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da-mesquita.bsky.social
Sandro Da Mesquita
@da-mesquita.bsky.social
1.8K followers 260 following 130 posts
Assistant Professor | Dept. of Neuroscience @ Mayo Clinic | Understanding the role of the meningeal lymphatic system in CNS aging & degeneration 🤓🧠🧪🔬 | Views=own. https://www.mayo.edu/research/labs/meningeal-lymphatics-neurological-disorders
www.mayo.edu
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da-mesquita.bsky.social
Sandro Da Mesquita @da-mesquita.bsky.social · May 30
CSF transport at the brain–meningeal border: effects on neurological health and disease - The Lancet Neurology www.thelancet.com/journals/lan...
CSF transport at the brain–meningeal border: effects on neurological health and disease
The existence of specialised structures that allow a continuous exchange of CSF between different anatomical compartments at the brain–meningeal border is challenging conventional notions around molec...
www.thelancet.com
4 11
Reposted by Sandro Da Mesquita
jsabatino37.bsky.social
Joe Sabatino @jsabatino37.bsky.social · 14h
Immune signatures link myelin oligodendrocyte glycoprotein antibody–associated disease to other autoantibody-mediated conditions

www.science.org/doi/10.1126/...
Immune signatures link myelin oligodendrocyte glycoprotein antibody–associated disease to other autoantibody-mediated conditions
Single-cell immunoprofiling uncovered systemic immune cell signatures of neurological MOG antibody–associated disease.
www.science.org
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Reposted by Sandro Da Mesquita
natrevimmunol.nature.com
Nature Reviews Immunology @natrevimmunol.nature.com · 2d
Happy #treg day everyone - congratulations to Mary Brunkow, Fred Ramsdell, Shimon Sakaguchi and to all the immunologists who have contributed to this incredible field. See our collection: www.nature.com/collections/...
Nobel Prize in Physiology or Medicine 2025
The 2025 Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries ...
www.nature.com
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cp-cell.bsky.social
Cell - a Cell Press journal @cp-cell.bsky.social · 2d
The editorial team at #Cell wishes heartfelt congratulations to the winners of the 2025 #NobelPrize in Physiology or Medicine, Drs. Mary Brunkow, Fred Ramsdell, & Shimon Sakaguchi!

View their related research published in Cell Press journals: spkl.io/6013AVK2P
@cherisirois.bsky.social
The editorial team at Cell extends warm congratulations to Drs. Shimon Sakaguchi, Mary Brunkow, and Fred Ramsdell for their discoveries that defined regulatory T cells as the basis for peripheral immune tolerance. “Tregs” are at the heart of immunity, and the foundational work of the laureates has set up fascinating questions that remain active areas for understanding how our bodies work and for leveraging the immune system to treat disease. We can’t wait to see how their legacy and humanity’s knowledge of peripheral tolerance grow from here. -Cheri Sirois, Scientific Editor, Cell.
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natureportfolio.nature.com
Nature Portfolio @natureportfolio.nature.com · 2d
The 2025 Nobel Prize in Physiology or Medicine was awarded jointly to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.” This Collection celebrates the award and recognizes the winners’ achievements. #medsky 🧪
Nobel Prize in Physiology or Medicine 2025
The 2025 Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries ...
go.nature.com
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da-mesquita.bsky.social
Sandro Da Mesquita @da-mesquita.bsky.social · 2d
What?! Are you implying that research involving animal models led to the groundbreaking scientific discovery of Tregs, which are conserved in several mammalian species, and play a crucial role in human biology and disease?!! How dare you sir?! Blasphemy!… 😜😂
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da-mesquita.bsky.social
Sandro Da Mesquita @da-mesquita.bsky.social · 2d
Immunology Rocks! Immune tolerance is crucial in health and disease, even when it comes to our brain! Congratulations to the new Nobel Laureates in Physiology or Medicine! 🤩😁🎉

www.nobelprize.org/prizes/medic...
Nobel Prize in Physiology or Medicine 2025
The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
www.nobelprize.org
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odedrechavi.bsky.social
Oded Rechavi @odedrechavi.bsky.social · 4d
Thanking the reviewers
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nature.com
Nature @nature.com · 7d
Nature research paper: Autoimmune response to C9orf72 protein in amyotrophic lateral sclerosis

