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Yue Kris Wu

@kriswu.bsky.social

560 followers 240 following 3 posts

Postdoc at the Center for Theoretical Neuroscience at Columbia University

Wu Yue may refer to the following:Wuyue, a 10th-century kingdom during the Five Dynasties and Ten Kingdoms period Sacred Mountains of China, also known as "Wu Yue" in Chinese

Source: Wikipedia

Environmental science 42%

Computer science 38%

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Reposted by Yue Wu

Julia Veit @juliaveit.bsky.social · 7d

Happy to share that I just started a W2 professorship at the University of Bremen! Yay tenure! While I already start teaching now, the lab will stay in Freiburg until May while we get things ready. Super excited about this new chapter! We’re also hiring! Please get in touch if you’re interested!

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Reposted by Yue Wu

Wu Tsai Institute | Yale University @wutsaiyale.bsky.social · 8d

📣 WTI is hiring faculty positions! Are you interested in advancing our understanding of the brain + how it gives rise to cognition?

Two calls are open:

Open-rank search, Neurocomputation, deadline: 12.1.25
Senior search, Neurodevelopment, rolling review

🔗 wti.yale.edu/opportunities

#KnowTogether

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Reposted by Jennifer Bussell, Yue Wu

Thomas Luo @thomas-zhihao-luo.bsky.social · 23d

How does the brain decide? 🧠

Our new @nature.com paper shows that neural activity switches from an 'evidence gathering' to a 'commitment' state at a precise moment we call nTc.

After nTc, new evidence is ignored, revealing a neural marker for the instant when the mind is made up.

rdcu.be/eGUrv

Transitions in dynamical regime and neural mode during perceptual decisions - Nature

Simultaneous recordings were made of hundreds of neurons in the rat frontal cortex and striatum, showing that decision commitment involves a rapid, coordinated transition in dynamical regime and neura...

www.nature.com

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Reposted by Yue Wu

Allen Institute @alleninstitute.org · 25d

Do you see a white square?

A new study, supported by our #OpenScope team, identified the key neural circuit and cell type involved with inferring details that don't exist in illusions like the one below.

🔗 alleninstitute.org/news/scienti...

#OpenScienceWeek

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Reposted by Yue Wu

mchurchland.bsky.social @mchurchland.bsky.social · Sep 8

Of potential interest to those keen on motor control and/or multi-task networks. Congrats to Elom and Eric.
www.biorxiv.org/content/10.1...

Motor cortex flexibly deploys a high-dimensional repertoire of subskills

Skilled movement often requires flexibly combining multiple subskills, each requiring dedicated control strategies and underlying computations. How the motor system achieves such versatility remains u...

www.biorxiv.org

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Reposted by Yue Wu

Robert Rosenbaum @robertrosenbaum.bsky.social · Sep 3

The University of Notre Dame is hiring 5 tenure or tenure-track professors in Neuroscience, including Computational Neuroscience, across 4 departments.

Come join me at ND! Feel free to reach out with any questions.

And please share!

apply.interfolio.com/173031

Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio

apply.interfolio.com

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Reposted by Yue Wu

Janelia Research Campus @hhmijanelia.bsky.social · Aug 26

📢We're #hiring Group Leaders!

Apply to lead a lab at Janelia & advance biology using theory, computational modeling & machine learning.

🔹5-year renewable appointment
🔹Pioneer new tools & approaches
🔹Collaborate across disciplines

Apply by Nov. 4👉 https://janelia.link/groupleader

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Max-Planck-Gesellschaft @maxplanck.de · Aug 1

Director at Max Planck - a unique position! The Open Call for Expressions of Interest in Max Planck Directorships is open now and can be submitted by the 31st of October 2025. ➡️ mpg.de/directors - Please share the Open Call among potential candidates.

Open Call for Expressions of Interest in Max Planck Directorships:
Expressions of interest can be submitted until 31 October 2025.

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Reposted by Yue Wu

Christoph Miehl @cmiehl.bsky.social · Jul 25

Excited to share our new preprint in which we propose a biologically plausible mechanistic solution to the problem of how the brain can flexibly learn and store new representations without forgetting previously learned information.

www.biorxiv.org/content/10.1...

Detailed 🧵 below 👇 1/12

Assembly-based computations through contextual dendritic gating of plasticity

Neuronal assemblies — groups of strongly connected neurons — are considered the basic building blocks of perception and memory in the brain by encoding representations of specific concepts. Despite re...

www.biorxiv.org

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Reposted by Yue Wu

Jason Climer @jrclimer.bsky.social · Jul 23

I’m excited to share my final co-first author paper from my postdoc in Dan Dombeck's lab!

We explored how behavior, senses, and neurons influence how much information in the brain changes over time.

www.nature.com/articles/s41...

