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Reposted by Behnam Nabet

Micha Rapé Lab @micharapelab.bsky.social · 27d

Excited that our study identifying TRIP12 - an essential E3 ligase mutated in a neurodevelopmental disease - as a critical component of the oxidative stress response is now online. Congratulations to Andrew, Devlon and Jenny! @ucberkeleyofficial.bsky.social

www.sciencedirect.com/science/arti...

Dynamic regulation of the oxidative stress response by the E3 ligase TRIP12

Centered on the transcription factor NRF2 and its E3 ligase CUL3KEAP1, the oxidative stress response protects cells from damage by reactive oxygen spe…

www.sciencedirect.com

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Alex Merz 🇺🇸🇨🇦🇺🇦 @merz.bsky.social · Aug 28

I am delighted to announce that the UW Department of Biochemistry has opened searches for TWO tenure-track positions.

Descriptions and links in the following two posts.

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Avgousti lab @avgoustilab.bsky.social · Aug 23

Excited to share our latest paper on how macroH2A is targeted by IE1 during HCMV infection- featured as an editors pick in Nature Communications! Fantastic work by Laurel and team!!

www.nature.com/articles/s41...

Human cytomegalovirus induces neuronal gene expression through IE1 for viral maturation - Nature Communications

HCMV rearranges the host cell to produce infectious virus but molecular details are still unclear. Here, the authors analyze the transcriptome of infected cells and show that HCMV turns on dormant neu...

www.nature.com

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Behnam Nabet @behnamnabet.bsky.social · Jul 25

The first Nabet lab paddle boarding outing was a success! Couldn’t be prouder of this amazing group — grateful to lead such a committed, collaborative, and inspiring team.

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DrawImpacts @drawimpacts.bsky.social · Jul 22

We turn complex science into striking visuals, like this cover we illustrated for Dr. @behnamnabet.bsky.social et al. on FAK inhibitors and PROTACs. 🦋
👩‍🔬 Know someone doing great research? Tag them, we’d love to help share their story. #JournalCovers #DrawImpacts #SciArt

The cover picture depicts a firefly (BSJ-04-146) luring a moth (FAK) to the carnivorous plant (proteasome) and was designed by DrawImpacts.

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Katherine A Donovan @katherinedonovan.bsky.social · Jul 16

🎉 2025 DFCI TPD event registration is open!
📆 Sep 11, 11:30 AM–8 PM ET, Boston
🔑 Keynote: Nathanael Gray
📝 Registration link: forms.gle/NLUSa51Btrtf...
#TPD #ProteinDegradation #DrugDiscovery #Boston #DFCI

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Milka Kostic @milkakostic.bsky.social · Jun 30

We are looking to hire an Assistant/Associate Professor interested in creating an innovative (and exciting) program of research in chemical biology, medicinal chemistry, ML/AI, drug discovery - all in the context of cancer biology!
careers.dana-farber.org/job/11813/as...

Faculty/Health Educator Job: Assistant/Associate Professor, Chemical Biology at Dana-Farber Cancer Institute in 450 Brookline Ave, Boston, MA

Assistant/Associate Professor, Chemical Biology job

careers.dana-farber.org

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Avgousti lab @avgoustilab.bsky.social · Jun 26

Postdoc positions available! Please re-post!

Are you interested in how viruses manipulate chromatin? Are you excited to discover unknown facets of molecular biology? If so, we’d love to hear from you! Come check us out at:
avgoustilab.org

Avgousti Lab

Investigating viral manipulation of host chromatin dynamics

avgoustilab.org

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Behnam Nabet @behnamnabet.bsky.social · Jun 25

Plug: @sauravk05.bsky.social is hitting the faculty job market, aiming to launch the Kumar lab in 2026. He’s truly exceptional and is building a cutting-edge induced proximity research program. Reach out!

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Behnam Nabet @behnamnabet.bsky.social · Jun 25

This study was a fantastic collaboration with @fleurmferguson.bsky.social, @afederation.bsky.social, Andrea Gutierrez, Mia Donald-Paladino, Joy Chen, Frank Szuzlewsky, and Eric Holland. We are all grateful for funding from the NIH, NSF, and the Hartwell Innovation Fund - Swim Across America.

