REMAP Therapeutics
@remaptherapeutics.bsky.social
Exploring and innovating at the intersection of psychedelics and chronic pain.
remaptherapeutics.com
psychedelicsandpain.org
remaptherapeutics.com
psychedelicsandpain.org
Pinned
Refractory CRPS pain treated with psilocybin: A case report
Psilocybin shows promise as a treatment for CRPS, offering significant pain relief and functional improvement in a patient with refractory symptoms. This case highlights the need for further research...
onlinelibrary.wiley.com
Introductory post: if you missed it, here is our case study on using psilocybin to treat refractory CRPS.
Second known case study on psilocybin & CRPS, and third known case study of psychedelics with adjunctive therapies.
Additional results to discuss.
onlinelibrary.wiley.com/doi/10.1002/...
Second known case study on psilocybin & CRPS, and third known case study of psychedelics with adjunctive therapies.
Additional results to discuss.
onlinelibrary.wiley.com/doi/10.1002/...
Reposted by REMAP Therapeutics
Excellent story from @aniloza.bsky.social and colleague at STAT on the MOSAIC program.
www.statnews.com/2025/12/08/t...
1/4
www.statnews.com/2025/12/08/t...
1/4
NIH shut out hundreds of young scientists from funding to start their own labs
Special Report: The NIH has shut out hundreds of young scientists from funding to start their own labs.
www.statnews.com
December 8, 2025 at 2:48 PM
Excellent story from @aniloza.bsky.social and colleague at STAT on the MOSAIC program.
www.statnews.com/2025/12/08/t...
1/4
www.statnews.com/2025/12/08/t...
1/4
Reposted by REMAP Therapeutics
Psilocybin helps the brain unlearn fear by silencing specific neural pathways
Psilocybin helps the brain unlearn fear by silencing specific neural pathways
Scientists have observed how psilocybin rewires the brain to overcome fear. The drug coordinates the silencing of trauma neurons and the activation of safety signals to promote behavioral flexibility in mice.
www.psypost.org
December 8, 2025 at 3:19 PM
Psilocybin helps the brain unlearn fear by silencing specific neural pathways
Reposted by REMAP Therapeutics
TIL about a memorial ceremony in Iceland in 2019 to mark the end of a glacier, changing the place name from Okjökull to Ok (jökull = glacier). Uncompromising wording on the bronze plaque:
"This is to acknowledge that we know what is happening and what needs to be done. Only you know if we did it".
"This is to acknowledge that we know what is happening and what needs to be done. Only you know if we did it".
December 7, 2025 at 5:17 PM
TIL about a memorial ceremony in Iceland in 2019 to mark the end of a glacier, changing the place name from Okjökull to Ok (jökull = glacier). Uncompromising wording on the bronze plaque:
"This is to acknowledge that we know what is happening and what needs to be done. Only you know if we did it".
"This is to acknowledge that we know what is happening and what needs to be done. Only you know if we did it".
Reposted by REMAP Therapeutics
Further evidence that widespread covid vaccination is better for everybody.
A study on 1.7 million people in Hong Kong shows superior hybrid immunity to Covid in people who got vaccinated before infection vs. people who got infected first. "Our findings are a direct rebuttal to arguments for natural immunity," the authors write. doi.org/10.1016/j.va...
Redirecting
doi.org
December 8, 2025 at 1:03 AM
Further evidence that widespread covid vaccination is better for everybody.
Reposted by REMAP Therapeutics
For only the second time in recorded history, an Atlantic season has produced three Category 5 hurricanes... the previous year was 2005. This puts 2025 in an elite class of hurricane seasons. It also means that nearly 7% of all known Category 5 hurricanes have occurred just in this year.
#Melissa
#Melissa
Melissa becomes third Category 5 hurricane of the extraordinary 2025 season
Updates and summaries on tropical Atlantic activity... including easterly waves, tropical storms, subtropical storms, and hurricanes.
bmcnoldy.blogspot.com
October 27, 2025 at 11:21 AM
For only the second time in recorded history, an Atlantic season has produced three Category 5 hurricanes... the previous year was 2005. This puts 2025 in an elite class of hurricane seasons. It also means that nearly 7% of all known Category 5 hurricanes have occurred just in this year.
