Lightnews — Scholar-powered news

Tamas Nagy @tamasnagy.com · 27d

I feel like the reasonable solution is to ask during the upload process (with notifications selected by default) whether folks want to receive notifications when reviews are posted?

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Tamas Nagy @tamasnagy.com · 27d

Is there no notification system built into this? Seems like there should be

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Tamas Nagy @tamasnagy.com · Sep 4

With some new sorbothane feet from @thorlabs.bsky.social, the Rando lab’s @cephlainc.bsky.social Squid+ is rapidly approaching its final form.

We wrapped a cheap 3D printer enclosure off of Amazon with some matte black vinyl and it’s working great as a darkbox.

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Tamas Nagy @tamasnagy.com · Sep 1

Congrats Maik!!

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Tamas Nagy @tamasnagy.com · Aug 27

Amazing work @lhinderling.bsky.social! I think tissue-scale opto is the future 😎

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Tamas Nagy @tamasnagy.com · Aug 27

This is a CMOS camera cooled to -20C. I tried summing 60x1s exposures but that’s significantly worse than one long exposure

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Tamas Nagy @tamasnagy.com · Aug 27

Hey #microscopy 🧪 folks. Have you all noticed similar dark current patterns with cameras where you have a nonlinear response to exposure time?

100ms and 1s exposures are extremely quiet but once I do a 60s exposure, certain pixels just get super bright.

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Reposted by Tamas Nagy

Tanner Fadero @tanner-fadero.bsky.social · Aug 20

Here's a six-month time-lapse of me building the single objective light sheet fluorescence microscope at the UCSF Center for Advanced Light Microscopy!

Also pictured is @nicostuurman.bsky.social and @kahsage.bsky.social.

#snouty

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Tamas Nagy @tamasnagy.com · Aug 19

Chugging along as best I can!

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Tamas Nagy @tamasnagy.com · Aug 18

Congrats Jenny!!

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Reposted by Tamas Nagy

Jenny Sachweh @jennysachweh.bsky.social · Aug 18

My PhD paper is in press @cellpress.bsky.social and now online: www.sciencedirect.com/science/arti...!

Contents: weird #NPCs in yeast and flies, #CLEM, in situ #cryoET and more!

Made possible by the amazing @becklab.bsky.social team at @mpibp.bsky.social and collaborators! #TeamTomo

The small GTPase Ran defines nuclear pore complex asymmetry

Nuclear pore complexes (NPCs) bridge across the nuclear envelope and mediate nucleocytoplasmic exchange. They consist of hundreds of nucleoporin build…

www.sciencedirect.com

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Tamas Nagy @tamasnagy.com · Aug 17

I’ve been looking at the UDR7, you like it?

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Tamas Nagy @tamasnagy.com · Aug 16

Which router did you go for? I’m looking to replace my ancient Ubiquiti Amplifi.

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Tamas Nagy @tamasnagy.com · Aug 13

Congrats Carolin! 🎉

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Reposted by Tamas Nagy

Carolin Klose @carolinklose.bsky.social · Aug 11

Super excited to share our new #preprint on #BioRxiv ✨
We reveal the structural basis of a partnership between the ER membrane complex (EMC) and the P5A-ATPase Spf1 — an insertase–dislocase duo that coordinates membrane protein biogenesis and quality control.
www.biorxiv.org/content/10.1...

Structural basis of an EMC:Spf1 insertase-dislocase complex in the eukaryotic endoplasmic reticulum

Most eukaryotic membrane proteins are inserted into the membrane at the endoplasmic reticulum (ER). This essential but error-prone process relies on molecular quality control machineries to prevent mi...

www.biorxiv.org

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Reposted by Tamas Nagy

Michael Hendricks 🇨🇦 @michaelhendricks.bsky.social · Aug 5

Hmm. I think there are separate--but perhaps a little overlapping--things going on here that are being somewhat conflated...