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Behnam Nabet @behnamnabet.bsky.social · Jun 25

🚨 New preprint!

Excited to share our latest work, led by @sauravk05.bsky.social (Nabet lab) and Jiewei Jiang (Ferguson‬ lab), on targeting oncogenic TRK fusions. We report potent and selective degraders of TPM3-TRKA, a driver of adult and pediatric cancers. www.biorxiv.org/content/10.1...

Development of PROTACs for targeted degradation of oncogenic TRK fusions

Chromosomal translocations leading to the fusion of tropomyosin receptor kinases (TRK) with diverse partner proteins have been identified as oncogenic drivers in many adult and pediatric cancers. Whil...

www.biorxiv.org

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Jonathan Pruneda @jnpruneda.bsky.social · May 17

Sharing the next installment of our fun collaboration with @michaelnadbio.bsky.social at the interface of #ubiquitin and #ADP-ribosylation! Building upon our identification of cellular MARUbylation, we now identify reader/writer E3 ligases that extend K11 polyUb! 🧵
www.biorxiv.org/content/10.1...

A family of E3 ligases extend K11 polyubiquitin on sites of MARUbylation

Ubiquitin (Ub) cooperation with other post-translational modifications provides a tiered opportunity for protein regulation. Small modifications to Ub such as phosphorylation, acetylation, or ADP-ribo...

www.biorxiv.org

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Fred Hutch Basic Sciences Division @hutchbasicsci.bsky.social · May 16

Two great talks lined up for the final Friday Afternoon Seminars of the season!

For everyone @FredHutch.bsky.social, join us at 4pm in Pelton to hear about the latest discoveries from Rina Hirano in the Tsukiyama Lab and @christinakuismi.bsky.social in Human Biology’s @behnamnabet.bsky.social Lab.

Friday Afternoon Seminar (FAS), this Friday 5/16 at 4pm in Pelton.

Rina Hirano, Tsukiyama Lab
Elucidating 3D chromatin structure and its regulatory mechanism of rDNA in quiescence

Christina Kuismi, Nabet Lab
Targeted degradation of non-receptor tyrosine kinases PYK2 and FAK

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Micha Rapé Lab @micharapelab.bsky.social · May 7

Excited that our work revealing the structure and function of the monster stress response silencing factor, the E3 ligase SIFI, is now out! Congratulations to the most amazing team of Zhi Yang, Diane Haakonsen, Michael Heider and Sam Witus!

www.nature.com/articles/s41...

Molecular basis of SIFI activity in the integrated stress response - Nature

Nature - Molecular basis of SIFI activity in the integrated stress response

www.nature.com

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Subramaniam Lab @rasilab.bsky.social · May 2

Excited to share the work of postdoc Rachael Bakker in collaboration with @lapointelab.bsky.social!

We show that RNA base editors can be repurposed for deep mutational scanning of RNA-RBP interactions at scale both in vitro and in vivo.

www.biorxiv.org/content/10.1...

Deaminase-based RNA recording enables high throughput mutational profiling of protein-RNA interactions

Protein-RNA interactions govern nearly every aspect of RNA metabolism and are frequently dysregulated in disease. While individual protein residues and RNA nucleotides critical for these interactions ...

www.biorxiv.org

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Ophir Shalem @ophirshalem.bsky.social · May 1

Excited to to see our collaboration with @gburslem.bsky.social published today! This is part of our ongoing long term goal of achieving scalable non-disruptive and direct imaging and perturbation of the endogenous proteome

George Burslem @gburslem.bsky.social · May 1

Excited to see this out in @science.org today!! www.science.org/doi/10.1126/...

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Barzin Nabet @barzin-nabet.bsky.social · Apr 29

Awesome work as usual from @davidmacphersonlab.bsky.social , wonderful to play a small part!

