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Sara Wickstrom @sarawickstrom.bsky.social · 9d

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology

McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

www.nature.com

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Silvia Fre lab @frelab.bsky.social · 9d

So proud of the exciting story from my PhD student Jakub Sumbal on contractile fibroblasts shaping branching morphogenesis!
Fantastic collaboration with the lab of Zuzana Koledova in Prague!
@sumbalovakoledova.bsky.social

It just came out online, check it out here:
rdcu.be/eIIKD

Contractile fibroblasts form a transient niche for the branching mammary epithelium

Nature Communications - Fibroblasts represent a heterogenous cell population but how their differences reflect their plasticity and origin is not fully understood. Here, the authors map the origin...

rdcu.be

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Audrey Desgrange @audreydsg.bsky.social · 14d

Ventricle position can be remodeled after heart looping!
In a model of heterotaxy we uncovered a new asymmetric morphogenesis process during which the heart reorients its chambers.
So grateful to all the authors for their expertise and input during this long (but fun) ride 💪
Read more here ⬇️

Sigolène Meilhac @meilhacsigolene.bsky.social · 14d

New publication | Science Advances www.science.org/doi/10.1126/...

Plasticity of ventricle position after heart looping in heterotaxy with right isomerism

The left/right position of ventricles needs to be maintained after heart looping, an unexpected step affected in heterotaxy.

www.science.org

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Matthew Alexander, PhD @mattmuscleguy.bsky.social · 27d

New #stemcellreports paper: Unraveling the matrisome signatures of quiescent and activated muscle stem cells. #Myoblue tinyurl.com/ycyy3nw5

Unraveling the matrisome signatures of quiescent and activated muscle stem cells

The extracellular matrix (ECM) niche regulates skeletal muscle stem cell (MuSC) behavior. Using transcriptomic data and 3D imaging, they show that quiescent MuSCs express unique ECM markers, including...

tinyurl.com

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Jean-Yves Tinevez @jytinevez.bsky.social · 28d

Save the date! The @pasteur.fr Pasteur course on image analysis is announced:

It will happen from the 1st of June to the 5th 2026.

This year there will be only one track: the Early Career Investigator track (beginners). 👇

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Thibaut Brunet @thibautbrunet.bsky.social · 29d

New short paper from our lab @currentbiology.bsky.social, in which we discover of a new mode of cell motility for choanoflagellates: flagellar gliding. www.cell.com/current-biol... - A 🧵

Flagellar gliding in choanoflagellates

Freire-Delgado and Brunet discover a new mode of cell motility in choanoflagellates, the closest relatives of animals. Under mild confinement, choanoflagellate move over surfaces without cell deformat...

www.cell.com

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Institut Cochin @institutcochin.bsky.social · 29d

Tuesday, Sept. 16, seminar at noon by Bert Blaauw (Veneto Inst. of Molecular Medicine, Univ of Padova, Italy): Reduced ATP turnover during hibernation in relaxed skeletal muscle
institutcochin.fr/en/agenda/re...
@inserm.fr @cnrs-idf-villejuif.bsky.social @cnrsbiologie.bsky.social @upcite.bsky.social

Reduced ATP turnover during hibernation in relaxed skeletal muscle

Hibernating brown bears, due to a drastic reduction in metabolic rate, show only moderate muscle wasting. Here, we evaluate if ATPase activity of resting skeletal muscle myosin can contribute to this ...

institutcochin.fr

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Institut Cochin @institutcochin.bsky.social · 29d

Do not hesitate to register for Sept 18. Please repost this message.

Florence Niedergang @florenceniedergang.bsky.social · Sep 6

Pleased to announce launching Institut Cochin Foundation, on Sept. 18 at 6 p.m., upon registration, either in the Rosalind Franklin room, 22 rue Méchain, Paris or via video conference: presentation of @institutcochin.bsky.social, meet researchers and call for donations-thanks for your support!

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John De Vos @jdevos.bsky.social · Sep 3

🔬 Don’t miss the 7th Annual FSSCR Meeting in Lyon!
✨ #StemCells research & future clinical applications.
📆 Register by 19 Oct 2025 for regular rates 👉

FSSCR ANNUAL MEETING

French Society on Stem Cell Research (FSSCR)

buff.ly

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Thiago Carvalho @cyrilpedia.bsky.social · Jul 26

'The problem is that AAV-based therapies inevitably come with their own risks, and (in my opinion) these should be balanced by impressive efficacy data to make a convincing profile. Obviously this wasn’t present here, which sort of leaves everyone out there to soak up the risk part'

Sarepta, Sarepta

www.science.org

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EMBO Reports @emboreports.org · Jul 19

Rémi Mounier, Bénédicte Chazaud @benchazaud.bsky.social ‬ @inserm.fr at Université Claude Bernard Lyon and co-workers show that immune #aging impairs #muscle #regeneration via #macrophage-derived anti-oxidant selenoprotein P.

-> www.embopress.org/doi/full/10....

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Frank Schnorrer @frankschnorrer.bsky.social · Jul 10

SARCOMERES divide! Mechanism how muscles grow while contracting - daughter sarcomeres appear everywhere. Seen live, registered on our cover. Pioneered by @clementrodier.bsky.social @friedrich-group.bsky.social Ian Estabrook @ibdm.bsky.social $ by @hfspo.bsky.social www.science.org/doi/10.1126/...