Carl Zimmer @carlzimmer.com · Aug 4

“If these trends are not stopped, science is going to be destroyed." Here's my story on the accelerating growth of systemic research fraud--aka paper mills. Gift link: nyti.ms/45rDirw

Fraudulent Scientific Papers Are Rapidly Increasing, Study Finds

A statistical analysis found that the number of fake journal articles being churned out by “paper mills” is doubling every year and a half.

nyti.ms

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Reposted by Tamas Nagy

Reto Fiolka @retof.bsky.social · Aug 4

Terence Tao, youngest ever participant of the Math Olympiad, Field Medal Winner 2006, author of over 300 papers, and considered the greatest living mathematician, lost his NSF funding: mathstodon.xyz/@tao/1149568... 😞

Terence Tao (@[email protected])

The current administration in the US has, through various funding agencies such as the NSF and NIH, has recently suspended virtually all federal grants to my home university, UCLA (including my own p...

mathstodon.xyz

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Tamas Nagy @tamasnagy.com · Jul 30

Dug up an old movie of neutrophils solving a maze…it’s still so satisfying!

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Reposted by Tamas Nagy

Mark Peifer (He, him) @peiferlabunc.bsky.social · Jul 26

A recent paper reveals a surprising insight. The length of the cell cycle in a particular tissue determines the oncogenic transformation capacity of particular oncogenes, with tissues with shorter cell cycles most susceptible 3/n

Cell cycle duration determines oncogenic transformation capacity

Danian Chen, Suying Lu, Katherine Huang, Joel D. Pearson, Marek Pacal, Phillipos Peidis, Sean McCurdy, Tao Yu, Monika Sangwan, Angela Nguyen, Philippe P. Monnier, Daniel Schramek, Liang Zhu, David Santamaria, Mariano Barbacid, Nagako Akeno, Kathryn A. Wikenheiser-Brokamp & Rod Bremner

https://www.nature.com/articles/s41586-025-08935-x

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Tamas Nagy @tamasnagy.com · Jul 26

Are they plated on a stiff surface like glass or plastic? That might explain why the nuclei are so flat since cells tend to spread more on stiff surfaces. Pretty imaging!

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Tamas Nagy @tamasnagy.com · Jul 23

The latest on the 🌊 complex from my PhD lab. Super cool experiments to unravel mechanistically how the WAVE complex templates lamellipodia in migrating cells. Congrats Muziyue!

Rockefeller University Press @rupress.org · Jul 16

In new @jcb.org study from Muziyue Wu et al. @oweinerlab.bsky.social, in vivo biochemistry sheds new light on how the WAVE complex templates the characteristic shape of lamellipodial protrusions. rupress.org/jcb/article/...

#Cytoskeleton #Actin #Migration #Motility #Biophysics

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Reposted by Tamas Nagy

Jeremy Berg @jeremymberg.bsky.social · Jul 22

If this all sounds like a calculated plan to reduce the size of the federally funding biomedical research enterprise, I believe that is exactly what is it.

The notion that this "facilitates efficient management" of grants and the appropriation is, to use an official NIH term, horseshit.

/fin

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Tamas Nagy @tamasnagy.com · Jul 18

Brb cancelling all my nondisruptive science….we’re so back 🥳

Maria Antoniak @mariaa.bsky.social · Jul 17

Is disruption in science decreasing? Maybe not...

"Due to a factual plotting mistake, database entries with zero references were omitted in the CD index distributions, hiding a large number of outliers with a maximum CD index of one, while keeping them in the analysis"

the classic Seaborn bug 🫣

Dataset Artefacts are the Hidden Drivers of the Declining Disruptiveness in Science

Park et al. [1] reported a decline in the disruptiveness of scientific and technological knowledge over time. Their main finding is based on the computation of CD indices, a measure of disruption in c...

arxiv.org

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Reposted by Tamas Nagy

David Mick @mick-lab.bsky.social · Jul 13

Beautiful work on the development of protein kinase reporters. Congrats all! www.nature.com/articles/s41...

Molecular recording of cellular protein kinase activity with chemical labeling - Nature Chemical Biology

Molecular recorders based on kinase activity-dependent protein labeling track specific kinase activities to understand their link to cellular phenotypes in heterogeneous cell populations and in vivo.

www.nature.com

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Tamas Nagy @tamasnagy.com · Jul 11

I find that they are incredibly useful even when you might know the field’s jargon but the jargon is too generic for keyword searching. You can simply spell out in detail what you’re looking for and it can increase the chance of you finding it.

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