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Pedro Papotto

@ph-papotto.bsky.social

300 followers 200 following 26 posts

Dean's Prize Fellow @ The University of Manchester Currently using worms to uncover the secrets of rare immune cell populations 🇧🇷🇬🇧

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Pedro Papotto @ph-papotto.bsky.social · Jan 10

What a great way to start this account and end the week: our preprint describing how dermal γδ T cells mediate a skin-lung axis during parasite infection in mice is online! I'm excited to show the findings of my main postdoc project with @profjudiallen.bsky.social!🧵👇
www.biorxiv.org/content/10.1...

Migratory dermal gamma delta T cells determine the balance between lung immunity and tissue damage during Nippostrongylus brasiliensis infection

Many helminth parasites migrate through multiple host organs during infection but how immunity is regulated across these tissues is still poorly understood. To investigate the cellular and molecular a...

www.biorxiv.org

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Reposted by Pedro Papotto

Joana F Neves @nevesjf.bsky.social · 1d

PhD opportunity to study intestinal immune cells using our pioneer human organoid models at the Joana F Neves and Robin Dart labs @kingscollegelondon.bsky.social through #MRC Doutoral training program
kcl-mrcdtp.com/project/deco...
Applications opening soon!
#gdTcells #IBD #gut #organoids

Decoding γδ T cell-epithelial interactions in the human intestine in health and disease - MRC DTP

The human gut epithelium performs vital absorptive functions, while simultaneously forming a physical barrier between the gut contents and the body. As such it is essential for health and its dysregul...

kcl-mrcdtp.com

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Pedro Papotto @ph-papotto.bsky.social · Aug 4

Needing some help from all the mouse doctors around! Does anyone know who might keep a B10.D2 mouse colony in the UK (or even mainland Europe)?

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Judi Allen @profjudiallen.bsky.social · Jul 16

Super excited to announce that MRC has funded a new Centre of Research Excellence in Exposome Immunology. Working together, Manchester and Oxford are going to tackle a major challenge of our times. For those who wonder what the Exposome is - see yesterday's posts! www.ukri.org/news/centre-...

Centre to study how exposome causes chronic inflammatory disease

A new Medical Research Council (MRC) centre will investigate how the environment interacts with our immune system to trigger chronic inflammatory diseases.

www.ukri.org

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Reposted by Pedro Papotto

Lydia Becker Institute @lydiabeckeriii.bsky.social · Jul 16

🚨 A new £50M MRC Centre at @manchester.ac.uk and @ox.ac.uk will explore how pollution, microbes & other environmental exposures rewire our immune system and cause chronic inflammatory diseases.
#Exposome #ImmunoSky

sites.manchester.ac.uk/lydia-becker...

New £50m MRC Centre to study how environmental exposures cause chronic inflammatory diseases

A groundbreaking £50M research centre at Manchester and Oxford will explore how environmental exposures, like pollution and microbes, rewire our immune system and drive chronic inflammatory diseases.

sites.manchester.ac.uk

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Reposted by Pedro Papotto

Worboys Lab @worboyslab.bsky.social · Jul 14

Delighted to advertise a collaborative postdoc position available in the lab to develop new proximity labelling tools, funded by a BBSRC Transformative Research Technology grant:

www.jobs.manchester.ac.uk/Job/JobDetai...
#ChemicalBiology #SyntheticChemistry

Research Associate in Synthetic Chemistry and Chemical Biology:Oxford Road

www.jobs.manchester.ac.uk

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Bertuzzi Lab @bertuzzilab.bsky.social · Jul 4

Interested in working on Mucorales adaptation? Thanks to new funding from @wellcometrust.bsky.social, we will have two postdoc and a technician positions advertised very soon! if interested, please get in touch for more information.

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Reposted by Pedro Papotto

Thiago Carvalho @cyrilpedia.bsky.social · Jul 1

ICYMI: Junior PI positions in Kyoto at @ccii-kyoto.bsky.social, a new center led by Tasuku Honjo (DIrector) & Sidonia Fagarasan (Vice Director)
#Immunology #Immunotherapy #ScienceJobs

Center for Cancer Immunotherapy and Immunobiology @ccii-kyoto.bsky.social · Jul 1

Our streamlined Junior PI application process asks you to submit:
a cover letter;
a research plan;
a current curriculum vitae;
brief narrative summary of your main research achievements;
Contact information for three references
#Immunology #Immunotherapy

www.ccii.med.kyoto-u.ac.jp/en/careers-e...

