Robert Grosse @ grosselab
@grosselab.bsky.social
all things cytoskeleton - nuclear actin dynamics and genome - nucleoskeleton and nuclear organisation - cancer cell invasion and pharmacology
@University of Freiburg
https://www.pharmakologie.uni-freiburg.de/en/i/research/grosse
@University of Freiburg
https://www.pharmakologie.uni-freiburg.de/en/i/research/grosse
Reposted by Robert Grosse @ grosselab
Motivational video for #MigrationMovieMonday. A persistent 4T1 breast cancer cell squeezing itself through a tight constriction despite undergoing repetitive nuclear envelope rupture. Credit: Kristen Nedza @weillinstitute.bsky.social
November 25, 2025 at 1:36 AM
Motivational video for #MigrationMovieMonday. A persistent 4T1 breast cancer cell squeezing itself through a tight constriction despite undergoing repetitive nuclear envelope rupture. Credit: Kristen Nedza @weillinstitute.bsky.social
Reposted by Robert Grosse @ grosselab
📢 Paper alert 📢
Chirality is known to be important for the movement of microorganisms and active matter. In our new paper out today in @natphys.nature.com, we show that chirality is used by malaria parasites to control their motion patterns:
doi.org/10.1038/s415...
Here comes a 🧵 ... (1/9)
Chirality is known to be important for the movement of microorganisms and active matter. In our new paper out today in @natphys.nature.com, we show that chirality is used by malaria parasites to control their motion patterns:
doi.org/10.1038/s415...
Here comes a 🧵 ... (1/9)
November 24, 2025 at 5:50 PM
📢 Paper alert 📢
Chirality is known to be important for the movement of microorganisms and active matter. In our new paper out today in @natphys.nature.com, we show that chirality is used by malaria parasites to control their motion patterns:
doi.org/10.1038/s415...
Here comes a 🧵 ... (1/9)
Chirality is known to be important for the movement of microorganisms and active matter. In our new paper out today in @natphys.nature.com, we show that chirality is used by malaria parasites to control their motion patterns:
doi.org/10.1038/s415...
Here comes a 🧵 ... (1/9)
Reposted by Robert Grosse @ grosselab
Happy to share our new protocol on modelling acute kidney injury in vitro using organoids:
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Protocol for a mouse tubuloid model of myoglobinuric acute kidney injury
Myoglobinuric acute kidney injury (AKI) occurs as a result of rhabdomyolysis. Here, we present a protocol based on mouse primary renal tubular epithel…
www.sciencedirect.com
November 24, 2025 at 8:04 AM
Happy to share our new protocol on modelling acute kidney injury in vitro using organoids:
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Robert Grosse @ grosselab
Please share: we have an open postdoc position!🪰🪰👾We are looking for a motivated Drosophilist to join our team and explore the role of hemocytes in interorgan signaling! Interested?😎send us your application or contact me! Looking forward to hear from you!
www.uniklinik-freiburg.de/karriere/ste...
www.uniklinik-freiburg.de/karriere/ste...
Postdoctoral Researcher (m/f/d) | Universitätsklinikum Freiburg
www.uniklinik-freiburg.de
November 12, 2025 at 8:12 AM
Please share: we have an open postdoc position!🪰🪰👾We are looking for a motivated Drosophilist to join our team and explore the role of hemocytes in interorgan signaling! Interested?😎send us your application or contact me! Looking forward to hear from you!
www.uniklinik-freiburg.de/karriere/ste...
www.uniklinik-freiburg.de/karriere/ste...
Reposted by Robert Grosse @ grosselab
Last call! Applications for the @crg.eu International PhD Programme 2025 in beautiful Barcelona close next week! Join us and our inspiring colleagues at the CRG - an exceptional environment for discovery, creativity, and scientific growth.
Apply here: www.crg.eu/en/content/t...
Apply here: www.crg.eu/en/content/t...
November 22, 2025 at 1:36 PM
Last call! Applications for the @crg.eu International PhD Programme 2025 in beautiful Barcelona close next week! Join us and our inspiring colleagues at the CRG - an exceptional environment for discovery, creativity, and scientific growth.
Apply here: www.crg.eu/en/content/t...
Apply here: www.crg.eu/en/content/t...
