7/ 👅Licking is an affective-motivational behavior emerging during Pain States
This structure supports the original Gate Control Theory that rubbing/licking is an antinociceptive negative feedback loop to reduce pain
Pain drives licking → licking reduces pain → licking stops
This structure supports the original Gate Control Theory that rubbing/licking is an antinociceptive negative feedback loop to reduce pain
Pain drives licking → licking reduces pain → licking stops
January 8, 2026 at 6:04 PM
7/ 👅Licking is an affective-motivational behavior emerging during Pain States
This structure supports the original Gate Control Theory that rubbing/licking is an antinociceptive negative feedback loop to reduce pain
Pain drives licking → licking reduces pain → licking stops
This structure supports the original Gate Control Theory that rubbing/licking is an antinociceptive negative feedback loop to reduce pain
Pain drives licking → licking reduces pain → licking stops
Mu opioid receptor agonists with a preference for the non-GTP-bound state of the G protein promote GTP release, thereby potentiating antinociceptive effects of drugs such as morphine and fentanyl without also increasing their respiratory or cardiac effects.
GTP release-selective agonists prolong opioid analgesic efficacy - Nature
www.nature.com
December 19, 2025 at 4:15 AM
Mu opioid receptor agonists with a preference for the non-GTP-bound state of the G protein promote GTP release, thereby potentiating antinociceptive effects of drugs such as morphine and fentanyl without also increasing their respiratory or cardiac effects.
Vivanco-Estela et al. find that cannabidiol’s antinociceptive properties in trigeminal neuralgia modulate ascending/descending transmissions of nociceptive input, with gender-specific effects. Learn more in #PAIN bit.ly/4nnY8zI
November 4, 2025 at 9:00 PM
Vivanco-Estela et al. find that cannabidiol’s antinociceptive properties in trigeminal neuralgia modulate ascending/descending transmissions of nociceptive input, with gender-specific effects. Learn more in #PAIN bit.ly/4nnY8zI
Antinociceptive and neuromodulatory effects of the scorpion venom tetrapeptide tetrascorpin-1 in a long-lasting pain hypersensitivity model in mice todayheadline
We evaluated the effects of Tetrascorpin-1 from Androctonus australis (AaTs-1), a tetrapeptide obtained from scorpion venom, previously…
We evaluated the effects of Tetrascorpin-1 from Androctonus australis (AaTs-1), a tetrapeptide obtained from scorpion venom, previously…
Antinociceptive and neuromodulatory effects of the scorpion venom tetrapeptide tetrascorpin-1 in a long-lasting pain hypersensitivity model in mice todayheadline
We evaluated the effects of Tetrascorpin-1 from Androctonus australis (AaTs-1), a tetrapeptide obtained from scorpion venom, previously hypothesized to bind the formyl peptide receptor like-1 (FPRL-1) known as formyl peptide receptor-2 (FPR-2) in vitro, on pain responses and cytokines, neuronal and glial morpho-functional alterations in the spinal cord of mice with formalin-induced long-lasting pain hypersensitivity. Due to the peptide chemical nature and for favoring its penetration into the central nervous system, AaTs-1 was daily administered intranasally for 10 days.
todayheadline.co
October 7, 2025 at 3:32 PM
Antinociceptive and neuromodulatory effects of the scorpion venom tetrapeptide tetrascorpin-1 in a long-lasting pain hypersensitivity model in mice todayheadline
We evaluated the effects of Tetrascorpin-1 from Androctonus australis (AaTs-1), a tetrapeptide obtained from scorpion venom, previously…
We evaluated the effects of Tetrascorpin-1 from Androctonus australis (AaTs-1), a tetrapeptide obtained from scorpion venom, previously…
Antinociceptive and neuromodulatory effects of the scorpion venom tetrapeptide tetrascorpin-1 in a long-lasting pain hypersensitivity model in mice
We evaluated the effects of Tetrascorpin-1 from Androctonus australis (AaTs-1), a tetrapeptide obtained from scorpion venom, previously hypothesized…
We evaluated the effects of Tetrascorpin-1 from Androctonus australis (AaTs-1), a tetrapeptide obtained from scorpion venom, previously hypothesized…
Antinociceptive and neuromodulatory effects of the scorpion venom tetrapeptide tetrascorpin-1 in a long-lasting pain hypersensitivity model in mice
We evaluated the effects of Tetrascorpin-1 from Androctonus australis (AaTs-1), a tetrapeptide obtained from scorpion venom, previously hypothesized to bind the formyl peptide receptor like-1 (FPRL-1) known as formyl peptide receptor-2 (FPR-2) in vitro, on pain responses and cytokines, neuronal and glial morpho-functional alterations in the spinal cord of mice with formalin-induced long-lasting pain hypersensitivity. Due to the peptide chemical nature and for favoring its penetration into the central nervous system, AaTs-1 was daily administered intranasally for 10 days.
