Jonathan Wilde
@neurogtx.bsky.social
I make gene therapies for neurological disorders. Lover of synthesizers, coffee, biotech, and all things Philly sports.
Reposted by Jonathan Wilde
What’s so pernicious about this is that science works by testing a hypothesis (call it H1) vs the null hypothesis (H0). The burden of proof is on those asserting H1 as correct. This gets our standards of proof completely backwards. This is an attack on the very foundation of scientific epistemology.
CDC has overhauled its website to assert that “the claim ‘vaccines do not cause autism’ is not an evidence-based claim”
November 20, 2025 at 2:44 AM
What’s so pernicious about this is that science works by testing a hypothesis (call it H1) vs the null hypothesis (H0). The burden of proof is on those asserting H1 as correct. This gets our standards of proof completely backwards. This is an attack on the very foundation of scientific epistemology.
Reposted by Jonathan Wilde
Influenza remains an important cause of illness and death. In a phase 3 trial, a nucleoside-modified mRNA (modRNA) quadrivalent vaccine was found to be superior to a standard quadrivalent vaccine in preventing influenza illness. Full trial results: nej.md/43udoTG
#MedSky #IDSky
#MedSky #IDSky
November 19, 2025 at 10:40 PM
Influenza remains an important cause of illness and death. In a phase 3 trial, a nucleoside-modified mRNA (modRNA) quadrivalent vaccine was found to be superior to a standard quadrivalent vaccine in preventing influenza illness. Full trial results: nej.md/43udoTG
#MedSky #IDSky
#MedSky #IDSky
Reposted by Jonathan Wilde
a “Space Force”, if you will
November 13, 2025 at 2:27 PM
a “Space Force”, if you will
The incredible power of a kidney transplant. Still can’t believe this when I look at it. Not even 3 weeks out and I honestly can’t remember the last time I felt this good. #nephsky
November 12, 2025 at 7:02 PM
The incredible power of a kidney transplant. Still can’t believe this when I look at it. Not even 3 weeks out and I honestly can’t remember the last time I felt this good. #nephsky
lol my alma mater is cursed
November 8, 2025 at 8:28 PM
lol my alma mater is cursed
Reposted by Jonathan Wilde
Someday I will not have to write about Sarepta Therapeutics and their ineffective drugs that never should have been approved by the FDA in the first place.
This is not that day.
This is not that day.
Sarepta: Enough, For God's Sake
www.science.org
November 5, 2025 at 1:33 PM
Someday I will not have to write about Sarepta Therapeutics and their ineffective drugs that never should have been approved by the FDA in the first place.
This is not that day.
This is not that day.
Reposted by Jonathan Wilde
This is pretty cool. Can't believe I hadn't heard about it before.
www.kidneyregistry.com/for-donors/v...
www.kidneyregistry.com/for-donors/v...
Voucher Program | Donate a Kidney to a Family Member or Friend
The National Kidney Registry’s Voucher Program was created to overcome compatibility issues between donors and recipients, as well as to make the process more convenient for donors and allow the best ...
www.kidneyregistry.com
October 16, 2025 at 5:14 PM
This is pretty cool. Can't believe I hadn't heard about it before.
www.kidneyregistry.com/for-donors/v...
www.kidneyregistry.com/for-donors/v...
It’s a US Ryder Cup performance fitting of the current state of America.
September 27, 2025 at 9:40 PM
It’s a US Ryder Cup performance fitting of the current state of America.
Reposted by Jonathan Wilde
Reposted by Jonathan Wilde
"So Do" Dennis reads a speech written by Charlie -Its Always Sunny In Philadelphia
YouTube video by Joe A
youtu.be
September 22, 2025 at 9:37 PM
Reposted by Jonathan Wilde
go to super bowl
lose offensive coordinator
promote from inside the org
suck
hire outside oc
go to super bowl
lose offensive coordinator
promote from inside the org
YOU ARE HERE
lose offensive coordinator
promote from inside the org
suck
hire outside oc
go to super bowl
lose offensive coordinator
promote from inside the org
YOU ARE HERE
September 21, 2025 at 6:05 PM
go to super bowl
lose offensive coordinator
promote from inside the org
suck
hire outside oc
go to super bowl
lose offensive coordinator
promote from inside the org
YOU ARE HERE
lose offensive coordinator
promote from inside the org
suck
hire outside oc
go to super bowl
lose offensive coordinator
promote from inside the org
YOU ARE HERE
Reposted by Jonathan Wilde
Could not be a more Philly start to this title defense. 🤦🏻♂️
September 5, 2025 at 12:27 AM
Could not be a more Philly start to this title defense. 🤦🏻♂️
Reposted by Jonathan Wilde
It takes a special kind of person to give part of yourself so someone else can live 🧡 Congratulations to Mohamed on getting your new kidney — and thank you Julian for being a living donor hero.
July 23, 2025 at 2:04 PM
It takes a special kind of person to give part of yourself so someone else can live 🧡 Congratulations to Mohamed on getting your new kidney — and thank you Julian for being a living donor hero.
Reposted by Jonathan Wilde
Re $SRPT, huge doses are used, for Elevidys approx 10exp16 genomes for 70kg+, 100x > # of cells in the human body, or an MOI of 100 for every cell the patient has, ie trying to force AAV to do something it's not really capable of: Is it really surprising if tox issues may result?
July 19, 2025 at 12:40 PM
Re $SRPT, huge doses are used, for Elevidys approx 10exp16 genomes for 70kg+, 100x > # of cells in the human body, or an MOI of 100 for every cell the patient has, ie trying to force AAV to do something it's not really capable of: Is it really surprising if tox issues may result?
