Andreas Müller
@andimicroscopy.bsky.social
Scientist at Paul Langerhans Institute Dresden. Interested in the structural features of pancreatic beta cell function and signaling. 🔬
Pinned
Ok, let's start this thing here with my favorite 3D animation connected to our recent paper on structure and interactions of beta cell primary cilia. www.nature.com/articles/s41...
Still super ecited about cilia-axon contacts in the pancreas.
Still super ecited about cilia-axon contacts in the pancreas.
Happy that we could contribute to this amazing study.
New from The Tomas Lab Key pathways linking GLP-1R signaling to regulate β-cell mitochondrial remodelling and function #islets #diabetes www.nature.com/articles/s41... @tomaslab-imperial.bsky.social
GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function - Nature Communications
Following its internalisation, active endosomal GLP-1R engages with VAPB and SPHKAP at ER membrane contact sites to assemble a local cAMP/PKA condensate for the control of MICOS complex phosphorylatio...
www.nature.com
December 13, 2025 at 1:07 PM
Happy that we could contribute to this amazing study.
Reposted by Andreas Müller
💥I am excited to present our first research paper from the lab about caveolae lipid trafficking 🎉 Led by my fantastic PhD candidate @estherocket.bsky.social
Here we looked into caveolae mediated dietary lipid uptake and how this process is mechanistically facilitated 👇 1/n
Here we looked into caveolae mediated dietary lipid uptake and how this process is mechanistically facilitated 👇 1/n
Lipid-induced Caveolin1-Lipid droplet trafficking is associated with lipid droplet growth https://www.biorxiv.org/content/10.64898/2025.12.10.693432v1
December 11, 2025 at 7:08 AM
💥I am excited to present our first research paper from the lab about caveolae lipid trafficking 🎉 Led by my fantastic PhD candidate @estherocket.bsky.social
Here we looked into caveolae mediated dietary lipid uptake and how this process is mechanistically facilitated 👇 1/n
Here we looked into caveolae mediated dietary lipid uptake and how this process is mechanistically facilitated 👇 1/n
Reposted by Andreas Müller
Our Method of the Year 2025 is...drumroll please...EM-based connectomics!!
Our Editorial introduces our choice and highlights six Comments and other related content in this special issue. Please join us in celebrating EM-based connectomics! 🎉🧠🔬
www.nature.com/articles/s41...
Our Editorial introduces our choice and highlights six Comments and other related content in this special issue. Please join us in celebrating EM-based connectomics! 🎉🧠🔬
www.nature.com/articles/s41...
Method of the Year 2025: electron microscopy-based connectomics - Nature Methods
A large network of interconnected neurons serves as the basis of brain function and of behavior. Methodological advances have enabled the reconstruction of large-scale and even whole-brain connectomes...
www.nature.com
December 8, 2025 at 4:59 PM
Our Method of the Year 2025 is...drumroll please...EM-based connectomics!!
Our Editorial introduces our choice and highlights six Comments and other related content in this special issue. Please join us in celebrating EM-based connectomics! 🎉🧠🔬
www.nature.com/articles/s41...
Our Editorial introduces our choice and highlights six Comments and other related content in this special issue. Please join us in celebrating EM-based connectomics! 🎉🧠🔬
www.nature.com/articles/s41...
Reposted by Andreas Müller
The TUD has made a very nice video in their "Kurze Frage" series featuring PLID member Andreas Müller where he explains how insulin is produced by the beta cells of the pancreas and why this is important in diabetes (German only)
#TUDresden #DiabetesResearch #PLID #HelmholztzMunich
#TUDresden #DiabetesResearch #PLID #HelmholztzMunich
Wie wird Insulin produziert? 🩸 | Kurze Frage über Diabetesforschung & Betazellen
YouTube video by TU Dresden entdecken
www.youtube.com
December 3, 2025 at 12:24 PM
The TUD has made a very nice video in their "Kurze Frage" series featuring PLID member Andreas Müller where he explains how insulin is produced by the beta cells of the pancreas and why this is important in diabetes (German only)
#TUDresden #DiabetesResearch #PLID #HelmholztzMunich
#TUDresden #DiabetesResearch #PLID #HelmholztzMunich
Here is a short video by @tudresden.bsky.social (in German) of me explaining what beta cells do and talking about our research on investigating the structural features of their function and dysfunction.
