Diana
@pharmphoodtm.bsky.social
Regulation of partial pressure oxygen by 5HT in hypoxia (https://pubmed.ncbi.nlm.nih.gov/23312111/) pharm pH O2 diet
Reposted by Diana
#Medsky🧪 #IDsky #immunosky #Neurosky #publichealth #PostCOVID sequelas (PCCo) affects 5-10% of individuals following #COVID infection, with cognitive disturbances being a major feature .
This study provides first in vivo evidence of impaired brain energy metabolism in PCCo,
This study provides first in vivo evidence of impaired brain energy metabolism in PCCo,
January 11, 2026 at 1:32 PM
#Medsky🧪 #IDsky #immunosky #Neurosky #publichealth #PostCOVID sequelas (PCCo) affects 5-10% of individuals following #COVID infection, with cognitive disturbances being a major feature .
This study provides first in vivo evidence of impaired brain energy metabolism in PCCo,
This study provides first in vivo evidence of impaired brain energy metabolism in PCCo,
Reposted by Diana
Building bird boxes: Size Matters
#TheOutpost 🪶🌿🌱👨🌾
Birdhouse dimensions chart - because one size doesn't fit all dev.welcomewildlife.com/birdhouse-di...
#TheOutpost 🪶🌿🌱👨🌾
Birdhouse dimensions chart - because one size doesn't fit all dev.welcomewildlife.com/birdhouse-di...
Birdhouse dimensions chart - because one size doesn't fit all
Because one size doesn't fit all, give birds what they want. Here's a birdhouse dimensions chart to guide you.
dev.welcomewildlife.com
December 15, 2025 at 3:36 AM
Building bird boxes: Size Matters
#TheOutpost 🪶🌿🌱👨🌾
Birdhouse dimensions chart - because one size doesn't fit all dev.welcomewildlife.com/birdhouse-di...
#TheOutpost 🪶🌿🌱👨🌾
Birdhouse dimensions chart - because one size doesn't fit all dev.welcomewildlife.com/birdhouse-di...
Reposted by Diana
#Medsky🧪 #IDsky #Neurosky #publichealth
#SARSCoV2 #nucleocapsid (N) protein induces microglia senescence
& associated cognitive impairment by causing mitochondrial dysfunction which forces a metabolic shift ➡️ #glycolysis. The glycolytic reprogramming triggers the activation of cellular senescence.
#SARSCoV2 #nucleocapsid (N) protein induces microglia senescence
& associated cognitive impairment by causing mitochondrial dysfunction which forces a metabolic shift ➡️ #glycolysis. The glycolytic reprogramming triggers the activation of cellular senescence.
December 15, 2025 at 10:02 AM
#Medsky🧪 #IDsky #Neurosky #publichealth
#SARSCoV2 #nucleocapsid (N) protein induces microglia senescence
& associated cognitive impairment by causing mitochondrial dysfunction which forces a metabolic shift ➡️ #glycolysis. The glycolytic reprogramming triggers the activation of cellular senescence.
#SARSCoV2 #nucleocapsid (N) protein induces microglia senescence
& associated cognitive impairment by causing mitochondrial dysfunction which forces a metabolic shift ➡️ #glycolysis. The glycolytic reprogramming triggers the activation of cellular senescence.
Reposted by Diana
Why do heart attacks during the night cause less damage than during daytime? The role of neutrophils and circadian clock genes in reducing inflammation and injury in experimental model
rupress.org/jem/article/...
rupress.org/jem/article/...
December 12, 2025 at 3:22 PM
Why do heart attacks during the night cause less damage than during daytime? The role of neutrophils and circadian clock genes in reducing inflammation and injury in experimental model
rupress.org/jem/article/...
rupress.org/jem/article/...
Reposted by Diana
Israel reports 12th child died of measles
outbreaknewstoday.substack.com/p/israel-rep...
outbreaknewstoday.substack.com/p/israel-rep...
Israel reports 12th measles death in infant
The Israel Ministry of Health reports an 11-month-old baby with no underlying illnesses, who had not yet been vaccinated, died today due to complications of measles.
outbreaknewstoday.substack.com
December 10, 2025 at 3:48 PM
Israel reports 12th child died of measles
outbreaknewstoday.substack.com/p/israel-rep...
outbreaknewstoday.substack.com/p/israel-rep...