#science #research #neuroscience #hippocampus #placecells

Hippocampal representations drift in stable multisensory environments - Nature

Tracking of individual place cells in mouse CA1 shows that representational drift is not influenced by changes in environment or behaviour, and is lower for more excitable place cells.

www.nature.com

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Reposted by Yue Wu, Alessandro Gozzi

Anna Beyeler 🐝 @anna-beyeler.bsky.social · Jul 10

👨‍💻 Open PI position in our institute 👨‍💻 !! If you are an expert in Computational Neuroscience and want to start your lab in Bordeaux, contact us !
www.fens.org/careers/job-...
@neuromagendie.bsky.social
@neurobordeaux.bsky.social

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Reposted by Yue Wu

Max Planck Institute for Biological Cybernetics @mpicybernetics.bsky.social · Jul 8

We are seeking two independent Max Planck Research Groups working in scientific disciplines relevant to our institute. Applications should be sent in PDF format no later than 15th August 2025. Visit our call for applications on our institute website for detailed information!

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Reposted by Yue Wu

Bernstein Network Computational Neuroscience @bernsteinneuro.bsky.social · Jul 8

⌛ One week left to submit your poster abstracts and travel grant applications for the #BernsteinConference 2025!

🗓️ Deadline: July 15

All info and submission 👉 bernstein-network.de/bernstein-co...

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Yue Kris Wu @kriswu.bsky.social · Jul 7

I would be happy to help, Joao. Just send me the document via email.

Reposted by Yue Wu

Yoni Couderc @yonicouderc.bsky.social · Jul 4

New group leader position in computational neuroscience @ Neurocentre Magendie, INSERM, Bordeaux! More info here: www.bordeaux-neurocampus.fr/group-leader...

⚠️ Application deadline: end of September 2025

@neurobordeaux.bsky.social @neuromagendie.bsky.social

Group leader tenured-track position in Computational Neuroscience - Bordeaux Neurocampus

Neurocentre Magendie

www.bordeaux-neurocampus.fr

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Reposted by Yue Wu, Urška Demšar, Todd M. Gureckis , and 1 more Yue Wu, Urška Demšar, Todd M. Gureckis, Alessandro Gozzi

Marcelo Mattar @marcelomattar.bsky.social · Jul 2

Thrilled to see our TinyRNN paper in @nature! We show how tiny RNNs predict choices of individual subjects accurately while staying fully interpretable. This approach can transform how we model cognitive processes in both healthy and disordered decisions. doi.org/10.1038/s415...

Discovering cognitive strategies with tiny recurrent neural networks - Nature

Modelling biological decision-making with tiny recurrent neural networks enables more accurate predictions of animal choices than classical cognitive models and offers insights into the underlying cog...

doi.org

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Yue Kris Wu @kriswu.bsky.social · Jun 30

Congrats, Claire!

Reposted by Yue Wu

Tatiana Engel @engeltatiana.bsky.social · Jun 25

Out today in @nature.com: we show that individual neurons have diverse tuning to a decision variable computed by the entire population, revealing a unifying geometric principle for the encoding of sensory and dynamic cognitive variables.
www.nature.com/articles/s41...

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Reposted by Yue Wu

Wei Wen🫩 @wwenneuro.bsky.social · May 31

Very happy that this work is finally out in ‪@pnas.org‬! We show that synaptic and intrinsic forms of homeostatic plasticity sense distinct aspects of network activity, and can thus be independently recruited by distinct network functions. A thread:
www.pnas.org/doi/10.1073/...

Modular arrangement of synaptic and intrinsic homeostatic plasticity within visual cortical circuits | PNAS

Neocortical circuits use synaptic and intrinsic forms of homeostatic plasticity to stabilize key features of network activity, but whether these di...

www.pnas.org

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Yue Kris Wu @kriswu.bsky.social · May 15

Happy to share our new preprint! We show how cell-type-specific synaptic scaling mechanisms shape memory representations during associative learning and highlight a critical role of top-down inputs in modulating this process. www.biorxiv.org/content/10.1...

Cell-type-specific synaptic scaling mechanisms differentially contribute to associative learning

Excitatory synaptic scaling regulates network dynamics by proportionally adjusting excitatory synaptic strengths after sensory perturbations. During associative learning, blocking excitatory scaling i...

www.biorxiv.org

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Reposted by Yue Wu

Paul Frankland @franklandlab.bsky.social · May 14

Sharing a new paper from the lab. This paper, led by Sangyoon Ko, represents a merging of two longstanding research themes in the lab-- adult neurogenesis and systems consolidation.

rdcu.be/el18q

A short thread follows for those interested.