Wie wird #Insulin produziert? Was passiert bei #Diabetes im Körper? 🩸 In der »Kurzen Frage« spricht @andimicroscopy.bsky.social vom Paul Langerhans Institut von @helmholtzmunich.bsky.social & #TUDresden über seine Forschung an den Betazellen der Bauchspeicheldrüse. Zum Video ➡️ youtu.be/KAeSulc4Neo
December 3, 2025 at 11:28 AM
Here is a short video by @tudresden.bsky.social (in German) of me explaining what beta cells do and talking about our research on investigating the structural features of their function and dysfunction.
Reposted by Andreas Müller
Interested in applying U-ExM to cells, tissues, organoids, or cryo-sections? Our EMBO workshop is open for applications!
🧫🔬 Deadline: 12 Jan 2026 — don’t miss it!
🧫🔬 Deadline: 12 Jan 2026 — don’t miss it!
Have you applied for 'Ultrastructure expansion microscopy: from cells to tissue' yet? #EMBOExM
🔬 Advance your microscopy skills by joining us to explore U-ExM techniques and gain hands-on expertise in applying this powerful approach to mammalian cells.
Apply now: s.embl.org/uex26-01-bl
🔬 Advance your microscopy skills by joining us to explore U-ExM techniques and gain hands-on expertise in applying this powerful approach to mammalian cells.
Apply now: s.embl.org/uex26-01-bl
December 2, 2025 at 3:13 PM
Interested in applying U-ExM to cells, tissues, organoids, or cryo-sections? Our EMBO workshop is open for applications!
🧫🔬 Deadline: 12 Jan 2026 — don’t miss it!
🧫🔬 Deadline: 12 Jan 2026 — don’t miss it!
Reposted by Andreas Müller
Do you have 2D-to-3D image registration challenges? Let me know about them here
forum.image.sc/t/toward-bet...
forum.image.sc/t/toward-bet...
Toward better 2D - 3D registration in BigWarp
BigWarp has so far focused on 2D-2D or 3D-3D registration, and not on 2D-3D registration. After a conversation with @Christian_Tischer , we thought some simple UI changes could make the support for 2...
forum.image.sc
November 29, 2025 at 6:03 PM
Do you have 2D-to-3D image registration challenges? Let me know about them here
forum.image.sc/t/toward-bet...
forum.image.sc/t/toward-bet...
Reposted by Andreas Müller
Our new paper showcasing molecular connectomics with pan-expansion microscopy is out in @natbiotech.nature.com! www.nature.com/articles/s41...
This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)
This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)
November 27, 2025 at 4:40 AM
Our new paper showcasing molecular connectomics with pan-expansion microscopy is out in @natbiotech.nature.com! www.nature.com/articles/s41...
This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)
This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)
Reposted by Andreas Müller
#Cilia and #Centrosome friends- tomorrow is the big day!! 🎉 🎉
Organoids for #PCD, #CryoET of the base of motile cilia, TZ organization in #IRDs, macrophages & cystic niches in #PKD, how pro-inflammatory lipids & #adipogenesis AND cilia as signal-sending organelles shedding #EVs! 🤩 😍 Join us!!
Organoids for #PCD, #CryoET of the base of motile cilia, TZ organization in #IRDs, macrophages & cystic niches in #PKD, how pro-inflammatory lipids & #adipogenesis AND cilia as signal-sending organelles shedding #EVs! 🤩 😍 Join us!!
🎆 Join us for an unmissable finale to 2025! 🎆 We're thrilled to bring our #cilia & #centrosome community together 25/11/2025 15:00-17:45 GMT! Our 53rd @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social e-symposium schedule is live: www.eventbrite.co.uk/e/bscb-genso... /1
November 24, 2025 at 11:04 AM
#Cilia and #Centrosome friends- tomorrow is the big day!! 🎉 🎉
Organoids for #PCD, #CryoET of the base of motile cilia, TZ organization in #IRDs, macrophages & cystic niches in #PKD, how pro-inflammatory lipids & #adipogenesis AND cilia as signal-sending organelles shedding #EVs! 🤩 😍 Join us!!
