Diogenes, PhD
@iamdiogenes.bsky.social
Virologist against Fascism. Anonymous because of my position. Supporting truth, justice, and democracy, for the least of us.
Terrible model. How far down the basic research pipeline will this go? Not far enough to support any kind of sustainable research enterprise. And how excited will this PE group be to support trainees? Also - Trump admin will step in to block foreign investment in research, like they have at NIH.
Because all of us here understand basic economics we know that this kind of thing will never scale.
This is a lab that is on the cusp of producing new drugs. Do private financial firms want to invest in labs like this so they can capture the upside? Yes.
www.statnews.com/202...
This is a lab that is on the cusp of producing new drugs. Do private financial firms want to invest in labs like this so they can capture the upside? Yes.
www.statnews.com/202...
Private equity firm will finance Harvard research lab, in possible template for future
A private equity firm will finance a Harvard University research lab, a possible template for the future as schools nationwide absorb federal funding cuts.
www.statnews.com
June 20, 2025 at 2:52 AM
Terrible model. How far down the basic research pipeline will this go? Not far enough to support any kind of sustainable research enterprise. And how excited will this PE group be to support trainees? Also - Trump admin will step in to block foreign investment in research, like they have at NIH.
Reposted by Diogenes, PhD
This is pretty obviously trolling for people to flip out and swear at him so he can go back to Musk Pravda with screenshots demonstrating that Bluesky is a hysterical mob. Just block and channel your attention somewhere more interesting.
June 19, 2025 at 1:30 AM
This is pretty obviously trolling for people to flip out and swear at him so he can go back to Musk Pravda with screenshots demonstrating that Bluesky is a hysterical mob. Just block and channel your attention somewhere more interesting.
Reposted by Diogenes, PhD
Latest preprint from the lab, many years in the making!
By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.
This could have big implications for our understanding of viral replication & assembly (🧵)
www.biorxiv.org/content/10.1...
By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.
This could have big implications for our understanding of viral replication & assembly (🧵)
www.biorxiv.org/content/10.1...
June 18, 2025 at 6:32 AM
Latest preprint from the lab, many years in the making!
By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.
This could have big implications for our understanding of viral replication & assembly (🧵)
www.biorxiv.org/content/10.1...
By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.
This could have big implications for our understanding of viral replication & assembly (🧵)
www.biorxiv.org/content/10.1...
Reposted by Diogenes, PhD
NYT: “If you saw all this in any other country — soldiers sent to crush dissent, union leaders arrested, opposition politicians threatened — it would be clear that autocracy had arrived.” 😳🇺🇸 www.nytimes.com/2025/06/09/o...
June 10, 2025 at 11:47 AM
NYT: “If you saw all this in any other country — soldiers sent to crush dissent, union leaders arrested, opposition politicians threatened — it would be clear that autocracy had arrived.” 😳🇺🇸 www.nytimes.com/2025/06/09/o...
Reposted by Diogenes, PhD
Strategy to overcome a nirmatrelvir resistance mechanism in the SARS-CoV-2 nsp5 protease www.science.org/doi/10.1126/...
Strategy to overcome a nirmatrelvir resistance mechanism in the SARS-CoV-2 nsp5 protease
Conformational flexibility is used to overcome nirmatrelvir resistance in the SARS-CoV-2 nsp5 protease.
www.science.org
June 9, 2025 at 4:52 PM
Strategy to overcome a nirmatrelvir resistance mechanism in the SARS-CoV-2 nsp5 protease www.science.org/doi/10.1126/...
Reposted by Diogenes, PhD
Can’t shake the thought that having all this matériel in DC and provoking anti-ICE riots in LA, Chicago, and gods-know-where would make a handy little setup for declaring martial law.
Meh, it’s probably nothing. 😬
Meh, it’s probably nothing. 😬
NEW: Unbelievable. A seemingly endless line of tanks & other military vehicles arrive in DC ahead of next week's parade.
They departed Texas 5 days ago.