animeaura.store
October 7, 2025 at 2:51 PM
Antinociceptive and neuromodulatory effects of the scorpion venom tetrapeptide tetrascorpin-1 in a long-lasting pain hypersensitivity model in mice
We evaluated the effects of Tetrascorpin-1 from Androctonus australis (AaTs-1), a tetrapeptide obtained from scorpion venom, previously hypothesized…
We evaluated the effects of Tetrascorpin-1 from Androctonus australis (AaTs-1), a tetrapeptide obtained from scorpion venom, previously hypothesized…
#Honokiol: more than a polyphenol. This mechanistic review highlights its promising analgesic effects in inflammatory, neuropathic, and gouty #pain, alongside anti-cancer, anti-inflammatory, and antioxidant benefits. #Analgesia #Antinociceptive journals.sagepub.com/doi/10.1177/...
EXPRESS: Honokiol and analgesia: a mechanistic review on the current capacities and challenges - Behrang Nooralishahi, Mehdi Dehghani, Fatemeh Rezaee Tazangi, 2025
Pain is an unfavorable subjective sensation influencing 20% of the public population, giving rise to substantial health and economic issues. Several categories ...
journals.sagepub.com
October 6, 2025 at 6:01 AM
#Honokiol: more than a polyphenol. This mechanistic review highlights its promising analgesic effects in inflammatory, neuropathic, and gouty #pain, alongside anti-cancer, anti-inflammatory, and antioxidant benefits. #Analgesia #Antinociceptive journals.sagepub.com/doi/10.1177/...
Contulakin G (CAS 229180-41-0) | GMP Supplier & Manufacturer
Contulakin G (CAS 229180-41-0) is a glycosylated neuropeptide that functions as a neurotensin receptor agonist with antinociceptive properties. It is widely used in preclinical studies exploring pain modulation, receptor pharmacology,…
Contulakin G (CAS 229180-41-0) is a glycosylated neuropeptide that functions as a neurotensin receptor agonist with antinociceptive properties. It is widely used in preclinical studies exploring pain modulation, receptor pharmacology,…
Contulakin G (CAS 229180-41-0) | GMP Supplier & Manufacturer
Contulakin G (CAS 229180-41-0) is a glycosylated neuropeptide that functions as a neurotensin receptor agonist with antinociceptive properties. It is widely used in preclinical studies exploring pain modulation, receptor pharmacology, and neuropeptide signaling. Manufactured under GMP conditions, Contulakin G is intended strictly for laboratory research use.(Please contact our staff to place an order or learn about product wholesale prices, specifications, uses and lists)
arizona-mall.com
August 28, 2025 at 12:03 PM
Contulakin G (CAS 229180-41-0) | GMP Supplier & Manufacturer
Contulakin G (CAS 229180-41-0) is a glycosylated neuropeptide that functions as a neurotensin receptor agonist with antinociceptive properties. It is widely used in preclinical studies exploring pain modulation, receptor pharmacology,…
Contulakin G (CAS 229180-41-0) is a glycosylated neuropeptide that functions as a neurotensin receptor agonist with antinociceptive properties. It is widely used in preclinical studies exploring pain modulation, receptor pharmacology,…
instead of acetaminophen you could take capsaicin but I've no idea how much for the same or greater antinociceptive effect
August 14, 2025 at 6:05 AM
instead of acetaminophen you could take capsaicin but I've no idea how much for the same or greater antinociceptive effect
DPDPE – Purity ≥99.83% | CAS No.: 88373-73-3 | GMP Grade
DPDPE ([D-Pen², D-Pen⁵]-enkephalin) is a cyclic enkephalin peptide highly selective for δ-opioid receptors. It exhibits potent antinociceptive activity and serves as a research tool in neuropharmacology and analgesia studies. Purity ≥99.83%,…