Reposted by Jonathan Wilde
the people driving science into freefall aren’t just malign, but also incurious and dull
fed lies & luxury, they never wrestled with nature or saw the beauty of its hidden truths — much less discovered any
they lack the ability or desire to invent, to cure, to solve big problems facing humanity
fed lies & luxury, they never wrestled with nature or saw the beauty of its hidden truths — much less discovered any
they lack the ability or desire to invent, to cure, to solve big problems facing humanity
July 15, 2025 at 1:19 PM
the people driving science into freefall aren’t just malign, but also incurious and dull
fed lies & luxury, they never wrestled with nature or saw the beauty of its hidden truths — much less discovered any
they lack the ability or desire to invent, to cure, to solve big problems facing humanity
fed lies & luxury, they never wrestled with nature or saw the beauty of its hidden truths — much less discovered any
they lack the ability or desire to invent, to cure, to solve big problems facing humanity
Reposted by Jonathan Wilde
My patients live at the margins of society. They don’t have much. Just getting to dialysis three times a week is a big ask. Taking from them to fund tax breaks for the rich is just cruel.
I want to be outraged but I just feel like crying.
I want to be outraged but I just feel like crying.
July 2, 2025 at 12:20 AM
My patients live at the margins of society. They don’t have much. Just getting to dialysis three times a week is a big ask. Taking from them to fund tax breaks for the rich is just cruel.
I want to be outraged but I just feel like crying.
I want to be outraged but I just feel like crying.
Reposted by Jonathan Wilde
The photos coming from Trump’s birthday parade are just incredible. No one showed up.
June 14, 2025 at 10:56 PM
The photos coming from Trump’s birthday parade are just incredible. No one showed up.
Reposted by Jonathan Wilde
Acceptable names for a dog:
Biff
Speedy
Jennifer
Acceptable names for a cat:
Mork
Potato
Arturo Perez-Reverte
Acceptable names for a horse:
Pulchritude
The Securities and Exchange Commission
A Single Man in Possession of a Good Fortune
Biff
Speedy
Jennifer
Acceptable names for a cat:
Mork
Potato
Arturo Perez-Reverte
Acceptable names for a horse:
Pulchritude
The Securities and Exchange Commission
A Single Man in Possession of a Good Fortune
June 13, 2025 at 7:52 PM
Acceptable names for a dog:
Biff
Speedy
Jennifer
Acceptable names for a cat:
Mork
Potato
Arturo Perez-Reverte
Acceptable names for a horse:
Pulchritude
The Securities and Exchange Commission
A Single Man in Possession of a Good Fortune
Biff
Speedy
Jennifer
Acceptable names for a cat:
Mork
Potato
Arturo Perez-Reverte
Acceptable names for a horse:
Pulchritude
The Securities and Exchange Commission
A Single Man in Possession of a Good Fortune
Reposted by Jonathan Wilde
this is pretty wild
The most energetic molecule ever, and only the second ever neutral nitrogen molecule, hexanitrogen, has been isolated and characterised by researchers in Germany. #ChemSky
Most energetic molecule ever made is stable – in liquid nitrogen
Nitrogen allotrope releases double the energy of the most powerful chemical explosives
www.chemistryworld.com
June 13, 2025 at 11:01 PM
this is pretty wild
Reposted by Jonathan Wilde
I made a survey over at Mastodon and found that Fusilli are mostly right-handed spirals, but about a third of the brands is left-handed.
So far there seems to be no racemic Fusilli brand. Pasta producerst have achieved a degree of enantiomeric purity chemists can only dream of.
🧪
#chemsky
So far there seems to be no racemic Fusilli brand. Pasta producerst have achieved a degree of enantiomeric purity chemists can only dream of.
🧪
#chemsky
What about pasta salad? Are Fusilli enantiomerically pure? And if so, are there brands which sell D-Fusilli and others that sell L-Fusilli? Has anyone ever researched that?
#chemsky
🧪
#chemsky
🧪
don’t worry everyone, #chemsky can be perfect so long as we all get along. first things first, we simply need to agree whether sandwiches can be "a bit chiral".
May 31, 2025 at 9:38 AM
I made a survey over at Mastodon and found that Fusilli are mostly right-handed spirals, but about a third of the brands is left-handed.
So far there seems to be no racemic Fusilli brand. Pasta producerst have achieved a degree of enantiomeric purity chemists can only dream of.
🧪
#chemsky
So far there seems to be no racemic Fusilli brand. Pasta producerst have achieved a degree of enantiomeric purity chemists can only dream of.
🧪
#chemsky
Reposted by Jonathan Wilde
Today "a milestone in the evolution of personalized therapies for rare & ultra-rare inborn errors of metabolism"
—the 1st human to undergo custom genome editing
—from decades of NIH funded research
www.nejm.org/doi/full/10....
@nejm.org
www.nejm.org/doi/full/10....
www.nytimes.com/2025/05/15/h...
—the 1st human to undergo custom genome editing
—from decades of NIH funded research
www.nejm.org/doi/full/10....
@nejm.org
www.nejm.org/doi/full/10....
www.nytimes.com/2025/05/15/h...
May 15, 2025 at 6:05 PM
Today "a milestone in the evolution of personalized therapies for rare & ultra-rare inborn errors of metabolism"
—the 1st human to undergo custom genome editing
—from decades of NIH funded research
www.nejm.org/doi/full/10....
@nejm.org
www.nejm.org/doi/full/10....
www.nytimes.com/2025/05/15/h...
—the 1st human to undergo custom genome editing
—from decades of NIH funded research
www.nejm.org/doi/full/10....
@nejm.org
www.nejm.org/doi/full/10....
www.nytimes.com/2025/05/15/h...