Lightnews — Scholar-powered news

Alberto Elosegui-Artola @aeloseguiartola.bsky.social · 14m

The Francis Crick Institute PhD programme recruitment is now live and our lab is recruiting. If you are interested in studying the role of the extracellular matrix in tissue dynamics during development and cancer please apply – link below. Please share. www.crick.ac.uk/careers-stud...

Elosegui-Artola Lab | Mechanical regulation of tissue dynamics by the extracellular matrix in development and cancer

www.crick.ac.uk

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Reposted by Alberto Elosegui-Artola

Barriga Lab @eliasbarrigalab.bsky.social · 15d

Are you interested on how regenerating tissues transit between stages? Am sharing here our work showing that during #Xenopus tail regeneration, tissue stiffening activates a Piezo1-Yap1 mechanosensitive cascade to allow wounded epithelia to transit into regenerative states!

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Reposted by Alberto Elosegui-Artola

Zena Hadjivasiliou @zenahadjivasiliou.bsky.social · 22d

Fresh from the press💥 We asked what happens when you evolve gene regulatory networks computationally at scale. Do general principles of GRN evolution jump out? Is the process predictable? Read on to find out @prxlife.bsky.social @crick.ac.uk @ucl-ipls.bsky.social 👉 journals.aps.org/prxlife/abst...

Gene Network Organization, Mutation, and Selection Collectively Drive Developmental Pattern Evolvability and Predictability

The historical order in which mutations appear during evolution determine the evolutionary trajectory of gene regulatory networks and influence how developmental patterns change and diversify over tim...

journals.aps.org

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Reposted by Alberto Elosegui-Artola

James Briscoe @jamesbriscoe.bsky.social · Aug 26

Our latest: We developed a chemo-optogenetic system for precise spatiotemporal control of morphogen production. Using dual light + small molecule control of Sonic Hedgehog production, we recapitulated neural tube patterning in vitro & measured spread of Shh

🧵

www.sciencedirect.com/science/arti...

Investigating morphogen and patterning dynamics with optogenetic control of morphogen production

Morphogen gradients provide the patterning cues that instruct cell fate decisions during development. Here, we establish an optogenetic system for the…

www.sciencedirect.com

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Reposted by Alberto Elosegui-Artola

Kate Miroshnikova @katemiro.bsky.social · Aug 15

Pathologists have used nuclear & tissue shapes to diagnose #cancer for decades, but what is the molecular basis for this? In our latest work, we develop a computational pipeline to figure this out in #colorectalcancer! Check out 🧵& preprint #mechanobiology #stemcells www.biorxiv.org/content/10.1...

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Reposted by Alberto Elosegui-Artola

Alberto Elosegui-Artola @aeloseguiartola.bsky.social · Aug 14

Don’t miss the exciting ISSCR Digital Webinar: Integrating Biophysics into Stem Cell Biology on October 14,2025!
Together with Windie Höfs we have organized this webinar that features paired tandem talks of experimentalists and theorists working at the interface of stem cell biology and biophysics!

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Alberto Elosegui-Artola @aeloseguiartola.bsky.social · Aug 14

🔬 Speakers:
CarenNorden nordenlab.bsky.social and Carl Modes
@nicolettapetridou.bsky.social and zenahadjivasiliou.bsky.social
Yonit Maroudas-Sacks and Marko Popović
Vasudha Srivastava and Asa Kalish

www.isscr.org/upcoming-pro...

#ISSCR #StemCells #Biophysics #Mechanobiology #ScienceSpotlight

NordenLab (@nordenlab.bsky.social)

How do organs form from cells to tissue? Zebrafish and organoids; live imaging; quantitative biology; theory. Comments by Caren Norden

nordenlab.bsky.social

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Alberto Elosegui-Artola @aeloseguiartola.bsky.social · Aug 14

Don’t miss the exciting ISSCR Digital Webinar: Integrating Biophysics into Stem Cell Biology on October 14,2025!
Together with Windie Höfs we have organized this webinar that features paired tandem talks of experimentalists and theorists working at the interface of stem cell biology and biophysics!

