Andrew MacBride
@amacbride.com
biology + computers + a leavening of snark | 👨👨👧👧🏳️🌈| nanomedicine | cancer genomics 🧬 | ML | biomaterials | #compchem #matsky #chemsky #ai4science #materialsinformatics #md | startups | @Cal 🐻 @Stanford @UniversityOfOxford @OxfordNano (swimsf on the Bad Place)
Reposted by Andrew MacBride
Prof. Laura Dassama (Stanford Chem) is developing a small-molecule therapy for sickle cell disease that removes BCL11A, restoring fetal hemoglobin without gene editing. Her goal is a simpler, more affordable sickle cell therapy. brnw.ch/21wXP8k
November 26, 2025 at 9:10 PM
Prof. Laura Dassama (Stanford Chem) is developing a small-molecule therapy for sickle cell disease that removes BCL11A, restoring fetal hemoglobin without gene editing. Her goal is a simpler, more affordable sickle cell therapy. brnw.ch/21wXP8k
When there was that *one year* long ago when we forgot to get the turkey bag…
November 27, 2025 at 2:52 PM
When there was that *one year* long ago when we forgot to get the turkey bag…
Reposted by Andrew MacBride
November 26, 2025 at 6:35 PM
Reposted by Andrew MacBride
Fifteen Years
xkcd.com
November 24, 2025 at 10:57 PM
Reposted by Andrew MacBride
TorchSim continues its growth aiming to be the high-performance engine for MLIP-powered atomistic simulation.
With this release (4.1), there improvements across the entire stack with new features, bug fixes, and improved documentation.
With this release (4.1), there improvements across the entire stack with new features, bug fixes, and improved documentation.
November 24, 2025 at 6:08 PM
TorchSim continues its growth aiming to be the high-performance engine for MLIP-powered atomistic simulation.
With this release (4.1), there improvements across the entire stack with new features, bug fixes, and improved documentation.
With this release (4.1), there improvements across the entire stack with new features, bug fixes, and improved documentation.
Reposted by Andrew MacBride
Reposted by Andrew MacBride
Can’t believe the whole country has to suffer through the return of Dickensian childhood diseases because the worst, most ignorant attention-demanders decided other people’s expertise makes them feel bad
November 20, 2025 at 4:19 AM
Can’t believe the whole country has to suffer through the return of Dickensian childhood diseases because the worst, most ignorant attention-demanders decided other people’s expertise makes them feel bad
Reposted by Andrew MacBride
Complex de novo structural variants are an underestimated cause of rare disorders www.nature.com/articles/s41...
November 17, 2025 at 5:02 PM
Complex de novo structural variants are an underestimated cause of rare disorders www.nature.com/articles/s41...
Reposted by Andrew MacBride
I can’t believe this monumental paper has finally been published! Congrats to all the very many brilliant researchers involved, including @molecularxtal.bsky.social and @jrkermode.co.uk 😃 What an exciting step in computational chemistry this represents!
pubs.aip.org/aip/jcp/arti...
pubs.aip.org/aip/jcp/arti...
A foundation model for atomistic materials chemistry
Atomistic simulations of matter, especially those that leverage first-principles (ab initio) electronic structure theory, provide a microscopic view of the worl
pubs.aip.org
November 14, 2025 at 9:31 AM
I can’t believe this monumental paper has finally been published! Congrats to all the very many brilliant researchers involved, including @molecularxtal.bsky.social and @jrkermode.co.uk 😃 What an exciting step in computational chemistry this represents!
pubs.aip.org/aip/jcp/arti...
pubs.aip.org/aip/jcp/arti...
Reposted by Andrew MacBride
I had the option of getting this comp chem book as a physical book or an eBook. Normally I read pdfs on Kindle, and the eBook cost less, so I went with that.
They have now sent me a link to an awkward, locked-down platform called VitalSource. I have regrets 😂 I'll know for next time...
They have now sent me a link to an awkward, locked-down platform called VitalSource. I have regrets 😂 I'll know for next time...
November 11, 2025 at 8:24 PM
I had the option of getting this comp chem book as a physical book or an eBook. Normally I read pdfs on Kindle, and the eBook cost less, so I went with that.
They have now sent me a link to an awkward, locked-down platform called VitalSource. I have regrets 😂 I'll know for next time...
They have now sent me a link to an awkward, locked-down platform called VitalSource. I have regrets 😂 I'll know for next time...
Reposted by Andrew MacBride
That fable about the scorpion and the frog comes to mind right now...
