Yue Kris Wu
kriswu.bsky.social
Yue Kris Wu
@kriswu.bsky.social

Postdoc at the Center for Theoretical Neuroscience at Columbia University
yuekriswu.github.io

Wu Yue may refer to the following:Wuyue, a 10th-century kingdom during the Five Dynasties and Ten Kingdoms period Sacred Mountains of China, also known as "Wu Yue" in Chinese

Source: Wikipedia
Environmental science 42%
Computer science 38%

It is gratifying to see the growing appreciation of theoretical and computational neuroscience over the years. A deep understanding of the brain undoubtedly requires close collaborations between experimentalists and theorists. magazine.columbia.edu/article/20-y...
20 Years of Modeling the Brain
At Columbia’s Center for Theoretical Neuroscience, scientists have spent the past two decades using computational models to predict neural behavior
magazine.columbia.edu

Reposted by Yue Wu

New preprint: visual attention may follow decisions more than it shapes them.
We identify behavioral signatures inconsistent with models in which attention affects value, instead pointing to a substantial post-decisional component.
www.biorxiv.org/content/10.6...
Behavioral Signatures of Post-Decisional Attention in Preferential Choice
Attention plays a key role in decision-making by directing limited cognitive resources to relevant information. It has been proposed that attention also biases the decision process, due to a multiplic...
www.biorxiv.org

Reposted by Yue Wu

Please spread the word🔊My lab is looking to hire two international postdocs. If you want to do comp neuro, combine machine learning and awesome math to understand neural circuit activity, then come work with us! Bonn is such a cool place for neuroscience now, you don't want to miss out.

Jeff is an extremely nice and enjoyable person to work with. Highly recommended!
By the way, if you’re interested in working together on problems like this, I’m starting my lab at UCSF this summer. Get in touch if you’re interested in doing a postdoc! More info here: wj2.github.io/postdoc_ad (7/7)
W. Jeffrey Johnston - Postdoctoral position ad
wj2.github.io

Reposted by Yue Wu

By the way, if you’re interested in working together on problems like this, I’m starting my lab at UCSF this summer. Get in touch if you’re interested in doing a postdoc! More info here: wj2.github.io/postdoc_ad (7/7)
W. Jeffrey Johnston - Postdoctoral position ad
wj2.github.io

Reposted by Yue Wu

When and why do modular representations emerge in neural networks?

@stefanofusi.bsky.social and I posted a preprint answering this question last year, and now it has been extensively revised, refocused, and generalized. Read more here: doi.org/10.1101/2024... (1/7)

Reposted by Yue Wu

The new Cajal Center is opening 8 CSIC permanent research positions (CT, IC & PF levels) via national competitive exams. We welcome candidates eager to shape an ambitious 🧠 research hub in Spain.
🔗 sede.csic.gob.es/tramites/con... 📣
#Neuroscience #CNC #CSIC #ScienceJobs 👇🏼

Reposted by Yue Wu

What would it really mean to achieve experimental goals that currently seem out of reach: a new blog post.

Part I - connectomics
gcamp6f.com/2025/12/27/a...
Annual report of my intuition about the brain (2025, part I)
How does the brain work, and how can we understand it? To approach this big question from a broad perspective, I want to report on some ideas about the brain that marked me most over the …
gcamp6f.com

Reposted by Yue Wu

www.cell.com/cell/fulltex...

We had a lot of fun working on this project (led by Itzel Ishida, not on bluesky). Some interesting highlights from the paper -
Neuronal calcium spikes enable vector inversion in the Drosophila brain
In the fly central complex, PFNa neurons switch from firing classical sodium spikes when depolarized to firing non-canonical T-type calcium spikes when hyperpolarized. This bidirectional spiking allow...
www.cell.com

Reposted by Yue Wu

Joint junior faculty position in Computational Neuroscience, between Ctr for Computational Neuroscience at @flatironinstitute.org and the CUNY Graduate Center @thegraduatecenter.bsky.social . Application deadline: 16 Jan 2026!

