Lightnews — Scholar-powered news

Reposted by Yogesh Kulathu

Ylva Ivarsson @ivarssonlab.bsky.social · 16d

Finally out! Thrilled to share our collaboration with @kulathu.bsky.social, @orafurman.bsky.social, and N Davey. We screened auxiliary domains of USP family #deubiquitinases, revealing short linear motifs (SLiMs), contributing to specificity in complex assembly.
www.biorxiv.org/content/10.1...

Systematic Discovery of Motif-based Interactions of the Auxiliary Domains of USP Family Deubiquitinases

The ubiquitin-specific proteases (USPs) family is the largest family of human deubiquitinating enzymes (DUBs). While most USPs are agnostic to polyubiquitin linkage-type, their substrate specificity i...

www.biorxiv.org

1 6 12

Reposted by Yogesh Kulathu

Rune Busk Damgaard @rbdamgaard.bsky.social · 22d

A few months ago, our review “The Molecular Toolbox for Linkage Type-Specific Analysis of Ubiquitin Signaling” 🧬🧰🛠️ came out in ChemBioChem. Time to give it a spotlight!

chemistry-europe.onlinelibrary.wiley.com/doi/full/10....

1 9 17

Reposted by Yogesh Kulathu

The Lister Institute of Preventive Medicine @thelisterinstitute.bsky.social · 25d

The annual meeting highlights how the Lister is so unique - such a wonderful community of kind, committed people. Stellar scientists, of course. But also deeply passionate about nurturing teams, opening doors, and enabling others to develop skills and meaningful careers. Thank you.

1 2

Yogesh Kulathu @kulathu.bsky.social · Mar 25

Congrats Leo!

1 1

Reposted by Yogesh Kulathu

Leo Kiss @leokiss.bsky.social · Mar 24

Super excited to share our latest work on deciphering the #Ubiquitin Code

“𝗨𝗯𝗶𝗥𝗘𝗔𝗗 𝗱𝗲𝗰𝗶𝗽𝗵𝗲𝗿𝘀 𝗽𝗿𝗼𝘁𝗲𝗮𝘀𝗼𝗺𝗮𝗹 𝗱𝗲𝗴𝗿𝗮𝗱𝗮𝘁𝗶𝗼𝗻 𝗰𝗼𝗱𝗲 𝗼𝗳 𝗵𝗼𝗺𝗼𝘁𝘆𝗽𝗶𝗰 𝗮𝗻𝗱 𝗯𝗿𝗮𝗻𝗰𝗵𝗲𝗱 𝗞48 𝗮𝗻𝗱 𝗞63 𝘂𝗯𝗶𝗾𝘂𝗶𝘁𝗶𝗻 𝗰𝗵𝗮𝗶𝗻𝘀”

@cp-molcell.bsky.social

1/8

www.cell.com/molecular-ce...

UbiREAD deciphers proteasomal degradation code of homotypic and branched K48 and K63 ubiquitin chains

Ubiquitin chains determine the fates of their modified proteins, including proteasomal degradation. Kiss et al. present UbiREAD, a technology to monitor cellular degradation and deubiquitination at hi...

www.cell.com

16 44 130

Reposted by Yogesh Kulathu

Elton Zeqiraj @zeqiraj.bsky.social · Mar 17

Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes.

rdcu.be/edRwF

5 19 51

Reposted by Yogesh Kulathu

UK Proteostasis Network @ukproteostasis.bsky.social · Mar 17

Registration for the second UK Proteostasis Network meeting in Dundee is open!
The conference will run from Tuesday 3 June 2025 - Thursday 5 June 2025 and is joint with Autophagy UK. Please follow the link below to sign up: dundee.ac.uk/events/joint...

Joint 2025 Autophagy UK and Proteostasis UK conference

dundee.ac.uk

1 8 11

Reposted by Yogesh Kulathu

Jonathan Pruneda @jnpruneda.bsky.social · Feb 26

Such a fun collaboration with @michaelnadbio.bsky.social! Check out the latest form of #ubiquitin modification- MARUbylation!

