Jeff Carroll, PhD
@jcarroll42.bsky.social
Neuroscientist; Assoc.Prof. at University of Washington; Huntington’s Disease researcher; Army veteran. https://sites.uw.edu/jeffcarr/
Really horrible news in the Huntington’s field, sounds like the FDA completely chasing their mind about a study designed to they’d previously agreed to: en.hdbuzz.net/uniqure-and-...
UniQure and FDA No Longer in Alignment on Approval Pathway for AMT-130 – HDBuzz
en.hdbuzz.net
November 3, 2025 at 10:00 PM
Really horrible news in the Huntington’s field, sounds like the FDA completely chasing their mind about a study designed to they’d previously agreed to: en.hdbuzz.net/uniqure-and-...
Hey that's me! This was a huge and unexpected honor. The HDF and Wexler family has been a huge inspiration for me, and so this couldn't be a nicer recognition to receive.
Congrats @jcarroll42.bsky.social, 2025 recipient of the Leslie Gehry Prize for Innovation in Science! Jeff's personal connection to #Huntingtonsdisease has fueled an impactful scientific career and an unwavering commitment to the HD community. We're so proud!
Learn more: tinyurl.com/2025-Gehry-P...
Learn more: tinyurl.com/2025-Gehry-P...
September 11, 2025 at 6:13 PM
Hey that's me! This was a huge and unexpected honor. The HDF and Wexler family has been a huge inspiration for me, and so this couldn't be a nicer recognition to receive.
Glad to see this out in the world. We observe remarkable rescue in an HD mouse using an ASO targeting intron-1 of Huntingtin, rather than downstream. The intron-1 targeting ASO essentially completely eliminates aggregates, whereas the more distal ASO does nothing: www.biorxiv.org/content/10.1...
www.biorxiv.org
July 31, 2025 at 5:57 PM
Glad to see this out in the world. We observe remarkable rescue in an HD mouse using an ASO targeting intron-1 of Huntingtin, rather than downstream. The intron-1 targeting ASO essentially completely eliminates aggregates, whereas the more distal ASO does nothing: www.biorxiv.org/content/10.1...
Scientists, especially Seattle ones! One of my research scientists is heading to her PhD and we're looking to fill her spot, if not replace her. If you know someone looking to do cool and impactful translational research give them this:
uwhires.admin.washington.edu/ENG/Candidat...
uwhires.admin.washington.edu/ENG/Candidat...
UW Human Resources
University of Washington Human Resources
uwhires.admin.washington.edu
July 21, 2025 at 6:56 PM
Scientists, especially Seattle ones! One of my research scientists is heading to her PhD and we're looking to fill her spot, if not replace her. If you know someone looking to do cool and impactful translational research give them this:
uwhires.admin.washington.edu/ENG/Candidat...
uwhires.admin.washington.edu/ENG/Candidat...
And cost of living in several key cities (eg Vancouver and Toronto) not feasible with academic salaries in those towns. Even if you can get a grant!
You should see how small the choose 🇨🇦 fund is. See the vertical black dividing line? It’s considerably narrower than that.
If people think American scientists are somehow going to land in Europe, I've got news for you about the difference between millions and billions.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
July 5, 2025 at 2:02 PM
And cost of living in several key cities (eg Vancouver and Toronto) not feasible with academic salaries in those towns. Even if you can get a grant!
Reposted by Jeff Carroll, PhD
5. Wars are easy to start and hard to stop
June 22, 2025 at 4:28 AM
5. Wars are easy to start and hard to stop
Reposted by Jeff Carroll, PhD
Support the troops baby!!
Also: Apparently, their deployments are broken up into 29 day blocks so DoD doesn't have to pay them active duty benefits INCLUDING no allowance for housing.
“Currently, there is no plan for where everyone is sleeping tonight,” the source said, adding that there was an urgent need to find more portable bathrooms and dumpsters for garbage.
June 9, 2025 at 11:19 PM
Support the troops baby!!
Tump's bullying is just his psychopathic personality. Vance is, actually, kind of worse because he's strictly doing it to impress other guys he perceives as tougher. He's like the punk ass kid who takes a kick at someone after the bully knocks him down.
The Department of Homeland Security and Vice-President JD Vance are publicly targeting @dieworkwear.bsky.social
June 9, 2025 at 7:47 PM
Tump's bullying is just his psychopathic personality. Vance is, actually, kind of worse because he's strictly doing it to impress other guys he perceives as tougher. He's like the punk ass kid who takes a kick at someone after the bully knocks him down.
