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Gautham SANKARA

@gauthamsankara.bsky.social

130 followers 330 following 9 posts

Scientist @ Institut Pasteur Mechanobiology ⚙️ + Cryo-ET 🧊 | Capturing battles 🛡️ between host & pathogen 🦠 | Science at intersection of physics 🔭 and life 🧬

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Gautham SANKARA @gauthamsankara.bsky.social · Apr 28

When cutting-edge tech, brilliant minds, and powerful science communication come together — that's Institut Pasteur! Grateful to be part of this inspiring community. #PasteurCommunity #ScienceLife

Institut Pasteur | 130 years of biomedical research @pasteur.fr · Apr 28

🔬 Dive into the invisible!

At Institut Pasteur, @gauthamsankara.bsky.social uses confocal microscopy to track E. coli division in real time — turning hours of bacterial life into seconds of insight.

Science, precision, innovation. #Research #Microbiology

Reposted by Gautham SANKARA

Enninga Lab @enningalab.bsky.social · 20d

🦠 Mycobacteria aren't just tough, they're interior designers! 🦠 Check out our latest #preprint 🚨, led by our PhD student @camimille.bsky.social , where we show that #Mycobacterium tuberculosis builds secret cytoplasmic membranes to adapt its metabolism and sneak past immunity 🤫

Thread coming soon!

bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 21d

Nitrate-responsive Mycobacterial Intracytoplasmic Membranes dampen Inflammation during Mycobacterium tuberculosis Infection https://www.biorxiv.org/content/10.1101/2025.09.17.676823v1

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Gautham SANKARA @gauthamsankara.bsky.social · Jun 6

The cell looks like Inkay Pokémon🔬 — yellow glowing arms, pink heart.
Under attack by cyan bacteria🦠, but it’s just vibing on the glass, dancing🪩, unaware of the aftermath☠️. #FluorescenceFriday #Microscopy #CellBiology #mechanobiology @pasteuredu.bsky.social #hostpathogeninteraction @pasteur.fr

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Reposted by Gautham SANKARA

Institut Pasteur | 130 years of biomedical research @pasteur.fr · Jun 2

🦠 The plague bacillus became less virulent, extending the duration of two major pandemics. @yersiniaunit.bsky.social @pierrelebury.bsky.social @mcmasteruniversity.bsky.social @ravneetksidhu.bsky.social

The plague bacillus became less virulent, prolonging the duration of two major pandemics

Scientists at the Institut Pasteur and McMaster University have discovered that the evolution of a gene in the bacterium that causes bubonic plague, Yersinia pestis, may have prolonged the duration of...

www.pasteur.fr

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Reposted by Gautham SANKARA

Broad Institute @broadinstitute.org · May 29

A new combination technique enables DNA sequencing and high-resolution imaging in intact cells — offering new insights into progeria and aging. broad.io/expansion-in-situ @jbuenrostro.bsky.social

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Reposted by Gautham SANKARA

NBC News @nbcnews.com · May 29

Harvard president receives standing ovation during commencement.

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Reposted by Gautham SANKARA

Ed Boyden @eboyden3.bsky.social · May 30

Just published, expansion in situ genome sequencing, where you can sequence DNA while still inside the cell, mapping its organization relative to proteins and other markers, with the help of expansion microscopy! Led by @jbuenrostro.bksy.social. www.science.org/doi/10.1126/...

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Reposted by Gautham SANKARA

Cell - a Cell Press journal @cp-cell.bsky.social · May 16

The new issue is out! 👉 cell.com/cell/current

On the cover, Beckwith and Brunner et al. uncover that chromosomes self-organize into their characteristic mitotic rod shape through the formation of large and extensively overlapping DNA loops

📷credit: Andreas Brunner.

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Reposted by Gautham SANKARA

Cell Host & Microbe @cp-cellhostmicrobe.bsky.social · May 13

Cohabitation shifts gut bacteria to protect the liver:

Sharing gut bacteria via cohabitation, notably Rikenellamicrofusus, boosts isoflavone conversion to biochanin-A, reducing liver injury from acetaminophen overdose by enhancing liver cell metabolism and defense
www.cell.com/cell-host-mi...

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Reposted by Gautham SANKARA

Nature Reviews Disease Primers @natrevdiseaseprimers.nature.com · May 13

Major depressive disorder is a complex condition that cannot be fully explained by any one single established biological or environmental pathway www.nature.com/articles/s41...

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Gautham SANKARA @gauthamsankara.bsky.social · May 3

FIJI (ImageJ) is an easier way to make Kymographs
imagej.net/tutorials/ge...

Generate and exploit Kymographs

The ImageJ wiki is a community-edited knowledge base on topics relating to ImageJ, a public domain program for processing and analyzing scientific images, and its ecosystem of derivatives and variants...

imagej.net

Reposted by Gautham SANKARA

Science Magazine @science.org · May 1

This week in Science, researchers delve into the #mathematics that shapes growing rose petals. 🌹

Explore our latest issue—featuring a new print design: scim.ag/42DasUT

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Reposted by Gautham SANKARA

PLOS Biology @plosbiology.org · May 2

How do intracellular #bacteria breach vacuoles to enter the host cytosol? @leaswistak.bsky.social @matthijnvos.bsky.social @enningalab.bsky.social &co show that #Shigella uses its T3SS system to damage endomembranes via mechanoporation to initiate cytosolic access @plosbiology.org 🧪 plos.io/4jXrr9Z

