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Reposted by Andrea Dallapè

Trish Greenhalgh @trishgreenhalgh.bsky.social · 10h

Awesome re-analysis of the Franklin / Crick / Watson story. Explains how Franklin produced (with considerable skill) the *pictures* that made the penny drop for slow-on-the-uptake Watson. Sadly, paywalled.

www.cambridge.org/core/journal...

Reassessing Discovery: Rosalind Franklin, Scientific Visualization, and the Structure of DNA | Philosophy of Science | Cambridge Core

Reassessing Discovery: Rosalind Franklin, Scientific Visualization, and the Structure of DNA - Volume 79 Issue 1

www.cambridge.org

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Andrea Dallapè @daddea.bsky.social · 2d

Wait uh, what?? 🤩

cryoEM papers @cryoempapers.bsky.social · 2d

Ballistic Microscopy (BaM) www.biorxiv.org/content/10.1101/2025.10.07.681030v1 #cryoem

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Reposted by Andrea Dallapè

Science Magazine @science.org · 5d

This year’s #NobelPrize in Physiology or Medicine has been awarded to three scientists for discovering how the immune system distinguishes friend from foe. https://scim.ag/3Wt5rdi

Medicine Nobel goes to three researchers who identified immune system’s security guards

Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi discovered regulatory T cells that prevent autoimmune disease

scim.ag

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Reposted by Andrea Dallapè

Jakob Meier-Credo @meiercredo.bsky.social · 22d

Check out our new preprint on an integrated pipeline combining in situ #cryo-ET with MALDI #MSImaging for single-cell identification and classification from previously analysed EM-grids.
Link: www.biorxiv.org/content/10.1...

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Jan-Hannes Schaefer @jhschaef.bsky.social · 7d

Helical Reconstruction of Amyloids in cryoSPARC?
We present guidelines, limitations & future perspectives for processing amyloids in cryoSPARC @structurabio.bsky.social.
Great collaboration of the Kelly Lab and @landerlab.bsky.social #cryoEM #amyloid www.biorxiv.org/content/10.1...

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Edward T Eng @edwardteng.bsky.social · 7d

Muyuan Chen has turned structural biology into an immersive experience with his new video game Meowtabolism, now available on Steam.
Try the demo here: store.steampowered.com/app/4045010/...
Give Muyuan feedback: steamcommunity.com/app/4045010
#ScienceGaming #StructuralBiology #CryoEM #STEMOutreach

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Harvard Med Cell Biology @harvardcellbio.bsky.social · 9d

Historically, viruses were thought to primarily use host cell's translational machinery. New work from @harvardcellbio.bsky.social faculty Amy Lee reveals that a giant DNA virus encodes its own IF4F initiation complex, suggesting an unexpected evolutionary innovation. www.biorxiv.org/content/10.1...

Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life

In contrast to living organisms, viruses were long thought to lack protein synthesis machinery and instead depend on host factors to translate viral transcripts. Here, we discover that giant DNA virus...

www.biorxiv.org

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Oli Clarke @olibclarke.bsky.social · 16d

Initial attempt at replicating in relion (parameters in next post). This is for Aca2-RNA, using a 100k subset of the 2D-classified particles (no prior 3D cleanup).

A 1-class ab initio in relion, then local refinement in relion (1.8deg searches+blush) gives a nominally 3.3Å map; 3.5 Å w/out blush.

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Ben Engel @cellarchlab.com · 16d

Time for a thread!🧵 How different is the molecular organization of thylakoids in “higher” plants🌱? To find out, we teamed up with @profmattjohnson.bsky.social to dive into spinach chloroplasts with #CryoET ❄️🔬. Curious? ..Read on!

#TeamTomo #PlantScience 🧪 🧶🧬 🌾
elifesciences.org/articles/105...
1/🧵

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Florian Schur @schurlab.bsky.social · 16d

Huntingtin binds and bundles F-actin!
Thrilled to team up with the Humbert (Sorbonne Université) and Song (KAIST) labs on this discovery.
We had a blast doing cryo-ET on this unexpected complex — and now so many new questions lie ahead!
#TeamTomo #CryoET #HTT #actin

doi.org/10.1126/scia...

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Shyamal @shyamalm.bsky.social · 18d

Ever wondered how to position organelles in bacteria? Wonder no more!
Happy to have contributed to this fantastic story from @cellforganized.bsky.social' lab.

The avenues this opens in the synthetic biology space are enormous!

Movie: Carboxysomes positioned in E. coli!

Preprint: shorturl.at/D6xVg

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Reposted by Andrea Dallapè

Ben Engel @cellarchlab.com · 21d

A molecular-resolution look into the near-native architecture of the spinach chloroplast🌱. This one was a long time in the oven, but we're happy to finally share our "version of record". What long-standing debates did we settle? Check back for a short thread🧵 on Monday. #TeamTomo #PlantScience 🧪🧶🧬🔬🌾

eLife @elife.bsky.social · 21d

🌱 Using ‘compelling’ methods, including #CryoET, researchers mapped spinach thylakoid membranes at single-molecule precision, revealing how photosynthetic complexes are organised and settling long-standing debates on chloroplast architecture.
buff.ly/j3TSIkn

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bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 25d

Structural dynamics of mitochondrial ATP synthase in Chlamydomonas reinhardtii revealed by in situ CryoET https://www.biorxiv.org/content/10.1101/2025.09.10.674987v1

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Andrea Dallapè @daddea.bsky.social · Aug 30

Impressive! Congratulations!