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Reposted by Alberto Elosegui-Artola

Michael Way @drmichaelway.bsky.social · Aug 11

Congrats to everyone including JCS @jcellsci.bsky.social Editor Megan King @luskinglab.bsky.social & Editorial Advisory Board members Dennis Discher, Miho Iijima, James Olzmann @olzmannlab.bsky.social, Kristen Verhey @kjverhey1.bsky.social‬ for becoming ASCB fellows ‬
www.ascb.org/society-news...

Fourteen Visionary Scientists Named 2025 ASCB Fellows - ASCB

The American Society for Cell Biology (ASCB) is proud to announce the election of 14 outstanding scientists as 2025 ASCB Fellows—a prestigious honor recognizing their exceptional contributions to cell...

www.ascb.org

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Reposted by Alberto Elosegui-Artola

Marta Shahbazi @marta-shahbazi.bsky.social · Aug 9

🤩 Very excited to share our new work! We have derived euploid and aneuploid trophoblast organoids and extra-embryonic mesoderm cell lines from early human embryos. In doing so, we have characterised the tissue requirements for their specification. If you want to know more, continue reading….

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Reposted by Alberto Elosegui-Artola

Marta Shahbazi @marta-shahbazi.bsky.social · Aug 9

www.biorxiv.org/content/10.1...

A blastocyst-derived in vitro model of the human chorion

The placenta supports the foetus by mediating nutrient and gas exchange, hormone production, and immune protection. Yet, human placental biology remains poorly understood due to limited in vitro model...

www.biorxiv.org

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Alberto Elosegui-Artola @aeloseguiartola.bsky.social · Aug 11

Beautiful work! Congrats Rashmi, Toby and team!

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Reposted by Alberto Elosegui-Artola

Flor Iacaruso @flor-iacaruso.bsky.social · Aug 1

1/N What are the organizational principles underlying crossmodal cortical connections?
We address this in this new preprint, led by @alexegeaweiss.bsky.social & ‪@bturner-bridger.bsky.social‬ in collab w/ ‪@petrznam.bsky.social‬ @crick.ac.uk
www.biorxiv.org/content/10.1...

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Reposted by Alberto Elosegui-Artola

Rashmi Priya @rashmi-priya.bsky.social · Jul 23

Paper accepted 🥳 Many congratulations @tobyandrews.bsky.social So proud of what you have achieved! Can’t wait to see what you do next... Onwards and upwards from here!

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Reposted by Alberto Elosegui-Artola

Naba Lab UIC @nabalabuic.bsky.social · Jul 15

Data drop! We just released an updated list of anti-ECM antibodies curated from the #HumanBioMolecularAtlasProgram Organ Mapping Antibody Panels #OMAP and the 9th release of the Human Reference Atlas #HRA. Check it out: sites.google.com/uic.edu/matr...

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Reposted by Alberto Elosegui-Artola

Jacky Goetz @goetzjacky.bsky.social · Jul 7

Check out our latest preprint, which is the latest production from our long-lasting collaboration with Andrey Klymchenko

> functionnalizing NPs with humanized antibodies (i.e. Trastuzumab).

Work performed by @vmittelheisser.bsky.social & O.Lefebvre in my lab.

www.biorxiv.org/content/10.1...

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Reposted by Alberto Elosegui-Artola

Maria Alcolea @mariapalcolea.bsky.social · Jul 4

⏳Only 1 week left to submit your talk for the Fusion Stem Cells & Cancer Conference!
🧪Share your exciting discoveries with us!!
📍Malta
🗓️Talk Deadline: July 10
🔗http://bit.ly/49sCfJp
@joneslabucsf.bsky.social, Kathrin Plath, @katemiro.bsky.social at @fusionconf.bsky.social

Maria Alcolea @mariapalcolea.bsky.social · Jul 2

One Month to Go!🚨
Countdown for the STEM CELLS & CANCER Fusion Conference — a unique gathering of global leaders sharing their ground breaking research.
🧬Ignite new ideas by Mediterranean Sea-Malta 🏝️
📅Final Deadline: 31 July
🎤Unmissable speakers...🧵
bit.ly/49sCfJp

Stem Cells & Cancer Conference | Fusion Conferences

Our scientific research conferences support the development of physical, medical and life sciences, providing a powerful platform that encourages discussion and collaboration in luxury locations acros...

bit.ly

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Reposted by Alberto Elosegui-Artola

Nimesh Chahare @onenimesa.bsky.social · Jul 3

Have you ever thought about inflating tissues?
Or maybe quickly deflating those inflated tissues?