Left: Group of three T3SS localizing in the same zone of the bacteria surface. T3SS n°1 and 2 contact, deform, and perforate the vacuole membrane at the same spot. T3SS n°1 needle (83 nm) is long and seems to deviate from basal body axis showing that strong constraints between T3SS and the vacuole at are play. The locally relaxed vacuole to bacteria space (~50–55 nm) potentially limits additional damage by the T3SS n°3 needle (56 nm) that only slightly deforms the membrane. Right: Model of initial vacuolar membrane breaching by T3SS-induced mechanoporation. Shigella actively enters host cells in a specialized endomembrane compartment, the vacuole, that is rapidly injured and ruptured for cytosolic access. After host cell entry, the vacuole membrane is intact and tightly juxtaposed to the surface of Shigella, permitting contact between T3SSs and the endomembrane. In the authors’ proposed model, vacuole membrane injury is supported both by the vacuole tightness and the length of individual T3SSs.

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Gautham SANKARA @gauthamsankara.bsky.social · May 2

Watching fission yeast divide is cool🦠. But showing it with a kymograph? Even cooler 😎, shows it all—mitosis, cell wall—packed into spatiotemporal magic🪄. Flattening time into 2D just makes it easier to understand. #FluorescenceFriday @pasteur.fr @pasteuredu.bsky.social #Microscopy #Microbiology🔬

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Gautham SANKARA @gauthamsankara.bsky.social · Apr 28

When cutting-edge tech, brilliant minds, and powerful science communication come together — that's Institut Pasteur! Grateful to be part of this inspiring community. #PasteurCommunity #ScienceLife

Institut Pasteur | 130 years of biomedical research @pasteur.fr · Apr 28

Reposted by Gautham SANKARA

Cell - a Cell Press journal @cp-cell.bsky.social · Apr 21

Now online! Tissue geometry spatiotemporally drives bacterial infections

Tissue geometry spatiotemporally drives bacterial infections

Tissue-geometry-regulated cellular traction forces trigger the activation of Piezo1 and its co-localization with bacteria to facilitate the formation of specific bacterial invasion patterns to promote infection.

dlvr.it

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Reposted by Gautham SANKARA

Nature @nature.com · Apr 24

An origami-inspired ‘metamaterial’ has been engineered to have properties not found in natural materials — enabling it to undergo large, reversible deformations

www.nature.com/articles/d41...

Shapeshifting origami material shrinks when twisted

An origami-inspired ‘metamaterial’ has been engineered to have properties not found in natural materials — enabling it to undergo large, reversible deformations.

www.nature.com

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Reposted by Gautham SANKARA

Paul & Virginie - Centriole Lab @centriolelab.bsky.social · Apr 23

New lab preprint! Unveiling the Molecular Architecture of T Cells and Immune Synapses with Cryo-Expansion Microscopy (Cryo-ExM). A fantastic collaboration with Dr. Benita Wolf. Congratulations to all authors, especially Florent Lemaitre, for leading this amazing work! www.biorxiv.org/content/10.1...

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Reposted by Gautham SANKARA

Jesse Veenvliet @jesseveenvliet.bsky.social · Apr 19

😱 A very hungry #PacManoid ate the original post 🍬🍬🍬

Here’s the 🧵 on our latest in @cp-cellstemcell.bsky.social again!

Gastruloids w/ a sweet tooth better model natural embryos: doi.org/10.1016/j.st...

Spearheaded by @cryaaa.bsky.social & Alba Villaronga-Luque @mpi-cbg.de @poldresden.bsky.social

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Reposted by Gautham SANKARA

Benoit Ladoux @bladoux.bsky.social · Apr 19

Flocking and active solid behavior of epithelial cells in our new study in @pnas.org
Great work of Y. Shen, J. O'Byrne and
@andreasschoenit.bsky.social and collaboration with A. Maitra and R. Voituriez!
| PNAS www.pnas.org/doi/10.1073/...

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Gautham SANKARA @gauthamsankara.bsky.social · Apr 4

Fission yeast doing the splits— Microtubule push nucleus from inside, while cell membrane finishes the party. Shout-out @pasteur.fr and #PFAM course for the science vibes! #FluorescenceFriday #Microscopy #CellBiology @pasteuredu.bsky.social

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Gautham SANKARA @gauthamsankara.bsky.social · Mar 21

Wrapping up two weeks of Principles and Applications of Fluorescence Microscopy #PAFM at @pasteur.fr
Hands-on with the FV4000 confocal microscope, chasing glowing E. coli colonies. #FluorescenceFriday #Microscopy

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Gautham SANKARA @gauthamsankara.bsky.social · Mar 7

Sunny days in Paris, and this cell’s matching the vibe 🌞 Focal adhesions flaring up rocket TIRF 🚀 #FluorescenceFriday @pasteur.fr #Microscopy #cellbiology #biophysics #mechanobiology #hostpathogeninteraction

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Gautham SANKARA @gauthamsankara.bsky.social · Feb 28

Yes indeed PIV :)

Gautham SANKARA @gauthamsankara.bsky.social · Feb 28

Cells in motion remains in motion😇 #FluorescenceFriday
@pasteur.fr #Microscopy #cellbiology #biophysics #mechanobiology #hostpathogeninteraction

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Reposted by Gautham SANKARA

Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · Feb 19

Our methods paper made it to bioRxiv:
doi.org/10.1101/2025...

Full #cryoET workflows for #plant tissues. Plus some general tricks and tweaks on serial Lift-Out and cryo-FLM. 🧪🧵1/5

#teamtomo #PlantScience #Physcomitrium #Arabidopsis #cryoEM #CLEM

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