Reposted by Robert Grosse @ grosselab
“Scientific editing is the best job one can imagine, if you thrive on knowledge,” says Ieva Gailite, Senior Scientific #Editor at The EMBO Journal. 🧪
Read more here:
https://www.embo.org/people/a-love-for-too-many-things/
#publishing #LifeSciences #career
Read more here:
https://www.embo.org/people/a-love-for-too-many-things/
#publishing #LifeSciences #career
November 23, 2025 at 5:50 PM
“Scientific editing is the best job one can imagine, if you thrive on knowledge,” says Ieva Gailite, Senior Scientific #Editor at The EMBO Journal. 🧪
Read more here:
https://www.embo.org/people/a-love-for-too-many-things/
#publishing #LifeSciences #career
Read more here:
https://www.embo.org/people/a-love-for-too-many-things/
#publishing #LifeSciences #career
Reposted by Robert Grosse @ grosselab
I tried an even harder example on Gemini Pro image generation and this is quite scary/amazing. I asked for a microscopy image of around 20 HeLa cells, GFP tagged 20% nuclear, 10% membrane, +1 nuclear staining, + overlap. Image below and prompt in the following post.
November 21, 2025 at 5:32 PM
I tried an even harder example on Gemini Pro image generation and this is quite scary/amazing. I asked for a microscopy image of around 20 HeLa cells, GFP tagged 20% nuclear, 10% membrane, +1 nuclear staining, + overlap. Image below and prompt in the following post.
Reposted by Robert Grosse @ grosselab
Why IDPs Are Poor Candidates for Homotypic LLPS
🧵👇A thread
🧵👇A thread
November 20, 2025 at 6:32 PM
Why IDPs Are Poor Candidates for Homotypic LLPS
🧵👇A thread
🧵👇A thread
Reposted by Robert Grosse @ grosselab
Junior professor position at the University of Kaiserslautern! Our Department of Biology is seeking a colleague working with microalgae. This is a wonderful place to do wonderful science with great people! Please, repost :)
Further details:
jobs.rptu.de/jobposting/1...
Further details:
jobs.rptu.de/jobposting/1...
November 20, 2025 at 3:28 PM
Junior professor position at the University of Kaiserslautern! Our Department of Biology is seeking a colleague working with microalgae. This is a wonderful place to do wonderful science with great people! Please, repost :)
Further details:
jobs.rptu.de/jobposting/1...
Further details:
jobs.rptu.de/jobposting/1...
Reposted by Robert Grosse @ grosselab
Quite a busy day on #Bluesky !
Been a while since we have been #preLight -ed !
Discover HAK-Actin if you haven't already ;)
Been a while since we have been #preLight -ed !
Discover HAK-Actin if you haven't already ;)
Reliable actin labelling in expansion #microscopy 🔬
Beautiful #preprint from Olivier Mercey, @lreymond.bsky.social & team @dudinlab.bsky.social @centriolelab.bsky.social
Read the latest #preLight from @kanishka03.bsky.social ⬇️👀
prelights.biologists.com/highlights/h...
Beautiful #preprint from Olivier Mercey, @lreymond.bsky.social & team @dudinlab.bsky.social @centriolelab.bsky.social
Read the latest #preLight from @kanishka03.bsky.social ⬇️👀
prelights.biologists.com/highlights/h...
HAK-actin, U-ExM-compatible probe to image the actin cytoskeleton - preLights
HAK-actin is a new probe that may help researchers see the actin cytoskeleton in sharper detail using expansion microscopy.
prelights.biologists.com
November 19, 2025 at 12:36 PM
It was inspiring and fun hosting Patrick Lusk @luskinglab.bsky.social as our seminar guest, here looking at cell nuclei and peppers with AFM expert Dennis @denfra.bsky.social
November 17, 2025 at 3:00 PM
It was inspiring and fun hosting Patrick Lusk @luskinglab.bsky.social as our seminar guest, here looking at cell nuclei and peppers with AFM expert Dennis @denfra.bsky.social
Reposted by Robert Grosse @ grosselab
New from Mishima & Balasubramanian (@sporemohan.bsky.social) labs in @warwickmed.bsky.social: “Actin arginylation alters myosin engagement & F-actin patterning despite structural conservation.” Explore the physiology of #arginylated #actin 👉 rupress.org/jcb/article/...
