Nikos Kouvelas
@nickkouvelas.bsky.social
1.7K followers
530 following
19 posts
RNA-curious PhD student | Mühlemann Lab | NCCR_RNADisease
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Reposted by Nikos Kouvelas
William Garland
@willgarland.bsky.social
· Jul 22
Torben Heick Jensen
@heick.bsky.social
· Jun 27
A postdoc position in the Torben Heick Jensen lab, Aarhus University, Denmark: Mammalian Nuclear RNA Production and Turnover Systems - Vacancy at Aarhus University
Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University
mbg.au.dk
Nikos Kouvelas
@nickkouvelas.bsky.social
· Jul 13
m6A alters ribosome dynamics to initiate mRNA degradation
m6A is a potent inducer of ribosome stalling and collisions that trigger YTHDF-mediated
mRNA degradation, a process that highlights the ribosome as a critical sensor linking
translation dynamics to m6...
www.cell.com
Reposted by Nikos Kouvelas
Eugene Valkov
@eugenevalkov.bsky.social
· Jul 13
Intracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay - Nature Communications
Intracellular pathogens hijack host gene expression to subvert cellular processes. Here, the authors show that Legionella pneumophila’s PieF effector inhibits the human CCR4-NOT deadenylation machiner...
www.nature.com
Reposted by Nikos Kouvelas
Reposted by Nikos Kouvelas
Reposted by Nikos Kouvelas
Reposted by Nikos Kouvelas
Sendoel Lab
@sendoellab.bsky.social
· May 26
The alternative initiation factor eIF2A regulates 40S subunit turnover in ribosome-associated quality control
The noncanonical translation initiation factor eIF2A plays critical roles in diverse cellular processes, including the integrated stress response, neurodegeneration and tumorigenesis. However, the pre...
www.biorxiv.org
Reposted by Nikos Kouvelas
Nikos Kouvelas
@nickkouvelas.bsky.social
· Apr 24
Attenuating ribosome load improves protein output from mRNA by limiting translation-dependent mRNA decay
Bicknell et al. demonstrate that exogenously delivered mRNAs are degraded in a translation-dependent
manner at a rate that correlates with ribosome load. ORF sequences leading to high
ribosome load ca...
www.cell.com
Nikos Kouvelas
@nickkouvelas.bsky.social
· Apr 17
Re-adenylation by TENT5A enhances efficacy of SARS-CoV-2 mRNA vaccines - Nature
Upon intramuscular administration, COVID-19 mRNA vaccines are primarily taken up by macrophages, in which the cellular machinery extends their poly(A) tails, thereby increasing mRNA stability and tran...
www.nature.com
Reposted by Nikos Kouvelas
Reposted by Nikos Kouvelas
Nikos Kouvelas
@nickkouvelas.bsky.social
· Apr 10
A nuclear RNA degradation code is recognized by PAXT for eukaryotic transcriptome surveillance
Soles et al. demonstrate that the combination of a 5′ splice site and a poly(A) junction
constitutes a nuclear RNA degradation code that targets RNAs for degradation by the
PAXT adaptor and the RNA ex...
www.cell.com
Reposted by Nikos Kouvelas
Nikos Kouvelas
@nickkouvelas.bsky.social
· Mar 31
UPF1 shuttles between nucleus and cytoplasm independently of its RNA binding and ATPase activities
The ATP-dependent RNA helicase Up-frameshift 1 (UPF1) is an essential protein in mammalian cells and a key factor in nonsense-mediated mRNA decay (NMD), a translation-dependent mRNA surveillance proce...
www.biorxiv.org
Reposted by Nikos Kouvelas
Karousis Lab
@karousislab.bsky.social
· Mar 28
The impact of Coronavirus Nsp1 on host mRNA degradation is independent of its role in translation inhibition
Bäumlin et al. investigate the roles of coronavirus Nsp1 in translation inhibition
and mRNA degradation using a human cell-free translation system. They demonstrate
that SARS-CoV-2 Nsp1 mediates mRNA ...
www.cell.com