#Melissa
#Melissa
Reposted by REMAP Therapeutics
What do you think the findings of Zheng et al., published in @science.org’s #ScienceAdvances mean for the emotional experience of pain? Check out Qiufu Ma’s comment on this and his other #PapersoftheWeek picks here bit.ly/3LoHSjB #PRF
October 27, 2025 at 12:00 PM
What do you think the findings of Zheng et al., published in @science.org’s #ScienceAdvances mean for the emotional experience of pain? Check out Qiufu Ma’s comment on this and his other #PapersoftheWeek picks here bit.ly/3LoHSjB #PRF
Reposted by REMAP Therapeutics
Welcome to the new Dark Ages. In one self inflicted blow the US is giving up on knowledge generation, technical innovation and medical advances for a generation or more. This is Trump and Vought. This is their doing.
The pipeline for Ph.D.s out of U.S. universities is shrinking www.axios.com/2025/10/26/p...
The pipeline for Ph.D.s out of U.S. universities is shrinking
America graduates more Ph.D.s than any other country. They go on to invent things, cure diseases and win Nobel Prizes. But admission slots are disappearing.
www.axios.com
October 26, 2025 at 9:41 PM
Welcome to the new Dark Ages. In one self inflicted blow the US is giving up on knowledge generation, technical innovation and medical advances for a generation or more. This is Trump and Vought. This is their doing.
Reposted by REMAP Therapeutics
🧠The Amygdala in the brain makes and regulates Emotions.
👃People with post-COVID smell loss show microstructural changes in their Amygdala and have higher depression and anxiety scores.
SARS-CoV-2 can affect smell & also emotions long term. buff.ly/904lVX4
#medsky 🛟😷🧪
👃People with post-COVID smell loss show microstructural changes in their Amygdala and have higher depression and anxiety scores.
SARS-CoV-2 can affect smell & also emotions long term. buff.ly/904lVX4
#medsky 🛟😷🧪
October 23, 2025 at 10:54 PM
🧠The Amygdala in the brain makes and regulates Emotions.
👃People with post-COVID smell loss show microstructural changes in their Amygdala and have higher depression and anxiety scores.
SARS-CoV-2 can affect smell & also emotions long term. buff.ly/904lVX4
#medsky 🛟😷🧪
👃People with post-COVID smell loss show microstructural changes in their Amygdala and have higher depression and anxiety scores.
SARS-CoV-2 can affect smell & also emotions long term. buff.ly/904lVX4
#medsky 🛟😷🧪
Reposted by REMAP Therapeutics
Big week for all you second-gen psychedelics and non-hallucinatory neuroplastogens fans! New results from Zalsupindole - promotes greater neuroplasticity than ketamine, psilocybin, or DMT, without any of the pesky psychedelic side (fun?) effects.
pubs.acs.org/doi/abs/10.1...
pubs.acs.org/doi/abs/10.1...
Zalsupindole is a Nondissociative, Nonhallucinogenic Neuroplastogen with Therapeutic Effects Comparable to Ketamine and Psychedelics
Many neuropsychiatric conditions, including depression, involve synaptic loss and atrophy of the prefrontal cortex. The rapid regrowth of cortical neurons has been hypothesized to explain the rapid an...
pubs.acs.org
October 24, 2025 at 12:17 PM
Big week for all you second-gen psychedelics and non-hallucinatory neuroplastogens fans! New results from Zalsupindole - promotes greater neuroplasticity than ketamine, psilocybin, or DMT, without any of the pesky psychedelic side (fun?) effects.
pubs.acs.org/doi/abs/10.1...
pubs.acs.org/doi/abs/10.1...
Reposted by REMAP Therapeutics
So they didn’t like the ad. Let’s just post Reagan’s 5 min speech against tariffs as it appears on YouTube.
Over and over. On all platforms (some of y’all are still on X).
*1981 Sherrilyn horrified by 2025 Sherrilyn saying “let’s post Reagan’s speech.”
youtu.be/5t5QK03KXPc
Over and over. On all platforms (some of y’all are still on X).
*1981 Sherrilyn horrified by 2025 Sherrilyn saying “let’s post Reagan’s speech.”
youtu.be/5t5QK03KXPc
President Reagan's Radio Address on Free and Fair Trade on April 25, 1987
YouTube video by Reagan Library
youtu.be
October 24, 2025 at 5:14 PM
So they didn’t like the ad. Let’s just post Reagan’s 5 min speech against tariffs as it appears on YouTube.
Over and over. On all platforms (some of y’all are still on X).
*1981 Sherrilyn horrified by 2025 Sherrilyn saying “let’s post Reagan’s speech.”
youtu.be/5t5QK03KXPc
Over and over. On all platforms (some of y’all are still on X).
*1981 Sherrilyn horrified by 2025 Sherrilyn saying “let’s post Reagan’s speech.”
youtu.be/5t5QK03KXPc
Reposted by REMAP Therapeutics
Women are being erased at the Pentagon. Women are being erased from history. And now a woman has been erased from the desecrated White House.
