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Ina Huppertz

@inahuppertz.bsky.social

2.2K followers 990 following 20 posts

Research group leader at the Max Planck Institute for Biology of Ageing in Cologne, Germany. Excited by RNA-binding proteins, metabolism, stem cells and ageing research

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Ina Huppertz @inahuppertz.bsky.social · Sep 9

Wonderful work, congratulations Leo and team! 🥳

Reposted by Ina Huppertz

Kurianlab @kurianlab.bsky.social · Sep 8

Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? We show that splicing fidelity is actively enforced through a QKI-U6 checkpoint at the U1→U6 handover in essential cardiac genes during organogenesis.
www.biorxiv.org/content/10.1...

QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites

During organogenesis, precise pre-mRNA splicing is essential to assemble tissue architecture. Many developmentally essential exons bear weak 5'splice sites (5'SS) yet are spliced with high precision, ...

www.biorxiv.org

Reposted by Ina Huppertz

Nisha Hemandhar @nishahemandhar.bsky.social · Aug 20

Excited to share my PhD research, now on bioRxiv! We report a proteo-transcriptomic reprogramming and resource reallocation in the aging brain.

Co–first author with Verena Kluever. Grateful to @forna.bsky.social‬ for mentorship, and to @tatjanat.bsky.social‬, Carlos López Otín & all collaborators🧠

Reposted by Ina Huppertz

David Vilchez @thevilchezlab.bsky.social · Sep 2

New work from the lab! C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules - Bilican - FEBS Letters - Wiley Online Library febs.onlinelibrary.wiley.com/doi/10.1002/...

Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient-derived neurons and C. elegans models, w...

febs.onlinelibrary.wiley.com

Ina Huppertz @inahuppertz.bsky.social · Aug 25

Thank you, Kathrin 🫶🏻

Reposted by Ina Huppertz

bioRxivpreprint @biorxivpreprint.bsky.social · Aug 24

Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells https://www.biorxiv.org/content/10.1101/2025.08.20.671247v1

Ina Huppertz @inahuppertz.bsky.social · Aug 24

We’re so excited to finally share this with the world. Have a read and let us know what you think! 🧬🚀

Ina Huppertz @inahuppertz.bsky.social · Aug 24

And a huge thanks to all of our collaborators, especially Yasmin Barenco Abbas from the Tessarz lab @petertessarz.bsky.social for expertly carrying out the CUT&RUN experiments and Patrick Giavalisco for being our metabolomics guru, we couldn’t have done it without you! 🧪✨

Ina Huppertz @inahuppertz.bsky.social · Aug 24

I am incredibly proud of this work and want to give a massive shoutout to our amazing first authors Virginia Kroef and Lea Hund, with Virginia leading the charge from day one! 💪👏

Ina Huppertz @inahuppertz.bsky.social · Aug 24

We can show that the generated acetate is essential for lipid synthesis and histone acetylation, both key for exiting pluripotency.
💥 In other words: we’ve identified a previously hidden metabolic route that connects phosphate sugar metabolism to stem cell fate decisions!

Ina Huppertz @inahuppertz.bsky.social · Aug 24

This project uncovers a brand-new metabolic link in stem cells, showing how the hexosamine biosynthetic pathway (HBP) does not just make UDP-GlcNAc for glycosylation, but also fuels acetate production via the enzyme AMDHD2 utilising N-acetylgucosamine-6-phosphate(GlcNAc6P).

Ina Huppertz @inahuppertz.bsky.social · Aug 24

🎉 We’re excited to share our very first preprint!! 🎉
"Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells"
👉 doi.org/10.1101/2025...

#FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience

Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells

Pluripotent stem cells (SCs) rely on metabolic rewiring to regulate self-renewal and differentiation. The hexosamine biosynthetic pathway (HBP) integrates multiple metabolic inputs to produce uridine ...

Reposted by Ina Huppertz

Ryan Flynn @raflynn5.bsky.social · Aug 6

RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...

Reposted by Ina Huppertz

DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · Aug 5

Our RAPPL purification of ribosomes and associated material is out. I am really proud of this study in collaboration primary with Pavlovic-Djuranovic lab, as well as Jovanovic and Hashem Labs. This method aims to replace 60 years old purification of ribosomes by sucrose cushions

rdcu.be/ezlhg

A rapid, simple, and economical method for the isolation of ribosomes and translational machinery for structural and functional studies

Nature Communications - Here, the authors present a method to rapidly isolate actively translating ribosomes in a time- and cost-effective manner using poly-lysine. The method is compatible with a...

Reposted by Ina Huppertz

Buszczak Lab @buszczaklab.bsky.social · Aug 4

Excited to announce our paper describing how allelic variants in ribosome biogenesis factors cause neurodevelopmental disorders. Congratulations to Chunyang Ni, Yudong Wei and Barbara Vona, our collaborators Jun Wu, Reza Maroofian, and Leqian Yu, and all the other authors from across the globe.