Organoids for #PCD, #CryoET of the base of motile cilia, TZ organization in #IRDs, macrophages & cystic niches in #PKD, how pro-inflammatory lipids & #adipogenesis AND cilia as signal-sending organelles shedding #EVs! 🤩 😍 Join us!!
Reposted by Andreas Müller
Scientific journals: we don’t want you using generative AI because it makes shit up.
Same journal: here is an AI summary or evaluation of this paper. This might be more useful than the actual abstract or paper that the authors freaking wrote
Same journal: AI cover art which makes no sense? Oooh!
Same journal: here is an AI summary or evaluation of this paper. This might be more useful than the actual abstract or paper that the authors freaking wrote
Same journal: AI cover art which makes no sense? Oooh!
November 23, 2025 at 1:51 AM
Scientific journals: we don’t want you using generative AI because it makes shit up.
Same journal: here is an AI summary or evaluation of this paper. This might be more useful than the actual abstract or paper that the authors freaking wrote
Same journal: AI cover art which makes no sense? Oooh!
Same journal: here is an AI summary or evaluation of this paper. This might be more useful than the actual abstract or paper that the authors freaking wrote
Same journal: AI cover art which makes no sense? Oooh!
Reposted by Andreas Müller
Calling on my #science network! TeamNDF is #hiring a postdoc to start in 2026!
Are you fascinated by metabolism and the brain? Do you want to dig into life long impacts and the molecular cause?
Learn more about the team and our research here: www.dife.de/en/research/...
Please share! 🧠 🍔 💉
Are you fascinated by metabolism and the brain? Do you want to dig into life long impacts and the molecular cause?
Learn more about the team and our research here: www.dife.de/en/research/...
Please share! 🧠 🍔 💉
November 22, 2025 at 12:15 PM
Calling on my #science network! TeamNDF is #hiring a postdoc to start in 2026!
Are you fascinated by metabolism and the brain? Do you want to dig into life long impacts and the molecular cause?
Learn more about the team and our research here: www.dife.de/en/research/...
Please share! 🧠 🍔 💉
Are you fascinated by metabolism and the brain? Do you want to dig into life long impacts and the molecular cause?
Learn more about the team and our research here: www.dife.de/en/research/...
Please share! 🧠 🍔 💉
Reposted by Andreas Müller
New on bioRxiv! 🚨
“Pericyte and Endothelial Primary Cilia and Centrioles have Disparate Organization Across the Brain Microvasculature”
This project studying #microvascular cells took an unexpected turn when we discovered that #pericytes have primary #cilia!
🔗 www.biorxiv.org/content/10.1...
🧪 🧵1/8
“Pericyte and Endothelial Primary Cilia and Centrioles have Disparate Organization Across the Brain Microvasculature”
This project studying #microvascular cells took an unexpected turn when we discovered that #pericytes have primary #cilia!
🔗 www.biorxiv.org/content/10.1...
🧪 🧵1/8
November 20, 2025 at 9:04 PM
New on bioRxiv! 🚨
“Pericyte and Endothelial Primary Cilia and Centrioles have Disparate Organization Across the Brain Microvasculature”
This project studying #microvascular cells took an unexpected turn when we discovered that #pericytes have primary #cilia!
🔗 www.biorxiv.org/content/10.1...
🧪 🧵1/8
“Pericyte and Endothelial Primary Cilia and Centrioles have Disparate Organization Across the Brain Microvasculature”
This project studying #microvascular cells took an unexpected turn when we discovered that #pericytes have primary #cilia!
🔗 www.biorxiv.org/content/10.1...
🧪 🧵1/8
Reposted by Andreas Müller
We just released a new major version of TrackMate (v8), the cell and organelle tracking plugin of Fiji.
It ships many new features, detailed below, but that are articulated around the following:
It ships many new features, detailed below, but that are articulated around the following:
November 20, 2025 at 11:42 AM
We just released a new major version of TrackMate (v8), the cell and organelle tracking plugin of Fiji.