DPDPE ([D-Pen², D-Pen⁵]-enkephalin) is a cyclic enkephalin peptide highly selective for δ-opioid receptors. It exhibits potent antinociceptive activity and serves as a research tool in neuropharmacology and analgesia studies. Purity ≥99.83%,…
DPDPE – Purity ≥99.83% | CAS No.: 88373-73-3 | GMP Grade
DPDPE ([D-Pen², D-Pen⁵]-enkephalin) is a cyclic enkephalin peptide highly selective for δ-opioid receptors. It exhibits potent antinociceptive activity and serves as a research tool in neuropharmacology and analgesia studies. Purity ≥99.83%, GMP-manufactured. Laboratory use only.（For wholesale prices, other specifications and uses, please consult our staff）
arizona-mall.com
August 10, 2025 at 11:59 AM
DPDPE – Purity ≥99.83% | CAS No.: 88373-73-3 | GMP Grade
DPDPE ([D-Pen², D-Pen⁵]-enkephalin) is a cyclic enkephalin peptide highly selective for δ-opioid receptors. It exhibits potent antinociceptive activity and serves as a research tool in neuropharmacology and analgesia studies. Purity ≥99.83%,…
DPDPE ([D-Pen², D-Pen⁵]-enkephalin) is a cyclic enkephalin peptide highly selective for δ-opioid receptors. It exhibits potent antinociceptive activity and serves as a research tool in neuropharmacology and analgesia studies. Purity ≥99.83%,…
"Moclobemide has also been demonstrated in a single dose research study to possess antinociceptive properties.[113]" seriously, what CAN'T moclobemide do??
Moclobemide - Wikipedia
en.wikipedia.org
August 7, 2025 at 8:33 AM
"Moclobemide has also been demonstrated in a single dose research study to possess antinociceptive properties.[113]" seriously, what CAN'T moclobemide do??
ICYMI: Antinociceptive properties of thiamine, pyridoxine and cyanocobalamin following repeated oral administration to mice
Antinociceptive properties of thiamine, pyridoxine and cyanocobalamin following repeated oral administration to mice
Following repeated oral administration for 7 days thiamine (thiamine nitrate, CAS 532-43-4), pyridoxine (pyridoxol hydrochloride, CAS 58-56-0), and cyanocobalamin (CAS 68-19-9) exhibited at high dose levels alone or in combination dose-rela...
eurekamag.com
July 3, 2025 at 6:01 AM
ICYMI: Antinociceptive properties of thiamine, pyridoxine and cyanocobalamin following repeated oral administration to mice
Antinociceptive properties of thiamine, pyridoxine and cyanocobalamin following repeated oral administration to mice
Antinociceptive properties of thiamine, pyridoxine and cyanocobalamin following repeated oral administration to mice
Following repeated oral administration for 7 days thiamine (thiamine nitrate, CAS 532-43-4), pyridoxine (pyridoxol hydrochloride, CAS 58-56-0), and cyanocobalamin (CAS 68-19-9) exhibited at high dose levels alone or in combination dose-rela...
eurekamag.com
July 2, 2025 at 5:59 AM
Antinociceptive properties of thiamine, pyridoxine and cyanocobalamin following repeated oral administration to mice
Cardoso-Cruz et al. find that optogenetic inhibition of LHb CaMKIIα-expressing neurons partially reverse neuropathic pain-related WM impairments and achieve antinociceptive effects. Learn more in #PAIN bit.ly/3FQRiSG
June 24, 2025 at 12:00 PM
Cardoso-Cruz et al. find that optogenetic inhibition of LHb CaMKIIα-expressing neurons partially reverse neuropathic pain-related WM impairments and achieve antinociceptive effects. Learn more in #PAIN bit.ly/3FQRiSG
Our latest research highlight covers a paper in Cell on a biased allosteric modulator of a GPCR, neurotensin receptor 1, that shows antinociceptive properties in rodent pain models without causing side effects or exhibiting addiction potential www.nature.com/articles/d41...