A programmed decline in ribosome levels governs human early neurodevelopment - Nature Cell Biology

Ni, Wei, Vona and colleagues use human brain organoids to dissect patient AIRIM variants associated with neurodevelopmental features. A subset of variants impaired ribosome production and protein synt...

Reposted by Ina Huppertz

Trentini Lab @trentini-lab.bsky.social · Aug 1

🚨 Happy to share our first pre-print 🎉 on the causes of ribosome-associated degradation of CFTR and other transmembrane proteins.
We explore how protein folding, ER insertion, and elongation dynamics influence translation arrests in this new class of RQC targets.👇
www.biorxiv.org/content/10.1...

Principles of ribosome-associated protein quality control during the synthesis of CFTR

Prolonged translational arrests caused by defective mRNAs activate the ribosome-associated protein quality control (RQC) pathway, which marks harmful incomplete proteins for degradation. Multipass tra...

www.biorxiv.org

Reposted by Ina Huppertz

Eileen Furlong @eileen-furlong.bsky.social · Jul 30

To all post-docs: The Genome Biology dept ‪@embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Group Leader - Genome Biology Unit

Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...

embl.wd103.myworkdayjobs.com

Reposted by Ina Huppertz

Erika Girardi @alphaerika.bsky.social · Jul 18

I am happy to share our last preprint, where we identified FASN as an endogenous dsRNA-associated factor and demonstrated that its depletion triggers endodsRNA accumulation and a stronger antiviral response to exogenous dsRNAs,#RNA, #interferon,#immunometabolism
www.biorxiv.org/cgi/content/...

Fatty Acid Synthase binds endogenous dsRNAs and dampens the innate immune response to exogenous dsRNAs by limiting their accumulation.

In mammalian cells, the presence of double-stranded RNA (dsRNA) in the cytoplasm is a danger signal indicative of viral infection. Cells establish and maintain an antiviral state via the production of...

www.biorxiv.org

Reposted by Ina Huppertz

Manuel Irimia @mirimiam.bsky.social · Jul 23

🚨🚨🚨

Please RT!

We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.

Deadline: 30/09/25👇

Reposted by Ina Huppertz

Eva Kowalinski @kowaeva.bsky.social · Jul 17

Postdoc positions in structural biology of RNA processing complexes.

An ERC-funded position will dissect pre-mRNA processing pathways in the infective organism Trypanosoma brucei. An ANR-funded position will characterise large complexes in RNA modification.

Details: tinyurl.com/postdoc-RNA-...

Postdoc in Structural Biology of RNA processing complexes

Postdoctoral positions in structural biology of macromolecular complexes are available in the laboratory of Dr. Eva Kowalinski at the EMBL Grenoble, France. We are looking for highly motivated and amb...

Ina Huppertz @inahuppertz.bsky.social · Jul 17

Congratulations 🥳🥳 It looks great!

Ina Huppertz @inahuppertz.bsky.social · Jul 11

So shiny ✨I am so happy to be part of this amazing initiative!

CRC1678 @crc1678.bsky.social · Jul 11

Freshly launched! 🚀 Check out the new CRC 1678 website 🌐
👉 crc1678.uni-koeln.de

About CRC 1678 - CRC1678 - Collaborative Research Center

CRC 1678 investigates how age and stress-driven declines in the accuracy of mRNA and protein production affect cellular and organismal health. By taking an

crc1678.uni-koeln.de

Reposted by Ina Huppertz

CRC1678 @crc1678.bsky.social · Jul 11

Freshly launched! 🚀 Check out the new CRC 1678 website 🌐
👉 crc1678.uni-koeln.de

About CRC 1678 - CRC1678 - Collaborative Research Center

CRC 1678 investigates how age and stress-driven declines in the accuracy of mRNA and protein production affect cellular and organismal health. By taking an

crc1678.uni-koeln.de

Reposted by Ina Huppertz

Kelly Nguyen @kellythd-nguyen.bsky.social · Jul 10

Proud to share our work where we resolved a longstanding question regarding the existence of a human telomerase dimer and provided insights into its function. Led by 3 amazing lab members in collaboration with @yiliangding.bsky.social and @rdaslab.bsky.social.
www.science.org/doi/10.1126/...

Cryo-EM structure of human telomerase dimer reveals H/ACA RNP-mediated dimerization

Telomerase ribonucleoprotein (RNP) synthesizes telomeric repeats at chromosome ends using a telomerase reverse transcriptase (TERT) and a telomerase RNA (hTR in humans). Previous structural work showe...

www.science.org

Reposted by Ina Huppertz

CRC1678 @crc1678.bsky.social · Jul 9

Currently our Mercator Fellow Alice E. Lee from Harvard Medical School is visiting us. We very much welcome Alice in Cologne and we are looking forward to many stimulating discussions with her! 👉 labs.childrenshospital.org/lee-lab