It ships many new features, detailed below, but that are articulated around the following:
It ships many new features, detailed below, but that are articulated around the following:
Reposted by Andreas Müller
My new ImageJ / Fiji toolkit is out 🔥! The goal is to make image handling & visualization easy, with an intuitive interface! Install it on Fiji with the "Image Viewer" update site
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
November 4, 2025 at 10:40 PM
My new ImageJ / Fiji toolkit is out 🔥! The goal is to make image handling & visualization easy, with an intuitive interface! Install it on Fiji with the "Image Viewer" update site
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
Reposted by Andreas Müller
As a neuroscientist, I’d suggest there is a profound disconnect between what *some* computer scientists think is representative of “intelligence”, cognitive ability, or descriptions of consciousness from some in AI work.
LLMs are not how neural systems process information, nor how brains function.
LLMs are not how neural systems process information, nor how brains function.
November 6, 2025 at 5:19 PM
As a neuroscientist, I’d suggest there is a profound disconnect between what *some* computer scientists think is representative of “intelligence”, cognitive ability, or descriptions of consciousness from some in AI work.
LLMs are not how neural systems process information, nor how brains function.
LLMs are not how neural systems process information, nor how brains function.
Reposted by Andreas Müller
We are looking for motivated #postdocs to join the lab! Biochemistry/microbiology/cryo-EM experience? Excited by #cryo-EM/ET, #chromatin? ❄️🧬🧫
Interdisciplinary projects, top EMBL facilities!
Email CV + short cover letter → [email protected]
Info about the group: www.embl.org/groups/dodon...
Interdisciplinary projects, top EMBL facilities!
Email CV + short cover letter → [email protected]
Info about the group: www.embl.org/groups/dodon...
Dodonova Group – Organisational principles and 3D architecture of archaeal chromatin
www.embl.org
October 15, 2025 at 10:38 AM
We are looking for motivated #postdocs to join the lab! Biochemistry/microbiology/cryo-EM experience? Excited by #cryo-EM/ET, #chromatin? ❄️🧬🧫
Interdisciplinary projects, top EMBL facilities!
Email CV + short cover letter → [email protected]
Info about the group: www.embl.org/groups/dodon...
Interdisciplinary projects, top EMBL facilities!
Email CV + short cover letter → [email protected]
Info about the group: www.embl.org/groups/dodon...
Reposted by Andreas Müller
Everything you wanted to know about #cilia & #signaling in one big beautiful poster format from field thought leaders @wachtenlab.bsky.social & @sorentc.bsky.social- from our just live @jcellsci.bsky.social Special Issue… 🤩🤩🤩
I’m excited to share this collaborative work with Prof. Dagmar Wachten (@wachtenlab.bsky.social), providing an accessible overview of primary cilia signalling and recent advances in cellular signaling in health and disease. Many thanks to Dagmar for a fantastic collaboration! doi.org/10.1242/jcs....
Primary cilia signalling at a glance
Summary: We explore the primary cilium as a master regulator of cellular communication that integrates diverse signalling pathways to guide development and maintain homeostasis. Its dysfunction trigge...
doi.org
October 30, 2025 at 1:11 PM
Everything you wanted to know about #cilia & #signaling in one big beautiful poster format from field thought leaders @wachtenlab.bsky.social & @sorentc.bsky.social- from our just live @jcellsci.bsky.social Special Issue… 🤩🤩🤩
Reposted by Andreas Müller
Our Special Issue on Cilia and Flagella: from Basic Biology to Disease, guest edited by @cilialab.bsky.social and @lottepedersen.bsky.social, is building. We’ll be highlighting all the articles over the next couple of weeks. Follow along at #JCSciliaSI.
journals.biologists.com/jcs/issue/13...
journals.biologists.com/jcs/issue/13...
Volume 138 Issue 20 | Journal of Cell Science | The Company of Biologists
journals.biologists.com
October 27, 2025 at 10:30 AM
Our Special Issue on Cilia and Flagella: from Basic Biology to Disease, guest edited by @cilialab.bsky.social and @lottepedersen.bsky.social, is building. We’ll be highlighting all the articles over the next couple of weeks. Follow along at #JCSciliaSI.
journals.biologists.com/jcs/issue/13...
journals.biologists.com/jcs/issue/13...