www.simonsfoundation.org/flatiron/car...
cuny.jobs/new-york-ny/...
Careers
Careers on Simons Foundation
www.simonsfoundation.org

Very nice work on the role of inhibitory neurons in controlling plasticity.
New preprint from the lab! 🚀
We find that hippocampal OLM interneurons provide a circuit-level inhibitory feedback signal that dynamically controls when and where behavioral timescale synaptic plasticity can occur.
Feedback welcome!
Dendrite-targeting OLM interneurons regulate the formation of learning-related CA1 place cell representations https://www.biorxiv.org/content/10.64898/2025.12.21.695825v1

Reposted by Yue Wu

New preprint from the lab! 🚀
We find that hippocampal OLM interneurons provide a circuit-level inhibitory feedback signal that dynamically controls when and where behavioral timescale synaptic plasticity can occur.
Feedback welcome!
Dendrite-targeting OLM interneurons regulate the formation of learning-related CA1 place cell representations https://www.biorxiv.org/content/10.64898/2025.12.21.695825v1
What is the computational role of dendritic excitations? Byung Hun Lee and team mapped voltage dynamics throughout the dendritic trees of CA1 pyramidal neurons in mice navigating in virtual reality. www.biorxiv.org/content/10.6...

It’s encouraging to see this thoughtful perspective paper emerge from a Bernstein workshop that brought together researchers from different labs.
At the Bernstein Conference 2024, Jeremie Lefebvre and I organized a workshop on the computational consequences of neural heterogeneity. Now, slightly more than a year later, we funneled the emerging discussions into a perspective piece: www.cell.com/neuron/fullt...
How heterogeneity shapes dynamics and computation in the brain
No two neurons are the same, yet models often treat neural populations as pools of identical and interchangeable elements. Here, Dahmen et al. highlight recent theoretical advances that reveal the imp...
www.cell.com

Reposted by Yue Wu

At the Bernstein Conference 2024, Jeremie Lefebvre and I organized a workshop on the computational consequences of neural heterogeneity. Now, slightly more than a year later, we funneled the emerging discussions into a perspective piece: www.cell.com/neuron/fullt...
How heterogeneity shapes dynamics and computation in the brain
No two neurons are the same, yet models often treat neural populations as pools of identical and interchangeable elements. Here, Dahmen et al. highlight recent theoretical advances that reveal the imp...
www.cell.com

Reposted by Yue Wu

How distributed is the brain-wide network that is recruited for cognition? A Perspective by Matthew C. Rosen & David J. Freedman

#neuroscience #neuroskyence

www.nature.com/articles/s41...
How distributed is the brain-wide network that is recruited for cognition? - Nature Reviews Neuroscience
Both localized and distributed views on the functional organization of the brain have been put forward. In this Perspective, Rosen and Freedman examine the degree to which these two views account for ...
www.nature.com

Reposted by Yue Wu

We are opening a FACULTY POSITION (tenure track, permanent) in the University of Cambridge at the interface of control and biology, interpreted broadly. Theorists and wet lab quantitative biologists with backgrounds in control, EE, applied math, ... apply by Jan 28!

www.cam.ac.uk/jobs/univers...
University Assistant/Associate Professor in Control Theory and Systems Biology
Applications are invited for a University Assistant/Associate Professorship in the broad area of Control Theory and Systems Biology. The successful candidate will join the Control Group
www.cam.ac.uk

Reposted by Yue Wu

Inviting apps for a workshop to develop a project focused on a mechanistic understanding of canonical cortical computations at the circuit level. Deadline is 1/5/2026: https://www.simonsfoundation.org/simons-foundation-now-accepting-applications-for-workshop-on-canonical-cortical-computations
Simons Foundation Now Accepting Applications for Workshop on Canonical Cortical Computations
Simons Foundation Now Accepting Applications for Workshop on Canonical Cortical Computations on Simons Foundation
www.simonsfoundation.org

Reposted by Yue Wu

Episode #34 in #TheoreticalNeurosciencePodcast: On balanced neural networks – with Nicolas Brunel

theoreticalneuroscience.no/thn34

Cortical neurons seem to receive about the same amount of excitation and inhibition. One of the founders of this key idea in 1990s explains.
After 13 years in the US, I’ve made the difficult decision to leave. Having packed up everything and rethought about priorities, rather painstakingly, while I’m sad to leave the life I’ve made here, I’m also relieved that I won’t have to plan my life around immigration policies anymore.