Reposted by Diana
What we eat is making us obese and sick — but science shows solutions are within reach www.nature.com/articles/d41...
Book debunks
- obsession with protein (most get enough!)
- supplements industry
- personalization trend
Hear, hear!
Authors @kevinh-phd.bsky.social @juliabelluz.bsky.social 🙏
Book debunks
- obsession with protein (most get enough!)
- supplements industry
- personalization trend
Hear, hear!
Authors @kevinh-phd.bsky.social @juliabelluz.bsky.social 🙏
What we eat is making us obese and sick — but science shows solutions are within reach
An ambitious book challenges long-held assumptions on diet and nutrition and exposes gaps in public-health guidance.
www.nature.com
December 10, 2025 at 5:52 PM
What we eat is making us obese and sick — but science shows solutions are within reach www.nature.com/articles/d41...
Book debunks
- obsession with protein (most get enough!)
- supplements industry
- personalization trend
Hear, hear!
Authors @kevinh-phd.bsky.social @juliabelluz.bsky.social 🙏
Book debunks
- obsession with protein (most get enough!)
- supplements industry
- personalization trend
Hear, hear!
Authors @kevinh-phd.bsky.social @juliabelluz.bsky.social 🙏
Reposted by Diana
The path to this paper has so many stories.
Today I want to tell one about the value of saying so when you don't have the answer - and of the importance of community.
Today I want to tell one about the value of saying so when you don't have the answer - and of the importance of community.
Very excited to see our paper, led by @amilangscience.bsky.social, out today in @pnas.org!
This one was a true adventure, filled with surprises at every turn.
“Erythroid precursors regulate local oxygen tension and repair outcomes in the bone marrow niche.”
www.pnas.org/eprint/NJ8XC...
This one was a true adventure, filled with surprises at every turn.
“Erythroid precursors regulate local oxygen tension and repair outcomes in the bone marrow niche.”
www.pnas.org/eprint/NJ8XC...
Erythroid precursors regulate local oxygen tension and repair outcomes in the bone marrow niche | PNAS
Oxygen tension dynamically regulates stem cell fate and tissue regeneration, yet how
local oxygen availability is controlled within the bone marrow...
www.pnas.org
December 10, 2025 at 6:25 PM
The path to this paper has so many stories.
Today I want to tell one about the value of saying so when you don't have the answer - and of the importance of community.
Today I want to tell one about the value of saying so when you don't have the answer - and of the importance of community.
Reposted by Diana
A study on 1.7 million people in Hong Kong shows superior hybrid immunity to Covid in people who got vaccinated before infection vs. people who got infected first. "Our findings are a direct rebuttal to arguments for natural immunity," the authors write. doi.org/10.1016/j.va...
Redirecting
doi.org
December 6, 2025 at 5:02 PM
A study on 1.7 million people in Hong Kong shows superior hybrid immunity to Covid in people who got vaccinated before infection vs. people who got infected first. "Our findings are a direct rebuttal to arguments for natural immunity," the authors write. doi.org/10.1016/j.va...
Reposted by Diana
#Medsky🧪 #IDsky #immunosky #publichealth In this small study patients with ESRD who receiving hemodialysis &The study found that All patients developed an immune response with detectable IgG anti-S antibodies after receiving 4 doses of the #COVID19vaccine.
December 6, 2025 at 5:47 AM
#Medsky🧪 #IDsky #immunosky #publichealth In this small study patients with ESRD who receiving hemodialysis &The study found that All patients developed an immune response with detectable IgG anti-S antibodies after receiving 4 doses of the #COVID19vaccine.
Reposted by Diana
Multiple large natural experiments have documented Shingles vaccine is linked with ~20-25% reduced risk of dementia and Alzheimer's disease. A new report today adds to that and extends the to slowing the progression of dementia @cellcellpress.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
December 2, 2025 at 4:00 PM
Multiple large natural experiments have documented Shingles vaccine is linked with ~20-25% reduced risk of dementia and Alzheimer's disease. A new report today adds to that and extends the to slowing the progression of dementia @cellcellpress.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Diana
Dysregulated calcium signaling contributes to Alzheimer’s, but the molecular details are unresolved.
