Alejandro Adam
@aleadam.bsky.social
Cell and #vascular #biologist obsessed with transcriptional control of #inflammation
Associate professor at Albany Medical College in Upstate New York.
www.adamlabs.org
https://orcid.org/0000-0001-6285-7235
#AcademicSky #science #endothelium #shock
Associate professor at Albany Medical College in Upstate New York.
www.adamlabs.org
https://orcid.org/0000-0001-6285-7235
#AcademicSky #science #endothelium #shock
Reposted by Alejandro Adam
Since AI slop is again all over Scientific Reports, a thread on the economics of grey-zone publishing.
Why does slop keep getting published? What does it mean for science? How can we stop this?
Background readings:
Understand the strain: tinyurl.com/2b6wxx5r
Stop the drain: tinyurl.com/3jfscscy
Why does slop keep getting published? What does it mean for science? How can we stop this?
Background readings:
Understand the strain: tinyurl.com/2b6wxx5r
Stop the drain: tinyurl.com/3jfscscy
November 30, 2025 at 11:10 AM
Since AI slop is again all over Scientific Reports, a thread on the economics of grey-zone publishing.
Why does slop keep getting published? What does it mean for science? How can we stop this?
Background readings:
Understand the strain: tinyurl.com/2b6wxx5r
Stop the drain: tinyurl.com/3jfscscy
Why does slop keep getting published? What does it mean for science? How can we stop this?
Background readings:
Understand the strain: tinyurl.com/2b6wxx5r
Stop the drain: tinyurl.com/3jfscscy
Reposted by Alejandro Adam
Socialism is what they called public power.
Socialism is what they called social security.
Socialism is what they called the growth of free and independent labor organizations.
Socialism is their name for almost anything that helps all the people.
—Harry Truman, 1952
Socialism is what they called social security.
Socialism is what they called the growth of free and independent labor organizations.
Socialism is their name for almost anything that helps all the people.
—Harry Truman, 1952
November 21, 2025 at 5:15 PM
Socialism is what they called public power.
Socialism is what they called social security.
Socialism is what they called the growth of free and independent labor organizations.
Socialism is their name for almost anything that helps all the people.
—Harry Truman, 1952
Socialism is what they called social security.
Socialism is what they called the growth of free and independent labor organizations.
Socialism is their name for almost anything that helps all the people.
—Harry Truman, 1952
Reposted by Alejandro Adam
This team are searching for new "Asgard archaea" to sequence.
Let's talk about why these bacteria-like organisms are so fascinating, why they're named for Norse mythology, and why looking at them is unlocking a better understanding of our own genomes.
Once considered a type of oddball bacteria🦠...
Let's talk about why these bacteria-like organisms are so fascinating, why they're named for Norse mythology, and why looking at them is unlocking a better understanding of our own genomes.
Once considered a type of oddball bacteria🦠...
#AsgardArchaea team, led by @archaeal.bsky.social fr @texasscience.bsky.social — sequencing the DNA collected fr mouth of Rio de la Plata to the continental shelf of Uruguay to detect Asgards, a group of single-celled organisms & our closest microbial relatives on the tree of life. bit.ly/3MdniTH
November 21, 2025 at 1:25 PM
This team are searching for new "Asgard archaea" to sequence.
Let's talk about why these bacteria-like organisms are so fascinating, why they're named for Norse mythology, and why looking at them is unlocking a better understanding of our own genomes.
Once considered a type of oddball bacteria🦠...
Let's talk about why these bacteria-like organisms are so fascinating, why they're named for Norse mythology, and why looking at them is unlocking a better understanding of our own genomes.
Once considered a type of oddball bacteria🦠...
Reposted by Alejandro Adam
So, I have read articles written by people who claim that the entire concept of modern medicine is bad, because "artificially" saving people's lives has put a stop to human evolution by letting genetically inferior people breed. Great that those folks are in charge of the CDC now.
EXCLUSIVE: CDC to end all monkey studies. Decision handed down by recent college grad and former DOGE employee who is now deputy chief of staff at the agency. Animals were being used in studies of HIV prevention. Some may be euthanized. My latest for @science.org
Exclusive: CDC to end all monkey research
Studies related to HIV and other infectious diseases will be phased out, sources say; fate of the agency's animals remains unclear
www.science.org
November 21, 2025 at 2:50 PM
So, I have read articles written by people who claim that the entire concept of modern medicine is bad, because "artificially" saving people's lives has put a stop to human evolution by letting genetically inferior people breed. Great that those folks are in charge of the CDC now.
Congratulations Margarida Barroso @barroso8.bsky.social for receiving the Carpenter Ranch Award from @histochemicalsoc.bsky.social ! So well deserved!
