Lightnews — Scholar-powered news

Anup Parchure @anupap.bsky.social · 4d

A new set of very cool results in support of cisternal maturation of the Golgi apparatus. It is very intriguing that the debate is ongoing with new approaches.

MRC Laboratory of Molecular Biology @mrclmb.bsky.social · 4d

Providing order amongst constant traffic: #LMBResearch from Sean Munro (@cellbiol-mrclmb.bsky.social) with John Briggs (@mpibiochem.bsky.social) reveals how GOLPH3 allows COPI vesicles to distinguish between Golgi residents & ER-bound proteins.
Read more: www2.mrc-lmb.cam.ac.uk/protein-sort...

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Reposted by Anup Parchure

Paul & Virginie - Centriole Lab @centriolelab.bsky.social · 24d

Be our new colleague! 🎉
The Dept of Molecular and Cellular Biology at the University of Geneva is hiring an Assistant Professor or Associate Professor.

👉 More details here: lnkd.in/e8Z9eAm4
👉 Our department: mocel.unige.ch

Please feel free to share this opportunity with your network.

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Reposted by Anup Parchure

Felix Campelo @felixmendu.bsky.social · 17d

🧵 I've been meaning to write a #Skytorial on our recently posted prepring in which we show evidence that the Golgi 🥞 is a mechanoresponsive organelle. Extracellular mechanical forces also tune Golgi export capacity! 👉 www.biorxiv.org/content/10.1...

Mechanical forces stimulate Golgi export

Human cells face a wide range of external mechanical stimuli that vary with cell type, state, and pathological conditions. The rapidly growing field of mechanobiology investigates how cells sense and ...

www.biorxiv.org

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Anup Parchure @anupap.bsky.social · 17d

Very cool story. There was a paper a couple of years back on links between mechanical signaling and regulation of sec23a and b. Wondering what happens to the secretory flux from er to golgi when you block golgi export.

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Anup Parchure @anupap.bsky.social · 27d

Congratulations

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Reposted by Anup Parchure

Sandhya Koushika @wormlockholmes.bsky.social · Jul 8

Important.......

Richard Sever @richardsever.bsky.social · Jul 8

"Our observations should prompt an essential re-evaluation of the literature concerning astrocyte-neuron mitochondrial transfer" www.biorxiv.org/content/10.1...

MitoTracker transfers from astrocytes to neurons independently of mitochondria

The neuroprotective transfer of mitochondria from astrocytes to neurons has been primarily investigated by labelling astrocytic mitochondria with the dye MitoTracker. Here we report that MitoTracker transfers to neurons from both astrocytes and astrocyte-conditioned media, independently of mitochondrial transfer. Our observations should prompt an essential re-evaluation of the literature concerning astrocyte-neuron mitochondrial transfer and in other systems in which contact-independent transfer has been observed using mitochondrial dyes. ### Competing Interest Statement The authors have declared no competing interest. MSD (United Kingdom), https://ror.org/004nn4n27, PRJ_20446 DEVINE MSD MRC The Francis Crick Institute, https://ror.org/04tnbqb63, CC2206

www.biorxiv.org

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Reposted by Anup Parchure

Alexis Barr @alexisbarr.bsky.social · Jul 7

We're recruiting junior team leaders @mrc-lms.bsky.social This time we're looking for those working in human metabolic disease.

It's a great place to start your lab. Fantastic colleagues, exciting science, world class facilities. Join us!

lms.mrc.ac.uk/work/vacanci...

Programme Leader Track - MRC Laboratory of Medical Sciences

We are recruiting Programme Leader Track positions focusing on 1) Metabolic Physiology using murine and/or human in vivo models and 2) Immunometabolism.

lms.mrc.ac.uk

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Anup Parchure @anupap.bsky.social · Jul 2

Thanks, Mike

Reposted by Anup Parchure

Sandhya Koushika @wormlockholmes.bsky.social · Jul 2

Role of clathrin adaptor complex AP3 in secretion of dense core vesicles from the Sahu lab, NBRC.