What a colossal waste of time, money & military resources. All for a President who has shown zero respect for service personnel.
(🎥 DW)
They departed Texas 5 days ago.
What a colossal waste of time, money & military resources. All for a President who has shown zero respect for service personnel.
(🎥 DW)
June 7, 2025 at 8:14 PM
Can’t shake the thought that having all this matériel in DC and provoking anti-ICE riots in LA, Chicago, and gods-know-where would make a handy little setup for declaring martial law.
Meh, it’s probably nothing. 😬
Meh, it’s probably nothing. 😬
Reposted by Diogenes, PhD
This is brilliant because it takes advantage of academics’ natural willingness to talk about their work.
Please consider doing one of these!
Please consider doing one of these!
Are you a scientist and not sure what to do to help with all the awfulness all around us? Inspired by Vietnam era activism, @standupforscience.bsky.social is hosting a series of "teach ins," in which scientists share a bit about their area of expertise and why it's important with the public. 🧪🦑🌎
May 28, 2025 at 12:19 PM
This is brilliant because it takes advantage of academics’ natural willingness to talk about their work.
Please consider doing one of these!
Please consider doing one of these!
Reposted by Diogenes, PhD
You voted for this @hassan.senate.gov @shaheen.senate.gov
@democrats.senate.gov @housedemocrats.bsky.social
@democrats.senate.gov @housedemocrats.bsky.social
May 23, 2025 at 10:23 AM
You voted for this @hassan.senate.gov @shaheen.senate.gov
@democrats.senate.gov @housedemocrats.bsky.social
@democrats.senate.gov @housedemocrats.bsky.social
Reposted by Diogenes, PhD
👎
Anyway: Worth keeping track of filmmakers who are making their stance known on AI
Anyway: Worth keeping track of filmmakers who are making their stance known on AI
Darren Aronofsky has launched a new venture alongside Google DeepMind to help develop generative AI short films.
Darren Aronofsky Partners with Google DeepMind on Generative AI Short Film Initiative
Darren Aronofsky has launched a new venture alongside Google DeepMind to help develop generative AI short films.
bit.ly
May 20, 2025 at 7:19 PM
👎
Anyway: Worth keeping track of filmmakers who are making their stance known on AI
Anyway: Worth keeping track of filmmakers who are making their stance known on AI
Reposted by Diogenes, PhD
This kid is 15, and so has a moral clarity and uprightness that no adult elected official would or could ever have. There aren't really and never have been two sides of this issue, but if it has to be argued as a binary thing I don't see how anything less than this could seem like the side to be on.
this is a letter to the editor from a high school track runner who came in second to a trans girl in a race. her state house rep in maine started talking about it. so she wrote this: www.pressherald.com/2025/05/14/r...
May 16, 2025 at 3:52 AM
This kid is 15, and so has a moral clarity and uprightness that no adult elected official would or could ever have. There aren't really and never have been two sides of this issue, but if it has to be argued as a binary thing I don't see how anything less than this could seem like the side to be on.
Reposted by Diogenes, PhD
RFK Jr. said multiple times during his house and senate hearings today that no scientists have been fired from federal agencies. Our reporting has shown that hundreds, if not thousands, of scientists have been let go from NIH/CDC/FDA
May 15, 2025 at 12:11 AM
RFK Jr. said multiple times during his house and senate hearings today that no scientists have been fired from federal agencies. Our reporting has shown that hundreds, if not thousands, of scientists have been let go from NIH/CDC/FDA
Just announced: recall on fighter jets due to issues with parking brakes.
May 13, 2025 at 2:13 PM
Just announced: recall on fighter jets due to issues with parking brakes.
Reposted by Diogenes, PhD
I got to figure 1 in the paper and took a look at these survival curves and weight data.
Oh hey, that's fully reconstructed 1918 (unsurprising since Jeff Taubenberger, the senior author & acting NIAID director, reconstructed it). Also, what does "chimeric" mean for the H7N1, H6N1, and H10N7?