Oli Clarke @olibclarke.bsky.social · Aug 30

Happy to share a new preprint from the Clarke & Vallese (@fravallese.bsky.social) labs reporting #cryoem structures of two RBC stomatin complexes – with AQP1 & UT-B - continuing the SPFH theme from our recent vault preprint! This was a fun one and has been cooking for a while - read on for more! ⬇️

Upper - cryo-EM reconstruction of stomatin AQP1 complex. Lower - reconstruction of stomatin-UT-B complex.

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Andrea Dallapè @daddea.bsky.social · Aug 12

Wow, those membranes!

Reposted by Andrea Dallapè

SBGrid Consortium @sbgrid.bsky.social · Aug 12

New Title Alert: AITom- an open-source platform for AI driven cellular electron cryo-tomography analysis.

Learn more here: buff.ly/LLGhjvY

#SBGrid #SBGridSoftware #StructuralBiology

Research

Xu Lab of Computational Biology

buff.ly

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Reposted by Andrea Dallapè

Vasil Gaisin @vasilgaisin.bsky.social · Aug 12

We found a new #ecological factor in #microbial mats: the #bacterial contractile injection system. Using #cryoET, #metagenomics, & quantitative #immunoTEM, we studied this feature directly in natural populations of bacterial #cells.

Pilhofer Lab 🦠❄️🔬 @pilhoferlab.bsky.social · Aug 12

Check out 🧐 our new preprint 📜:
www.biorxiv.org/content/10.1...
Congrats🎉 to @vasilgaisin.bsky.social and Corina Hadjicharalambous, who studied contractile injection systems directly in hot spring♨️ bacterial mats🦠
#microsky #teamtomo #Chloroflexota

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Andrea Dallapè @daddea.bsky.social · Aug 8

I knew Texas was big, but I didn’t know it encompasses 4 states

Andrea Dallapè @daddea.bsky.social · Aug 8

Lovely.
So many US states I never heard of before, I definitely have to study an US map much better

radams @radamssmash.bsky.social · Aug 8

My goto is to ask LLMs how many states have R in their name. They always fail. GPT 5 included Indiana, Illinois, and Texas in its list. It then asked me if I wanted an alphabetical highlighted map. Sure, why not.

A shitty map created by ChatGPT5. it purports to be US States with an R in their name, but it's wrong and dumb and worthless just like LLMs.

Reposted by Andrea Dallapè

Brett Collins @brettcollins.bsky.social · Aug 6

Not my area at all, but how cool are these cryoEM structures of purely RNA-based assemblies!
www.nature.com/articles/s41...

High resolution CryoEM maps of RNA assemblies

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Carter Lab @carter-lab.bsky.social · Aug 5

Here is the correct link: www.biorxiv.org/content/10.1...

Cryo-EM structures of Egl-BicD-RNA complexes reveal how diverse mRNAs are selected for subcellular localization

Localization of mRNAs is a widespread mechanism for controlling where proteins operate in cells and underpins many fundamental processes, from embryonic patterning to synaptic plasticity. This spatial...

www.biorxiv.org

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Reposted by Andrea Dallapè

cryoEM papers @cryoempapers.bsky.social · Aug 3

Cryo-EM structures of Egl-BicD-RNA complexes reveal how diverse mRNAs are selected for subcellular localization www.biorxiv.org/content/10.1101/2025.08.02.668268v1 #cryoem

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Ahmad Jomaa @jomaalab.bsky.social · Aug 1

Check out our new preprint on the discovery of a molecular switch in NAC that mediates nascent chain sorting on the ribosome and prevents mitochondrial protein mistargeting by SRP. A great collaboration with the Shan Lab @Caltech and the Qi Lab @UVA: www.biorxiv.org/content/10.1...

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Science Magazine @science.org · Jul 31

The National Institutes of Health’s budget, and structure, would be preserved under a Senate bill for the 2026 fiscal year.

With boost to NIH budget, Senate panel rejects Trump’s plan to slash agency

Republicans on spending committee push back against proposed reorganization and overhead cuts

scim.ag

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Basil Greber @bjgreber.bsky.social · Jul 30

Now out in Structure: Paper on high-resolution #cryoEM using the 100 kV Tundra cryo-TEM by Dimple Karia, Adrian Koh, @abhaykot.bsky.social, @lingboyu.bsky.social, @landerlab.bsky.social and many others. Happy to have contributed to this effort. Check it out:
www.sciencedirect.com/science/arti...

Sub-3 Å resolution protein structure determination by single-particle cryo-EM at 100 keV

Cryoelectron microscopy (cryo-EM) has transformed structural biology by providing high-resolution insights into biological macromolecules. We report s…

www.sciencedirect.com

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