David MacPherson Lab @davidmacphersonlab.bsky.social · Apr 29

Our latest, in Science Advances: In vivo CRISPR screen revealed sgRNAs that switch chemosensitive SCLC PDXs to become resistant.We validated KEAP1 as key hit and found KEAP1 alterations in IMpower133 trial, where active NRF2 links to reduced survival in chemo arm www.science.org/doi/10.1126/... 1/2

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David MacPherson Lab @davidmacphersonlab.bsky.social · Apr 29

Our latest, in Science Advances: In vivo CRISPR screen revealed sgRNAs that switch chemosensitive SCLC PDXs to become resistant.We validated KEAP1 as key hit and found KEAP1 alterations in IMpower133 trial, where active NRF2 links to reduced survival in chemo arm www.science.org/doi/10.1126/... 1/2

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Nature Reviews Cancer @natrevcancer.nature.com · Apr 28

REVIEW 🚨

Targeted protein degradation (TPD) is an emerging pharmacological modality in cancer therapy. Here, Winter + colleagues, outline the mechanistic bases of TPD and outline both established + upcoming classes of degraders.

📖 👇

Targeted protein degradation for cancer therapy - Nature Reviews Cancer

Targeted protein degradation (TPD) is an emerging pharmacological modality in cancer therapy. In this Review, Hinterndorfer et al. outline the mechanistic bases of TPD and discuss the characteristics, advantages and applications of established compounds as well as upcoming classes of degraders.

bit.ly

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Fred Hutch Basic Sciences Division @hutchbasicsci.bsky.social · Mar 28

Cell biologist and former @FredHutch.bsky.social division leader Dr. Jonathan Cooper retires. Learn about his many years of scientific discovery and time directing the Basic Sciences Division:

Cell biologist and former Fred Hutch division leader Dr. Jonathan Cooper retires

After 40 years of asking good questions of his own science and the science of his colleagues at Fred Hutch, cell biologist Dr. Jonathan Cooper has retired from the Basic Sciences Division.

www.fredhutch.org

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Behnam Nabet @behnamnabet.bsky.social · Mar 7

Standing up for science in Seattle!

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Denis Wirtz @deniswirtz.bsky.social · Mar 6

These are extremely challenging times for early-career faculty. Here is my office's small contribution to make their hard and important work a bit easier:

Download our curated and comprehensive database of funding opportunities for early-career faculty.

Here: research.jhu.edu/rdt/funding-...

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Harmit Singh Malik @harmitmalik.bsky.social · Mar 4

Hope to see many of my colleagues on Friday.

www.eventbrite.com/e/stand-up-f...

Science is for everyone.

For everyone to do, and for everyone to benefit from.

Weather forecast has also improved for Friday, but waterproof your posters just in case.

Stand Up for Science 2025 - Seattle, WA

Stand up for science with us on March 7th, 2025, because science is for everyone! More info at www.standupforscience2025.org

www.eventbrite.com

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Lucas Sullivan @lucasbsullivan.bsky.social · Feb 20

Next, our 2nd preprint of the week (!), this one driven by @madelouhart.bsky.social

Previously: Mitochondrial inhibition impairs cell proliferation by constraining aspartate (ASP) availability.

Here: we investigate the kinetics of ASP depletion/ proliferation impairments and...surprises ensue!

bioRxivpreprint @biorxivpreprint.bsky.social · Feb 19

Succinate Dehydrogenase loss causes cascading metabolic effects that impair pyrimidine biosynthesis https://www.biorxiv.org/content/10.1101/2025.02.18.638948v1

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Lucas Sullivan @lucasbsullivan.bsky.social · Feb 20

Excited to share a recent preprint by Oliver Newsom, where we evaluate the functional contributions of serum for cancer cell proliferation. Inside:

A broadly applicable serum-free media,
Quantitative lipid uptake characterization,
Evidence lipid scavenging > synthesis for cancer cell proliferation.

bioRxivpreprint @biorxivpreprint.bsky.social · Feb 17

Defined media reveals the essential role of lipid scavenging to support cancer cell proliferation https://www.biorxiv.org/content/10.1101/2025.02.12.637975v1

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