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Reposted by Pedro Papotto

Marc Veldhoen @marcveld.bsky.social · Jun 3

🚨Great new MSc and PhD positions available @gimmfoundation!

Check out the links or use the QR code.

MSc:
www.medicina.ulisboa...

PhD:
gimm.pt/course/phd-p...

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Reposted by Pedro Papotto

Worboys Lab @worboyslab.bsky.social · May 29

The deadline for this PhD is fast approaching. We are looking for a promising synthetic chemist to make new chemical biology tools to learn more about nucleic acid interactions. This is a collaborative project with the Trowbridge Lab in @uomscieng.bsky.social. If interested, get in touch soon!

Worboys Lab @worboyslab.bsky.social · May 16

We have a PhD available in the lab to design new chemical tools to do super resolution proximity labelling of nucleotides. Come join us!!

#ChemSky #ChemBio

www.findaphd.com/phds/project...

(EPSRC DTP) Super-resolution proximity nucleotide labelling at The University of Manchester on FindAPhD.com

PhD Project - (EPSRC DTP) Super-resolution proximity nucleotide labelling at The University of Manchester, listed on FindAPhD.com

www.findaphd.com

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Reposted by Pedro Papotto

Worboys Lab @worboyslab.bsky.social · May 14

Our latest research is now available as a pre-print at BioRxiv. We show that the immune checkpoint receptor TIGIT cannot signal in T cells without simultaneous TCR stimulation.

#ImmunoSky

www.biorxiv.org/content/10.1...

Inhibitory TIGIT signalling is dependent on T cell receptor activation

TIGIT is an immune checkpoint receptor that can signal via cytoplasmic ITT-like and ITIM motifs to regulate T cell function. The signalling molecules that mediate inhibitory TIGIT signalling in T cell...

www.biorxiv.org

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Reposted by Pedro Papotto

Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · May 8

Hi everyone 👋 I’ve been nominated for the role of ECR representative position on the Member Representative Forum at @britsocimm.bsky.social. If you’d like to see me in this position and want to vote for me, you can follow this link: www.immunology.org/news/bsi-com... #immunosky

BSI committee elections 2025 | British Society for Immunology

www.immunology.org

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Reposted by Pedro Papotto

Worboys Lab @worboyslab.bsky.social · May 16

We have a PhD available in the lab to design new chemical tools to do super resolution proximity labelling of nucleotides. Come join us!!

#ChemSky #ChemBio

www.findaphd.com/phds/project...

(EPSRC DTP) Super-resolution proximity nucleotide labelling at The University of Manchester on FindAPhD.com

PhD Project - (EPSRC DTP) Super-resolution proximity nucleotide labelling at The University of Manchester, listed on FindAPhD.com

www.findaphd.com

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Reposted by Pedro Papotto

Doug Dyer @douglaspdyer.bsky.social · Apr 28

So excited to share our first neuro focused paper from the lab, we show that CXCL4 (PF4) is transported into the brain by proteoglycans within the endothelial glycocalyx and that GAG binding also mediates the pro neurogenesis effects of CXCL4. www.biorxiv.org/content/10.1...

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Payal Yokota @payalyokota.bsky.social · Apr 25

Excited to share our latest study
@cp-immunity.bsky.social. Heartfelt thanks to the editorial and review teams , to my co-first @yeungadventures.bsky.social, our co-authors, and to @khannakm.bsky.social
for his outstanding mentorship throughout! Pls read/share!👇
www.cell.com/immunity/ful...

Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling

The local immunoregulatory mechanisms that safeguard the host from excessive lung infection inflammation remain unclear. Yeung, Yokota et al. uncover the essential role of nerve- and airway-associated...

www.cell.com

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Reposted by Pedro Papotto

γδ T cell Forum @forum-gd.bsky.social · Apr 17

Dual modulation of cytotoxic and checkpoint receptors tunes the efficacy of adoptive Delta One T cell therapy against colorectal cancer.

#gdTcells

Dual modulation of cytotoxic and checkpoint receptors tunes the efficacy of adoptive Delta One T cell therapy against colorectal cancer - Nature Cancer

Silva-Santos and colleagues provide in vivo preclinical evidence supporting a therapeutic use of Delta One T cells to tackle colorectal cancer and propose activating natural killer cell receptor NKG2D...

www.nature.com

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Reposted by Pedro Papotto

D’Agostino Lab @dagostinolab.bsky.social · Apr 7

Our latest study
@science.org #Immunology on perception of #hunger and #immunity.