go.nature.com/46xxuOX
Autoimmune response to C9orf72 protein in amyotrophic lateral sclerosis - Nature
An analysis of T cell responses in people with amyotrophic lateral sclerosis shows that the C9orf72 antigen is a key target of autoimmune responses in the disease, and identifies C9orf72 epitopes that are recognized.
go.nature.com
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Reposted by Sandro Da Mesquita
erictopol.bsky.social
Eric Topol @erictopol.bsky.social · 15d
To be clear, there are no data that provide a link between short-term use of Tylenol during pregnancy and autism. In fact, one of the best prospective studies w/ sibling controls, if anything, pointed to a protective effect for use less than 7 days
acamh.onlinelibrary.wiley.com/doi/10.1002/...
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leadcoalition.bsky.social
Ian Kremer @leadcoalition.bsky.social · 15d
New landscape of the diagnosis of Alzheimer's disease www.thelancet.com/journals/lan... by @thelancet.com

#Alzheimers #dementia #biomarkers #neuroscience #NeuroSkyence
New landscape of the diagnosis of Alzheimer's disease
Alzheimer's disease involves a drastic departure from the cognitive, functional, and behavioural trajectory of normal ageing, and is both a dreaded and highly prevalent cause of disability to individu...
www.thelancet.com
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Reposted by Sandro Da Mesquita
genelayinstitute.bsky.social
The Gene Lay Institute of Immunology and Inflammation @genelayinstitute.bsky.social · 15d
#RTN2025
thexavierlab.bsky.social @thexavierlab.bsky.social · 15d
The @genelayinstitute.bsky.social
is excited to host its third #ReThinkNeuroimmunology meeting from October 14-16th, 2025. This year will focus on discussing major discoveries & breakthroughs in neuroimmunology, single cell genomics, immunology, & neuroscience.

genelayinstitute.org/rtn/
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rupress.org
Rockefeller University Press @rupress.org · 20d
New in @jem.org: Florescu et al. investigate an animal model of progressive #MultipleSclerosis & uncover a population of anti-CD20–resistant dural B cells that remain in the brain parenchyma at disease remission rupress.org/jem/article/...
@jengommerman.bsky.social
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Reposted by Sandro Da Mesquita
rupress.org
Rockefeller University Press @rupress.org · 19d
In @jem.org, Qing Chang, Jian-Fu Chen et al. @usc.edu identify lymphatic vasculature on the outer surface of the skull but not inside the skull bone marrow, and reveal skull channel and bone marrow heterogeneity varying by region and age. rupress.org/jem/article/...

#HumanDiseaseGenetics
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da-mesquita.bsky.social
Sandro Da Mesquita @da-mesquita.bsky.social · May 30
CSF transport at the brain–meningeal border: effects on neurological health and disease - The Lancet Neurology www.thelancet.com/journals/lan...
CSF transport at the brain–meningeal border: effects on neurological health and disease
The existence of specialised structures that allow a continuous exchange of CSF between different anatomical compartments at the brain–meningeal border is challenging conventional notions around molec...
www.thelancet.com
4 11
Reposted by Sandro Da Mesquita
latorrelab.bsky.social
Anna La Torre @latorrelab.bsky.social · 22d
🎉 New preprints from the lab! (1) www.biorxiv.org/content/10.1...
Novel Roles of Sonic Hedgehog Signaling in Retinal Patterning and Neurogenesis During Mammalian Eye Development
The Sonic Hedgehog (Shh) signaling pathway is essential for the patterning, growth, and morphogenesis of many tissues. During early eye development, Shh is critical for the formation of the two optic ...
www.biorxiv.org
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Reposted by Sandro Da Mesquita
latorrelab.bsky.social
Anna La Torre @latorrelab.bsky.social · 22d
We explored the roles of Let-7 in cortical development, and we found a novel mechanism by which Let-7 regulates migration independently of cell fate specification. And this was SO much fun! Don't forget to check out the time-lapse data. It's always my favorite
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venkatesh-lab.bsky.social
The Venkatesh Lab @venkatesh-lab.bsky.social · 22d
We are excited to share the Venkatesh Lab’s first publication in collaboration with @michellemonje.bsky.social team uncovering how neuronal activity influences the progression of small cell lung cancer #SCLC in the lung and brain. www.nature.com/articles/s41...
Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis - Nature
Glutamatergic and GABAergic (γ-aminobutyric acid-producing) cortical neuronal activity drives proliferation of small lung cell cancer via paracrine interactions and through synapses formed with tumour...
www.nature.com
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da-mesquita.bsky.social
Sandro Da Mesquita @da-mesquita.bsky.social · 22d
Congrats Humsa and team!!! 👏🏻🎉🍾
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da-mesquita.bsky.social
Sandro Da Mesquita @da-mesquita.bsky.social · 23d
Thank you, Julie! All the credit goes to Patty and folks from the lab (and it was veeeery tasty as well!) 😁
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da-mesquita.bsky.social
Sandro Da Mesquita @da-mesquita.bsky.social · 23d
The Da Mesquita Lab turned 5! Kudos to all present & past members!
@lilianacorreia.bsky.social @shanonrego.bsky.social @sanchezlulu.bsky.social
Virginia, Patty, Parul, Rae, Megan, Nicole & Sofia 🤩😍
It is your creativity, intelligence & hard work that make it all worth it. Here’s to another 5!!! 🎉🍾🥂
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caitlynfastenau.bsky.social
Caitlyn Fastenau, PhD @caitlynfastenau.bsky.social · 27d
Infection and ADRD?? Heck yes!