Actin arginylation alters myosin engagement and F-actin patterning despite structural conservation | Journal of Cell Biology | Rockefeller University Press
Actin is vital for cell functions and is regulated by posttranslational modifications like arginylation. The structure of arginylated β-actin (R-β-actin) i
rupress.org
November 14, 2025 at 9:09 PM
New from Mishima & Balasubramanian (@sporemohan.bsky.social) labs in @warwickmed.bsky.social: “Actin arginylation alters myosin engagement & F-actin patterning despite structural conservation.” Explore the physiology of #arginylated #actin 👉 rupress.org/jcb/article/...
Reposted by Robert Grosse @ grosselab
Launching celldynamicslab.com, the homepage of our new group at EPFL working on cell fragmentation, membrane and cortex mechanics, FLIM imaging, and microfluidics tools. MSc/PhD or postdocs interested in quantitative cell biology are welcome to reach out. We're also hiring a lab manager in 2026!
Main - Cell Dynamics and Fragmentation Lab
The Cell Dynamics and Fragmentation lab at We study how single cells move and fragment in complex environments using microfluidics. We bring tools and concep...
celldynamicslab.com
November 11, 2025 at 5:10 PM
Launching celldynamicslab.com, the homepage of our new group at EPFL working on cell fragmentation, membrane and cortex mechanics, FLIM imaging, and microfluidics tools. MSc/PhD or postdocs interested in quantitative cell biology are welcome to reach out. We're also hiring a lab manager in 2026!
Reposted by Robert Grosse @ grosselab
Job Alert! The Institute for Neuro- and Behavioural Biology at the Faculty of Biology @uni-muenster.de invites applications for a Full Professorship (W3) in “Systems Neuroscience” - Highly attractive research environment at the Multiscale Imaging Center. Apply by January 5th. See shorturl.at/VczFp
November 12, 2025 at 5:42 PM
Job Alert! The Institute for Neuro- and Behavioural Biology at the Faculty of Biology @uni-muenster.de invites applications for a Full Professorship (W3) in “Systems Neuroscience” - Highly attractive research environment at the Multiscale Imaging Center. Apply by January 5th. See shorturl.at/VczFp
how cool is that? Congrats!!
We are very happy to share our new PrePrint: Myosin VI orchestrates estrogen-driven gene expression in breast
cancer cells. www.biorxiv.org/content/10.1...
We characterise how Myosin VI is a key regulator of the Estrogen Receptor. Perturbation of Myosin VI impedes ER functionality.
cancer cells. www.biorxiv.org/content/10.1...
We characterise how Myosin VI is a key regulator of the Estrogen Receptor. Perturbation of Myosin VI impedes ER functionality.
November 14, 2025 at 2:36 PM
how cool is that? Congrats!!
Reposted by Robert Grosse @ grosselab
We are recruiting the next scientific leaders - Our HUMAN program offers junior group leader positions to push the boundaries of infection biology and integrating #AI to advance global health🧫.
Apply by November 26:
🦠 www.helmholtz-hzi.de/en/career/jo...
🧬 www.helmholtz-hzi.de/en/career/jo...
Apply by November 26:
🦠 www.helmholtz-hzi.de/en/career/jo...
🧬 www.helmholtz-hzi.de/en/career/jo...
November 13, 2025 at 9:34 AM
We are recruiting the next scientific leaders - Our HUMAN program offers junior group leader positions to push the boundaries of infection biology and integrating #AI to advance global health🧫.
Apply by November 26:
🦠 www.helmholtz-hzi.de/en/career/jo...
🧬 www.helmholtz-hzi.de/en/career/jo...
Apply by November 26:
🦠 www.helmholtz-hzi.de/en/career/jo...
🧬 www.helmholtz-hzi.de/en/career/jo...
Reposted by Robert Grosse @ grosselab
What a crazy cool paper! First author @pierreucla.bsky.social with a large crew knocked it out of the park. (GIF below from @the.3i.social LLS) Quantifying cell traction forces at the single-fiber scale in 3D: An approach based on deformable photopolymerized fiber arrays www.pnas.org/doi/10.1073/...