#BrainBody #Melanocortin #AgRP #POMC neurons. #Brain-liver axis. Permissive action of #stress #hormones.

@ukri.org @fbmh-uom.bsky.social

www.science.org/doi/10.1126/...

Brain sensing of metabolic state regulates circulating monocytes

Brain-initiated hunger signals control circulating monocyte dynamics.

www.science.org

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Reposted by Pedro Papotto

The University of Manchester @manchester.ac.uk · Apr 7

What really happens to your immune system when you fast?

New research from @fbmh-uom.bsky.social could be a game-changer for how we think about immunity, nutrition, and inflammation.

Let’s break it down. #scicomms

a close up of a woman 's face with a surprised look on her face .

Alt: a close up of a woman 's face with a surprised look on her face .

media.tenor.com

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Hepworth Lab @hepworth-lab.bsky.social · Apr 5

www.manchester.ac.uk/about/news/s...

Scientists cast new light on how fasting impacts the immune system

New research from The University of Manchester may reshape our understanding of what happens to the immune system when we fast.Funded by the Biotechnology and Biological Sciences Research Council (BBS...

www.manchester.ac.uk

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Pedro Papotto @ph-papotto.bsky.social · Apr 8

Really thrilled to have been awarded an @acmedsci.bsky.social Springboard Award! This new PI thing is definitely starting to feel real now!

The #Springboard25 will help me to kickstart some cool work on innate-like T cells in skin and lungs at the @lydiabeckeriii.bsky.social! Exciting times ahead!

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Academy of Medical Sciences @acmedsci.bsky.social · Apr 7

📢 We're making our largest ever investment in early-career researchers

Through #Springboard25, we’re investing £7.6m in 62 researchers to drive innovations that improve health and wellbeing 🔬

Congrats to all 2025 awardees! 🎉

👉 bit.ly/springboard2...

@thebhf.bsky.social @wellcometrust.bsky.social

Three people wearing lab coats and talking to each other while writing on a whiteboard

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Worboys Lab @worboyslab.bsky.social · Mar 26

Our lab has a postdoc position available to use super-resolution microscopy to understand how nanoscopic localisation of immune checkpoints dictates their function.

Please get in touch if interested in applying.

www.jobs.manchester.ac.uk/Job/JobDetai...

#ImmunoSky #Imaging #Microscopy

Research Associate in Imaging Human Immunology:Oxford Road

www.jobs.manchester.ac.uk

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Reposted by Pedro Papotto

The Minutti Lab @minuttilab.bsky.social · Mar 8

🔬 Looking for OP9 cells overexpressing Notch ligands (Jagged1, Jagged2, Delta1, Delta3, Delta4). We already have Jagged1, Delta1, and Delta4 but need the full set—happy to cover shipping & set up an MTA! Any leads? 🧫 #immunology #Notch

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Joana F Neves @nevesjf.bsky.social · Mar 3

Looking for an excellent & highly motivated postdoctoral researcher to join our team to develop an exciting project focused on the generation of beneficial Innate Lymphoid Cells #ILC for the treatment of Inflammatory Bowel Disease #IBD using #organoids. Please share!
www.kcl.ac.uk/jobs/109186-...

www.kcl.ac.uk

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Reposted by Pedro Papotto

Seth Coffelt @coffeltlab.bsky.social · Feb 7

#hiring #postdoc
We are looking for a postdoc to work on anti-tumor gamma delta T cells in breast cancer metastasis mouse models. Apply here:
www.gla.ac.uk/explore/jobs...

University of Glasgow - Explore - Jobs at Glasgow - Appointments - Research Associate (Breast Cancer Now) [164192]Search iconClose menu iconMenu icon bar 1Menu icon bar 2Menu icon bar 3

www.gla.ac.uk

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Adrian Liston @labliston.bsky.social · Jan 19

#PhD researchers - want to build your #career options for post-PhD? This article provides you the necessary goals and timeline to ensure you have a good range of career options after you graduate. 🧵1/4

@immunolcellbiol.bsky.social with @makaroff.bsky.social

onlinelibrary.wiley.com/doi/10.1111/...

<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library

PhD training is incredibly versatile, with the possibility of leading to a myriad of downstream careers. However, it is often only in retrospect that the options and optimal strategies behind your ca...

onlinelibrary.wiley.com

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