The cytoskeleton, a dynamic and intricate network of protein filaments, is found within the cytoplasm of all cells, from bacteria and archaea to complex eukaryotes. This essential cellular component …

This Review explores how cells sense and respond to mechanical signals across timescales. By integrating mechanosensing at membranes, mechanotransduction in the cytoplasm, and nuclear reprogramming, it reveals a role of temporal dynamics in tissue development and disease.

Mitochondria are highly adaptable organelles that change their shape, distribution, and movement to meet cellular needs. We investigate how EGF stimulation remodels mitochondrial behavior in human A43...

Endoplasmic reticulum exit sites (ERES) are specialized ER subdomains that regulate the export of secreted cargo. This Roadmap explores how ERES integrate biochemical and mechanical signals to coordinate trafficking and proposes a multidisciplinary strategy to investigate their function, including in disease.

McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

Join us for MechBio2025, the annual meeting of the Australian Society for Mechanobiology. November 5-7, 2025 at the University of Queensland, Brisbane. Featuring international keynote speakers and sho...

A vaccine to protect Australia's koalas against chlamydia has been approved for the first time, a development that scientists believe could stop the spread of the deadly disease that has ravaged populations of the beloved endangered animal.

The switch between proliferation and invasion is triggered by mechanical force.