New #EpithelialMechanics pre-print: doi.org/10.1101/2025...
🧵 with pressure control, multiscale buckling, controlled wrinkling

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Reposted by Alberto Elosegui-Artola

Xavier Trepat @xaviertrepat.bsky.social · Jul 3

🚨 Second preprint of the week!

We uncover the multiscale dynamics of active viscoelastic buckling in epithelia.

We harness these mechanical instabilities for synthetic morphogenesis.

Led by @onenimesa.bsky.social 🙌. Theory by Marino Arroyo etal. @ibecbarcelona.eu

www.biorxiv.org/content/10.1...

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Reposted by Alberto Elosegui-Artola

Monica Bettencourt-Dias @monicabettencourt.bsky.social · Jul 1

Happy to be the next (and 1st female) @crg.eu director. The CRG always stood out to me, for its excellence in understanding life's principles, with implications for health and biodiversity, & its collaborative, open and innovative way of doing science. Thrilled to join its amazing community in 2026!

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Reposted by Alberto Elosegui-Artola

Robin Journot 🔬| 🎾 @robinjournot.bsky.social · Jul 1

🧵Just out !
We reveal how 4 branched epithelia—mammary, lacrimal, salivary & prostate—use a conserved YAP–Notch–p63 circuit to self-organize during development & regeneration.
Here’s the story👇
authors.elsevier.com/c/1lM285Sx5g...
Work done in @frelab.bsky.social at ‪
‪ @institutcurie.bsky.social

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Reposted by Alberto Elosegui-Artola

Rainero lab @erainerolab.bsky.social · May 28

Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells.
pubmed.ncbi.nlm.nih.gov/40419795/

Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells - PubMed

Integrins provide an essential bridge between cancer cells and the extracellular matrix, playing a central role in every stage of disease progression. Despite the recognized importance of integrin pho...

pubmed.ncbi.nlm.nih.gov

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Reposted by Alberto Elosegui-Artola

Campàs Lab @campaslab.bsky.social · May 26

We did it! 🎉 🍾🥂

Our Excellence Cluster Physics of Life (PoL) got renewed until 2032! I am so proud of our team and all the great work we did to achieve this.

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Reposted by Alberto Elosegui-Artola

Alejo Rodriguez-Fraticelli @alejofraticelli.bsky.social · May 21

Our work on lineage tracing with somatic epimutations is finally out in @nature.com!

Check out the thread by @larsplus.bsky.social below.

EPI-clone is a revolutionary technique for lineage tracing and it will immediately impact how we trace clones everywhere.

Detailed protocols coming out soon!

Lars Velten @larsplus.bsky.social · May 21

Out @nature.com: Clonal tracing with somatic epimutations

🧬 Single cell methylome encodes cell state & clonal identity

🔨 EPI-Clone reads out both (+mutations, +RNA) at scale

🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations

doi.org/10.1038/s415...
🧵

Clonal tracing with somatic epimutations reveals dynamics of blood ageing - Nature

The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing th...

doi.org

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Alberto Elosegui-Artola @aeloseguiartola.bsky.social · May 16

Impressive work by @santoslab.bsky.social creating a 3D model of human amnion from hESCs! www.cell.com/cell/fulltex...

Post-gastrulation amnioids as a stem cell-derived model of human extra-embryonic development

An embryonic stem cell-based 3D model that accurately recapitulates the size, morphology, and functional features of the human amnion at 4 weeks, termed the post-gastrulation amnioid (PGA), is develop...

www.cell.com

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