Mike Cohen @michaelnadbio.bsky.social · Feb 25

I'm super excited to share our study in collaboration with @jnpruneda.bsky.social, published today in @embojournal.org! We show that PARPs are modified with a non-canonical ester-linked mono-ADP-ribosylated ubiquitin species for the first time in cells: www.embopress.org/doi/full/10....

Ubiquitin is directly linked via an ester to protein-conjugated mono-ADP-ribose | The EMBO Journal

imageimageCertain E3 ligases have been found to ubiquitylate hydroxyl groups on free NAD+ and ADP-ribose in vitro, but the in vivo occurrence of this dual post-translational modification has remained ...

www.embopress.org

2 12 27

Yogesh Kulathu @kulathu.bsky.social · Feb 16

Autophagy UK & Proteostasis UK joint meeting -June 3-5. Exploring the lifecycle of cellular components from synthesis to degradation. Going to be a great meeting and we look forward to welcoming you to Dundee! Exciting lineup of speakers and opportunities for ECRs
Register here: tinyurl.com/mr3p49f9

Joint 2025 Autophagy UK and Proteostasis UK conference | University of Dundee, UK

Welcome to the 2025 joint “Autophagy UK and Proteostasis UK” conference!

tinyurl.com

24 21

Reposted by Yogesh Kulathu

Ian Kelsall @iankelsall.bsky.social · Jan 16

By my reckoning, yesterday marked the 50th anniversary of ubiquitin's discovery! 🎈🎉🎁🥂
www.pnas.org/doi/10.1073/...

Isolation of a polypeptide that has lymphocyte-differentiating properties and is probably represented universally in living cells. | PNAS

A polypeptide of 8500 molecular weight is described that induces the differentiation of T (thymus-derived) cell and B (bone-marrow-derived) cell im...

www.pnas.org

9 18

Yogesh Kulathu @kulathu.bsky.social · Dec 13

Congrats Ana on the first paper feom your lab 🎉🎉

1

Reposted by Yogesh Kulathu

Jonathan Pruneda @jnpruneda.bsky.social · Nov 17

Excited to share this work from former Pruneda Lab superstar Cameron Roberts! Cam tackled the challenge of identifying #ubiquitin regulators secreted by pathogenic bacteria, and found an entirely new type of E3 ligase that regulates P. aeruginosa virulence!

www.biorxiv.org/content/10.1...

A functional screen for ubiquitin regulation identifies an E3 ligase secreted by Pseudomonas aeruginosa

Ubiquitin signaling controls many aspects of eukaryotic biology, including targeted protein degradation and immune defense. Remarkably, invading bacterial pathogens have adapted secreted effector prot...

www.biorxiv.org

10 32

Reposted by Yogesh Kulathu

Malte Gersch @maltegersch.bsky.social · Nov 25

Could't think of a better inaugural post here. Very excited to share that our manuscript on the "Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53" was published today at Nature Chemical Biology. Congratulations Kim, Kai, and all authors! www.nature.com/articles/s41...

6 18 110

Reposted by Yogesh Kulathu

Micha Rapé Lab @micharapelab.bsky.social · Nov 26

Excited to report our discovery of an important component of the oxidative stress response: the E3 ligase TRIP12. It acts as a chain elongation factor that amplifies CUL3-KEAP1 activity to drive NRF2 degradation as cells recover from stress.

www.biorxiv.org/content/10.1...

Dynamic regulation of the oxidative stress response by the E3 ligase TRIP12

The oxidative stress response is centered on the transcription factor NRF2 and protects cells from reactive oxygen species (ROS). While ROS inhibit the E3 ligase CUL3-KEAP1 to stabilize NRF2 and elici...

www.biorxiv.org

5 25 73

Reposted by Yogesh Kulathu

Yamuna Krishnan @krishnanyamuna.bsky.social · Nov 26

I want to write a paper titled “the sky is blue, the ocean is deep and trees are green”

Madhu Pai, MD, PhD @madhupai.bsky.social · Nov 25

"Non-White scientists appear on fewer editorial boards, spend more time under review, and receive fewer citations"

www.pnas.org/doi/abs/10.1...

