Prachi Stafford
@dodoscientist.bsky.social
1.2K followers
790 following
61 posts
Senior lecturer & Researcher in #microbiology, #cellbiology #platelets at Sheffield Hallam University, Sheffield, UK.
Speaks English, Français, Mauritian Creole (from the land of the dodos) & basic Hindi. She/her #WomenInStem #EDI
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Reposted by Prachi Stafford
Reposted by Prachi Stafford
Christian Frezza
@frezzalab.bsky.social
· Apr 14
Integrator loss leads to dsRNA formation that triggers the integrated stress response
Integrator (INT) prevents the escape of immature RNAPII to ensure full-length mRNA
production. INT deficiency causes defects in RNAPII maturation that lead to premature
termination, accumulation of im...
www.cell.com
Reposted by Prachi Stafford
Alex K
@alexkzis.bsky.social
· Mar 25
Consensus protocol for platelet desialylation (β-galactose exposure) quantification using lectins by flow cytometry: Communication from the ISTH SSC Subcommittee on Platelet Physiology.
Platelets contain many heterogeneous carbohydrates (glycans): often capped by sialic
acid. The removal of sialic acid (desialylation) is important for platelet function
and clearance, leading to novel...
www.jthjournal.org
Reposted by Prachi Stafford
De Camilli Lab
@pdc-lab.bsky.social
· Apr 10
The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage
Nature Cell Biology - Wang et al. show the recruitment of the lipid channel protein VPS13C and formation of VPS13C-dependent contacts between endoplasmic reticulum and lysosomes after lysosomal...
rdcu.be
Reposted by Prachi Stafford
Jacky Goetz
@goetzjacky.bsky.social
· Apr 2
The impact of a high fat diet and platelet activation on pre-metastatic niche formation - Nature Communications
Previous work has identified a link between obesity and breast cancer metastasis. Here, using preclinical mouse models, the authors show that high-fat diet promotes platelet and endothelial cell activ...
www.nature.com
Reposted by Prachi Stafford
Christian Frezza
@frezzalab.bsky.social
· Mar 26
Plasticity of the mammalian integrated stress response - Nature
A study describes the split integrated stress response, a cellular stress response mechanism characterized by reduced eIF2B activity without eIF2α phosphorylation, which activates the eIF4E–ATF4–PCK2 ...
www.nature.com
Reposted by Prachi Stafford
Reposted by Prachi Stafford
Alberto Sanz
@albertosanzmon1.bsky.social
· Mar 23
Developmental mitochondrial complex I activity determines lifespan | EMBO reports
imageimageTemporal manipulation of CI function reveals development as critical window where
reduction of CI produces short-lived and stress sensitive adults characterised by
maladaptive transcriptomic...
www.embopress.org
Reposted by Prachi Stafford
Anupam Patgiri
@apatgiri.bsky.social
· Mar 23
Mitochondria transplantation transiently rescues cerebellar neurodegeneration improving mitochondrial function and reducing mitophagy in mice - Nature Communications
Cerebellar ataxia, a hallmark of cerebellar degeneration (CBND), is driven by mitochondrial dysfunction in Purkinje cells. In this study, transplanting mitochondria into CBND mice improve mitochondria...
www.nature.com
Reposted by Prachi Stafford
Reposted by Prachi Stafford
Reposted by Prachi Stafford
Reposted by Prachi Stafford