Here, Lauren H. Sansing & team report on changes of GLO1 with age & its association with calcium leak in degeneration, using mouse and macaque models: insight.jci.org/articles/vie...
Here, Lauren H. Sansing & team report on changes of GLO1 with age & its association with calcium leak in degeneration, using mouse and macaque models: insight.jci.org/articles/vie...
November 25, 2025 at 2:02 PM
Dysregulated calcium signaling contributes to Alzheimer’s, but the molecular details are unresolved.
Here, Lauren H. Sansing & team report on changes of GLO1 with age & its association with calcium leak in degeneration, using mouse and macaque models: insight.jci.org/articles/vie...
Here, Lauren H. Sansing & team report on changes of GLO1 with age & its association with calcium leak in degeneration, using mouse and macaque models: insight.jci.org/articles/vie...
Reposted by Diana
#Medsky🧪 #virosk #idsky #immunosky #publichealth Structural and functional characterizations of infectivity & immune evasion of #SARSCoV2 Omicron revival
@cellpress.bsky.social
www.cell.com/cell/fulltex...
@cellpress.bsky.social
www.cell.com/cell/fulltex...
Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron
(Cell 185, 860–871.e1–e4; March 3, 2022)
www.cell.com
November 25, 2025 at 1:50 PM
#Medsky🧪 #virosk #idsky #immunosky #publichealth Structural and functional characterizations of infectivity & immune evasion of #SARSCoV2 Omicron revival
@cellpress.bsky.social
www.cell.com/cell/fulltex...
@cellpress.bsky.social
www.cell.com/cell/fulltex...
Reposted by Diana
Things online are often not as they appear.
November 24, 2025 at 11:30 PM
Things online are often not as they appear.
Reposted by Diana
Paper about fetal autopsy after maternal COVID infection.
“Our observations reveal that SARS-CoV-2 can be widely distributed in fetal organs through vertical transmission… Further, proteomic profiling reveals DNA damage and immune imbalance in infected organs.”
www.nature.com/articles/s41...
“Our observations reveal that SARS-CoV-2 can be widely distributed in fetal organs through vertical transmission… Further, proteomic profiling reveals DNA damage and immune imbalance in infected organs.”
www.nature.com/articles/s41...
Presence of SARS-CoV-2 in fetal organs via intraamniotic infection - Nature Communications
Infection with SARS-CoV-2 during pregnancy may result in maternal and fetal complications. Here, the authors analyze 18 fetuses following maternal SARS-CoV-2 infection and identify distribution in fet...
www.nature.com
November 24, 2025 at 11:39 PM
Paper about fetal autopsy after maternal COVID infection.
“Our observations reveal that SARS-CoV-2 can be widely distributed in fetal organs through vertical transmission… Further, proteomic profiling reveals DNA damage and immune imbalance in infected organs.”
www.nature.com/articles/s41...
“Our observations reveal that SARS-CoV-2 can be widely distributed in fetal organs through vertical transmission… Further, proteomic profiling reveals DNA damage and immune imbalance in infected organs.”
www.nature.com/articles/s41...
Reposted by Diana
#Medsky🧪#IDsky #publichealth @plosone.org In the cohort, 59% of #PostCovid patients could not return to their previous level of independence or employment due to symptoms, & 81% reported fatigue on the WEIMuS questionnaire.
November 25, 2025 at 6:57 AM
#Medsky🧪#IDsky #publichealth @plosone.org In the cohort, 59% of #PostCovid patients could not return to their previous level of independence or employment due to symptoms, & 81% reported fatigue on the WEIMuS questionnaire.
Reposted by Diana
🫁🧬 Preclinical signal: can lung clots protect? Moderate thrombosis in sepsis ARDS limited endothelial injury via ALOX15-driven lipids.
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory #Sepsis #ARDS
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory #Sepsis #ARDS
New Clues to Protecting Lungs in Sepsis Lung Injury
Mouse and human data suggest endothelial ALOX15 and its lipids may help turn some lung clots into protection in sepsis lung injury, highlighting future therapeutic opportunities.
www.emjreviews.com
November 25, 2025 at 11:43 AM
🫁🧬 Preclinical signal: can lung clots protect? Moderate thrombosis in sepsis ARDS limited endothelial injury via ALOX15-driven lipids.
