Wolfgang Huber
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wkhuber.bsky.social
Wolfgang Huber
@wkhuber.bsky.social

Statistician, Computational Biologist, R |> Bioconductor
https://www.huber.embl.de

Textbook: Modern Statistics for Modern Biology https://www.huber.embl.de/msmb/ (with @sherlockpholmes.bsky.social)

Wolfgang Huber is a prominent German theologian and ethicist. Huber served as bishop of the Evangelical Church of Berlin-Brandenburg-Silesian Upper Lusatia until November 2009. Huber succeeded Manfred Kock as Chairperson of the Council of the Evangelical Church in Germany (EKD) in November 2003 and was succeeded by Bishop Margot Käßmann, the first woman in that position, in October 2009. .. more

History 31%
Philosophy 24%
Pinned
CSAMA 2026 - Biological Data Science Summer School
Bressanone-Brixen, South Tyrol / Italy
24-29 May 2026
csama2026.bioconductor.eu

Statistical & computational methods for single cell and spatial omics, with lectures and hands-on exercises in R/Bioconductor.

Reposted by Wolfgang Huber

Lasst euch nichts einreden, minderjährige arabische Flüchtlinge, schwule Berliner Berghain-Fans und grüne Frauen mit sehr kurzem Pony sind der Anfang vom Ende des Abendlandes, nicht reiche weiße mächtige Männer.

Ich bin SO wütend. Es ist 2026. Wahnsinn.

What a website www.jmail.world
Jmail, Jphotos, Jdrive, ....
Next month the Cambridge Philosophical Society is hosting an event to celebrate David MacKay and his work on the tenth anniversary of his passing. The organizers are soliciting notes sharing how his work has impacted people -- you can submit at docs.google.com/forms/d/e/1F....
A tribute to David MacKay
“I didn’t know David personally but was a great admirer of his work.” “David seemed to have infinite patience.” “He treated the audience with respect, trusted them with complexity, and showed that r...
docs.google.com

A paper by Jeff Leek, Rafa Irizarry and others in Nature Biotech 2010 was quite ground-breaking, because it addressed such mundane statistics topics, in a biologist-friendly manner, in a glamourous venue that they respect:

doi.org/10.1038/nrg2...

Thanks, Simon!
But I think Paul's question is a good one... why isn't there more? I think partly b/c it's truly interdisciplinary, but not glamorous. Many biologists learn about controls the hard way, via reviewer requests. And there is certainly a good deal of cargo cult going on, as well.

- apply experimental design, negative and positive controls, replicates, adjust for batch effects (‘distribution shifts’) and do proper statistics,
- do knock-out and -in experiments, find genetic interactions and solve other combinatorial riddles.

(2/2)

Computer science needs more biologists. They are used to:
- study systems that are mindbogglingly complex and complicated,
- use reductionism to study and describe such systems, using famously clumsy and fiddly tools to collect noisy and incomplete data,

(1/2)

Reposted by Wolfgang Huber

🎉 We’re excited to welcome Natalia da Silva and @andrew as new editors for rOpenSci’s Statistical Software Peer Review program!

Their experience in statistics, R, reproducible research, and open science will help strengthen our collaborative, transparent, and community-driven review process […]
Original post on hachyderm.io
hachyderm.io

Some colleagues have solved this by defining that 'doing things' is talking.
So much of being a professor is stacked meetings where we talk about doing things and then never have the time to actually do the things.

Reposted by Wolfgang Huber

"Beste Hauptdarstellerin": Infantino zeichnet Melania Trump mit FIFA-Oscar aus www.der-postillon.com/2026/02/fifa...
"Beste Hauptdarstellerin": Infantino zeichnet Melania Trump mit FIFA-Oscar aus
New York (dpo) - Erst seit wenigen Tagen läuft die Dokumentation "Melania" in den Kinos, doch schon gibt es eine erste große Auszeichnung: Gianni Infa
www.der-postillon.com

Reposted by Wolfgang Huber

❄️ Good morning from freezing Kharkiv...

Such cold temperatures will last for another week at least.

Reposted by Wolfgang Huber

Many of my science colleagues are not speaking out-I suspect due to the fear Phil notes, that they'll targeted for loss of funding. I hope they read this account of what happened at a faculty meeting at Frankfurt University in 1933 as the Nazi's took control 🧪
www.facinghistory.org/resource-lib...

with a classic Judo principle, Kuzushi (Breaking Balance): use the opponent's own strength to destabilize them, then a small but well-placed move to topple them over

In terms of Northern Hemisphere day length changes, February is the best month. Day length is increasing rapidly now, and the month brings us from the middle of winter to the first signs of spring.

Reposted by Wolfgang Huber

They helping people stay warm and cared for during the freezing temperatures.

Horrible times reveal the best people.
📹: Yan Dobronosov

Reposted by Wolfgang Huber

In great spirits&to the sound of music,Oleh Bibikov,Ihor Kukobko,their charitable food truck team prepare more than 10,000 hot meals each day for residents of Kyiv&Kyiv region-with plans to increase that number to 20,000

Working 18-19 hours a day,they have been going nonstop for nearly a month

7yo has been watching Brainchild, an educational series on science for kids made in 2018 USA, that with its happiness, demonstrative diversity, and celebration of science feels like from a bygone era

www.imdb.com/title/tt9203...

Reposted by Wolfgang Huber

Liebe alles an dieser Werbung 🥰
🚀 Hinaus ins All: Welche deutsche Raketenbauer durchstarten wollen
🌌 Derzeit können nur Ariane 6 und Vega C Satelliten in eine Umlaufbahn bringen. Der Bedarf wird kräftig steigen. Auf diesen Markt setzen junge Firmen, die eigene Raketen entwickeln. buff.ly/gEB0W6Y

10/10

Дякую, що звернули на це увагу. Я надіслав сто євро.

And it doesn't stop there.

Reposted by Wolfgang Huber

“What has changed today, more than the nature of the problem, is the likelihood that it could materialise abruptly: extraterritorial sanctions, access restrictions, regulatory blackmail (...) In that context, decoupling stops being a theoretical hypothesis and becomes a risk-management scenario.”
France pushes state workers away from Zoom as Europe eyes tech decoupling
Initiative for homegrown tools reflects rising anxiety over relying on US platforms amid shifting geopolitics
www.ft.com

But that's fine, right? Using 'predicted' implies that you're aware you saw a shadow (phosphorylation of substrates) and try to infer what caused it. The method of prediction is clear from context.

In my view, the problem starts when people gloss over the prediction part& just say 'kinase activity'

That too, but that's already the 2nd level, shadows of shadows. I am thinking of confusing measurements with the thing we're interested in.
E.g., read counts in sc-RNA-seq vs activity of the protein; output of a gene set or ligand-receptor enrichment calculation with real biological activity; etc.
I'm at the Willard Hotel where I've been denied entry and kicked out of the Reclaiming Science event with NIH director Bhattacharya & other top agency leaders.

@jocelynkaiser.bsky.social and I registered for the event months ago yet were told capacity was full, even as they let in dozens of others.

Plato's allegory of the cave is so relevant to the natural sciences, yet so many colleagues seem to think they can get away with writing about the shadows.