Badal from my lab has added an experiment testing the role of AP3 in secretion of neuropeptides in C. elegans.

bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · Jul 2

AP-3 complex sorts preferential cargo to govern dense core vesicle function in neuroendocrine cells https://www.biorxiv.org/content/10.1101/2025.06.27.661901v1

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Anup Parchure @anupap.bsky.social · Jul 1

An important piece of my postdoctoral work now out. My first entry into the early secretory pathway regulation had many interesting surprises. Thanks for the collaboration @ishier.bsky.social. The deflects in collagen secretion really elevated the paper.

Ishier Raote @ishier.bsky.social · Jul 1

Is the ERGIC a stable organelle? How are its identity and diverse roles maintained? @anupap.bsky.social (Bogan lab, Yale) shows TUG maintains ERGIC integrity, shaping cargo flux and functions like collagen secretion and autophagy—a cargo-selective brake via ERGIC organisation.
rdcu.be/euig6

TUG protein acts through a disordered region to organize the early secretory pathway

Nature Communications - TUG protein localizes to the endoplasmic reticulum-Golgi intermediate compartment, forms biomolecular condensates, and organizes and stabilizes these membranes to support...

rdcu.be

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Anup Parchure @anupap.bsky.social · May 19

Farewell America. I am leaving with many new deep connections and bonds. I couldn't be more content and thrilled about my postdoctoral work especially with positive news about a manuscript in the last few days. Hopefully a new chapter in my life will begin soon. Now back to applications 😀.

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Reposted by Anup Parchure

Cell Reports @cp-cellreports.bsky.social · May 18

ER stress disrupts insulin release in murine models of type 2 diabetes by impairing retromer action and constitutive secretion

Sue et al. show that ER stress impairs insulin secretion by misplacement of permissive proteins from the plasma membrane. This results from defects in the retromer and the constitutive secretory pathway. Thus, in type 2 diabetes, ER stress mediates β cell dysfunction, not just loss of β cell mass.

dlvr.it

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Reposted by Anup Parchure

jobRxiv @jobrxiv.org · May 17

Call for Group leaders in Innovative Biology #ScienceJobs #AcademicSky jobrxiv.org/job/mont...

Call for Group leaders in Innovative Biology

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobrxiv.org

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Anup Parchure @anupap.bsky.social · May 10

Condensates drive insulin granule biogenesis

Caroline Bartman @cbartman.bsky.social · May 10

Mitochondria is powerhouse of cell

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Reposted by Anup Parchure

Hesso Farhan @hessofarhan.bsky.social · Apr 23

Excited to present our unpublished data tomorrow on how Mechanosesing at the Endoplasmic Reticulum regulates Proteostasis. #Organelles #Mechanobiology

Ishier Raote @ishier.bsky.social · Apr 21

Join @felixmendu.bsky.social, @franbottanelli.bsky.social, @hessofarhan.bsky.social, Kelly Ten Hagen, and me for exciting #MembraneTrafficking science and great discussions.

Details on the website
felixcampelo.wixsite.com/membranetraf...

or Slack
join.slack.com/t/membranetr...

Join Membrane trafficking virtual community on Slack

Slack is a new way to communicate with your team. It’s faster, better organized, and more secure than email.

join.slack.com

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Reposted by Anup Parchure

Anupama @anupamahl.bsky.social · Mar 15

We will recruit PhD candidates through @fmiscience.bsky.social call due on May1. If you are interested in stem cell biology/ cancer biology and using either imaging or "omics" tools to study metabolism in vivo , please check out the talk and come meet me after.

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Reposted by Anup Parchure

Manuel Mendoza @longchrom.bsky.social · Feb 28

We're hiring! The Development & Stem Cells department at @igbmc.bsky.social, Strasbourg 🇫🇷 is recruiting a group leader working in cell & developmental biology. Our Integrated Structural Biology department also has an open call. More details below! + contact me for informal enquiries #sciencejobs

CALL FOR TWO GROUP LEADER POSITIONS
IGBMC 2025
The Institute of Genetics, Molecular and Cellular Biology (IGBMC), a
leading European research institute near Strasbourg, France, is seeking
two outstanding group leaders to establish independent research teams in
Development & Stem Cells & Integrated Structural Biology.

