Miklos Lengyel
@mikloslengyel.bsky.social
Postdoc in Niethammer lab@MSKCC. Cell biologist currently interested in detection and adaptation to chemical stress by various epithelia. MD/PhD in in ion channels and sensory neurobiology@Semmelweis University
All opinions my own.
All opinions my own.
Reposted by Miklos Lengyel
A substantially revised version of Zaza's outstanding PhD work is accepted (in principle) at Nature Communications. Many thanks to the reviewers and editor for their constructive comments and guidance!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Perivascular Macrophages Convert Physical Wound Signals Into Rapid Vascular Responses
Leukocytes detect distant wounds within seconds to minutes, which is essential for effective pathogen defense, tissue healing, and regeneration. Blood vessels must detect distant wounds just as rapidl...
www.biorxiv.org
December 19, 2025 at 5:13 PM
A substantially revised version of Zaza's outstanding PhD work is accepted (in principle) at Nature Communications. Many thanks to the reviewers and editor for their constructive comments and guidance!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Miklos Lengyel
Organelles do NOT have a single uniform pH.
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
Organelles harbour pH gradients https://www.biorxiv.org/content/10.64898/2025.12.12.694065v1
December 17, 2025 at 12:46 AM
Organelles do NOT have a single uniform pH.
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
Reposted by Miklos Lengyel
This review was a fun collaboration with
Pere Roca-Cusachs - just published in a journal! www.tandfonline.com/doi/full/10....
Pere Roca-Cusachs - just published in a journal! www.tandfonline.com/doi/full/10....
Mechanotransduction by nuclear envelope tension
Mechanotransduction mediated by the tension in lipid membranes is a well-established paradigm. This has been studied largely in the context of the plasma membrane, but recent work shows that it app...
www.tandfonline.com
December 17, 2025 at 10:27 AM
This review was a fun collaboration with
Pere Roca-Cusachs - just published in a journal! www.tandfonline.com/doi/full/10....
Pere Roca-Cusachs - just published in a journal! www.tandfonline.com/doi/full/10....
Reposted by Miklos Lengyel
De novo E-cadherin/catenin complex formation controls basal epithelial mechanics and force transmission for apoptotic cell clearance https://www.biorxiv.org/content/10.64898/2025.12.08.692667v1
December 9, 2025 at 6:30 PM
De novo E-cadherin/catenin complex formation controls basal epithelial mechanics and force transmission for apoptotic cell clearance https://www.biorxiv.org/content/10.64898/2025.12.08.692667v1
Reposted by Miklos Lengyel
Joe Shen’s and Zaza Gelashvili’s work on the role of the ER in nuclear membrane mechanotransduction finally came out in a journal!
Endoplasmic reticulum disruption stimulates nuclear membrane mechanotransduction
Nature Cell Biology - Shen, Gelashvili and Niethammer developed an inner nuclear membrane tension sensor and demonstrated that ER–nuclear membrane contiguity acts as a mechanical buffer.
rdcu.be
December 9, 2025 at 12:11 PM
Joe Shen’s and Zaza Gelashvili’s work on the role of the ER in nuclear membrane mechanotransduction finally came out in a journal!
Reposted by Miklos Lengyel
I agree with EVERY SINGLE ONE of these rules. I came to most of them on my own because I never had any mentorship for my mentorship. And despite being published in PLOS Comp Bio, they apply to EVERY undergraduate and masters student project.
From @plos.org #Computational #Biology | Ten simple rules for early-career researchers supervising short-term student projects | #Education #Bioinformatics #OpenScience #PLOSCBTSR #ECR 🧪 🔓 CC/ @knaegle.bsky.social
⬇️
journals.plos.org/ploscompbiol...
⬇️
journals.plos.org/ploscompbiol...
Ten simple rules for early-career researchers supervising short-term student projects
Author summary Supervising undergraduate or master’s research projects is a vital aspect of academic life, offering opportunities for both student development and supervisor growth. For many early-car...
journals.plos.org
November 19, 2025 at 6:26 PM
I agree with EVERY SINGLE ONE of these rules. I came to most of them on my own because I never had any mentorship for my mentorship. And despite being published in PLOS Comp Bio, they apply to EVERY undergraduate and masters student project.