November 17, 2025 at 6:11 PM
Congratulations Margarida Barroso @barroso8.bsky.social for receiving the Carpenter Ranch Award from @histochemicalsoc.bsky.social ! So well deserved!
Reposted by Alejandro Adam
I wanted to share probably the most important sermon I’ve given and it’s while I’m being arrested. It’s torture pure and simple what happens at #Broadview. I’m ok, though I was thrown to the ground and choked with my pectoral cross. A review of the video shows I was peaceful - did I deserve this?
November 15, 2025 at 5:57 AM
I wanted to share probably the most important sermon I’ve given and it’s while I’m being arrested. It’s torture pure and simple what happens at #Broadview. I’m ok, though I was thrown to the ground and choked with my pectoral cross. A review of the video shows I was peaceful - did I deserve this?
Reposted by Alejandro Adam
Research in primate brains has been essential for the development of brain-computer interfaces and artificial neural networks. New funding and policy changes put future such advances at risk, write Cory Miller, @movshon.bsky.social and Doris Tsao.
#neuroskyence
bit.ly/47MXYLH
#neuroskyence
bit.ly/47MXYLH
Without monkeys, neuroscience has no future
Research in primate brains has been essential for the development of BCIs, ANNs. New funding and policy changes put future such advances at risk.
bit.ly
November 10, 2025 at 2:56 PM
Research in primate brains has been essential for the development of brain-computer interfaces and artificial neural networks. New funding and policy changes put future such advances at risk, write Cory Miller, @movshon.bsky.social and Doris Tsao.
#neuroskyence
bit.ly/47MXYLH
#neuroskyence
bit.ly/47MXYLH
Reposted by Alejandro Adam
Chuck Schumer Helps Pull Democrats Back From Brink Of Courage
November 10, 2025 at 5:02 AM
Chuck Schumer Helps Pull Democrats Back From Brink Of Courage
Reposted by Alejandro Adam
Dems. Snatching defeat from the jaws of victory
November 10, 2025 at 2:12 PM
Dems. Snatching defeat from the jaws of victory
Reposted by Alejandro Adam
Previously shared: Systemic shock can lead to vascular dysfunction and organ failure.
This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA.
www.jci.org/articles/vie...
This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA.
www.jci.org/articles/vie...
November 9, 2025 at 2:01 PM
Previously shared: Systemic shock can lead to vascular dysfunction and organ failure.
This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA.
www.jci.org/articles/vie...
This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA.
www.jci.org/articles/vie...
Reposted by Alejandro Adam
Vinculin is a simple adapter protein right? Wrong!
That’s been the prevailing view for the 46 years since it was discovered.
Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.
www.science.org/doi/10.1126/...
That’s been the prevailing view for the 46 years since it was discovered.
Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.
www.science.org/doi/10.1126/...
The mechanical response of vinculin
Vinculin buffers force via dynamic domain unfolding/refolding under physiological load and lacks a stable head-tail lock.
www.science.org
October 31, 2025 at 6:29 PM
Vinculin is a simple adapter protein right? Wrong!
That’s been the prevailing view for the 46 years since it was discovered.
Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.
www.science.org/doi/10.1126/...
That’s been the prevailing view for the 46 years since it was discovered.
Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.
www.science.org/doi/10.1126/...
Here's a quick thread with pics summarizing the paper. Many thanks for all the hard work at Albany Med and by our collaborator Pilar Alcaide!
Very proud of this work that is now out on JCI describing a new #signaling pathway downstream of the #cytokine IL-6 in the #endothelium with implications in #sepsis and #shock. Short thread with a summary coming later today.
For now just enjoy that gorgeous image taken by my student Fatma Awadalla!
For now just enjoy that gorgeous image taken by my student Fatma Awadalla!
Systemic shock can lead to vascular dysfunction and organ failure.
This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA: www.jci.org/articles/vie...
This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA: www.jci.org/articles/vie...
November 4, 2025 at 12:47 AM
Here's a quick thread with pics summarizing the paper. Many thanks for all the hard work at Albany Med and by our collaborator Pilar Alcaide!
Very proud of this work that is now out on JCI describing a new #signaling pathway downstream of the #cytokine IL-6 in the #endothelium with implications in #sepsis and #shock. Short thread with a summary coming later today.
For now just enjoy that gorgeous image taken by my student Fatma Awadalla!
For now just enjoy that gorgeous image taken by my student Fatma Awadalla!
Systemic shock can lead to vascular dysfunction and organ failure.
This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA: www.jci.org/articles/vie...
This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA: www.jci.org/articles/vie...
November 3, 2025 at 6:34 PM
Very proud of this work that is now out on JCI describing a new #signaling pathway downstream of the #cytokine IL-6 in the #endothelium with implications in #sepsis and #shock. Short thread with a summary coming later today.