June 23, 2025 at 2:55 PM
Our latest research highlight covers a paper in Cell on a biased allosteric modulator of a GPCR, neurotensin receptor 1, that shows antinociceptive properties in rodent pain models without causing side effects or exhibiting addiction potential www.nature.com/articles/d41...
@karenddavis.bsky.social et al. find that individuals exhibiting inhibitory conditioned pain modulation, but not those with no or faciliatory conditioned pain modulation, have resting-state functional connectivity of their descending antinociceptive pathway #PAIN bit.ly/4kppx2l
June 9, 2025 at 12:00 PM
@karenddavis.bsky.social et al. find that individuals exhibiting inhibitory conditioned pain modulation, but not those with no or faciliatory conditioned pain modulation, have resting-state functional connectivity of their descending antinociceptive pathway #PAIN bit.ly/4kppx2l
New publication: Cardiovascular, antinociceptive and electroencephalographic effects of epidural and unintentional spinal anaesthesia in pigs: an observational prospective trial. Congratulations to the authors! pubmed.ncbi.nlm.nih.gov/40350336/
#CVRCBern
#CVRCBern
Cardiovascular, antinociceptive and electroencephalographic effects of epidural and unintentional spinal anaesthesia in pigs: an observational prospective trial - PubMed
Lumbosacral epidural or spinal administration of ropivacaine and morphine (0.2 mL kg-1) caused mild cardiovascular alterations, prevented autonomic responses during sternotomy and did not worsen elect...
pubmed.ncbi.nlm.nih.gov
June 4, 2025 at 11:12 AM
New publication: Cardiovascular, antinociceptive and electroencephalographic effects of epidural and unintentional spinal anaesthesia in pigs: an observational prospective trial. Congratulations to the authors! pubmed.ncbi.nlm.nih.gov/40350336/
#CVRCBern
#CVRCBern
The sweetest plants have been volunteering in my yard this year!
The newest friend to pop up is, what I believe to be, Fumaria Officinalis aka fumitory aka earth smoke.
This plant has medicinal properties: hepatoprotective, antiviral, anti-inflammatory, antinociceptive, antimicrobial, antioxidant…
The newest friend to pop up is, what I believe to be, Fumaria Officinalis aka fumitory aka earth smoke.
This plant has medicinal properties: hepatoprotective, antiviral, anti-inflammatory, antinociceptive, antimicrobial, antioxidant…
May 30, 2025 at 5:53 AM
The sweetest plants have been volunteering in my yard this year!
The newest friend to pop up is, what I believe to be, Fumaria Officinalis aka fumitory aka earth smoke.
This plant has medicinal properties: hepatoprotective, antiviral, anti-inflammatory, antinociceptive, antimicrobial, antioxidant…
The newest friend to pop up is, what I believe to be, Fumaria Officinalis aka fumitory aka earth smoke.