NEW: NBC News confirms that the Jacqueline Kennedy Garden, on the east side of the White House, has been destroyed as part of the demolition of the East Wing.
(📸 Getty Images)
(📸 Getty Images)
October 24, 2025 at 5:35 PM
Women are being erased at the Pentagon. Women are being erased from history. And now a woman has been erased from the desecrated White House.
Reposted by REMAP Therapeutics
Antarctica may have passed a climate tipping point of no return, scientists are warning, with mounting evidence that a sudden slump in sea ice formation since 2016 is linked to human-induced ocean warming.
Antarctica may have crossed a tipping point that leads to rising seas
Scientists are beginning to understand the sudden loss of sea ice in Antarctica – and there is growing evidence that it represents a permanent shift with potentially catastrophic consequences
www.newscientist.com
October 13, 2025 at 12:25 PM
Antarctica may have passed a climate tipping point of no return, scientists are warning, with mounting evidence that a sudden slump in sea ice formation since 2016 is linked to human-induced ocean warming.
Reposted by REMAP Therapeutics
“their nanoparticle-based vaccine can effectively prevent melanoma, pancreatic and triple-negative breast cancer in mice. Not only did up to 88% of the vaccinated mice remain tumor-free (depending on the cancer), but the vaccine reduced—and in some cases completely prevented—the cancer’s spread.”
If you’re hearing news about a cancer break-through and wonder what’s hype and what’s not, here’s a good explainer of the actual findings in animal studies.
This is some elegant science that pulls together several lines of long-standing inquiry, and yes, it’s a BFD.
www.umass.edu/news/article...
This is some elegant science that pulls together several lines of long-standing inquiry, and yes, it’s a BFD.
www.umass.edu/news/article...
UMass Amherst Researchers Create Nanoparticle Vaccine That Prevents Cancer in Mice | UMass Amherst
The vaccine also proves highly effective at preventing cancer’s deadly spread.
www.umass.edu
October 13, 2025 at 3:34 AM
“their nanoparticle-based vaccine can effectively prevent melanoma, pancreatic and triple-negative breast cancer in mice. Not only did up to 88% of the vaccinated mice remain tumor-free (depending on the cancer), but the vaccine reduced—and in some cases completely prevented—the cancer’s spread.”
Reposted by REMAP Therapeutics
Shingles vaccination is associated with a powerful reduction of the risk of dementia edzardernst.com/2025/10/shin...
Shingles vaccination is associated with a powerful reduction of the risk of dementia
Shingles or herpes zoster (HZ) is a neurotropic virus that causes a painful and hard to treat illness. Evidence is accumulating that HZ vaccinations might lower the risk of dementia. This effect is su...
edzardernst.com
October 5, 2025 at 3:59 AM
Shingles vaccination is associated with a powerful reduction of the risk of dementia edzardernst.com/2025/10/shin...
Reposted by REMAP Therapeutics
Neuroscientists are starting to unravel the amygdala’s complexity, shedding new light on PTSD
Neuroscientists are starting to unravel the amygdala’s complexity, shedding new light on PTSD
Often labeled the brain’s fear center, the amygdala is much more complex than that. A study in Translational Psychiatry suggests that PTSD is linked to altered connectivity in one of its subregions, with potential implications for emotion and body awareness.
www.psypost.org
October 4, 2025 at 2:05 PM
Neuroscientists are starting to unravel the amygdala’s complexity, shedding new light on PTSD
Reposted by REMAP Therapeutics
New episode: Joe & Kyle on breathwork, creativity myths, DMT & stroke findings, and our next chapter in community. Tune in: bit.ly/3It5N0v
Kyle Buller & Joe Moore — Breathwork, Community, Creativity, and Fresh Psychedelic Research
Joe and Kyle debrief a hometown Dreamshadow Transpersonal Breathwork weekend in Breckenridge, then sketch the next chapter for Psychedelics Today: a community-centric model (Navigators) that bundles e...
bit.ly
October 3, 2025 at 3:41 PM
New episode: Joe & Kyle on breathwork, creativity myths, DMT & stroke findings, and our next chapter in community. Tune in: bit.ly/3It5N0v
Reposted by REMAP Therapeutics
Has anyone performed a tone-pain conditioning task, specifically using a laser, in mice? If so, please answer this question on #PainResearcher bit.ly/3UKLXAl #PRF bit.ly/3VjLLZ9
October 3, 2025 at 4:00 PM
Has anyone performed a tone-pain conditioning task, specifically using a laser, in mice? If so, please answer this question on #PainResearcher bit.ly/3UKLXAl #PRF bit.ly/3VjLLZ9
Reposted by REMAP Therapeutics
In this article, Court Wing writes about the transdiagnostic potential of psychedelics, including but not limited to, MDMA, LSD, DMT, and Ibogaine.
