Outer mitochondrial membrane fusion is mediated by the mitofusin paralogs Mfn1 and Mfn2. Nucleotide-driven self-assembly and conformational changes are required for regulated membrane fusion activity,...

Tissue-resident memory CD4+ T cells (TRM) are key sentinels of the adaptive immune response that provide a rapid, robust inflammatory response upon reactivation in non-lymphoid tissues. While CD4+ TRM...

The Venezuelan opposition leader was forced to go into hiding in 2024 after being banned form standing in that year’s election.

The most common destination for eventual Nobel laureates in physics, chemistry and medicine since 2000 is the United States, Nature has found.

A term favoured by US progressives can help us understand Britain’s drift to the right

Inflammation is an essential response to infection and injury, but unregulated inflammation is damaging and must be limited by negative feedback signalling. Inflammasome signalling drives local inflam...

Cardiff University confirmed it cannot rule out compulsory redundancies as it also apologised to students for problems with a new timetabling system as the academic year begins

McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

It's a longstanding tradition to blame all manner of social ills on women, without any basis in fact.

Nature Methods - Clonalscope is a method for cancer subclone detection leveraging copy number profiles estimated using spatial and single-cell sequencing data.

The Galaxy single-cell and spatial omics community (SPOC) brings together over 175 tools, 120+ training resources, and a global user community in a unified FAIR platform. By integrating leading suites...

Nature Reviews Genetics, Published online: 30 September 2025; doi:10.1038/s41576-025-00892-5Spatial omics has empowered the discovery of developmental and disease-associated molecular signatures, cell states and multicellular niches, as well as the evaluation of disease heterogeneity within and across organs. The authors review spatially resolved molecular changes across diseases and discuss the potential of spatial multi-omics for clinical applications, including the recent impact of artificial intelligence.