Reposted by Miklos Lengyel
Great thread!
This week is particularly remarkable in terms of #CellDeath and infection biology-related discoveries: biomed.news/bims-cediti/...
Highlight 1: SIGLEC12 mediates plasma membrane rupture during necroptotic cell death:
Highlight 1: SIGLEC12 mediates plasma membrane rupture during necroptotic cell death:
SIGLEC12 mediates plasma membrane rupture during necroptotic cell death - Nature
CRISPR–Cas9-based genome-wide screening shows that SIGLEC12 mediates plasma membrane rupture in cells undergoing necroptosis, possibly through a human-specific mechanism, indicating its potential as a...
www.nature.com
November 16, 2025 at 9:18 AM
Great thread!
Reposted by Miklos Lengyel
Wound healing is a hallmark feature of all life, including single cells. In a new preprint, Ambika Nadkarni @biochembika.bsky.social investigates a new dimension in cellular wound healing: how cells recover AFTER the wound has been closed
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 10, 2025 at 5:47 PM
Wound healing is a hallmark feature of all life, including single cells. In a new preprint, Ambika Nadkarni @biochembika.bsky.social investigates a new dimension in cellular wound healing: how cells recover AFTER the wound has been closed
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Miklos Lengyel
When I ask a patient what medicines they take and they wave their hands and say “it’s in the chart” I need them to understand that “the patient’s chart” is a mythical concept, more akin to the scattered scribblings of the British constitution rather than a single, comprehensive document.
January 9, 2024 at 3:40 PM
When I ask a patient what medicines they take and they wave their hands and say “it’s in the chart” I need them to understand that “the patient’s chart” is a mythical concept, more akin to the scattered scribblings of the British constitution rather than a single, comprehensive document.
Reposted by Miklos Lengyel
1/New paper from Zheng Wu, Phong Nguyen et al. @cri-utsw.bsky.social shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT
Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...
www.science.org
November 6, 2025 at 7:01 PM
1/New paper from Zheng Wu, Phong Nguyen et al. @cri-utsw.bsky.social shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Miklos Lengyel
#microsky #phagesky #phage defence
Novel bacterial ubiquitination-like pathway!
www.nature.com/articles/s41...
Novel bacterial ubiquitination-like pathway!
www.nature.com/articles/s41...
Mechanistic basis for protein conjugation in a diverged bacterial ubiquitination pathway - Nature Structural & Molecular Biology
Ye et al. define the structure and mechanisms of a bacterial pathway that performs ubiquitination-like protein conjugation, revealing new insights into the evolution and biological roles of ubiquitina...
www.nature.com
November 3, 2025 at 8:56 PM
#microsky #phagesky #phage defence
Novel bacterial ubiquitination-like pathway!
www.nature.com/articles/s41...
Novel bacterial ubiquitination-like pathway!
www.nature.com/articles/s41...
Reposted by Miklos Lengyel
Now out in Cell! Congratulations to all involved, especially
@chiarafornetto.bsky.social
For a breakdown, see the bluetorial from when we posted the preprint: bsky.app/profile/neur...
Funding: @erc.europa.eu @wellcometrust.bsky.social @ukri.org @leverhulme.ac.uk @thelisterinstitute.bsky.social
@chiarafornetto.bsky.social
For a breakdown, see the bluetorial from when we posted the preprint: bsky.app/profile/neur...
Funding: @erc.europa.eu @wellcometrust.bsky.social @ukri.org @leverhulme.ac.uk @thelisterinstitute.bsky.social
Now online! Zebrafish use spectral information to suppress the visual background
Zebrafish use spectral information to suppress the visual background
Vertebrate eyes first evolved in water, where spectral content rapidly fades with distance. Zebrafish exploit this loss by antagonizing cone signals to suppress the background, pointing to distance estimation—rather than color—as an ancestral cone function.
dlvr.it
November 4, 2025 at 8:53 AM
Now out in Cell! Congratulations to all involved, especially
@chiarafornetto.bsky.social
For a breakdown, see the bluetorial from when we posted the preprint: bsky.app/profile/neur...
