike-wieczorek.bsky.socia @ethz.ch and colleagues: rupress.org/jcb/article/...
#Cytoskeleton #StructuralBiology #CryoEM
#Cytoskeleton #StructuralBiology #CryoEM
May 28, 2025 at 2:20 PM
Structure of the microtubule anchoring factor NEDD1 bound to the γ-tubulin ring complex. new study from Hugo Muñoz-Hernández, Yixin Xu, Michal Wieczorek @mike-wieczorek.bsky.socia @ethz.ch and colleagues: rupress.org/jcb/article/...
#Cytoskeleton #StructuralBiology #CryoEM
#Cytoskeleton #StructuralBiology #CryoEM
Reposted by Maïwen Caudron-Herger
Out now in @natchem.nature.com! Lots to unpack here, but in short - we show that SMM enabled fragment based design is useful on RNAs to improve chemical properties like affinity and brightness of fluorophore ligands.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Structure-informed design of an ultrabright RNA-activated fluorophore - Nature Chemistry
Fluorogenic RNA aptamers such as Mango are powerful tools for RNA imaging. An ultrabright RNA-activated fluorophore with improved photophysical performance has now been developed using a structure-inf...
www.nature.com
May 28, 2025 at 2:22 PM
Out now in @natchem.nature.com! Lots to unpack here, but in short - we show that SMM enabled fragment based design is useful on RNAs to improve chemical properties like affinity and brightness of fluorophore ligands.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Have a look at this short Journal Club I had the great pleasure to write for @natrevmcb.nature.com
about a 2012 landmark study by Castello et al.
Read only link: rdcu.be/elEYW
about a 2012 landmark study by Castello et al.
Read only link: rdcu.be/elEYW
May 12, 2025 at 5:33 PM
Have a look at this short Journal Club I had the great pleasure to write for @natrevmcb.nature.com
about a 2012 landmark study by Castello et al.
Read only link: rdcu.be/elEYW
about a 2012 landmark study by Castello et al.
Read only link: rdcu.be/elEYW
Reposted by Maïwen Caudron-Herger
An amazing new enabling technology. Measurements of molecular size and shape on a chip. Couldn't be prouder of our friend Madhavi Krishnan of @ox.ac.uk this was and is one among the must fun collaborations I ever had. www.science.org/doi/10.1126/...
Measurements of molecular size and shape on a chip
Size and shape are critical discriminators between molecular species and states. We describe a microchip-based high-throughput imaging approach offering rapid and precise determination of molecular pr...
www.science.org
May 9, 2025 at 8:00 AM
An amazing new enabling technology. Measurements of molecular size and shape on a chip. Couldn't be prouder of our friend Madhavi Krishnan of @ox.ac.uk this was and is one among the must fun collaborations I ever had. www.science.org/doi/10.1126/...
Reposted by Maïwen Caudron-Herger
Barbara McClintock proposed – over 40 years ago – that transposable element activity could be a response to stress, and I think that we are still only beginning to understand how right she was.
April 28, 2025 at 2:26 AM
Barbara McClintock proposed – over 40 years ago – that transposable element activity could be a response to stress, and I think that we are still only beginning to understand how right she was.
Reposted by Maïwen Caudron-Herger
#EMBOClimateResilience
“The way in which our universities have divided up the sciences does not reflect the ways in which nature has divided up its problems”
@embo.org
@monicabettencourt.bsky.social
“The way in which our universities have divided up the sciences does not reflect the ways in which nature has divided up its problems”
@embo.org
@monicabettencourt.bsky.social
April 14, 2025 at 10:48 AM
#EMBOClimateResilience
“The way in which our universities have divided up the sciences does not reflect the ways in which nature has divided up its problems”
@embo.org
@monicabettencourt.bsky.social
“The way in which our universities have divided up the sciences does not reflect the ways in which nature has divided up its problems”
@embo.org
@monicabettencourt.bsky.social
Reposted by Maïwen Caudron-Herger
We are organizing a conference for young researchers at the intersection between physics & biology: www.embl.org/about/info/c... @embl.org @events.embl.org @intcha.bsky.social
Please consider applying/registering -- the deadline is already in one week!
Please consider applying/registering -- the deadline is already in one week!
March 24, 2025 at 2:35 PM
We are organizing a conference for young researchers at the intersection between physics & biology: www.embl.org/about/info/c... @embl.org @events.embl.org @intcha.bsky.social
Please consider applying/registering -- the deadline is already in one week!
Please consider applying/registering -- the deadline is already in one week!
Reposted by Maïwen Caudron-Herger
Today all 27 EU countries endorsed the Warsaw Declaration.
Thank you for your solid support in calling for the independence of the European Research Council to be preserved and for the role of the ERC to be expanded.
polish-presidency.consilium.europa.eu/media/r5fa13...
🇪🇺
Thank you for your solid support in calling for the independence of the European Research Council to be preserved and for the role of the ERC to be expanded.
polish-presidency.consilium.europa.eu/media/r5fa13...
🇪🇺
polish-presidency.consilium.europa.eu
March 11, 2025 at 7:14 PM
Today all 27 EU countries endorsed the Warsaw Declaration.
Thank you for your solid support in calling for the independence of the European Research Council to be preserved and for the role of the ERC to be expanded.
polish-presidency.consilium.europa.eu/media/r5fa13...
🇪🇺
Thank you for your solid support in calling for the independence of the European Research Council to be preserved and for the role of the ERC to be expanded.
polish-presidency.consilium.europa.eu/media/r5fa13...
🇪🇺
Reposted by Maïwen Caudron-Herger
Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n
Homepage - openRxiv
openRxiv is an independent non-profit, the new organizational home for bioRxiv and medRxiv, enabling researchers to instantly share groundbreaking findings with the global scientific community.
openrxiv.org
March 11, 2025 at 1:20 PM
Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n