November 10, 2025 at 1:22 AM
That fable about the scorpion and the frog comes to mind right now...
Reposted by Andrew MacBride
Rep. Yassamin Ansari has set up a table and this sign outside Speaker Johnson’s office.
November 6, 2025 at 6:22 PM
Rep. Yassamin Ansari has set up a table and this sign outside Speaker Johnson’s office.
Reposted by Andrew MacBride
Work published today in @natbiotech.nature.com from Arc’s Luke Gilbert and Patrick Hsu labs presents a new way to insert large DNA sequences into the genome using engineered recombinases that don’t require DNA cutting or rely on the cell's repair machinery.
November 6, 2025 at 5:46 PM
Work published today in @natbiotech.nature.com from Arc’s Luke Gilbert and Patrick Hsu labs presents a new way to insert large DNA sequences into the genome using engineered recombinases that don’t require DNA cutting or rely on the cell's repair machinery.
Reposted by Andrew MacBride
Reposted by Andrew MacBride
A thread about keeping one’s head above water under the current conditions and not being incapacitated by rage, fear, despair or some mixture of those (1/11)
October 31, 2025 at 2:22 PM
A thread about keeping one’s head above water under the current conditions and not being incapacitated by rage, fear, despair or some mixture of those (1/11)
Reposted by Andrew MacBride
I have been loudly, persistently anti-Trump since the beginning. And tonight's election results just make me more sure: *there are more of us than there are of them* A good hard look at Trumpism in action has made that impossible to ignore.
Let's take this country back, and let's make it better.
Let's take this country back, and let's make it better.
November 5, 2025 at 2:37 AM
I have been loudly, persistently anti-Trump since the beginning. And tonight's election results just make me more sure: *there are more of us than there are of them* A good hard look at Trumpism in action has made that impossible to ignore.
Let's take this country back, and let's make it better.
Let's take this country back, and let's make it better.
Reposted by Andrew MacBride
And another one is out: a crystallographic and fundamental solid-state study of size-dependent properties in porous materials. A fun adventure that required quite a bit of coding - learned a lot in the process!
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Crystallographic Evidence of Size-Dependent Bond Flexibility in Metal–Organic Framework Nanocrystals
Size-dependent electronic, magnetic, and optical behavior suggests that metal–organic frameworks become softer materials as their particle sizes decrease, but direct evidence is lacking. Here, we rep...
pubs.acs.org
November 4, 2025 at 11:20 PM
And another one is out: a crystallographic and fundamental solid-state study of size-dependent properties in porous materials. A fun adventure that required quite a bit of coding - learned a lot in the process!
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Reposted by Andrew MacBride
About a strange and whimsical form of... art? www.skeptophilia.com/2025/11/chas...
Chasing uselessness
critical thinking blog skeptic analytics skepticism science rational education alternative medicine conspiracy theories debunk misinformation skepto
www.skeptophilia.com
November 5, 2025 at 11:29 AM
About a strange and whimsical form of... art? www.skeptophilia.com/2025/11/chas...
Reposted by Andrew MacBride
Faculty are the primary stewards and enactors of the mission of research and teaching; knowledge creation and dissemination. The administration exists only in its capacity to forward that mission.
November 2, 2025 at 11:07 AM
Faculty are the primary stewards and enactors of the mission of research and teaching; knowledge creation and dissemination. The administration exists only in its capacity to forward that mission.
Reposted by Andrew MacBride
I know this is obvious. And I know we all know this.
But if the President can raise taxes because an advert annoyed him, without even consulting Congress, then the US constitution is simply not functioning as intended.
But if the President can raise taxes because an advert annoyed him, without even consulting Congress, then the US constitution is simply not functioning as intended.
October 26, 2025 at 8:00 AM
I know this is obvious. And I know we all know this.
But if the President can raise taxes because an advert annoyed him, without even consulting Congress, then the US constitution is simply not functioning as intended.
But if the President can raise taxes because an advert annoyed him, without even consulting Congress, then the US constitution is simply not functioning as intended.
Reposted by Andrew MacBride
A very offline cousin sent this to fam group chat. This story is breaking containment.
October 24, 2025 at 11:36 PM
A very offline cousin sent this to fam group chat. This story is breaking containment.
Reposted by Andrew MacBride
A self explanatory title
October 23, 2025 at 11:09 AM
A self explanatory title
Reposted by Andrew MacBride
the Muppets have been real quiet since the Louvre heist
October 19, 2025 at 10:19 PM
the Muppets have been real quiet since the Louvre heist