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Reposted by Markus Mukenhirn

André Nadler @nadlerlab.bsky.social · 49m

Lipid imaging on the cover of @nature.com! Great times for lipid cell biology indeed. And a fantastic recognition of all the hard work by the team, especially Juan M. Iglesias-Artola and Kristin Böhlig (who made the cover). Link to article: www.nature.com/articles/s41...

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Miki Ebisuya @ebisuyamiki.bsky.social · 20h

New preprint from the lab! We discovered a transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to greater surface expansion in human forebrains
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doi.org/10.1101/2025...

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Pierre Haas @lepuslapis.bsky.social · 1d

#CellPhysics2025 @uni-saarland.de: looking forward to talking about "Mechanics of Lumina" (*) in the "Cell Collectives" session this morning.

(*) Note the use of the correct plural of "lumen".

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University of Cambridge @cam.ac.uk · 1d

It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the @gurdoninstitute.bsky.social

Read our tribute to the visionary Nobel Laureate and watch an interview from 2012, just after he won: https://bit.ly/4mM8o3r

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Seema Grewal @seemagrewal.bsky.social · 1d

So sad to hear the news - John truly was an inspiration to so many, and one of a kind.

www.cam.ac.uk/research/new...

Nobel Laureate Professor Sir John Gurdon dies aged 92

It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the Gurdon Institute.

www.cam.ac.uk

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Bardin Lab @bardinlab.bsky.social · 2d

The PhD work of @bboumard.bsky.social officially out in print! Happy to share this issue with our downstairs colleagues in the BDD @frelab.bsky.social @robinjournot.bsky.social

www.cell.com/developmenta...

Cell-type-specific nucleotide sharing through gap junctions impacts sensitivity to replication stress in Drosophila

Boumard et al. demonstrate gap-junction-dependent tissue-scale nucleotide sharing, which impacts cellular sensitivity to perturbation of nucleotide homeostasis and replication stress. Drosophila wing ...

www.cell.com

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Journal of Cell Science @jcellsci.bsky.social · 5d

Mario Ledesma-Terrón, Diego Pérez-Dones, David Míguez and colleagues @cbm-csic-uam.bsky.social @ifimacuam.bsky.social present OSCAR, a framework to quantify 3D stacks with high cellular density.
journals.biologists.com/jcs/article-...

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Katrin Göring-Eckardt @goering-eckardt.de · 6d

Der Tag der Deutschen Einheit ist ein Grund zum Feiern. Feiern wir also und vergessen nicht: Es gibt noch einiges zu tun! 35 Jahre nach der Wiedervereinigung bestehen die strukturellen Unterschiede zwischen Ost und West immer noch:

(1/2)

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Barriga Lab @eliasbarrigalab.bsky.social · 6d

New Review! #devbiol #bioelectricity #CellBiology #tissueregeneration

In our new @annualreviews.bsky.social piece, we explore how bioelectricity is generated, sensed & translated into responses that sculpt tissues, guide growth & enable tissue regeneration.

www.annualreviews.org/content/jour...

Bioelectricity in Morphogenesis

Bioelectricity is likely as old as life itself. From the moment the first proto-cell was enclosed in a lipid bilayer, a membrane potential arose. Thus, one can expect that bioelectrical activities inf...

www.annualreviews.org

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Freddy Frischknecht @freddyfrischknecht.bsky.social · 6d

Beautiful beasts: excited to see our first volume electron microscopy study on malaria parasites published: advanced.onlinelibrary.wiley.com/doi/10.1002/... revealing new insights into Plasmodium ookinete development. Thanks for great EMBL-Umea-Heidelberg collaboration.

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Ulrich Schwarz @ulrichschwarz.bsky.social · 6d

Congrats Nedal @ndarif.bsky.social, Yannick, Freddy and coworkers to this beautiful project. Another great work from #SFB1129. Special congrats to first author Nedal who very recently defended his PhD at #EMBL.

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Dr. Lutz Böhm @drlutzboehm.bsky.social · 6d

Toluoltropfen in Wasser mit Aceton als Stoffübergangskomponente. Der Tropfen steigt nicht auf, da er mittels Levitation in der kontinuierlichen Wasserphase in einem Schallknotenpunkt festgehalten wird. Konzentrationen von Aceton werden mittels Schlieren visualisiert.

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Kate Cavanaugh @katecavanaugh.bsky.social · 7d

See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...

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Pierre Haas @lepuslapis.bsky.social · Sep 8

Another #preprint: "Elasticity and plasticity of epithelial gap closure", from the #PhD work of Maryam Setoudeh:

arxiv.org/abs/2509.05110

This one required a lot of (I think) beautiful #mechanics!