Reposted by Yue Wu

How does our brain excel at complex object recognition, yet get fooled by simple illusory contours? What unifying principle governs all Gestalt laws of perceptual organization?

We may have an answer: integration of learned priors through feedback. New paper with @kenmiller.bsky.social! 🧵

Reposted by Yue Wu

Happy to share that I just started a W2 professorship at the University of Bremen! Yay tenure! While I already start teaching now, the lab will stay in Freiburg until May while we get things ready. Super excited about this new chapter! We’re also hiring! Please get in touch if you’re interested!

Reposted by Yue Wu

📣 WTI is hiring faculty positions! Are you interested in advancing our understanding of the brain + how it gives rise to cognition?

Two calls are open:

Open-rank search, Neurocomputation, deadline: 12.1.25
Senior search, Neurodevelopment, rolling review

🔗 wti.yale.edu/opportunities

#KnowTogether
How does the brain decide? 🧠

Our new @nature.com paper shows that neural activity switches from an 'evidence gathering' to a 'commitment' state at a precise moment we call nTc.

After nTc, new evidence is ignored, revealing a neural marker for the instant when the mind is made up.

rdcu.be/eGUrv
Transitions in dynamical regime and neural mode during perceptual decisions - Nature
Simultaneous recordings were made of hundreds of neurons in the rat frontal cortex and striatum, showing that decision commitment involves a rapid, coordinated transition in dynamical regime and neura...
www.nature.com

Reposted by Yue Wu

Do you see a white square?

A new study, supported by our #OpenScope team, identified the key neural circuit and cell type involved with inferring details that don't exist in illusions like the one below.

🔗 alleninstitute.org/news/scienti...

#OpenScienceWeek

Reposted by Yue Wu

Of potential interest to those keen on motor control and/or multi-task networks. Congrats to Elom and Eric.
www.biorxiv.org/content/10.1...
Motor cortex flexibly deploys a high-dimensional repertoire of subskills
Skilled movement often requires flexibly combining multiple subskills, each requiring dedicated control strategies and underlying computations. How the motor system achieves such versatility remains u...
www.biorxiv.org

Reposted by Yue Wu

The University of Notre Dame is hiring 5 tenure or tenure-track professors in Neuroscience, including Computational Neuroscience, across 4 departments.

Come join me at ND! Feel free to reach out with any questions.

And please share!

apply.interfolio.com/173031
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com

Reposted by Yue Wu

📢We're #hiring Group Leaders!

Apply to lead a lab at Janelia & advance biology using theory, computational modeling & machine learning.

🔹5-year renewable appointment
🔹Pioneer new tools & approaches
🔹Collaborate across disciplines

Apply by Nov. 4👉 https://janelia.link/groupleader
Director at Max Planck - a unique position! The Open Call for Expressions of Interest in Max Planck Directorships is open now and can be submitted by the 31st of October 2025. ➡️ mpg.de/directors - Please share the Open Call among potential candidates.

Reposted by Yue Wu

Excited to share our new preprint in which we propose a biologically plausible mechanistic solution to the problem of how the brain can flexibly learn and store new representations without forgetting previously learned information.

www.biorxiv.org/content/10.1...

Detailed 🧵 below 👇 1/12
Assembly-based computations through contextual dendritic gating of plasticity
Neuronal assemblies — groups of strongly connected neurons — are considered the basic building blocks of perception and memory in the brain by encoding representations of specific concepts. Despite re...
www.biorxiv.org