Markus Elsner
@markuselsner.bsky.social
Deputy Director of the Institute for Intelligent Biotechnologies at HelmholtzMunich, former editor @naturebiotech.bsky.social, all views expressed here are my own
Wow, this is really cool if it works as advertised.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
3D pathology-guided microdissection
Traditional micro- and macro-dissection techniques enable the extraction of localized regions in thin tissue sections for molecular analysis. Despite the growing use of 3D microscopy, analogous method...
www.biorxiv.org
November 25, 2025 at 11:29 AM
Wow, this is really cool if it works as advertised.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Markus Elsner
This year’s Nobel Prize in Chemistry was awarded for research on metal–organic frameworks, whose nanoscale cavities are being exploited for myriad industrial applications but are also beginning to make progress in the clinic www.nature.com/articles/s41...
rdcu.be/eRzse
rdcu.be/eRzse
Chemistry Nobel materials in the clinic - Nature Biotechnology
Nature Biotechnology - Chemistry Nobel materials in the clinic
www.nature.com
November 24, 2025 at 5:24 PM
This year’s Nobel Prize in Chemistry was awarded for research on metal–organic frameworks, whose nanoscale cavities are being exploited for myriad industrial applications but are also beginning to make progress in the clinic www.nature.com/articles/s41...
rdcu.be/eRzse
rdcu.be/eRzse
👏
November 24, 2025 at 8:28 PM
👏
So, who still thinks Trump would lift a finger when Russia attacks NATO territory?
November 21, 2025 at 9:14 PM
So, who still thinks Trump would lift a finger when Russia attacks NATO territory?
Reposted by Markus Elsner
![Comic. [Two people transferring cargo between a dock and a ship on a cart. A box has fallen off of it into the water labeled “EPIRB: Water-Activated Distress Beacons, 1600 ct”] [caption] “Hello, Coast Guard? We’d like to apologize once again for the 1,600 simultaneous false alarms this morning...”](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cz73r7iyiqn26upot4jtjdhk/bafkreidpifawma7njovmrjjqs75maq6ggimmrbjcfjtwhfejj65veo32pq@jpeg)
Reposted by Markus Elsner
Our first lab paper is out! We identify and solve the first structure of the SND3 translocon involved in fungal membrane protein insertion. Congratulations @tzujingyang.bsky.social, and our colleagues @saumyakm.bsky.social, @hummerlab.bsky.social and Julian Langer. Read more ⬇️ and ➡️ rdcu.be/eNgIO
SNDing proteins into the membrane! Our new publication from @melaniemcdowell.bsky.social ’s group identifies the SND3 protein as a new route for membrane protein insertion! 🍄 📘 Read more here: www.mpg.de/25599408/102... Image: Louise Duever.
October 30, 2025 at 5:42 PM
Our first lab paper is out! We identify and solve the first structure of the SND3 translocon involved in fungal membrane protein insertion. Congratulations @tzujingyang.bsky.social, and our colleagues @saumyakm.bsky.social, @hummerlab.bsky.social and Julian Langer. Read more ⬇️ and ➡️ rdcu.be/eNgIO
Reposted by Markus Elsner
FDA approves new mechanism to treat idiopathic pulmonary fibrosis, expanding limited arsenal www.nature.com/articles/s41...
FDA approves new mechanism to treat idiopathic pulmonary fibrosis, expanding limited arsenal - Nature Biotechnology
The first-in-class small molecule Jascayd targets a fibrotic signaling cascade, offering new hope in a stagnant therapeutic field, as several other programs near maturity.
www.nature.com
November 18, 2025 at 10:09 PM
FDA approves new mechanism to treat idiopathic pulmonary fibrosis, expanding limited arsenal www.nature.com/articles/s41...
