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Eric Topol @erictopol.bsky.social · 9h

New @nejm.org
One-shot gene therapy for a type of congenital deafness enabled some children to hear for the first time, and 3 of 12 kids achieved normal hearing
www.nejm.org/doi/full/10.1056/NEJMoa2400521

DB-OTO Gene Therapy for Inherited Deafness | NEJM

Genetic deficiency of otoferlin, a protein critical to synaptic transmission by the sensory hair cells of the ear, causes congenital deafness. Medicines to treat the condition are lacking; children...

www.nejm.org

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Jason Adams @jamnpp.bsky.social · 1d

Sometimes there's so much beauty in the world,... I feel like I can't take it. And my heart is just going to cave in.

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BikeMN @bikemn.bsky.social · 2d

If you are in the metro this Sunday, please join us for a roll down Summit Ave.

The adopted Regional Trail Plan is at risk because of the small wealthy group of homeowners who oppose this being a safer corridor.

Meet at 1pm at the WWI Memorial.

Saint Paul Bicycle Coalition @saintpaulbike.bsky.social · 4d

Absolutely gorgeous weather for riding recently - hope you've been getting out to enjoy it!
Join us for rides this weekend: 10/10, 6pm at Union Depot for a ride w/ @moveminnesota.bsky.social and @joyfulridersclub.bsky.social
and 10/12, 1pm at Summit and MRB (the WWI Memorial) w/ @bikemn.bsky.social

a person riding a bike passes through a golden fall forest

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Merriam-Webster @merriam-webster.com · 2d

Printing presses kept their letters in cases.

Capital letters went in the upper case.
Smaller letters went in the lower case.

This is why we say ‘UPPER CASE’ and ‘lower case.’

Ok, but what did we call them before the invention of the printing press?

MAJUSCULE and minuscule.

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American Fietser @americanfietser.bsky.social · 3d

How to design safer intersections:

1. Near-sided signals. Placed before the bike/ped crossing, they prevent drivers from creeping into the path.

2. Pavement differentiation. High-contrast, colored crossings (like this red asphalt) clearly establish priority and command driver attention.

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EurekaMSP @eurekamsp.bsky.social · 3d

I need a miracle cure for endometriosis so I can use HRT. Or pain and suffering into an early grave I go [dramatic].

Eric Topol @erictopol.bsky.social · 3d

Hormone replacement therapy helps restore immune function in menopausal women, reducing inflammaging and preserving monocyte function. open-access
onlinelibrary.wiley.com/doi/10.1111/...

Extends what I previously summarized from immune system clocks
erictopol.substack.com/p/new-anti-a...

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KARE 11 @kare11.bsky.social · 3d

Kingsley Bimpong was jailed instead of hospitalized; video shows guards ignored his suffering for hours.

KARE 11 Investigates: Postal worker died after police mistook stroke for drug impairment

Kingsley Bimpong was jailed instead of hospitalized; video shows guards ignored his suffering for hours.

www.kare11.com

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Jacob Shamsian @jayshams.bsky.social · 3d

I've been wondering why Dominion Voting Systems suddenly reached settlements with Rudy Giuliani, Sidney Powell, and One America News.

Turns out, it's been purchased by a Republican-owned election tech firm that insisted on it, per Axios.

www.axios.com/2025/10/09/d...

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EurekaMSP @eurekamsp.bsky.social · 3d

Just staring blankly at this combo of picture footnotes and article text. They do go on to point out that Walz also deployed the NG domestically, but without any real commentary.

Picture description: A National Guardsman deployed in downtown Minneapolis on Aug. 27, 2020.
Minnesota National Guard, Twitter
Text: Walz served in the National Guard for 24 years. The governor said he considers
Trump's use of federal troops as an abuse of power and he's been bracing for a deployment for quite some time.

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perennialcycle.bsky.social @perennialcycle.bsky.social · 3d

Pioneer Press is looking for a cargo bike family in St. Paul that’s interested in letting them take some pics/ videos of the fam doing cargo bike stuff. The writer reaching out recently had an Urban Arrow demo, but I don’t think he’s picky about what bike the fam is using. Let me know if interested.