Non-White scientists appear on fewer editorial boards, spend more time under review, and receive fewer citations | PNAS

Disparities continue to pose major challenges in various aspects of science. One such aspect is editorial board composition, which has been shown t...

www.pnas.org

1 16 72

Reposted by Yogesh Kulathu

Heran Darwin, PhD @heran.bsky.social · Nov 26

Finally out! A huge update from the preprint is a beautiful structure by James Chen of Pup-Dop-CoaX, the first known regulator of depupylation! www.pnas.org/doi/10.1073/...

www.pnas.org

3 9 21

Yogesh Kulathu @kulathu.bsky.social · Nov 26

Congrats Heran! Very cool story

1

Reposted by Yogesh Kulathu

Simon Bekker-Jensen lab @bekkerjensenlab.bsky.social · Nov 26

Time for our first post here 🥳 Our latest paper is online 🙌
We show that UV activates the ribotoxic stress response, which causes inflammation, cell death and thickening in skin. Read about a role for the RSR separate from DNA damage signaling in response to sunburn: ✨☀️ www.cell.com/molecular-ce...

The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo

The acute skin reaction to sunburn, encompassing keratinocyte cell death, inflammation, and epidermal thickening, has traditionally been ascribed to DNA damage responses. Using a mouse model deficient...

www.cell.com

7 23 68

Reposted by Yogesh Kulathu

Dr. Zoe R. Smith @drzoersmith.bsky.social · Nov 22

Yup! I hate the word resilience. I dream of a world where Black and Brown ppl never have to be resilient and get to be. Joyfully lovingly be.

MM @phdeez.bsky.social · Nov 22

"my least favorite thing in life is to be called “resilient,” bc it means that people only see me through the lens of difficulty. They love the idea that I am resilient, but they don’t actually care about any of the things that made me resilient."
@kss_phd www.vox.com/future-perfe...

Only 1 percent of neuroscience faculty is Black. Kaela Singleton hopes to change that.

Whatever you do, don’t call the Black in Neuro founder “resilient.”

www.vox.com

4 22

Reposted by Yogesh Kulathu

Michael Bang Petersen @m-b-petersen.bsky.social · Nov 20

A mapping of how Bluesky is becoming the new Scientific Twitter

mikeyoungacademy.dk/bluesky-is-e...

Bluesky is emerging as the new platform for science - Mike Young Academy

Scientific Twitter is about to find its true successor. And it is not X. This, our latest release, shows that the Bluesky network of scientists is growing — and growing.

mikeyoungacademy.dk

37 700 2.4K

Reposted by Yogesh Kulathu

Rune Busk Damgaard @rbdamgaard.bsky.social · Nov 15

Check out this list of ubiquitin and Ubl profiles to follow. Repost if you want me to add you to it. Let’s create a good community here ☁️ go.bsky.app/3VPQofn

6 48 49

Reposted by Yogesh Kulathu

Liz Miller @lizmillercu.bsky.social · Nov 13

Really proud of this paper just out in JCB. At almost every turn, SURF4 surprised us. Amazing PhD student, Julija Maldutyte, sleuthed it out.
rupress.org/jcb/article/...

ER export via SURF4 uses diverse mechanisms of both client and coat engagement | Journal of Cell Biology | Rockefeller University Press

Traffic of soluble secretory proteins from the endoplasmic reticulum by the export receptor, SURF4, is remarkably complex. Different cargoes use distinct m

rupress.org

1 17 53

Reposted by Yogesh Kulathu

Susan Shao @sshaolab.bsky.social · Nov 11

So many things happen on proteasomes! It was fun to dig into how a the active thioreductase TXNL1 engages the regulatory particle!

www.biorxiv.org/content/10.1...

Structure of the TXNL1-bound proteasome

Proteasomes degrade diverse proteins in different cellular contexts through incompletely defined regulatory mechanisms. Here, we report the cryo-EM structure of thioredoxin-like protein 1 (TXNL1) boun...

www.biorxiv.org

2 8 16