November 13, 2025 at 6:21 PM
What a crazy cool paper! First author @pierreucla.bsky.social with a large crew knocked it out of the park. (GIF below from @the.3i.social LLS) Quantifying cell traction forces at the single-fiber scale in 3D: An approach based on deformable photopolymerized fiber arrays www.pnas.org/doi/10.1073/...
Reposted by Robert Grosse @ grosselab
Our red calcium indicator, FRCaMPi, and its soma-localized version, SomaFRCaMPi, are now available from @addgene.bsky.social in various vectors, along with all the sensors used for benchmarking. www.addgene.org/browse/artic...
November 12, 2025 at 12:08 AM
Our red calcium indicator, FRCaMPi, and its soma-localized version, SomaFRCaMPi, are now available from @addgene.bsky.social in various vectors, along with all the sensors used for benchmarking. www.addgene.org/browse/artic...
Reposted by Robert Grosse @ grosselab
A wonderful collaboration between my lab and Andy Ellington and Edward Marcotte here at UT.
We obtained lots of thermal stable plastic degrading enzymes from the deep sea (Guaymas Basin, Gulf of California)
We obtained lots of thermal stable plastic degrading enzymes from the deep sea (Guaymas Basin, Gulf of California)
Plastic degradation by enzymes from uncultured deep sea microorganisms
Abstract. Polyethylene terephthalate (PET)-hydrolyzing enzymes (PETases) are a recently discovered enzyme class capable of plastic degradation. PETases are
academic.oup.com
November 10, 2025 at 6:04 PM
A wonderful collaboration between my lab and Andy Ellington and Edward Marcotte here at UT.
We obtained lots of thermal stable plastic degrading enzymes from the deep sea (Guaymas Basin, Gulf of California)
We obtained lots of thermal stable plastic degrading enzymes from the deep sea (Guaymas Basin, Gulf of California)
Reposted by Robert Grosse @ grosselab
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
November 10, 2025 at 1:26 PM
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Reposted by Robert Grosse @ grosselab
Join us for a joint seminar by Prof. Andreas Bausch @tum.de to explore how structure formation in organoid systems reveals fundamental principles of life.
🧫 CIBSS / SFB 1381 Seminar | 11 Nov 2025 · 12:00
📍 Lecture Hall, Biology I (Hauptstr. 1, Freiburg) & livestream
🔗https://kurzlinks.de/oz1f
🧫 CIBSS / SFB 1381 Seminar | 11 Nov 2025 · 12:00
📍 Lecture Hall, Biology I (Hauptstr. 1, Freiburg) & livestream
🔗https://kurzlinks.de/oz1f
November 10, 2025 at 7:54 AM
Join us for a joint seminar by Prof. Andreas Bausch @tum.de to explore how structure formation in organoid systems reveals fundamental principles of life.
🧫 CIBSS / SFB 1381 Seminar | 11 Nov 2025 · 12:00
📍 Lecture Hall, Biology I (Hauptstr. 1, Freiburg) & livestream
🔗https://kurzlinks.de/oz1f
🧫 CIBSS / SFB 1381 Seminar | 11 Nov 2025 · 12:00
📍 Lecture Hall, Biology I (Hauptstr. 1, Freiburg) & livestream
🔗https://kurzlinks.de/oz1f
Reposted by Robert Grosse @ grosselab
Exactly. We can deposit papers on preprint servers and we can even request an independent peer review (review commons) process all for free. While we keep needing the journal labels not much will change.
November 8, 2025 at 2:16 PM
Exactly. We can deposit papers on preprint servers and we can even request an independent peer review (review commons) process all for free. While we keep needing the journal labels not much will change.
Reposted by Robert Grosse @ grosselab
Agreed, this is really good (unpaywalled link if it can be useful to some: archive.is/lqSrX)
archive.is
November 8, 2025 at 9:33 AM
Agreed, this is really good (unpaywalled link if it can be useful to some: archive.is/lqSrX)
Reposted by Robert Grosse @ grosselab
Wondering if we can reform the publishing system without empowering the robot class
November 8, 2025 at 12:26 PM
Wondering if we can reform the publishing system without empowering the robot class
Reposted by Robert Grosse @ grosselab
We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.
November 7, 2025 at 11:02 AM
We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.