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Marten Chaillet

@martenchaillet.bsky.social

530 followers 220 following 25 posts

CryoET open-source software developer 🤓 Postdoc to tackle tilt-series alignment with deep-learning. Working at the Hubrecht Instute, with funding from Genentech. interests outside of work: DnD, cooking, cyling!

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Marten Chaillet @martenchaillet.bsky.social · Jun 9

Final PhD paper now reviewed and published in JSB:X. I was happy with some great reviews that improved the paper! Thanks to Sander Roet for his help with the code base, and Remco Veltkamp and @fridof.bsky.social

cryoEM papers @cryoempapers.bsky.social · Jun 8

pytom-match-pick: A tophat-transform constraint for automated classification in template matching pubmed.ncbi.nlm.nih.gov/40475324/ #cryoem

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Reposted by Marten Chaillet

Edward T Eng @edwardteng.bsky.social · 4d

Muyuan Chen has turned structural biology into an immersive experience with his new video game Meowtabolism, now available on Steam.
Try the demo here: store.steampowered.com/app/4045010/...
Give Muyuan feedback: steamcommunity.com/app/4045010
#ScienceGaming #StructuralBiology #CryoEM #STEMOutreach

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Reposted by Marten Chaillet

Ben Engel @cellarchlab.com · 13d

But there’s a curious loose end to this story. Scientists have been looking at PSII organization in thylakoids for over 50 years (including some really stunning freeze fracture 🔬😍). Sometimes PSII looks randomly oriented, and other times it forms extended 2D crystalline arrays in the membrane 💠

9/🧵

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Marten Chaillet @martenchaillet.bsky.social · 14d

It works but you still need to be careful with heating the sauce after blending. I thought it was too watery and tried to reduce it a bit while tossing with the pasta, still started to clump

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Marten Chaillet @martenchaillet.bsky.social · 14d

👀 this is really interesting!

cryoEM papers @cryoempapers.bsky.social · 14d

Dose-efficient cryo-electron microscopy for thick samples using tilt- corrected scanning transmission electron microscopy pubmed.ncbi.nlm.nih.gov/40987871/ #cryoem

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Reposted by Marten Chaillet

Alister Burt @alisterburt.bsky.social · 17d

PSA: 9 billion USD in research funds stolen by publishers over a 5 year period for open access fees - this takes away from your ability to pay your people what they are worth. Preprints forever.

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Marten Chaillet @martenchaillet.bsky.social · 18d

This is the research we need 😋 I have been struggling for years to make reliable cacio e pepe, can't wait to try it out
ista.ac.at/en/news/2025...

2025 Ig Nobel Prize for Perfect Pasta Sauce

The Ig Nobel Prize honors research that first makes people laugh, then makes them think. Its 35th award ceremony possibly also makes people hungry: ISTA physicist Fabrizio Olmeda and colleagues resear...

ista.ac.at

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Reposted by Marten Chaillet

bioRxivpreprint @biorxivpreprint.bsky.social · 22d

Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching https://www.biorxiv.org/content/10.1101/2025.09.11.675606v1

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Arjen Jakobi @cryotud.bsky.social · Sep 8

Together with colleagues at the Dept. of Microsystems Engineering, we are looking for a PhD student to develop methods for femtoliter-scale sample dispensing in cryoEM sample preparation.

edu.nl/h436k

If you like interdisciplinary research & fascinating physics at ultrasmall scales, please apply!

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Bronwyn Lucas @bronwynalucas.bsky.social · Aug 30

First pre-print from the Lucas Lab led by Matthew Giammar and @joshdcryoem.bsky.social online today! We develop a new, extensible Python implementation of 2DTM and apply it to build pixel size optimization, constrained search and characterize molecular motions in situ www.biorxiv.org/content/10.1...

Leopard-EM: An extensible 2DTM package to accelerate in situ structural biology

The ability to generate high-resolution views of cells with cryogenic electron microscopy (cryo-EM) can reveal the molecular mechanisms of biological processes in their native cellular context. The re...

www.biorxiv.org

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Reposted by Marten Chaillet

Florent Waltz @florentwaltz.bsky.social · Aug 28

Mitochondria finally made the headlines, yay!

Oh wait, ... oh no ....

jen sometimes aph 🌻 @bunnibytz.bsky.social · Aug 27

via @acyn.bsky.social

RFK JR: I’m looking at kids as I walk through the airports today...and I see these kids that are just overburdened with mitochondrial challenges, inflammation—you can tell from their faces, movements, and lack of social connection

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Reposted by Marten Chaillet

Science Magazine @science.org · Aug 23

As teams grow, new Ph.D. graduates are less likely to land tenure-track jobs and more likely to leave science—especially women and international researchers, according to research from last year. https://scim.ag/3JHinJs #ScienceMagArchives

Larger teams worsen academic career prospects

As teams grow, new Ph.D. graduates are less likely to land tenure-track jobs and more likely to leave science—especially women and international researchers

scim.ag

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Reposted by Marten Chaillet

Vera Moreijn @veramoreijn.bsky.social · Aug 23

PVV-programma wil trans mensen erkenning ontnemen, docenten screenen op "politieke neutraliteit", XR en Antifa als "terroristisch" aanmerken en verbieden, "Alle Syriërs terug", uit EVRM en VN-Vluchtelingenverdrag, verbod op "links-liberale seksuele indoctrinatie".