Learn more: maps.org/news/bulleti...
Learn more: maps.org/news/bulleti...
September 30, 2025 at 7:08 PM
In this article, Court Wing writes about the transdiagnostic potential of psychedelics, including but not limited to, MDMA, LSD, DMT, and Ibogaine.
Learn more: maps.org/news/bulleti...
Learn more: maps.org/news/bulleti...
Reposted by REMAP Therapeutics
The only thing wrong with this editorial is that is too late.
Where was this disbelief from 2020-2024?
It’s been obvious for years that Makary snd Bhattacharya are bad faith actors.
The evidence is abundant and public.
sciencebasedmedicine.org/questions/
Where was this disbelief from 2020-2024?
It’s been obvious for years that Makary snd Bhattacharya are bad faith actors.
The evidence is abundant and public.
sciencebasedmedicine.org/questions/
October 3, 2025 at 4:03 AM
The only thing wrong with this editorial is that is too late.
Where was this disbelief from 2020-2024?
It’s been obvious for years that Makary snd Bhattacharya are bad faith actors.
The evidence is abundant and public.
sciencebasedmedicine.org/questions/
Where was this disbelief from 2020-2024?
It’s been obvious for years that Makary snd Bhattacharya are bad faith actors.
The evidence is abundant and public.
sciencebasedmedicine.org/questions/
Reposted by REMAP Therapeutics
Some interesting little details in this new study. Particularly fascinating is the suggestion some therapeutic benefits from psilocybin emerge out of the complex interplay between both 5-HT2a and 5-HT1a receptors. It's not just one or the other.
Single-dose psilocybin rapidly and sustainably relieves allodynia and anxiodepressive-like behaviors in mouse models of chronic pain - Nature Neuroscience
Hammo et al. show that a single dose of psilocybin rapidly and sustainably relieves both chronic pain and anxiodepressive-like behaviors in mice by restoring prefrontal activity through partial agonism at 5-HT2A and 5-HT1A receptors.
www.nature.com
October 3, 2025 at 12:23 AM
Some interesting little details in this new study. Particularly fascinating is the suggestion some therapeutic benefits from psilocybin emerge out of the complex interplay between both 5-HT2a and 5-HT1a receptors. It's not just one or the other.
Reposted by REMAP Therapeutics
China started its own Visa to outcompete the US for talent since we recently tacked on a $100k fee. The plan they have could work but they are running into considerable domestic opposition. www.wired.com/story/china...
China Rolls Out Its First Talent Visa as the US Retreats on H-1Bs
The Chinese government unveiled a program to woo foreign talent just as the US cracked down on H-1Bs with a $100,000 fee. The move immediately provoked xenophobic backlash.
www.wired.com
October 2, 2025 at 6:15 PM
China started its own Visa to outcompete the US for talent since we recently tacked on a $100k fee. The plan they have could work but they are running into considerable domestic opposition. www.wired.com/story/china...
Reposted by REMAP Therapeutics
Your thoughts on the future of Long COVID clinics?
www.medscape.com/viewarticle/...
www.medscape.com/viewarticle/...
Cutbacks Force Long-COVID Clinic Closures: What Now?
Funding cuts in the US and abroad have forced long-COVID clinic closures when treatment and new research are needed most. Now patients and doctors are scrambling.
www.medscape.com
October 2, 2025 at 5:48 PM
Your thoughts on the future of Long COVID clinics?
www.medscape.com/viewarticle/...
www.medscape.com/viewarticle/...
Reposted by REMAP Therapeutics
Researchers increasingly seem to be moving data to EU platforms, primarily due to data privacy and surveillance concerns. I've also started to notice people who aren't in the tech world doing this too. Is anyone else observing this trend?
October 2, 2025 at 4:30 PM
Researchers increasingly seem to be moving data to EU platforms, primarily due to data privacy and surveillance concerns. I've also started to notice people who aren't in the tech world doing this too. Is anyone else observing this trend?
Reposted by REMAP Therapeutics
Whoa. From what I've seen it was tiny and would've burned up in our atmosphere, but I haven't seen any confirmation of that. If true we were in no danger.
An #asteroid passed just 300 km above Antarctica earlier today. It was not discovered until hours after close approach.
October 2, 2025 at 12:35 AM
Whoa. From what I've seen it was tiny and would've burned up in our atmosphere, but I haven't seen any confirmation of that. If true we were in no danger.