For now just enjoy that gorgeous image taken by my student Fatma Awadalla!
For now just enjoy that gorgeous image taken by my student Fatma Awadalla!
Reposted by Alejandro Adam
New work from Daoud et al. shows that removal of YAP/TAZ from vascular smooth muscle cells triggers inflammation and immune activation- indicating these factors as essential in vascular health.#vascularbiology
sciencedirect.com/science/arti...
#CardioSky
sciencedirect.com/science/arti...
#CardioSky
YAP/TAZ deletion in vascular smooth muscle cells mirrors atherosclerosis-associated transcriptional programs
The transcriptional co-activators YAP (YAP1) and TAZ (WWTR1) are central regulators of vascular smooth muscle cell (VSMC) phenotype and vascular homeo…
sciencedirect.com
November 3, 2025 at 12:47 PM
New work from Daoud et al. shows that removal of YAP/TAZ from vascular smooth muscle cells triggers inflammation and immune activation- indicating these factors as essential in vascular health.#vascularbiology
sciencedirect.com/science/arti...
#CardioSky
sciencedirect.com/science/arti...
#CardioSky
Reposted by Alejandro Adam
The BICAR-ICU-2 trial just dropped!
RCT involving IV bicarb in metabolic acidosis among patients with mod-severe AKI
Bicarb didn't affect mortality but it reduced the need for dialysis & risk of bacteremia
VERY similar conclusions to BICAR-ICU-1
🧵 #1/
jamanetwork.com/journals/jam... #EMIMCC
RCT involving IV bicarb in metabolic acidosis among patients with mod-severe AKI
Bicarb didn't affect mortality but it reduced the need for dialysis & risk of bacteremia
VERY similar conclusions to BICAR-ICU-1
🧵 #1/
jamanetwork.com/journals/jam... #EMIMCC
October 29, 2025 at 2:59 PM
The BICAR-ICU-2 trial just dropped!
RCT involving IV bicarb in metabolic acidosis among patients with mod-severe AKI
Bicarb didn't affect mortality but it reduced the need for dialysis & risk of bacteremia
VERY similar conclusions to BICAR-ICU-1
🧵 #1/
jamanetwork.com/journals/jam... #EMIMCC
RCT involving IV bicarb in metabolic acidosis among patients with mod-severe AKI
Bicarb didn't affect mortality but it reduced the need for dialysis & risk of bacteremia
VERY similar conclusions to BICAR-ICU-1
🧵 #1/
jamanetwork.com/journals/jam... #EMIMCC
Reposted by Alejandro Adam
Stem cell research is opening new doors for treating age-related #MacularDegeneration (AMD), a leading cause of vision loss.
Join our co-founders, Drs. Jeffrey Stern and Sally Temple on @BrightFocus Foundation's Macular Chat on Wed, Oct 29.
Join our co-founders, Drs. Jeffrey Stern and Sally Temple on @BrightFocus Foundation's Macular Chat on Wed, Oct 29.
October 24, 2025 at 1:40 PM
Stem cell research is opening new doors for treating age-related #MacularDegeneration (AMD), a leading cause of vision loss.
Join our co-founders, Drs. Jeffrey Stern and Sally Temple on @BrightFocus Foundation's Macular Chat on Wed, Oct 29.
Join our co-founders, Drs. Jeffrey Stern and Sally Temple on @BrightFocus Foundation's Macular Chat on Wed, Oct 29.
Reposted by Alejandro Adam
Monty Python understood p-hacking
October 23, 2025 at 8:43 AM
Monty Python understood p-hacking
Reposted by Alejandro Adam
Today, I’m joining millions of Americans participating in No Kings rallies across the nation to reject Trump’s corruption and cruelty – and to stand up for democracy. Read more in my latest newsletter, and visit nokings.org to find a rally near you:
tonko.house.gov/news/email/s...
tonko.house.gov/news/email/s...
Representative Paul D. Tonko
tonko.house.gov
October 18, 2025 at 2:54 PM
Today, I’m joining millions of Americans participating in No Kings rallies across the nation to reject Trump’s corruption and cruelty – and to stand up for democracy. Read more in my latest newsletter, and visit nokings.org to find a rally near you:
tonko.house.gov/news/email/s...
tonko.house.gov/news/email/s...
Reposted by Alejandro Adam
New this month in JHC: "Expression of Glial Cell Line–derived Neurotrophic Factor and Its Receptors in Glioblastoma."
Click to read: bit.ly/3L1NIHz
#glioblastoma #immunohistochemistry #insituhybridization
Click to read: bit.ly/3L1NIHz
#glioblastoma #immunohistochemistry #insituhybridization
October 16, 2025 at 10:16 PM
New this month in JHC: "Expression of Glial Cell Line–derived Neurotrophic Factor and Its Receptors in Glioblastoma."