NOS: "er zijn scherpe randjes af".

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Juan Nunez-Iglesias @jni.codes · Aug 1

It's hard to express how much gratitude I have to everyone involved in the journey, both mine and @napari.org's, that has led to this point. #EurekaPrizes A small attempt below: 👇

Australian Museum Eureka Prizes @eurekaprizes.bsky.social · Jul 30

@napari.org @jni.codes is a finalist in the @ardc.edu.au Eureka Prize for Excellence in Research Software.

Learn more: youtu.be/0g_MkTa_NwQ

#EurekaPrizes

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Jonas Möcking @cryonas.bsky.social · Jul 31

ASS is short for acephalic spermatozoa syndrome in which head and tail of sperm are detached⛓️‍💥, commonly caused by mutations in the gene encoding for SUN5. Using in situ cryo-ET❄️🔬 we find that SUN5 forms a protein lattice in the nuclear envelope (NE) at the head-tail junction of mammalian sperm.1/4

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Reposted by Marten Chaillet

Juha Huiskonen @juhahuiskonen.bsky.social · Jul 8

In our latest preprint on bioRxiv, we present the in situ structure of
the human gap junction at 14 Å resolution using cryo-ET.

The structure provides a blueprint for investigating how connexin
regulation shapes intercellular communication in health and disease.

CryoET tomogram with the gap junction (green), ribosomes (cyan) and microtubules (pink)

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Reposted by Marten Chaillet

Josh Dickerson @joshdcryoem.bsky.social · Jun 28

Check out our recent review discussing the merits of tilt series vs single micrographs for in situ cryo-EM! www.sciencedirect.com/science/arti...

To tilt or not to tilt? Strategies for in situ cryo-EM data collection

Recent breakthroughs in single-particle cryogenic electron microscopy (cryo-EM) and protein structure prediction have transformed our ability to resol…

www.sciencedirect.com

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Reposted by Marten Chaillet

Jan-Hannes Schaefer @jhschaef.bsky.social · Jun 23

Exited to share my first PostDoc contribution! Like Magellan explored the globe, you can explore your cryoEM data with Magellon. Congrats to all involved. Scott Stagg Lab & Michael Cianfrocco Lab @landerlab.bsky.social www.biorxiv.org/content/10.1... 🌎❄️🔬

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Reposted by Marten Chaillet

Max Renner @maxrenner.bsky.social · Jun 19

time.com/7295195/ai-c...

ChatGPT's Impact On Our Brains According to an MIT Study

The study, from MIT Lab scholars, measured the brain activity of subjects writing SAT essays with and without ChatGPT.

time.com

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Reposted by Marten Chaillet

Alister Burt @alisterburt.bsky.social · May 30

spent some time this evening updating the teamtomo.org site - if you're interested in cryo-EM + Python you might want to take a look around!

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Alister Burt @alisterburt.bsky.social · Jun 12

And it’s done! Thanks to everyone who came out for the first edition of FrostByte, our event for the local computational cryo-EMers in the Bay Area ❄️

Special thanks to @joshdcryoem.bsky.social and Ariana Peck for help organizing 🙏

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Marten Chaillet @martenchaillet.bsky.social · Jun 9

cryoEM papers @cryoempapers.bsky.social · Jun 8

pytom-match-pick: A tophat-transform constraint for automated classification in template matching pubmed.ncbi.nlm.nih.gov/40475324/ #cryoem

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Reposted by Marten Chaillet

Alister Burt @alisterburt.bsky.social · May 12

In the Bay Area? Love computational cryo-EM/ET?

Come join us for the first edition of FrostByte - a meeting for the local computational cryo-EM methods community!

Details and registration at frostbyte-cryoem.github.io

Thanks to @joshdcryoem.bsky.social and Ariana Peck for help organizing!

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Marten Chaillet @martenchaillet.bsky.social · May 9

Great guide, and very comprehensive! Also the scripts you wrote for converting aretomo3 to relion are so useful 😄

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Philippe Van der Stappen @phaips.vd.st · May 6

Hey #TeamTomo,
Ever been in need of a tutorial about the fundamentals of cryo-electron tomography? From preprocessing raw frames to high-res subtomogram averaging?
That's why @florentwaltz.bsky.social and I made this website!

tomoguide.github.io

Follow the thread 1 /🧵
#CryoET #CryoEM 🔬🧪

Welcome to TomoGuide

A step-by-step Cryo-ET guide

tomoguide.github.io

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Brady Johnston @bradyajohnston.bsky.social · Apr 29

Okay hear me out, what if building your protein model was a first person horror survival experience??

#MolecularNodes #b3d #GeometryNodes 🧪

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