Reposted by Andreas Müller
The dark truth behind FormatMyPaper.com
Beware giving this site your unpublished data
Users noticed the website had fake testimonials and a domain name registered seemingly overnight.
https://ubadah.substack.com/p/beware-giving-this-site-your-unpublished\
October 24, 2025 at 12:11 AM
The dark truth behind FormatMyPaper.com
Reposted by Andreas Müller
Are you studying synapses in electron microscopy? Tired of annotating vesicles? We have the tool for you! SynapseNet implements automatic segmentation and analysis of vesicles and other synaptic structures and has now been published:
www.molbiolcell.org/doi/full/10....
www.molbiolcell.org/doi/full/10....
October 17, 2025 at 11:09 AM
Are you studying synapses in electron microscopy? Tired of annotating vesicles? We have the tool for you! SynapseNet implements automatic segmentation and analysis of vesicles and other synaptic structures and has now been published:
www.molbiolcell.org/doi/full/10....
www.molbiolcell.org/doi/full/10....
Reposted by Andreas Müller
Ingenious concept - light sheet on serial sections by photo-etching the expanded hydrogel, layer by layer.
Photo-sectioning is quite slow, and the volumetric images are insanely large and complex, but the data look wonderful.
www.science.org/doi/10.1126/...
Photo-sectioning is quite slow, and the volumetric images are insanely large and complex, but the data look wonderful.
www.science.org/doi/10.1126/...
October 17, 2025 at 7:00 AM
Ingenious concept - light sheet on serial sections by photo-etching the expanded hydrogel, layer by layer.
Photo-sectioning is quite slow, and the volumetric images are insanely large and complex, but the data look wonderful.
www.science.org/doi/10.1126/...
Photo-sectioning is quite slow, and the volumetric images are insanely large and complex, but the data look wonderful.
www.science.org/doi/10.1126/...
Reposted by Andreas Müller
Reposted by Andreas Müller
1925: On this date, 100 years ago, The Company of Biologists is founded by George Parker Bidder III. Throughout today, we will be posting some of our key milestones. Read more about the past 100 years at bit.ly/3WnTVA1.
October 15, 2025 at 8:04 AM
1925: On this date, 100 years ago, The Company of Biologists is founded by George Parker Bidder III. Throughout today, we will be posting some of our key milestones. Read more about the past 100 years at bit.ly/3WnTVA1.
Reposted by Andreas Müller
I found these immune cells just finished mitosis but their midbody is still yet to be resolved. How cool? If you zoom in to the midbody, you can see its classical shape just like in the textbooks. I love these little details.
October 14, 2025 at 10:56 AM
I found these immune cells just finished mitosis but their midbody is still yet to be resolved. How cool? If you zoom in to the midbody, you can see its classical shape just like in the textbooks. I love these little details.
Reposted by Andreas Müller
Join us *next Monday*!
#CrickXrays25
X-ray #nanoimaging of biological tissues
🇬🇧🌐 @crick.ac.uk & online
tinyurl.com/crickxrays25
Sponsored by @dectris.bsky.social, @webknossos.org and @biologists.bsky.social and backed by @brukercorporation.bsky.social and Histomography
#CrickXrays25
X-ray #nanoimaging of biological tissues
🇬🇧🌐 @crick.ac.uk & online
tinyurl.com/crickxrays25
Sponsored by @dectris.bsky.social, @webknossos.org and @biologists.bsky.social and backed by @brukercorporation.bsky.social and Histomography
October 7, 2025 at 9:20 AM
Join us *next Monday*!
#CrickXrays25
X-ray #nanoimaging of biological tissues
🇬🇧🌐 @crick.ac.uk & online
tinyurl.com/crickxrays25
Sponsored by @dectris.bsky.social, @webknossos.org and @biologists.bsky.social and backed by @brukercorporation.bsky.social and Histomography
#CrickXrays25
X-ray #nanoimaging of biological tissues
🇬🇧🌐 @crick.ac.uk & online
tinyurl.com/crickxrays25
Sponsored by @dectris.bsky.social, @webknossos.org and @biologists.bsky.social and backed by @brukercorporation.bsky.social and Histomography