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Systems consolidation reorganizes hippocampal engram circuitry

Nature - A study shows that loss of memory precision associated with systems consolidation can be explained by neurogenesis-dependent reorganization of engram circuitry within the hippocampus over...

rdcu.be

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Reposted by Yue Wu

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · May 3

Theory of interaction between untuned modulatory inputs and tuned sensory inputs https://www.biorxiv.org/content/10.1101/2025.04.28.651100v1

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Reposted by Yue Wu, Michael Z. Lin

Takaki Komiyama @takakikomiyama.bsky.social · Apr 17

Our new paper is out in Science.

What is the synaptic plasticity rule in the brain, we asked. It turns out there are multiple, even within individual neurons.

Congrats Jake!

www.science.org/doi/10.1126/...

Distinct synaptic plasticity rules operate across dendritic compartments in vivo during learning

Synaptic plasticity underlies learning by modifying specific synaptic inputs to reshape neural activity and behavior. However, the rules governing which synapses will undergo different forms of plasti...

www.science.org

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Reposted by Yue Wu

Allen Institute @alleninstitute.org · Mar 25

Advances in neuroscience have yielded massive, rich datasets from various analysis techniques and modalities. 🧠📈

In a @natureneuro.bsky.social perspective, researchers underscore the importance of an integrative approach to render a more complete picture of the brain.

Integrating multimodal data to understand cortical circuit architecture and function - Nature Neuroscience

This paper discusses how experimental and computational studies integrating multimodal data, such as RNA expression, connectivity and neural activity, are advancing our understanding of the architectu...

www.nature.com

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Reposted by Yue Wu

Julijana Gjorgjieva @gjorjulijana.bsky.social · Mar 7

Recruiting postdocs! Please get in touch if you wanna discuss projects on biologically plausible learning in RNNs through TUM's global postdoctoral fellowship. I'll be at Cosyne this year if you wanna talk more. www.tum.de/ueber-die-tu...

TUM Global Postdoc Fellowship - TUM

www.tum.de

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Reposted by Yue Wu

Marine Biological Laboratory @mblscience.bsky.social · Mar 4

Applications are due in two weeks (March 18) for the MBL's Methods in Computational Neuroscience course! 🧠 🖥️ Explore the computational and mathematical techniques that are used to address how the brain solves problems.

Read more: bit.ly/3EZZ6Rs
#ScienceStartsHere

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Reposted by Yue Wu

Alex Williams @itsneuronal.bsky.social · Feb 17

📣 The 11th Statistical Analysis of Neuronal Data (SAND11) workshop will be held June 11-13, 2025 in New York at the @flatironinstitute.org with generous support from @simonsfoundation.org

Submissions for talks+posters are due March 21. See our website for details 👇

sandworkshop.github.io

SAND - 2025

sandworkshop.github.io

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Reposted by Yue Wu

Lorenzo Posani @lorenzoposani.com · Feb 13

Long-overdue thread on our latest work using the IBL data to reveal the shared organizational principles of the neural code in the cortex.
A systematic analysis of categoricality 🧱 and dimensionality 📐 of the neural code across 40+ cortical regions.
doi.org/10.1101/202...
👇 1/n

Rarely categorical, always high-dimensional: how the neural code changes along the cortical hierarchy

A long-standing debate in neuroscience concerns whether individual neurons are organized into functionally distinct populations that encode information differently ("categorical" representations) and the implications for neural computation. Here, we systematically analyzed how cortical neurons encode cognitive, sensory, and movement variables across 43 cortical regions during a complex task (14,000+ units from the International Brain Laboratory public Brainwide Map data set) and studied how these properties change across the sensory-cognitive cortical hierarchy. We found that the structure of the neural code was scale-dependent: on a whole-cortex scale, neural selectivity was categorical and organized across regions in a way that reflected their anatomical connectivity. However, within individual regions, categorical representations were rare and limited to primary sensory areas. Remarkably, the degree of categorical clustering of neural selectivity was inversely correlated to the dime

www.biorxiv.org

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Reposted by Yue Wu

Ken Miller @kenmiller.bsky.social · Jan 31

New preprint: "The geometry of the neural state space of decisions", work by Mauro Monsalve-Mercado, buff.ly/42wVHD5. Surprising results & predictions! (Thread) We analyze neuropixel population recordings in macaque area LIP during a reaction time, random-dot motion 1/

Picture of neural manifolds for the two choices in a decision-making task, depicted in 3D and in 2D

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Reposted by Yue Wu

David G. Clark @david-g-clark.bsky.social · Jan 29

(1/30) New preprint! "Symmetries and continuous attractors in disordered neural circuits" with Larry Abbott and Haim Sompolinsky
bioRxiv: www.biorxiv.org/content/10.1...

Symmetries and Continuous Attractors in Disordered Neural Circuits

A major challenge in neuroscience is reconciling idealized theoretical models with complex, heterogeneous experimental data. We address this challenge through the lens of continuous-attractor networks...

www.biorxiv.org

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