Oh hey, that's fully reconstructed 1918 (unsurprising since Jeff Taubenberger, the senior author & acting NIAID director, reconstructed it). Also, what does "chimeric" mean for the H7N1, H6N1, and H10N7?
May 2, 2025 at 4:21 AM
I got to figure 1 in the paper and took a look at these survival curves and weight data.
Oh hey, that's fully reconstructed 1918 (unsurprising since Jeff Taubenberger, the senior author & acting NIAID director, reconstructed it). Also, what does "chimeric" mean for the H7N1, H6N1, and H10N7?
Oh hey, that's fully reconstructed 1918 (unsurprising since Jeff Taubenberger, the senior author & acting NIAID director, reconstructed it). Also, what does "chimeric" mean for the H7N1, H6N1, and H10N7?
Reposted by Diogenes, PhD
The press release did not offer more details so I looked at a paper about it. This was testing a quadrivalent BPL-inactivated vaccine (vaccine made of 4 inactivated low path avian viruses) by a heterosubtypic (different HxNy subtype) challenge.
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
An inactivated multivalent influenza A virus vaccine is broadly protective in mice and ferrets
Influenza A viruses (IAVs) present major public health threats from annual seasonal epidemics and pandemics and from viruses adapted to a variety of animals including poultry, pigs, and horses. Vaccin...
pmc.ncbi.nlm.nih.gov
May 2, 2025 at 4:21 AM
The press release did not offer more details so I looked at a paper about it. This was testing a quadrivalent BPL-inactivated vaccine (vaccine made of 4 inactivated low path avian viruses) by a heterosubtypic (different HxNy subtype) challenge.
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Reposted by Diogenes, PhD
Can't complain about half a billion for a "next-generation universal vaccine platform"! What is this amazingly innovative new vaccine technology? Tell me more, because this says "BPL-inactivated, whole virus platform". That describes current flu vaccines.
www.hhs.gov/press-room/h...
www.hhs.gov/press-room/h...
www.hhs.gov
May 2, 2025 at 4:21 AM
Can't complain about half a billion for a "next-generation universal vaccine platform"! What is this amazingly innovative new vaccine technology? Tell me more, because this says "BPL-inactivated, whole virus platform". That describes current flu vaccines.
www.hhs.gov/press-room/h...
www.hhs.gov/press-room/h...
Reposted by Diogenes, PhD
Trump’s 100 day job approval polling is worse than any other president in the last 50 years by a minimum -10. It’s incredible that Republicans and business leaders continue to fall all over themselves to appease such a historically incompetent and epically unpopular leader.
Baier: If you look at our new Fox News poll at 100 days job approval compared to other presidents, there you see the president at 44% and you see his first term at 45% at this mark the 100 day mark
April 24, 2025 at 12:57 PM
Trump’s 100 day job approval polling is worse than any other president in the last 50 years by a minimum -10. It’s incredible that Republicans and business leaders continue to fall all over themselves to appease such a historically incompetent and epically unpopular leader.
Reposted by Diogenes, PhD
I do wish big-time media orgs would stop taking the bait of calling these cuts to "Brown" or "Harvard." These are cuts to alzheimers research, maternal health research, antiviral coronavirus innovations, not "insert school here." They are cuts to our medical future and scientific livelihood.
April 24, 2025 at 12:49 AM
I do wish big-time media orgs would stop taking the bait of calling these cuts to "Brown" or "Harvard." These are cuts to alzheimers research, maternal health research, antiviral coronavirus innovations, not "insert school here." They are cuts to our medical future and scientific livelihood.
Reposted by Diogenes, PhD
WE LITERALLY REGULATED THE HOLE IN THE OZONE LAYER OUT OF EXISTENCE
April 20, 2025 at 12:12 AM
WE LITERALLY REGULATED THE HOLE IN THE OZONE LAYER OUT OF EXISTENCE
Reposted by Diogenes, PhD
38 of the 43.
"38 of 43 experts cut last month from boards that review science and research in NIH laboratories are female, Black or Hispanic.