Reposted by Jeff Carroll, PhD
A hell of a lot of the California National Guard is made up of people from immigrant communities, fwiw.
June 8, 2025 at 1:53 AM
A hell of a lot of the California National Guard is made up of people from immigrant communities, fwiw.
Reposted by Jeff Carroll, PhD
Good lord, how can anyone serious about science even consider cutting funding for Flybase?
Flybase lost all of the NIH support overnight - it is a disaster for the community. Please consider donating. I just did! www.philanthropy.cam.ac.uk/give-to-camb...
Drosophila Genetic Database
The Drosophila Genetic Database, FlyBase, is on the brink of collapse due to the sudden termination of the FlyBase NIH grant, which includes salaries for 5 literature curators based at the University ...
www.philanthropy.cam.ac.uk
June 3, 2025 at 6:27 PM
Good lord, how can anyone serious about science even consider cutting funding for Flybase?
Reposted by Jeff Carroll, PhD
Just published, expansion in situ genome sequencing, where you can sequence DNA while still inside the cell, mapping its organization relative to proteins and other markers, with the help of expansion microscopy! Led by @jbuenrostro.bksy.social. www.science.org/doi/10.1126/...
May 30, 2025 at 11:37 AM
Just published, expansion in situ genome sequencing, where you can sequence DNA while still inside the cell, mapping its organization relative to proteins and other markers, with the help of expansion microscopy! Led by @jbuenrostro.bksy.social. www.science.org/doi/10.1126/...
God please. One on every corner.
If someone isn’t parking a TACO food truck outside the White House, what are we even doing with this stupid timeline!?
May 30, 2025 at 3:23 AM
God please. One on every corner.
Amazing news that she’s finally free
After nearly three months in immigration detention, University of Washington employee Lewelyn Dixon was released Thursday to the cheers and hugs of family, co-workers, and a crowd of supporters gathered in Tacoma.
Filipina green card holder and UW worker released from Tacoma ICE center
After nearly three months in immigration detention, University of Washington employee Lewelyn Dixon was released Thursday to the cheers and hugs of family, co-workers, and a crowd of supporters gather...
www.kuow.org
May 30, 2025 at 12:17 AM
Amazing news that she’s finally free
Reposted by Jeff Carroll, PhD
It's painful to read this, 5 years later. Study finds no increase in Covid spread in nursing home after visitation bans were lifted. Implication: The bans, which meant months of isolation for nursing home residents and heartbreak of their families, did no good.
pubmed.ncbi.nlm.nih.gov/40383139/
pubmed.ncbi.nlm.nih.gov/40383139/
May 21, 2025 at 7:11 PM
It's painful to read this, 5 years later. Study finds no increase in Covid spread in nursing home after visitation bans were lifted. Implication: The bans, which meant months of isolation for nursing home residents and heartbreak of their families, did no good.
pubmed.ncbi.nlm.nih.gov/40383139/
pubmed.ncbi.nlm.nih.gov/40383139/
So, if you search google scholar enough it will just flag you as a bot and then there's absolutely no recourse, nor a human that you can prove you're not a bot. Reminding me we shouldn't be outsourcing such a key academic service to a for profit company that normalized not talking to its customers.
May 21, 2025 at 3:21 PM
So, if you search google scholar enough it will just flag you as a bot and then there's absolutely no recourse, nor a human that you can prove you're not a bot. Reminding me we shouldn't be outsourcing such a key academic service to a for profit company that normalized not talking to its customers.
Reposted by Jeff Carroll, PhD
30 year Treasury above 5%. Also, I successfully used AI to do a Trump/Truss crossover, putting a Trump wig on a lettuce
paulkrugman.substack.com/p/a-liz-trus...
paulkrugman.substack.com/p/a-liz-trus...
A Liz Truss Moment for America?
Financial indicators are flashing yellow
paulkrugman.substack.com
May 21, 2025 at 1:58 PM
30 year Treasury above 5%. Also, I successfully used AI to do a Trump/Truss crossover, putting a Trump wig on a lettuce
paulkrugman.substack.com/p/a-liz-trus...
paulkrugman.substack.com/p/a-liz-trus...
