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Reposted by Pierfrancesco Pagella

Doudna Lab @doudna-lab.bsky.social · 6d

"Jane Goodall showed us what a life in science could look like: rigorous discovery paired with fierce advocacy for what you study. She gave the world six decades of groundbreaking research on chimpanzees and their habitats, then turned that knowledge into a global movement for conservation." (1/2)

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Carmelo Ferrai @carmeloferrai.bsky.social · 9d

SMAD4 induces opposite effects on metastatic growth from pancreatic tumors depending on the organ of residence

www.nature.com/articles/s43...

SMAD4 induces opposite effects on metastatic growth from pancreatic tumors depending on the organ of residence - Nature Cancer

Using mouse pancreatic cancer models, Tsanov et al. show that reactivation of SMAD4 at metastatic sites promotes tumor growth in the lung through RUNX1 but restrains metastatic growth through KLF4 in the liver, influenced by organ-specific epigenetic states.

www.nature.com

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Travis Faust @travisfaust.bsky.social · 26d

Thrilled to share our new paper @cp-cell.bsky.social:
“Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.”

This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling.

🔗 www.cell.com/cell/fulltex...

Faust et al., Cell 2025

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Pierfrancesco Pagella @ppagella86.bsky.social · Sep 3

We are hiring! 2 years postdoctoral fellowship, to work on the generation of all-human, vascularized and innervated organ-on-chip systems & model infection & inflammation - in Sweden 🇸🇪 @liu.se

Details in the link - please help me spreading the announcement!

liu.se/en/organisat...

Open positions in bioengineering

Learn more about open scholarship positions in bioengineering at IFM.

liu.se

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Pierfrancesco Pagella @ppagella86.bsky.social · Sep 7

Thank you Gustavo!

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Claudio Cantù @claudiocantu81.bsky.social · Aug 11

SOX2 and NR2F1 cooperate
to make #neurons in the #Thalamus
for visual input from the #retina

#DevBio

journals.biologists.com/bio/article/...
‪
@biologyopen.bsky.social

In collab w Sara Mercurio and Silvia Nicolis @btbsunimib.bsky.social

Driven by Linda Serra and @annanordin.bsky.social

SOX2 and NR2F1 coordinate the gene expression program of the early postnatal visual thalamus

Summary: The transcriptional regulators SOX2 and NR2F1 drive the development of the visual thalamus. Mutations in these genes cause visual impairment in humans.

journals.biologists.com

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Pierfrancesco Pagella @ppagella86.bsky.social · Sep 3

We are hiring! 2 years postdoctoral fellowship, to work on the generation of all-human, vascularized and innervated organ-on-chip systems & model infection & inflammation - in Sweden 🇸🇪 @liu.se

Details in the link - please help me spreading the announcement!

liu.se/en/organisat...

Open positions in bioengineering

Learn more about open scholarship positions in bioengineering at IFM.

liu.se

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Pierfrancesco Pagella @ppagella86.bsky.social · Aug 29

Glad to share the latest effort to emulate dental tissues on-chip: an organ-on-chip design including human dental pulp stem cells & HUVECs, odontoblasts, and a dentin powder-containing compartment, all innervated by mouse trigeminal ganglia! 👇🏼

advanced.onlinelibrary.wiley.com/doi/10.1002/...

An Innovative “Tooth‐On‐Chip” Microfluidic Device Emulating the Structure and Physiology of the Dental Pulp Tissue

This work presents a “tooth-on-chip” device that mimics dental pulp tissue. By co-culturing key cell types, it recreates vascular networks, stem cell niches, the odontoblast/dentine interface, and tr...

advanced.onlinelibrary.wiley.com

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Emma R Andersson @anderssonlab.bsky.social · Aug 15

If we lose our inner ear hair cells, we lose our hearing.. but reptiles can repair their sensory organs 🐊🤩

Tune in to Vetenskapspodden on Swedish radio P1, Sun 07:03, Mon 18:33, or bit.ly/4oCDHzP from Sunday, to hear me & Helge Rask-Andersen discuss crocodiles & regeneration with Lena Nordlund!

Portrait photo of me (Emma R Andersson, Associate Professor at Karolinska Institutet), Helge Rask-Andersen (Professor Emeritus at Uppsala University), and Lena Nordlund (journalist, host of Vetenskapspodden, and originally a chemist!)

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Guillaume Andrey @guandrey.bsky.social · Jul 9

Our work bridging enhancer-promoter proximity to phenotypic outcomes in vivo is out! Shout out to @olimpiabompadre.bsky.social, to Marie Kmita's lab, and to all the co-authors. www.nature.com/articles/s41...

Liebenberg syndrome severity arises from variations in Pitx1 locus topology and proportion of ectopically transcribing cells - Nature Communications

Here the authors show that reducing enhancer-promoter distance at the Pitx1 locus increases proportion of Pitx1 forelimb expressing cells, worsening skeletal defects in Liebenberg syndrome. They also ...

www.nature.com

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Jake Cornwall-Scoones @jcornwallscoones.bsky.social · Jul 3

Can using synthetic approaches to build biology help teach us the design principles of how embryos build themselves? 👷‍♀️🔧

If this is a question that interests you, come and share your thoughts at this Royal Society Workshop on Generative Biology

royalsociety.org/science-even...

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Pierfrancesco Pagella @ppagella86.bsky.social · Jul 2

Always a great pleasure to see high-level work on tooth 🦷& craniofacial development!

