Lightnews — Scholar-powered news

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Chise @sailorrooscout.bsky.social · 1h

Researchers envision their vaccine being used as both a treatment and a preventive, and as an approach to treating multiple cancer types.
• www.umass.edu/news/article...

The study has been published in Cell Reports Medicine. YES, it is PEER-REVIEWED.
• www.cell.com/cell-reports...

🧪🧵⬇️

HIGHLIGHTS
•Lipid NPs carrying STING and TLR4 agonists promote synergistic type I interferons
• NPs drain efficiently to lymph nodes and increase polyfunctional T and B cells
• NPs improve tumor-free outcomes with memory against multiple aggressive tumor models
SUMMARY
We report on the utility of a "super-adjuvant" nanoparticle (NP) system as a modular, customizable platform for next-generation cancer vaccination. Using nanomaterials engineering technology, we aim to harness not only the effective adjuvanticity of whole-pathogen vaccines, but also the safety of subunit vaccines.
Our lipid-based NP platform co-encapsulates agonists of the stimulator of interferon genes (STING) and Toll-like receptor 4 (TLR4) pathways to promote synergistic production of type I interferons and other
proinflammatory cytokines in innate antigen-presenting dendritic cells and macrophages.
Compared to empty NPs and free agonists, dual-adjuvant NPs administered with antigenic peptides or tumor cell lysate promote increased antigen processing and presentation, drain efficiently to nearby lymph nodes, increase polyfunctional tumor-specific T and B cells, and improve tumor-free outcomes upon vaccination and subsequent challenge with multiple aggressive tumor cells.

Graphical Abstract

The vaccine combines two immune-stimulating molecules (adjuvants) in a tiny lipid nanoparticle that enhances both innate and adaptive immune responses. The innate immune system acts as the body’s first line of defense, responding quickly and non-specifically to invaders using cells that release inflammatory signals. The adaptive immune system takes longer to activate but provides a targeted, long-lasting response, training T-cells and B- cells to recognize and remember specific threats. Together, they form a coordinated defense: the innate system alerts and activates the adaptive system, which then delivers precise and durable immunity.

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Chise @sailorrooscout.bsky.social · 1h

GOOD NEWS! Researchers have developed a cancer vaccine that has shown STUNNING results, PREVENTING up to 88% of MULTIPLE aggressive cancers by harnessing dual-pathway nanoparticles that train the immune system to recognize and destroy tumor cells. In some cases, it COMPLETELY prevented metastasis.

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WV @mrluck07.bsky.social · 10m

Aww

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tj WATCH INVINCIBLE FIGHT GIRL 😷😷😷 @atjscreams.blacksky.app · 15m

also you could commission amazing human artists to do this for you and i guarantee itll hit 100x harder than ai slop

Patrick, Not Pat @patricknotpat.bsky.social · 28m

Creating an AI image of your adult self hugging your childhood self is not a replacement for therapy. Please seek help y’all.

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Jack Tripper @chadstanton.blacksky.app · 16m

Really would like people to shift their thinking to the point where they see themselves and the people around them as the people who will collectively navigate through this moment.

Nom Sequitur @nomsequitur.bsky.social · 23m

Pritzker or Newsom aren’t perfect or even great but they are the only hope to take the country back from MAGA. It’s not gonna happen tho

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Henny Gesserit @nmjmredux.blacksky.app · 18m

The resource being you and the oxygen being your very breath

Southern Gothic @thesuburbanthug.bsky.social · 21m

People will drain the earth of is resources and suck oxygen from the atmosphere before they go to therapy!

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Stone Cold Skeet Austin @icequebe.bsky.social · 14m

How you get a concussion during pregame warmups? What were you doing?

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NPR @npr.org · 1h

The small town of Leland, Miss., was rocked by the shooting, which took place late Friday.

6 dead in a shooting after Mississippi homecoming game

The small town of Leland, Miss., was rocked by the shooting, which took place late Friday.

n.pr

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Dino Bae's Quest @onedrinktwodrink.blacksky.app · 1h

Don't stay in them DMs long. Put that shit in motion.

a white truck is parked on a dirt road near a grassy field

Alt: a white truck is parked on a dirt road near a grassy field

media.tenor.com

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Clitasaurus Rex 🦖 @naiijah.bsky.social · 1h

hop in them dm’s and let em know you put action to words #ShootYourShotSunday

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🎃🚨SEE PINNED🚨#ProtectJhordin🚨🎃 @blackapostate.blacksky.app · 57m

i find it fascinating that there's black people who don't recognize who laws are used against in reality, whether we're guilty or innocent. and in a time of rapid return to the days that tormented our elders/ancestors, that any of us would look to ban one of our only means of self defense. curious.