@mpipks.bsky.social @mpi-cbg.de @csbdresden.bsky.social

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Pierre Haas @lepuslapis.bsky.social · 9d

We recently submitted part of her #PhD work, "Elasticity and plasticity of epithelial gap closure" arxiv.org/abs/2509.05110: the summary of some very nice #mechanics is below. Stay tuned for more!

bsky.app/profile/lepuslapis.bsky.social/post/3lycptbyrcs2x

Pierre Haas @lepuslapis.bsky.social · Sep 8

Another #preprint: "Elasticity and plasticity of epithelial gap closure", from the #PhD work of Maryam Setoudeh:

arxiv.org/abs/2509.05110

This one required a lot of (I think) beautiful #mechanics!

@mpipks.bsky.social @mpi-cbg.de @csbdresden.bsky.social

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Reposted by Markus Mukenhirn

Sara Wickstrom @sarawickstrom.bsky.social · 9d

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology

McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

www.nature.com

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Edouard Hannezo @ehannezo.bsky.social · 12d

Now out in final published form - with a new title "Mechanical control of cell fate decisions in the skin epidermis" and simulations/quantifications! See below for thread of how unbalanced tensions can bias fate choices in minimal 3D models of tissues! www.nature.com/articles/s41...

Edouard Hannezo @ehannezo.bsky.social · Dec 17

Happy to share the latest work from Preeti Sahu, with Adriana Sanchez-Danes on the biomechanics of cell fate choices during tumor initiation! We implement/test a 3D vertex model with proliferation and fate choices for multilayered tissues! See 🧵 below (1/n) bit.ly/3ZXxJzk

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David Brückner @davidbrueckner.bsky.social · 12d

How do cells navigate up gradients of adhesive proteins?
🤔

Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood

We show that passive friction directs cells & explains complex trajectories on gradients

👉 www.nature.com/articles/s41...

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Akankshi Munjal @akankshi.bsky.social · 12d

Our latest preprint! Into morphogenesis, Yap, ECM, signaling, vertex models, feedbacks/robustness? There is something here for everyone. We discovered a positive feedback loop that extends inner ear canals, and a built-in mechanism that shuts it down when morphogenesis is done. tinyurl.com/464wsjhd

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Lori O'Brien @llobrienlab.bsky.social · 12d

For this #FluorescenceFriday, a gorgeous image of an adult mouse kidney labeled with AQP2 and alpha SMA antibodies. AQP2 (green) marks the collecting duct and distal connecting segment while SMA marks the arterial tree. Courtesy of talented postdoc Sarah McLarnon.

Image of a fluorescently labeled adult mouse kidney showing AQP2 staining of collecting ducts and connecting segment in green and alpha SMA staining of the arterial tree in magenta. The collecting ducts look like squiggly branches.

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Nils Lindstrom @lindstromlab.bsky.social · Sep 3

Excited we can generate nephron cells for preclinical trials. We will continue to perfect the proximal tubule model and are going deep into understanding nephron injury programs and following up on druggable targets that could solve acute kidney injury and maladaptive repair.

USC Stem Cell @stemcell.keck.usc.edu · Sep 3

A Nature Communications paper from Nils Lindström's lab at USC Stem Cell identifies key molecular switches that generate distinct cell types within the kidney’s filtering units, or nephrons. The lab is getting closer to making therapeutic kidney cells on demand! stemcell.keck.usc.edu/scientists-u...

Kidney images (Images by MaryAnne Achieng/Lindstrom Lab/USC Stem Cell)

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Barriga Lab @eliasbarrigalab.bsky.social · 15d

Are you interested on how regenerating tissues transit between stages? Am sharing here our work showing that during #Xenopus tail regeneration, tissue stiffening activates a Piezo1-Yap1 mechanosensitive cascade to allow wounded epithelia to transit into regenerative states!

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Markus Mukenhirn @markusmukenhirn.bsky.social · 19d

Congratulations 🎉

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Daniel Alber @danielalber.bsky.social · 20d

A ring of cells deforms into a triangular keyhole in just 15 minutes. Meet the hindgut, a model for boundary-driven morphogenesis!

Out now in @pnas.org at doi.org/10.1073/pnas... with @zhaoshh.bsky.social, Alex Jacinto, Eric Wieschaus, Stas Shvartsman, @lepuslapis.bsky.social (1/8)

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Pierre Haas @lepuslapis.bsky.social · 20d

Now #published @pnas.org: "A model for boundary-driven tissue morphogenesis", a great #biophysics #devbio collaboration led by @danielalber.bsky.social @zhaoshh.bsky.social:

doi.org/10.1073/pnas.2505160122

@mpipks.bsky.social @mpi-cbg.de @csbdresden.bsky.social @flatironinstitute.org

Pierre Haas @lepuslapis.bsky.social · Mar 6

New #preprint: "A model for boundary-driven tissue morphogenesis" arxiv.org/abs/2503.03688.

A great collaboration with @danielalber.bsky.social @zhaoshh.bsky.social, Alexandre Jacinto, Eric Wieschaus, Stas Shvartsman.

@flatironinstitute.org @mpipks.bsky.social @mpi-cbg.de @csbdresden.bsky.social

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