Click to read: bit.ly/3L1NIHz
#glioblastoma #immunohistochemistry #insituhybridization
Click to read: bit.ly/3L1NIHz
#glioblastoma #immunohistochemistry #insituhybridization
Reposted by Alejandro Adam
Add your name ✍ at www.nycures.org so Albany sees 10,000 scientists calling for the future of biomedical research to be built right here in New York.
Our first email to members goes out soon—introducing the statewide biomedical institute we’re proposing and how you can help power it forward.
Our first email to members goes out soon—introducing the statewide biomedical institute we’re proposing and how you can help power it forward.
October 15, 2025 at 12:55 PM
Add your name ✍ at www.nycures.org so Albany sees 10,000 scientists calling for the future of biomedical research to be built right here in New York.
Our first email to members goes out soon—introducing the statewide biomedical institute we’re proposing and how you can help power it forward.
Our first email to members goes out soon—introducing the statewide biomedical institute we’re proposing and how you can help power it forward.
Impressive demonstration of how a leukocyte separates the two ECs to squeeze by.
Time to update my TEM lecture slides!
Time to update my TEM lecture slides!
Excellent #postLight uploaded by @fadelvalle.bsky.social!
He revisits work from Werner van der Meer & colleagues originally posted as a preprint and now published in @cp-cellreports.bsky.social
postLight: prelights.biologists.com/highlights/l...
He revisits work from Werner van der Meer & colleagues originally posted as a preprint and now published in @cp-cellreports.bsky.social
postLight: prelights.biologists.com/highlights/l...
October 6, 2025 at 6:13 PM
Impressive demonstration of how a leukocyte separates the two ECs to squeeze by.
Time to update my TEM lecture slides!
Time to update my TEM lecture slides!
Reposted by Alejandro Adam
Staff members at the NIH seem to have done the impossible: spend the agency's $48 billion budget.
“Everyone has been rallying together to clean up the mess, but it’s a mess that did not need to be made,” an NIH program officer told me.
www.nature.com/articles/d41...
“Everyone has been rallying together to clean up the mess, but it’s a mess that did not need to be made,” an NIH program officer told me.
www.nature.com/articles/d41...
NIH races to spend its 2025 grant money — but fewer projects win funding
Despite political obstacles, officials are on track to disburse all of the research funds allocated to US biomedical behemoth.
www.nature.com
September 30, 2025 at 3:32 PM
Staff members at the NIH seem to have done the impossible: spend the agency's $48 billion budget.
“Everyone has been rallying together to clean up the mess, but it’s a mess that did not need to be made,” an NIH program officer told me.
www.nature.com/articles/d41...
“Everyone has been rallying together to clean up the mess, but it’s a mess that did not need to be made,” an NIH program officer told me.
www.nature.com/articles/d41...
@gabbyfredman.bsky.social
EPA+DHA may be considered as part of the management of patients with NYHA functional class II-IV HF, irrespective of etiology or LVEF.
EPA+DHA may be considered as part of the management of patients with NYHA functional class II-IV HF, irrespective of etiology or LVEF.
A long-awaited consensus statement on inflammation and heart disease
"We have thus entered an era when the evidence linking inflammation with ASCVD is no longer exploratory but is
compelling and clinically actionable."
@jaccjournals.bsky.social open-access
www.jacc.org/doi/10.1016/...
"We have thus entered an era when the evidence linking inflammation with ASCVD is no longer exploratory but is
compelling and clinically actionable."
@jaccjournals.bsky.social open-access
www.jacc.org/doi/10.1016/...
September 29, 2025 at 5:26 PM
@gabbyfredman.bsky.social
EPA+DHA may be considered as part of the management of patients with NYHA functional class II-IV HF, irrespective of etiology or LVEF.
EPA+DHA may be considered as part of the management of patients with NYHA functional class II-IV HF, irrespective of etiology or LVEF.
Reposted by Alejandro Adam
New vascular seminars coming up @evborg.bsky.social
September 25, 2025 at 2:39 PM
New vascular seminars coming up @evborg.bsky.social
Reposted by Alejandro Adam
Trump Administration Attempts To Link Autism To Tylenol
https://theonion.com/trump-administration-attempts-to-link-autism-to-tylenol/
https://theonion.com/trump-administration-attempts-to-link-autism-to-tylenol/
September 24, 2025 at 8:30 PM
Trump Administration Attempts To Link Autism To Tylenol
https://theonion.com/trump-administration-attempts-to-link-autism-to-tylenol/
https://theonion.com/trump-administration-attempts-to-link-autism-to-tylenol/