Such an important topic!🧠

Submit your research to #TRCI!
alzdemjournals.bsky.social
Alzheimer's & Dementia Journals @alzdemjournals.bsky.social · 27d
⭐CALL FOR PAPERS⭐

Infectious Agents- Causal or Risk?

▶️ Linking infection-related biomarkers to ADRD pathophysiology
▶️Relationships between infectious exposures and clinical trials & more!

⏰Deadline: June 1, 2026

#TRCI

alz-journals.onlinelibrary.wiley.com/hub/journal/...
Alzheimer's & Dementia: Translational Research & Clinical Interventions
<em>Alzheimer's & Dementia: Translational Research & Clinical Interventions</em> journal bridges drug discovery research and clinical studies for dementia & Alzheimer's.
alz-journals.onlinelibrary.wiley.com
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johnsonlab.bsky.social
Lance Johnson @johnsonlab.bsky.social · Sep 7
new preprint from @iostephens.bsky.social describes the potential benefits of increasing lipid turnover in microglia by eliminating PLIN2 from their surface
biorxiv-neursci.bsky.social
bioRxiv Neuroscience @biorxiv-neursci.bsky.social · Sep 6
Knockout of Perilipin 2 in Microglia Alters Lipid Droplet Accumulation and Response to Alzheimer's Disease Stimuli https://www.biorxiv.org/content/10.1101/2025.09.02.673815v1
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sonhita.bsky.social
Sonhita 🌞 @sonhita.bsky.social · 27d
Highly recommend for anyone considering a career as a journal editor! 🧪🧬🔬🥼 #sciencecareers #scientificediting #journaleditor #careersoutsidescademia
lifescienceeditors.bsky.social
Life Science Editors @lifescienceeditors.bsky.social · 28d
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glialclub.bsky.social
French Glial Cell Club @glialclub.bsky.social · Aug 18
📢 Join us for the 2nd Microglia & Neuroinflammation Workshop in Bordeaux, Nov 3–7, 2025!
Pre-registration deadline extended to Sept 3—don’t miss out!
#Neuroscience #Microglia #Workshop2025
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dementiaresearcher.bsky.social
Dementia Researcher @dementiaresearcher.bsky.social · 27d
Lecturer in Immunology at University of Aberdeen. Open to researchers with fresh approaches to immunity and neurodegeneration, including Alzheimer’s and Parkinson’s. Closing date: 9th October

www.dementiaresearcher.nihr.ac.uk/job/lecturer...
Lecturer: Neuroimmunology - DEMENTIA RESEARCHER
Lecturer in Immunology at University of Aberdeen. Open to researchers with fresh approaches to immunity & neurodegeneration, including Alzheimer’s & Parkinson’s
www.dementiaresearcher.nihr.ac.uk
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