Funding: @erc.europa.eu @wellcometrust.bsky.social @ukri.org @leverhulme.ac.uk @thelisterinstitute.bsky.social
@chiarafornetto.bsky.social
For a breakdown, see the bluetorial from when we posted the preprint: bsky.app/profile/neur...
Funding: @erc.europa.eu @wellcometrust.bsky.social @ukri.org @leverhulme.ac.uk @thelisterinstitute.bsky.social
Reposted by Miklos Lengyel
How do pluripotent stem cells resist harmful interferon responses to safeguard development? Through total epigenetic lockdown of ligands, sensors and effectors of IFN-I. In our preprint, James Holt shares his PhD discoveries on the ground state of immune evasion 😊: www.biorxiv.org/cgi/content/...
Epigenetic lockdown of type I interferon sensing and signalling in human pluripotent cells.
The Human Silencing Hub (HUSH) complex safeguards genome integrity in human somatic cells by repressing transposable elements and regulating type I interferon (IFN-I) induction. In early development, ...
www.biorxiv.org
October 29, 2025 at 6:03 PM
How do pluripotent stem cells resist harmful interferon responses to safeguard development? Through total epigenetic lockdown of ligands, sensors and effectors of IFN-I. In our preprint, James Holt shares his PhD discoveries on the ground state of immune evasion 😊: www.biorxiv.org/cgi/content/...
Reposted by Miklos Lengyel
Hot off the press, after years of work by many PG and undergrads and collaborators, we present you wilth a detailed analysis of oncogenic RAS driven cellular plasticity and host immune response within 24 hours of oncogene activation in a #zebrafish model www.cell.com/cell-reports...
Oncogenic Ras activation in permissive somatic cells triggers rapid-onset phenotypic plasticity and elicits a tumor-promoting neutrophil response
Ras mutations drive tumorigenesis yet persist in normal tissues. Elliot et al. explore
this paradox, finding that HRASG12V induces bifurcating cell fates in the zebrafish
larval epidermis, with lamc2+...
www.cell.com
October 29, 2025 at 5:01 PM
Hot off the press, after years of work by many PG and undergrads and collaborators, we present you wilth a detailed analysis of oncogenic RAS driven cellular plasticity and host immune response within 24 hours of oncogene activation in a #zebrafish model www.cell.com/cell-reports...
Reposted by Miklos Lengyel
What do the naked mole rat and bowhead whale (lives to ~200 years) have in common to explain their remarkable longevity?
Enhanced DNA repair
www.nature.com/articles/s41...
erictopol.substack.com/p/a-long-awa...
Enhanced DNA repair
www.nature.com/articles/s41...
erictopol.substack.com/p/a-long-awa...
Evidence for improved DNA repair in long-lived bowhead whale - Nature
Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein. &nbs...
www.nature.com
October 29, 2025 at 4:26 PM
What do the naked mole rat and bowhead whale (lives to ~200 years) have in common to explain their remarkable longevity?
Enhanced DNA repair
www.nature.com/articles/s41...
erictopol.substack.com/p/a-long-awa...
Enhanced DNA repair
www.nature.com/articles/s41...
erictopol.substack.com/p/a-long-awa...
Reposted by Miklos Lengyel
A sensory system for mating in octopus https://www.biorxiv.org/content/10.1101/2025.10.28.685082v1
October 29, 2025 at 4:30 AM
A sensory system for mating in octopus https://www.biorxiv.org/content/10.1101/2025.10.28.685082v1
Reposted by Miklos Lengyel
Fazekas, Kaszás, Vámosi et al @enyedilab.bsky.social describe a #fibroblast-specific synthetic promoter that enables #biosensor expression & targeted ablation in #zebrafish fins & reveal a role for fibroblasts in osmotic surveillance by wound-induced calcium patterns rupress.org/jcb/article/...
October 22, 2025 at 4:01 PM
Fazekas, Kaszás, Vámosi et al @enyedilab.bsky.social describe a #fibroblast-specific synthetic promoter that enables #biosensor expression & targeted ablation in #zebrafish fins & reveal a role for fibroblasts in osmotic surveillance by wound-induced calcium patterns rupress.org/jcb/article/...
