Intercellular nanotubular networks mediate material exchange, but their existence in neurons remains to be explored in detail. We identified long, thin dendritic filopodia forming direct dendrite–dend...

Neural mechanisms underlying flexible learning and decision-making are not fully understood. Using single-cell calcium imaging, authors here found that neurons in orbitofrontal and secondary motor cortex exhibit complementary roles in reward learning, with neurons in the former exerting a sustained role in conditions of uncertainty.

Background: Vestibular dysfunction occurs in 30% to 70% of cases with multiple sclerosis (MS). Objective: To compare the clinical and cost-effectiveness of a c...

Allergic airway matrix remodeling occurs independently of IL-13 and IL-17A and is driven instead by chitinase-like proteins.

Recent studies highlight microglial replacement as a promising therapeutic approach for neurological disease. Wu et al. demonstrated that transplanted bone marrow–derived cells halted ALSP progression, while Mader et al. introduced a strategy that avoids systemic bone marrow ablation toxicity and reduces immune rejection, collectively validating this strategy’s therapeutic potential.

Translational Psychiatry - LRRK2 deficiency mitigates amyloid β deposition-mediated pathology in a murine Alzheimer’s disease model by reprogramming microglia

The Nobel Prize in physiology or medicine for 2025 will be awarded jointly to Mary Brunkow, Fred Ramsdell and Shimun Sakaguchi for "for their discoveries concerning peripheral immune tolerance."

YouTube video by Medical Aid for Palestinians

A study in Science Immunology reports that regulatory T cells in the skin modulate neuronal tone directly through their production of the opioid enkephalin.