Reposted by Markus Elsner
Each year, we highlight companies that received sizeable early-stage funding in the previous year. Red Queen Therapeutics is combating infectious diseases with peptide viral fusion inhibitors go.nature.com/4r5k0C9
Editor’s pick: Red Queen Therapeutics - Nature Biotechnology
Each year, Nature Biotechnology highlights companies that received sizeable early-stage funding in the previous year. Red Queen Therapeutics is combating infectious diseases with peptide viral fusion ...
go.nature.com
November 18, 2025 at 3:36 PM
Each year, we highlight companies that received sizeable early-stage funding in the previous year. Red Queen Therapeutics is combating infectious diseases with peptide viral fusion inhibitors go.nature.com/4r5k0C9
Reposted by Markus Elsner
On Thursday, Anastasia Khvorova, PhD, received the 2025 Else Kröner Fresenius Prize for Medical Research, a $2.7 million award, for her pioneering work in the field of RNA-based therapies.
📸: Else Kröner-Fresenius-Stiftung
#EKFprize25 #EKFS #RNA @ekfstiftung.bsky.social @rti-umasschan.bsky.social
📸: Else Kröner-Fresenius-Stiftung
#EKFprize25 #EKFS #RNA @ekfstiftung.bsky.social @rti-umasschan.bsky.social
May 16, 2025 at 2:25 PM
On Thursday, Anastasia Khvorova, PhD, received the 2025 Else Kröner Fresenius Prize for Medical Research, a $2.7 million award, for her pioneering work in the field of RNA-based therapies.
📸: Else Kröner-Fresenius-Stiftung
#EKFprize25 #EKFS #RNA @ekfstiftung.bsky.social @rti-umasschan.bsky.social
📸: Else Kröner-Fresenius-Stiftung
#EKFprize25 #EKFS #RNA @ekfstiftung.bsky.social @rti-umasschan.bsky.social
Reposted by Markus Elsner
The November issue is live nature.com/nbt/volumes/...
On the cover, lipid nanoparticles targeting the lung, designed using neural networks. A method developed by Witten et al. identified two structures that efficiently delivered mRNA to ferret lungs go.nature.com/4fbj0VU
On the cover, lipid nanoparticles targeting the lung, designed using neural networks. A method developed by Witten et al. identified two structures that efficiently delivered mRNA to ferret lungs go.nature.com/4fbj0VU
November 12, 2025 at 7:03 PM
The November issue is live nature.com/nbt/volumes/...
On the cover, lipid nanoparticles targeting the lung, designed using neural networks. A method developed by Witten et al. identified two structures that efficiently delivered mRNA to ferret lungs go.nature.com/4fbj0VU
On the cover, lipid nanoparticles targeting the lung, designed using neural networks. A method developed by Witten et al. identified two structures that efficiently delivered mRNA to ferret lungs go.nature.com/4fbj0VU
I just watched House of Dynamite on Netflix. Insanely good and more scary than any horror movie.
November 12, 2025 at 10:01 PM
I just watched House of Dynamite on Netflix. Insanely good and more scary than any horror movie.
Reposted by Markus Elsner
It's been nearly two years since the first gene-editing therapy, Casgevy, was approved for sickle cell disease. Just 39 patients worldwide have received it in that time. This is from a Nov. 10 update from manufacturer Vertex:
November 12, 2025 at 4:58 PM
It's been nearly two years since the first gene-editing therapy, Casgevy, was approved for sickle cell disease. Just 39 patients worldwide have received it in that time. This is from a Nov. 10 update from manufacturer Vertex:
Flu and Corona shot for this year ✅️
November 11, 2025 at 10:45 AM
Flu and Corona shot for this year ✅️
Reposted by Markus Elsner
Big pharma shares its machine learning models with biotechs, but awaits definitive data on success of artificial intelligence-generated drugs www.nature.com/articles/s41...
Drugmakers share data to feed voracious foundation models - Nature Biotechnology
Big pharma shares its machine learning models with biotechs, but awaits definitive data on success of artificial intelligence-generated drugs.
www.nature.com
November 10, 2025 at 9:09 PM
Big pharma shares its machine learning models with biotechs, but awaits definitive data on success of artificial intelligence-generated drugs www.nature.com/articles/s41...
😮
The protein concentration in the cytoplasm is so high that the average protein has a water hydration shell with a thickness of only ≈ 10 water molecules separating it from the adjacent protein hydration shell.