Reposted by Miklos Lengyel
Reposted by Miklos Lengyel
Looking forward to Florida, where my brilliant PhD student Zaza Gelashvili and I are giving back-to-back talks. Among other things, we'll talk about our work on www.biorxiv.org/content/10.1... www.researchsquare.com/article/rs-5..., which will hopefully come out soon in much improved versions!
October 2, 2025 at 4:39 PM
Looking forward to Florida, where my brilliant PhD student Zaza Gelashvili and I are giving back-to-back talks. Among other things, we'll talk about our work on www.biorxiv.org/content/10.1... www.researchsquare.com/article/rs-5..., which will hopefully come out soon in much improved versions!
Reposted by Miklos Lengyel
1/11 In @science.org: A new perspective on how our intestines renew. Cells are not “pushed out” by crowding or die from apoptosis. Instead, cells play a mechanical tug-of-war, where weaker cells extrude, reframing gut renewal as force-regulated. www.science.org/doi/10.1126/...
Epithelial tension controls intestinal cell extrusion
Cell extrusion is essential for homeostatic self-renewal of the intestinal epithelium. Extrusion is thought to be triggered by crowding-induced compression of cells at the intestinal villus tip. In th...
www.science.org
September 6, 2025 at 7:36 PM
1/11 In @science.org: A new perspective on how our intestines renew. Cells are not “pushed out” by crowding or die from apoptosis. Instead, cells play a mechanical tug-of-war, where weaker cells extrude, reframing gut renewal as force-regulated. www.science.org/doi/10.1126/...
Reposted by Miklos Lengyel
Look at this crazy thing!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
One mother for two species via obligate cross-species cloning in ants - Nature
In a case of obligate cross-species cloning, female ants of Messor ibericus need to clone males of Messor structor to obtain sperm for producing the worker caste, resulting in males from the same moth...
www.nature.com
September 3, 2025 at 7:05 PM
Look at this crazy thing!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Miklos Lengyel
Happy to share our work on uMAIA, a framework for building metabolomic atlases from mass spectrometry imaging.
With uMAIA, we mapped the lipidome of zebrafish development, uncovering spatially organized metabolic programs .
www.nature.com/articles/s41...
#developmentalbiology #MSI #lipidtime
With uMAIA, we mapped the lipidome of zebrafish development, uncovering spatially organized metabolic programs .
www.nature.com/articles/s41...
#developmentalbiology #MSI #lipidtime
Unified mass imaging maps the lipidome of vertebrate development
Nature Methods - uMAIA is an analytical framework designed to enable the construction of metabolic atlases at high resolution using mass spectrometry imaging data.
www.nature.com
September 3, 2025 at 10:40 AM
Happy to share our work on uMAIA, a framework for building metabolomic atlases from mass spectrometry imaging.
With uMAIA, we mapped the lipidome of zebrafish development, uncovering spatially organized metabolic programs .
www.nature.com/articles/s41...
#developmentalbiology #MSI #lipidtime
With uMAIA, we mapped the lipidome of zebrafish development, uncovering spatially organized metabolic programs .
www.nature.com/articles/s41...
#developmentalbiology #MSI #lipidtime
Reposted by Miklos Lengyel
Can't wait to read this preprint from Misha Ahrens and team. Calcium imaging in larval zebrafish, in every cell in the body! Amazing.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
August 22, 2025 at 10:21 PM
Can't wait to read this preprint from Misha Ahrens and team. Calcium imaging in larval zebrafish, in every cell in the body! Amazing.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Miklos Lengyel
Academia may not give you job security, flexibility, or wealth, but it will let you unexpectedly connect to eduroam in foreign cities
August 20, 2025 at 4:58 PM
Academia may not give you job security, flexibility, or wealth, but it will let you unexpectedly connect to eduroam in foreign cities
Reposted by Miklos Lengyel
I don't know the exact number of Nobel Prize laureates who wrote cooking books, but here's a rösti recipe from Christiane Nüsslein-Volhard: artemilin.neocities.org/post/250817_nv
Postdoc Postpunk
artemilin.neocities.org
August 17, 2025 at 11:45 AM
I don't know the exact number of Nobel Prize laureates who wrote cooking books, but here's a rösti recipe from Christiane Nüsslein-Volhard: artemilin.neocities.org/post/250817_nv