This plant has medicinal properties: hepatoprotective, antiviral, anti-inflammatory, antinociceptive, antimicrobial, antioxidant…
Design, Synthesis, and Evaluation of Antinociceptive Properties of Novel CBD-Based Terpene-Cinnamoyl-Acyl-Hydrazone Analogues pubmed.ncbi.nlm.nih.gov/40430572/
May 30, 2025 at 2:02 AM
Design, Synthesis, and Evaluation of Antinociceptive Properties of Novel CBD-Based Terpene-Cinnamoyl-Acyl-Hydrazone Analogues pubmed.ncbi.nlm.nih.gov/40430572/
β-arrestin-2-biased allosteric modulator demonstrates potent antinociceptive effects in acute and chronic pain models. It works through both peripheral and central mechanisms to suppress pain transmission while avoiding opioid-related side effects. #PainResearch #DrugDiscovery #GPCR
buff.ly
May 28, 2025 at 2:03 PM
β-arrestin-2-biased allosteric modulator demonstrates potent antinociceptive effects in acute and chronic pain models. It works through both peripheral and central mechanisms to suppress pain transmission while avoiding opioid-related side effects. #PainResearch #DrugDiscovery #GPCR
7/
💡 Licking is an affective-motivational behavior emerging during Pain States
This structure supports the original Gate Control Theory
that rubbing/licking is an antinociceptive action to reduce pain aversion
Pain drives licking → licking reduces pain → licking stops = negative feedback loop
💡 Licking is an affective-motivational behavior emerging during Pain States
This structure supports the original Gate Control Theory
that rubbing/licking is an antinociceptive action to reduce pain aversion
Pain drives licking → licking reduces pain → licking stops = negative feedback loop
April 5, 2025 at 3:47 PM
7/
💡 Licking is an affective-motivational behavior emerging during Pain States
This structure supports the original Gate Control Theory
that rubbing/licking is an antinociceptive action to reduce pain aversion
Pain drives licking → licking reduces pain → licking stops = negative feedback loop
💡 Licking is an affective-motivational behavior emerging during Pain States
This structure supports the original Gate Control Theory
that rubbing/licking is an antinociceptive action to reduce pain aversion
Pain drives licking → licking reduces pain → licking stops = negative feedback loop
test :
Self-synergy antinociceptive effect of diclofenac: effect of peripheral inhibition of nitric oxide synthase. https://pubmed.ncbi.nlm.nih.gov/40172838/
Self-synergy antinociceptive effect of diclofenac: effect of peripheral inhibition of nitric oxide synthase. https://pubmed.ncbi.nlm.nih.gov/40172838/
April 2, 2025 at 6:10 PM
test :
Self-synergy antinociceptive effect of diclofenac: effect of peripheral inhibition of nitric oxide synthase. https://pubmed.ncbi.nlm.nih.gov/40172838/
Self-synergy antinociceptive effect of diclofenac: effect of peripheral inhibition of nitric oxide synthase. https://pubmed.ncbi.nlm.nih.gov/40172838/
🍊‘..this bioflavonoid has an antinociceptive effect & enhances the pain tolerance of the nervous system in vivo. Inflammatory cells released by pro-hyperalgesic cytokines eg IL-33, TNF-α, IL-1β & IL-6, activate..nociceptor neurons, leading to pain sensitisation’
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Naringenin and Its Derivatives—Health-Promoting Phytobiotic against Resistant Bacteria and Fungi in Humans
Naringenin is a trihydroxyflavanone present in large amount in different citrus fruits, e.g., oranges, pomelos, grapefruits, but also in tomatoes, fenugreek and coffee. It has a wide range of pharmaco...
pmc.ncbi.nlm.nih.gov
March 22, 2025 at 6:31 AM
🍊‘..this bioflavonoid has an antinociceptive effect & enhances the pain tolerance of the nervous system in vivo. Inflammatory cells released by pro-hyperalgesic cytokines eg IL-33, TNF-α, IL-1β & IL-6, activate..nociceptor neurons, leading to pain sensitisation’
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Development of Bioisosteric Iboga-alkaloids as Antinociceptive and Anxiolytic Agents with Neuroprotective Effects https://www.biorxiv.org/content/10.1101/2025.02.24.639821v1
March 1, 2025 at 1:02 AM
Development of Bioisosteric Iboga-alkaloids as Antinociceptive and Anxiolytic Agents with Neuroprotective Effects https://www.biorxiv.org/content/10.1101/2025.02.24.639821v1
Development of Bioisosteric Iboga-alkaloids as Antinociceptive and Anxiolytic Agents with Neuroprotective Effects https://www.biorxiv.org/content/10.1101/2025.02.24.639821v1
March 1, 2025 at 1:02 AM
Development of Bioisosteric Iboga-alkaloids as Antinociceptive and Anxiolytic Agents with Neuroprotective Effects https://www.biorxiv.org/content/10.1101/2025.02.24.639821v1