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Matthew Alexander, PhD @mattmuscleguy.bsky.social · Jun 29

New #NatureMedicine paper: AAV mini-dystrophin gene therapy for Duchenne muscular dystrophy: a phase 1b trial. #DMD #Myoblue tinyurl.com/bdhwrkka

AAV mini-dystrophin gene therapy for Duchenne muscular dystrophy: a phase 1b trial - Nature Medicine

In the primary report of a phase 1b trial, adeno-associated virus gene therapy with fordadistrogene movaparvovec in patients with Duchenne muscular dystrophy was well tolerated in an ambulatory cohort...

tinyurl.com

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Tajbakhsh Lab @tajbakhshlab.bsky.social · Jun 24

Pluripotency, CRISPR/Cas9, organoid days. Lectures to bench. With a precious and passionate lecture by Michele De Luca

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Tajbakhsh Lab @tajbakhshlab.bsky.social · Jun 24

Education… so important. Second day of the #ASCB course @institutpasteur with @LabTajbakhsh @zenlabpasteur @bgayraudmorel and a great group of interactive students. Once again with the irreplaceable trio: Laurence Daheron, Frank Yates, Michel Cohen-Tannoudji!

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BrunetLab @brunetlab.bsky.social · Jun 25

Excited to share our review on Hallmark of Stem Cell Aging! With Tom Rando and Peggy Goodell @goodell-lab.bsky.social!!

www.sciencedirect.com/science/arti...

Hallmarks of stem cell aging

As organisms age, somatic stem cells progressively lose their ability to sustain tissue homeostasis and support regeneration. Although stem cells are …

www.sciencedirect.com

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Michael Rera @michaelrera.bsky.social · Feb 27

I am happy to announce with @hanli-pasteur.bsky.social that we'll organise a summer school titled "Senescence from Cell Cultures to Humans through Model Organisms" in Paris, Fr on June 23-24, 2025
Aimed at 2nd and 3rd year PhD student + postdocs
Submit your provisional project tinyurl.com/2uhfzxbp

flyer of the event with the name of confirmed trainers Cléo Bishop, Eric Boulanger, Manuel Collado and Bill Keyes,
Deadline for application May 30th 2025,

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Zebrafish Rock! @zebrafishrock.bsky.social · Jun 21

#DanioDigest (May 2025)

Community News:

Prof Caren Norden @nordenlab.bsky.social‬ appointed Darwin Professor of Animal Embryology at PDN at the University of Cambridge.

Prof Elizabeth Chen @echenlab.bsky.social elected as President of @ascbiology.bsky.social‬ for 2027. (1/38)

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Jean-Yves Tinevez @jytinevez.bsky.social · Jun 11

Our paper describing the creation of a nationwide core facility for bioimage analysis if out in @plos Computational Biology!
🎉✌️

journals.plos.org/ploscompbiol...

So happy about this paper and how the work turned out.
A small thread 👇

#bioimageanalysis #corefacility

F-BIAS: Towards a distributed national core facility for bioimage analysis †

Author summary We describe our experience in creating a nationwide core facility offering services in bioimage analysis. This virtual facility federates existing resources scattered across the territo...

journals.plos.org

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Institut Cochin @institutcochin.bsky.social · Jun 11

Do not miss this seminar today: institutcochin.fr/en/agenda/ta...

Institut Cochin @institutcochin.bsky.social · May 30

#Seminar on June 12 at noon by Justin Fallon (Brown University, Providence, US): Targeting neural and muscle #stem cells to promote adult hippocampal #neurogenesis and #muscle growth
institutcochin.fr/en/agenda/ta...
@inserm.fr @upcite.bsky.social @cnrs-idf-villejuif.bsky.social

Targeting neural and muscle stem cells to promote adult hippocampal neurogenesis and muscle growth

Adult stem cells offer an attractive target for treating a range of diseases and for extending healthspan. Neural and muscle stem (satellite) cells are generally quiescent, but can be activated to gen...

institutcochin.fr

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Matthew Alexander, PhD @mattmuscleguy.bsky.social · May 26

New #NatureCancer paper: Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia. #Myoblue tinyurl.com/yhjx4sjt

Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia - Nature Cancer

Using multiple in vivo mouse models, Rehman and colleagues report that tumor-induced impairments in the muscle vasculature mediated by circulating activin A contribute to cachexia development during c...

tinyurl.com

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Aegean Conferences, Inc. @aegeanconf.bsky.social · May 7

Deadline Reminder June 1 for Early Registration / Abstract Submission: 6th Int'l Conference on #StemCells at the Kalimera Kriti Conference Center in #sissi #crete #Greece from Oct. 1-6, 2025 www.aegeanconferences.org/src/App/conf...

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F Jeffrey Dilworth @epigeneticsmsn.bsky.social · May 21

We have a fantastic group of speakers from the Stem Cell field. Don't miss the discounted early registration deadline of June 1st. Available trainee travel awards will be selected based on abstracts submitted before the June 1st deadline.

Aegean Conferences, Inc. @aegeanconf.bsky.social · May 7

Deadline Reminder June 1 for Early Registration / Abstract Submission: 6th Int'l Conference on #StemCells at the Kalimera Kriti Conference Center in #sissi #crete #Greece from Oct. 1-6, 2025 www.aegeanconferences.org/src/App/conf...

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Frank Schnorrer @frankschnorrer.bsky.social · May 10

Titin evolution, titin force and muscle contraction instruct sarcomere dimensions in insect muscles to allow high frequency flight, larval crawling and max force to cut leafs. @ibdm.bsky.social @mpi-nat.bsky.social @jfrupprecht.bsky.social @vincent-loreau.bsky.social
www.science.org/doi/epdf/10....

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Abigail Mackey @abigailmackey1.bsky.social · May 7

Our 2026 PhD course is now open for registration🤩

@ismcopenhagen.bsky.social
Copenhagen, 5-7 October 2026

Musculoskeletal tissue regeneration – mechanisms and clinical perspectives

Exciting topics and expert teachers - come join us!

phdcourses.ku.dk/DetailKursus...

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