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory #Sepsis #ARDS
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory #Sepsis #ARDS
Reposted by Diana
Let's talk about Peto's paradox, the multi-hit hypothesis & DNA repair.
Peto's Paradox:
Whales can live to 200 yrs old & they have 1,000 times as many cells as you do, any one of which could be the seed for tumor formation.
So why aren't they getting cancer at 1,000 times the rate of humans? 🐳🧪
Peto's Paradox:
Whales can live to 200 yrs old & they have 1,000 times as many cells as you do, any one of which could be the seed for tumor formation.
So why aren't they getting cancer at 1,000 times the rate of humans? 🐳🧪
November 24, 2025 at 2:27 PM
Let's talk about Peto's paradox, the multi-hit hypothesis & DNA repair.
Peto's Paradox:
Whales can live to 200 yrs old & they have 1,000 times as many cells as you do, any one of which could be the seed for tumor formation.
So why aren't they getting cancer at 1,000 times the rate of humans? 🐳🧪
Peto's Paradox:
Whales can live to 200 yrs old & they have 1,000 times as many cells as you do, any one of which could be the seed for tumor formation.
So why aren't they getting cancer at 1,000 times the rate of humans? 🐳🧪
Reposted by Diana
#Medsky🧪 #IDsky #Immunosky #publichealth some evidences show & some researchers are still in debate (immunity reset ) & but evidence does not support a complete "immunity reset" in most cases
Frontiers | T-cell immunity to SARS-CoV-2: what if the known best is not the optimal course for the long run? Adapting to evolving targets
Humanity did surprisingly well so far, considering how unprepared it was to respond to the coronavirus disease 2019 (COVID-19) threat. By blending old and in...
www.frontiersin.org
November 23, 2025 at 7:11 AM
#Medsky🧪 #IDsky #Immunosky #publichealth some evidences show & some researchers are still in debate (immunity reset ) & but evidence does not support a complete "immunity reset" in most cases
Reposted by Diana
PRMT5 di-methylates H3R8 & H4R3▶️
⏬Myocardin-dependent #SmoothMuscleCell contractile gene transcription
⏫SMC proliferation/migration & intimal hyperplasia in injured🐭carotid artery
PRMT5 (& PRMT4) ⬆️in PDGBB-treated SMC &👤coronary #Atherosclerosis
#CardiovascRes 2023
academic.oup.com/cardiovascre...
⏬Myocardin-dependent #SmoothMuscleCell contractile gene transcription
⏫SMC proliferation/migration & intimal hyperplasia in injured🐭carotid artery
PRMT5 (& PRMT4) ⬆️in PDGBB-treated SMC &👤coronary #Atherosclerosis
#CardiovascRes 2023
academic.oup.com/cardiovascre...
November 22, 2025 at 8:22 PM
PRMT5 di-methylates H3R8 & H4R3▶️
⏬Myocardin-dependent #SmoothMuscleCell contractile gene transcription
⏫SMC proliferation/migration & intimal hyperplasia in injured🐭carotid artery
PRMT5 (& PRMT4) ⬆️in PDGBB-treated SMC &👤coronary #Atherosclerosis
#CardiovascRes 2023
academic.oup.com/cardiovascre...
⏬Myocardin-dependent #SmoothMuscleCell contractile gene transcription
⏫SMC proliferation/migration & intimal hyperplasia in injured🐭carotid artery
PRMT5 (& PRMT4) ⬆️in PDGBB-treated SMC &👤coronary #Atherosclerosis
#CardiovascRes 2023
academic.oup.com/cardiovascre...
Reposted by Diana
River, 14, the Most Chill Cat in the World, wants everyone to know that in this chaotic world, adopting a senior pet guarantees you always have a calm best friend who loves you waiting at home at the end of each day...❤️
#Caturday #AdoptASeniorPetMonth
#Caturday #AdoptASeniorPetMonth
November 22, 2025 at 3:46 PM
River, 14, the Most Chill Cat in the World, wants everyone to know that in this chaotic world, adopting a senior pet guarantees you always have a calm best friend who loves you waiting at home at the end of each day...❤️
#Caturday #AdoptASeniorPetMonth
#Caturday #AdoptASeniorPetMonth
Reposted by Diana
Vaccines DO NOT cause autism - there is extensive research showing this. Resurrecting old, discredited, fraudulent work is shameful.