1/2
1/2
November 10, 2025 at 1:39 PM
😮
We went to see the fantastic exhibition on Marcus Aurelius in Trier today. Really worth a visit (ends in two weeks, though)
November 8, 2025 at 10:39 PM
We went to see the fantastic exhibition on Marcus Aurelius in Trier today. Really worth a visit (ends in two weeks, though)
💯
![Comic. [Person sitting at desk with laptop with machine labeled E-21 making “click click” noises on the floor behind] VOICE FROM LAPTOP: Hey all! Does your E-21 humidifier make an annoying clicking noise? Mine did, but I finally figured out that there’s an easy fix, so I made this video in case anyone else… PERSON AT DESK: Oh my god. Yes. *Yes.* [caption] I know there’s more important work in the world, but I feel like these people deserve, at minimum a statue.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cz73r7iyiqn26upot4jtjdhk/bafkreifdjde6wgflkeil7kf4kdh3zqk32k55rkljlwu6arzbw557ogbulu@jpeg)
November 6, 2025 at 7:03 AM
💯
Took a while, but here is the skeetorial for the latest reprint from our lab. Let us know what you think!
We are introducing LipiGo 🤗
A programmable DNA–lipid nanocarrier 🧬 with built-in targeting logic. It de-targets the liver and redirects mRNA delivery into lymphoid organs, enhancing therapies requiring the immune system. Precision delivery at the cell level isn't far! www.biorxiv.org/content/10.1...
A programmable DNA–lipid nanocarrier 🧬 with built-in targeting logic. It de-targets the liver and redirects mRNA delivery into lymphoid organs, enhancing therapies requiring the immune system. Precision delivery at the cell level isn't far! www.biorxiv.org/content/10.1...
November 4, 2025 at 4:09 PM
Took a while, but here is the skeetorial for the latest reprint from our lab. Let us know what you think!
🤣
Academics in Assyria in the 7th c BC complain that admin is preventing them from doing research and teaching
November 3, 2025 at 9:38 PM
🤣
Reposted by Markus Elsner
Wer unsere Arbeit unterstützen möchte, kann das über Patreon tun - oder ganz einfach hier entlang 👇
😊
sicherheitspod.de/spenden/
😊
sicherheitspod.de/spenden/
Spenden - Sicherheitspod
Sicherheitshalber ist eine Privatinitiative von Ulrike Franke, Carlo Masala, Frank Sauer und Thomas Wiegold. Wir freuen uns über Unterstützung für den Betrieb des Podcasts und dieser Webseite – das ge...
sicherheitspod.de
November 3, 2025 at 12:37 PM
Wer unsere Arbeit unterstützen möchte, kann das über Patreon tun - oder ganz einfach hier entlang 👇
😊
sicherheitspod.de/spenden/
😊
sicherheitspod.de/spenden/
And Germany?
November 3, 2025 at 8:30 PM
And Germany?
Reposted by Markus Elsner
Europa ist viel sicherer als die USA
November 2, 2025 at 7:22 PM
Europa ist viel sicherer als die USA
Reposted by Markus Elsner
#MosaicMonday - Central medallion of the Polydus Mosaic depicting a popular charioteer for the red faction (factio russata) and his lead horse Compressor. From a Roman villa in Augusta Treverorum, dated to the 3rd century AD.
Rheinisches Landesmuseum Trier, Germany.
Rheinisches Landesmuseum Trier, Germany.
November 3, 2025 at 4:55 PM
#MosaicMonday - Central medallion of the Polydus Mosaic depicting a popular charioteer for the red faction (factio russata) and his lead horse Compressor. From a Roman villa in Augusta Treverorum, dated to the 3rd century AD.
Rheinisches Landesmuseum Trier, Germany.
Rheinisches Landesmuseum Trier, Germany.
Reposted by Markus Elsner
Spend a day with me on the campaign trail in Virginia.
November 2, 2025 at 2:18 PM
Spend a day with me on the campaign trail in Virginia.