FLAVOR FLAV ⏰ @flavorflav.bsky.social · 2h

I post this article too much,,,
But we have mass shooting too much

www.newsweek.com/2025/07/18/f...

Why Flavor Flav says the US must ban firearms now | Opinion

The lack of U.S. gun laws has created a violence epidemic unlike anywhere else on Earth. This is domestic errorism

www.newsweek.com

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Elias☘️☘️☘️ @koraana.bsky.social · 1h

My son has been severely malnourished for three months, with digestive and immune system problems. Even after milk and food entered Gaza a week ago, he refuses to accept anything and is on intravenous drip. Help me treat him and be generous.
Vireted by @mommunism.bsky.social

gofund.me/015c8fe1

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✨Pretty, Witty, Girly, Worldly✨ @asdoseofreality.blacksky.app · 3h

Seeing things how they are doesn’t even mean you no longer want it or pursue it just allows your pursuit to be based in reality.

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The Little Yerrrmaid 🧜🏾‍♀️ @thee-beenasty.bsky.social · 1h

This is really it. A lot of times we’re holding out to wait on another sign for confirmation when we know we’ve already seen more than enough.

✨Pretty, Witty, Girly, Worldly✨ @asdoseofreality.blacksky.app · 3h

I’ve been asking for alignment in a certain situation and sometimes alignment is the universe snatching your rose colored glasses so you can see things for what they are.

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Lucius Fox In The Box @carnegro.bsky.social · 2h

Dude wrote “Holding Back the Years” when he was 17.

Eric Alper @thatericalper.com · 2h

40 years ago today, Simply Red released their debut album ‘Picture Book,’ featuring “Holding Back the Years” and “Money’s Too Tight (to Mention).” Smooth soul and pop perfection.

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Genie Lauren @moreandagain.social · 1h

They want us to believe the lie that we could capitalism our way out of racism

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Humble_One @humbleone.bsky.social · 1h

I still don’t understand how white collar corporate jobs for negros like myself, and money for Black businesses is the answer to police violence.

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Arif "Felonious Munk" Shahid @feloniousmunk.blacksky.app · 1h

Hard to get "the people" to fight fascism when "the people" support so many tenets of fascism. The folks looked up the definition and said "yeah...get THEM." You not articulate enough to convince them that they're also "them."

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Genie Lauren @moreandagain.social · 1h

This is why I rolled my eyes when the response to George Floyd's murder was DEI

Jack Tripper @chadstanton.blacksky.app · 4h

Part of the problem is that office holders are treated as if they’re somehow part of a noble elect who are entitled to their position, and it’s our job to personally identify with their struggles and understand just how tough they have it.

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Tiffany W @tiffany.thetriibe.com · 1h

this has been the case… for decades now.

Arif "Felonious Munk" Shahid @feloniousmunk.blacksky.app · 2h

Can't even watch the news to be informed if they let people come on air and lie, unchecked.

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NB 🖤 Princess Jade 🖤 @princessjade.bsky.social · 2d

hi! I’ve received $25/$248.51
Tysm 🙏🏾🙏🏾 only online to update 💕💸

cash.me/ikemi93
Venmo.com/jadedragon12

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💫 11•02 💫 your favorite Scorpio | they/them @lenadreamsingld.blacksky.app · 3h

$215 of $750 needed by 10/19 for bills while I continue to apply for jobs.

Thank you for the shares and donations over night.

$35 more to get to $250!

💫 11•02 💫 your favorite Scorpio | they/them @lenadreamsingld.blacksky.app · 23h

$190/$750 needed by 10/19 (was able to extend some bills).

$10 more to hit $200!

I’m still job hunting but bills are continuing. Thank you for your shares and donations thus far.

CA: $lenadreamsingold
PayPal: lenadreamsingold
Venmo: lenadreamsingold

DM for Zelle

a woman sitting on a couch with the words " i need a job offer " on the bottom

ALT: a woman sitting on a couch with the words " i need a job offer " on the bottom

media.tenor.com

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Jack Tripper @chadstanton.blacksky.app · 1h

“The African American unemployment rate has surged over the past four months, from 6 to 7.5 percent, while the rate for white people ticked down slightly to 3.7 percent. On top of a slowing economy, the White House’s actions have disproportionately harmed Black workers, economists said.”

Black Unemployment Is Surging Again. This Time Is Different.

www.nytimes.com

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Hadeel @nesamh9.bsky.social · 1h

Look at our situation...
Our homes have been destroyed, our security has been lost, and all that's left for us is hunger and pain.
Today, we are slowly dying from malnutrition, oppression, and helplessness in the face of the screams of our hungry children.💔

Donate to us🙏🏻😞

gofund.me/b47682b9

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WV @mrluck07.bsky.social · 1h

Top of the morning! 🤗

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