Reposted by Jeff Carroll, PhD
Although there has been many positive things happening lately for myself and my lab group, this week we've gotten the bad news of a grant termination, as the lead PI is at Harvard (and they've had all their federal funding terminated). It will be tough to stop the work that only last year 1/2
May 21, 2025 at 2:01 PM
Although there has been many positive things happening lately for myself and my lab group, this week we've gotten the bad news of a grant termination, as the lead PI is at Harvard (and they've had all their federal funding terminated). It will be tough to stop the work that only last year 1/2
Reposted by Jeff Carroll, PhD
I remember a story in the Army where a commander was dubious about intelligence soldiers working with people who had connections with the Taliban and could we trust people like that and the intel officer replied "the people who don't work with the Taliban have no information about them."
People get mad at Atwood's sequel "The Testaments" because they don't think Aunt Lydia "deserves" any sort of redemption but it is much closer to the darker reality that resistance against evil often requires the participation of people who have done awful things.
May 20, 2025 at 11:07 PM
I remember a story in the Army where a commander was dubious about intelligence soldiers working with people who had connections with the Taliban and could we trust people like that and the intel officer replied "the people who don't work with the Taliban have no information about them."
Reposted by Jeff Carroll, PhD
I'm always intrigued by people who miss very obvious points in art they love. Things like: people who are mad that "Star Trek is woke" or Paul Ryan loving Rage Against the Machine.
The tech billionaires are missing the point of their favorite sci-fi series. "[Iain M. Banks is an odd choice for a bunch of tech billionaires]. The author, who died in 2013, was a socialist and avowed hater of the super-rich." www.vox.com/culture/4135...
The tech billionaires are missing the point of their favorite sci-fi series
Iain Banks’s Culture novels take place in a socialist utopia. The broligarchs love them.
www.vox.com
May 20, 2025 at 4:00 PM
I'm always intrigued by people who miss very obvious points in art they love. Things like: people who are mad that "Star Trek is woke" or Paul Ryan loving Rage Against the Machine.
Reposted by Jeff Carroll, PhD
The profile that Vinay Prasad deserves. He's presence in this administration is sign of Trump's commitment to endangering public health. Excellent work @lauralew105.bsky.social ! 🩺 #medsky
newrepublic.com/article/1949...
newrepublic.com/article/1949...
An Anti-Science MAHA Extremist Is Playing a Major Role at the FDA
On first glance, Dr. Vinay Prasad’s medical credentials sound impressive. But look closer and you’ll find a narcissistic attention-seeker peddling misinformation, whose views will cost lives.
newrepublic.com
May 20, 2025 at 1:17 AM
The profile that Vinay Prasad deserves. He's presence in this administration is sign of Trump's commitment to endangering public health. Excellent work @lauralew105.bsky.social ! 🩺 #medsky
newrepublic.com/article/1949...
newrepublic.com/article/1949...
Reposted by Jeff Carroll, PhD
In a medical breakthrough, a team including IGI’s
@urnov.bsky.social & @giannikopoulosp.bsky.social created an on-demand #CRISPR therapy for an infant with a deadly gene mutation — developed, approved, and delivered to the patient in just 6 months.
Read more: ow.ly/G0Bg50VTonC
#RareDisease 🧬
@urnov.bsky.social & @giannikopoulosp.bsky.social created an on-demand #CRISPR therapy for an infant with a deadly gene mutation — developed, approved, and delivered to the patient in just 6 months.
Read more: ow.ly/G0Bg50VTonC
#RareDisease 🧬
May 15, 2025 at 5:04 PM
In a medical breakthrough, a team including IGI’s
@urnov.bsky.social & @giannikopoulosp.bsky.social created an on-demand #CRISPR therapy for an infant with a deadly gene mutation — developed, approved, and delivered to the patient in just 6 months.
Read more: ow.ly/G0Bg50VTonC
#RareDisease 🧬
@urnov.bsky.social & @giannikopoulosp.bsky.social created an on-demand #CRISPR therapy for an infant with a deadly gene mutation — developed, approved, and delivered to the patient in just 6 months.
Read more: ow.ly/G0Bg50VTonC
#RareDisease 🧬
Reposted by Jeff Carroll, PhD
Amazing that this has happened. Maddening that we are actively destroying the capability to do it again. www.nytimes.com/2025/05/15/h...
Baby Is Healed With World’s First Personalized Gene-Editing Treatment
www.nytimes.com
May 15, 2025 at 8:50 PM
Amazing that this has happened. Maddening that we are actively destroying the capability to do it again. www.nytimes.com/2025/05/15/h...