Noriaki Ono @noriakiono.bsky.social · Jul 2

Huge congratulations, Mizuki Nagata & Wanida Ono, on publishing these beautiful back-to-back papers in Nature Communications! Mizuki's 7 years of persistence finally paid off!
The second one is a story about Hedgehog and alveolar bone formation:
www.nature.com/articles/s41...

A Hedgehog–Foxf axis coordinates dental follicle-derived alveolar bone formation - Nature Communications

The alveolar bone supports the tooth’s lifelong functionality. Here, the authors identify a tooth-specific mechanism of bone formation in which the Hedgehog–Foxf pathway regulates the alveolar bone os...

www.nature.com

Pierfrancesco Pagella @ppagella86.bsky.social · Jun 28

Amazed as always by how this field combined top-notch science with unmatched collegiality and collaboration -
Thanks to all participants, organizers, and all who supported this great event - cannot wait for the next edition!
#WNT
@liu.se

Pierfrancesco Pagella @ppagella86.bsky.social · Jun 28

This field that spans the frontiers of biochemistry, molecular biology, genomics, developmental biology, cancer biology, regenerative medicine, and bioengineering (always remember: organoids are a child of the Wnt field 😀 ).

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Pierfrancesco Pagella @ppagella86.bsky.social · Jun 28

Closed up the Wnt Signaling GRS/GRC - honoured for the possibility of serving as co-chair in this amazing event!

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Pierfrancesco Pagella @ppagella86.bsky.social · Jun 8

Incredibly useful thread! Thank you @juliaeckert.bsky.social !!

epithelial mechanics fan club @epimechfc.bsky.social · Jun 8

What do we see when looking at cells under the microscope? 👉Some are bigger than others, some are elongated and align with the neighbors & others seem to move. Cool, right? But wouldn't it be cooler to quantify these observations?

I'm @juliaeckert.bsky.social. Let's explore some analysis software!‬

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epithelial mechanics fan club @epimechfc.bsky.social · May 25

What is buckling, and why is it relevant in understanding epithelial morphogenesis? 🧐

I am @onenimesa.bsky.social and I will share some papers to understand this aspect of #EpithelialMechanics

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Camp Lab @graycamplab.bsky.social · May 9

Modular integration of epithelial, microbial, and immune components to study human intestinal biology. Amazing team project with Rubén López-Sandoval, Marius F. Harter, Qianhui Yu, Matthias Lütolf, Mikhail Nikolaev, and Nikolche Gjorevski! biorxiv.org/content/10.1...

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Pierfrancesco Pagella @ppagella86.bsky.social · May 22

They even try to make you feel guilty 😆

Pierfrancesco Pagella @ppagella86.bsky.social · May 22

Always amazed by the sheer amount of e-mail traffic wasted by hopeless academic spam: this time, "dear Prof. [NAME]", "any contribution", from a "MEGA Journal of Case Reports" - waiting for Giga, Tera, and more!

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Pierfrancesco Pagella @ppagella86.bsky.social · May 21

Cannot thank you enough @neilshubin.bsky.social for such an amazing contribution 🦷!!

Neil Shubin @neilshubin.bsky.social · May 21

New paper from the lab: Our teeth arose as sensory organs on the outside of the body of ancient jawless fish.!! Congrats to Yara Haridy and the team!
Background and video: phys.org/news/2025-05...
Open Access Paper: www.nature.com/articles/s41...
News and Views: www.nature.com/articles/d41...

Teeth first evolved as sensory tissue in the armored exoskeletons of ancient fish, fossil scans find

Anyone who has ever squirmed through a dental cleaning can tell you how sensitive teeth can be. This sensitivity gives important feedback about temperature, pressure—and yes, pain—as we bite and chew ...

phys.org

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Reposted by Pierfrancesco Pagella

eLife @elife.bsky.social · May 18

YAP, a protein known to help #cancer cells survive treatment, behaves very differently in cell culture models depending on how they are grown in the lab, highlighting the importance of mimicking tumour architecture to guide better drug strategies.
buff.ly/KQ9bkLg

Immunofluorescence images of YAP, β-catenin, and DAPI in cell cultures

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Pierfrancesco Pagella @ppagella86.bsky.social · May 16

Thank you @shuntaroyamada.bsky.social and @unibergen.bsky.social for inviting me to give a talk at such a stimulating event - MRCRM 3rd International Meeting on Regenerative Medicine 2025 in Bergen, Norway!
www.helse-bergen.no/en/arrangeme...
Looking forward to our continued collaboration!

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Pierfrancesco Pagella @ppagella86.bsky.social · May 13

Fresh out of press: our new chapter on the TBX3/WNT liaison, and how it drives metastasis-related genes expression in colorectal cancer, out on @pnas.org

Enjoy the “bluetorial” by @claudiocantu81.bsky.social below! 👇🏼

#WNT #CRC @liu.se

www.pnas.org/doi/10.1073/...

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Pierfrancesco Pagella @ppagella86.bsky.social · May 5

Registration is still open for our upcoming Gordon Research Conference (GRC, June 22-27) and Seminar (GRS, June 21 -22) on Wnt Signaling in Maine, US
PhD students and postdocs, the GRS is for you, still possible to get selected for a talk - apply here!
👇🏼👇🏼
lnkd.in/d6ii4vDE
lnkd.in/dfZ_v3Qk

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