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Sean Kershaw @seankershaw.bsky.social · 4d

Great work by @cityofsaintpaul.bsky.social Solid Waste and Recycling team! www.fox9.com/video/1720922

St. Paul Halloween costume exchange

With Halloween only weeks away, St. Paul’s Public Works is “recycling” Halloween costume and party supplies by offering residents the chance to exchange their ideas with others. FOX 9's Lauren Andrego...

www.fox9.com

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Saint Paul Bicycle Coalition @saintpaulbike.bsky.social · 4d

Absolutely gorgeous weather for riding recently - hope you've been getting out to enjoy it!
Join us for rides this weekend: 10/10, 6pm at Union Depot for a ride w/ @moveminnesota.bsky.social and @joyfulridersclub.bsky.social
and 10/12, 1pm at Summit and MRB (the WWI Memorial) w/ @bikemn.bsky.social

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EurekaMSP @eurekamsp.bsky.social · 4d

“Book it!” was my favorite part 🤣

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EurekaMSP @eurekamsp.bsky.social · 4d

We’re well past requiring only that housing providers maintain working heat minimums. Heat maximums should be incorporated as we adapt and as a means of community resilience. This seems like a reasonable price to save a life.

Bloomberg News @bloomberg.com · 4d

The housing agency projects it’ll cost $5,450 to retrofit units with window heat pumps compared with the $40,000 per unit it paid to install centralized systems at some smaller housing complexes.

Boston Public Housing Upgrades Units With Window Heat Pumps

A pilot project aims to cut heating costs and provide air conditioning while reducing emissions.

bloom.bg

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Tom Flood @tomflood.bsky.social · 5d

An adult driver angry at a child they hit with their car.

Our car culture summed up in one video.

Robson Fletcher @robsonfletcher.com · 5d

Police in Airdrie, Alberta (just north of Calgary) say this driver hit a 17-year-old girl in a marked crosswalk, got out of the vehicle, and appeared to get upset at the teenager before driving away.

They released this video and are now trying to identify the driver.

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EurekaMSP @eurekamsp.bsky.social · 5d

A blue rolling plant shelf edited to have an angry face with arms raised in a threatening manner. A plant stand to be feared!

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EurekaMSP @eurekamsp.bsky.social · 5d

More like Dump Truck!

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ashley scarebanks 💀🕯️ @ziibiing.com · 5d

ACAB includes you and your doorbell camera:

"texas deputies did investigate this woman's abortion as a ‘death investigation,’ they did use flock safety’s ALPR network to track her down, and they did consult prosecutors about charging her."

Police Said They Surveilled Woman Who Had an Abortion for Her 'Safety.' Court Records Show They Considered Charging Her With a Crime

Court records show that the narrative Flock and a Texas Sheriff's Office has told the public isn't the whole story, and that police were conducting a 'death investigation' into the abortion.

www.404media.co

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EurekaMSP @eurekamsp.bsky.social · 5d

Give him a second one

The Guardian @theguardian.com · 5d

Nobel committee unable to reach prize winner who is ‘living his best life’ hiking off grid

Fred Ramsdell was among those honoured with a 2025 Nobel Prize in Medicine but might not know because he is somewhere in Idaho and uncontactable The Nobel committee has been unable to reach a winner of this year’s prize for medicine who is “living his best life” on an “off the grid” hiking foray. Fred Ramsdell shared Monday’s prestigious prize with Mary Brunkow of Seattle, Washington and Shimon Sakaguchi of Osaka University in Japan for their discoveries related to the functioning of the immune system. Continue reading...

www.theguardian.com

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EurekaMSP @eurekamsp.bsky.social · 7d

I have no idea what 1k feet looks like, but this was today’s 9am noise

A small plane flying an advertisement banner in the blue sky above.

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EurekaMSP @eurekamsp.bsky.social · 7d

TC Marathon 🐶

A black, white, and brown spotty dog sniffing the colorful leaf-covered boulevard, with water crews, spectators, and marathon runners in the background.

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Ian Coldwater 👻🌿 @lookitup.baby · 7d

I’m not crying, you’re crying

KOJAMF🤘🖤🤘 @kojamf.bsky.social · 7d

Dr. Jane Goodall filmed an interview with Netflix in March 2025 that she understood would only be released after her death.

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EurekaMSP @eurekamsp.bsky.social · 7d

There’s a plane flying an advertisement for a real estate agent. If she’s hoping for local customers she has made a terrible mistake 😅 I won’t even share her name.

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EurekaMSP @eurekamsp.bsky.social · 7d

Hah, you could and you should.

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