Vaccine-preventable illnesses are serious - this is going to cause real harms.
This is dangerous & disappointing.
Vaccine-preventable illnesses are serious - this is going to cause real harms.
This is dangerous & disappointing.
November 21, 2025 at 11:40 PM
Vaccines DO NOT cause autism - there is extensive research showing this. Resurrecting old, discredited, fraudulent work is shameful.
Vaccine-preventable illnesses are serious - this is going to cause real harms.
This is dangerous & disappointing.
Vaccine-preventable illnesses are serious - this is going to cause real harms.
This is dangerous & disappointing.
Reposted by Diana
#Medsky🧪 #IDsky #neurosky #neuroCovid #publichealth Common #longCOVID symptoms include memory disturbances and headaches, with neurophysiological methods potentially illuminating the mechanisms behind both central & peripheral components of these symptoms.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
November 22, 2025 at 8:01 AM
#Medsky🧪 #IDsky #neurosky #neuroCovid #publichealth Common #longCOVID symptoms include memory disturbances and headaches, with neurophysiological methods potentially illuminating the mechanisms behind both central & peripheral components of these symptoms.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Diana
NEW BIRD FLU.
IF WE ONLY HAD AN HHS...
H5N5 is a different subtype of bird flu than the circulating H5N1 strain.
The concern is reassortment (2 different flu strains infect the same host and swap genetic material) resulting in a new virus that is both highly lethal and transmissible among humans.
IF WE ONLY HAD AN HHS...
H5N5 is a different subtype of bird flu than the circulating H5N1 strain.
The concern is reassortment (2 different flu strains infect the same host and swap genetic material) resulting in a new virus that is both highly lethal and transmissible among humans.
Bird flu: first ever death from rare H5N5 strain is recorded in US | Bird flu
https://www.europesays.com/uk/586237/
A person in the US is believed to be the first human to die from a rare strain…
https://www.europesays.com/uk/586237/
A person in the US is believed to be the first human to die from a rare strain…
Bird flu: first ever death from rare H5N5 strain is recorded in US | Bird flu - United Kingdom
A person in the US is believed to be the first human to die from a rare strain of bird flu, but state health officials said on Friday the risk to the public
www.europesays.com
November 22, 2025 at 8:18 AM
NEW BIRD FLU.
IF WE ONLY HAD AN HHS...
H5N5 is a different subtype of bird flu than the circulating H5N1 strain.
The concern is reassortment (2 different flu strains infect the same host and swap genetic material) resulting in a new virus that is both highly lethal and transmissible among humans.
IF WE ONLY HAD AN HHS...
H5N5 is a different subtype of bird flu than the circulating H5N1 strain.
The concern is reassortment (2 different flu strains infect the same host and swap genetic material) resulting in a new virus that is both highly lethal and transmissible among humans.
Reposted by Diana
#COVID can trigger systemic hyperinflammation, including macrophage activation syndrome, which may result in PNS involvement & symptoms consistent with acute #polyradiculoneuropathy
- Evidences that #SARSCoV2 may directly affect peripheral nerves through neurotropic mechanisms,
- Evidences that #SARSCoV2 may directly affect peripheral nerves through neurotropic mechanisms,
November 22, 2025 at 8:19 AM
#COVID can trigger systemic hyperinflammation, including macrophage activation syndrome, which may result in PNS involvement & symptoms consistent with acute #polyradiculoneuropathy
- Evidences that #SARSCoV2 may directly affect peripheral nerves through neurotropic mechanisms,
- Evidences that #SARSCoV2 may directly affect peripheral nerves through neurotropic mechanisms,
Reposted by Diana
In a world of so much chaos, you are your only roadmap to the life you want to live…
🎹 Give the soul a chance to unwind.
music.apple.com/au/album/tro...
🎹 Give the soul a chance to unwind.
music.apple.com/au/album/tro...
October 26, 2025 at 2:13 PM
In a world of so much chaos, you are your only roadmap to the life you want to live…
🎹 Give the soul a chance to unwind.
music.apple.com/au/album/tro...
🎹 Give the soul a chance to unwind.
music.apple.com/au/album/tro...