"The scientists typically serve five-year terms and were not given a reason for their dismissal..."
www.washingtonpost.com/science/2025...
"38 of 43 experts cut last month from boards that review science and research in NIH laboratories are female, Black or Hispanic.
"The scientists typically serve five-year terms and were not given a reason for their dismissal..."
www.washingtonpost.com/science/2025...
Women, minorities fired in purge of NIH science review boards
Scientists, with expertise in fields that include mental health, cancer and infectious disease, typically serve five-year terms and were not given a reason for their dismissal.
www.washingtonpost.com
April 17, 2025 at 7:29 PM
38 of the 43.
"38 of 43 experts cut last month from boards that review science and research in NIH laboratories are female, Black or Hispanic.
"The scientists typically serve five-year terms and were not given a reason for their dismissal..."
www.washingtonpost.com/science/2025...
"38 of 43 experts cut last month from boards that review science and research in NIH laboratories are female, Black or Hispanic.
"The scientists typically serve five-year terms and were not given a reason for their dismissal..."
www.washingtonpost.com/science/2025...
Is it just me or is David Byrne mentioned in every week’s New Yorker?
April 14, 2025 at 7:07 PM
Is it just me or is David Byrne mentioned in every week’s New Yorker?
Still curious if @amersocvirology.bsky.social will show any leadership here? How about when your trainees are detained and harassed on their way to #ASV2025 ?
Again, what is a society except a means to advocate for your principles?
#LoveVirology? Wake up!
Again, what is a society except a means to advocate for your principles?
#LoveVirology? Wake up!
Very curious why @amersocvirology.bsky.social has said nothing in the last three months about any of the issues which are having deeply damaging impacts on their society members.
What is a society except a means to advocate for your principles?
Love Virology? Wake up!
What is a society except a means to advocate for your principles?
Love Virology? Wake up!
April 13, 2025 at 1:46 AM
Still curious if @amersocvirology.bsky.social will show any leadership here? How about when your trainees are detained and harassed on their way to #ASV2025 ?
Again, what is a society except a means to advocate for your principles?
#LoveVirology? Wake up!
Again, what is a society except a means to advocate for your principles?
#LoveVirology? Wake up!
Reposted by Diogenes, PhD
Amazing how every Trump rally gets wall-to-wall coverage — but when 36,000 people show up to protest him with Bernie and AOC, it barely makes a headline.
We get endless diner stories about ‘forgotten’ Trump voters. Where are the stories of Americans left behind by the GOP?
We get endless diner stories about ‘forgotten’ Trump voters. Where are the stories of Americans left behind by the GOP?
April 12, 2025 at 11:37 PM
Amazing how every Trump rally gets wall-to-wall coverage — but when 36,000 people show up to protest him with Bernie and AOC, it barely makes a headline.
We get endless diner stories about ‘forgotten’ Trump voters. Where are the stories of Americans left behind by the GOP?
We get endless diner stories about ‘forgotten’ Trump voters. Where are the stories of Americans left behind by the GOP?
Are we calling this #HomanTrafficking yet?
I've been to Dilley, the "family residential center" I think he's referring to.
It's a jail. They're surrounded by barbed wire fences and armed guards. It's a jail.
It's a jail. They're surrounded by barbed wire fences and armed guards. It's a jail.
Tom Homan spoke to local news about the children in his own town abducted by ICE: “First of all, the family is not in a jail. They’re in a family residential center, it’s an open air campus.”
Oh, ok.
Oh, ok.
April 6, 2025 at 12:19 PM
Are we calling this #HomanTrafficking yet?
Reposted by Diogenes, PhD
Having covered protests for the last quarter century or so I can tell you that this #handsoff happening extraordinary, and likely to build. (Oh, and that the big newspapers are acting typically clueless)
April 6, 2025 at 12:23 AM
Having covered protests for the last quarter century or so I can tell you that this #handsoff happening extraordinary, and likely to build. (Oh, and that the big newspapers are acting typically clueless)