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Reposted by Anup Parchure

Romain Koszul @rkoszul.bsky.social · Feb 13

Two more weeks to apply to join us in Paris !
research.pasteur.fr/en/call/call...

Call for applications 2025 - Creation of new research groups at the Institut Pasteur - Research

The Institut Pasteur launches an international call to recruit new junior research group leaders in the application of cutting-edge transdisciplinary approaches to the exploration of host-microbe, tis...

research.pasteur.fr

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Reposted by Anup Parchure

Yaniv Elkouby @yanivelkouby.bsky.social · Jan 9

💥Finally out!
Answering a two-centuries old question about a membraneless organelle that forms in #oocytes from insects to humans: the Balbiani body (Bb).
Now in
@currentbiology.bsky.social
:
cell.com/current-biol...
>

The Balbiani body is formed by microtubule-controlled molecular condensation of Buc in early oogenesis

Kar et al. demonstrate that Balbiani body (Bb) formation is achieved via developmental condensation in zebrafish oogenesis, driven by Buc phase separation and evolving from a dynamic liquid-like state into a solid-like stable compartment. Multistep regulation by microtubules controls condensation, ensuring proper Bb formation and oocyte polarity.

cell.com

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Reposted by Anup Parchure

Pierre-François Lenne @pflenne.bsky.social · Jan 17

Excited to share that IBDM (Institut de Biologie du Développement de Marseille) is expanding its research groups this year! A great place for developmental biology and interdisciplinary research located on the beautiful Marseille-Luminy campus!
Deadline for applications: March 30th, 2025

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Reposted by Anup Parchure

Kasia Siudeja @ksiudeja.bsky.social · Jan 16

6 more weeks to apply !

Become our new colleague at the Cell Biology Dpt and join the growing group of junior teams of @i2bcparissaclay.bsky.social shaping the scientific environment of the institute.

Apply if you are looking for a place to start a lab or forward to any potential candidates.

Kasia Siudeja @ksiudeja.bsky.social · Nov 25

📣📣📣
Come join us and set up your team in the I2BC Cell Bio Dept!

You will find great science, diverse topics and models, spacious labs, supportive environment, and fun colleagues. We are a short (train) ride south of Paris.

Please DM me with any questions and help us spread the word 🙏

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Reposted by Anup Parchure

bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · Jan 2

BORC segregates synaptic vesicle and lysosomal proteins through motors UNC-104/KIF1A and UNC-116/KIF5 https://www.biorxiv.org/content/10.1101/2024.12.31.630845v1

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Reposted by Anup Parchure

Maitreyi Das @daslabpombe.com · Dec 9

We recently tried using mEOS3.2 as a photoconvertible tag. Unfortunately our protein of interest is very low in abundance and barely visible. Are there brighter photoconvertible tags that are known to work is yeasts? #microscopy #yeast #cellbiology #imaging

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Anup Parchure @anupap.bsky.social · Dec 3

www.nature.com/articles/s42....

This one. Very cool. Solves a long standing mystery in protein sorting at the TGN but then has a major twist.

Inceptor binds to and directs insulin towards lysosomal degradation in β cells - Nature Metabolism

The insulin inhibitory receptor (inceptor) is found to bind to insulin and to regulate insulin stores by directing proinsulin and insulin towards lysosomal degradation.

www.nature.com

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Reposted by Anup Parchure

Bianca Schrul @biancaschrul.bsky.social · Nov 26

Interested in #organelle biogenesis, subcellular #membrane #protein targeting or #LipidMetabolism? We are hiring! #PhD student or #postdoc.
We combine #Biochemistry & #CellBiology with Computational Modeling & Experimental Physics / Physical Chemistry approaches.
#research #academicsky #AcademicJob

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