Jonne Sikkens
@dewittehi.bsky.social
Internist acute medicine & infectious diseases, interested in clinical reasoning, General internal medicine, statistics/epidemiology, POCUS, research. Also MSc in clinical epi & neuropsychology
Reposted by Jonne Sikkens
Would be interesting to run this by an AI agent, as an experiment.
Would it choose A or A+B?
Could it see any connection with collider bias?
Would it choose A or A+B?
Could it see any connection with collider bias?
@verybadwizards.bsky.social I watched a recent talk on Collider bias, where he discusses the Monty Hall problem as one of Collider bias (18:11), which made me think that it's one way it's connected to Newcomb's paradox, conditioning on future outcomes. www.youtube.com/watch?v=m56Y...
BEMC NOV 2024 - William Lowe - Collider bias (complimentary)
YouTube video by Berlin Epidemiological Methods Colloquium
www.youtube.com
April 24, 2025 at 12:07 AM
Would be interesting to run this by an AI agent, as an experiment.
Would it choose A or A+B?
Could it see any connection with collider bias?
Would it choose A or A+B?
Could it see any connection with collider bias?
Reposted by Jonne Sikkens
Why you should know your viral exposure status (i.e CMV) if you're going to undergo immunotherapy for cancer (but almost no one knows)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
CMV serostatus is associated with improved survival and delayed toxicity onset following anti-PD-1 checkpoint blockade - Nature Medicine
Analysis of multiple cohorts of patients with melanoma demonstrates a positive association between cytomegalovirus serostatus and overall survival in patients treated with monotherapy but not combinat...
www.nature.com
April 24, 2025 at 12:43 AM
Why you should know your viral exposure status (i.e CMV) if you're going to undergo immunotherapy for cancer (but almost no one knows)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Jonne Sikkens
The ASIs have arrived
www.nejm.org/doi/full/10....
Aldosterone synthase inhibitors - first one to finish the phase 3 line
#Lorundrostat #Hypertension
www.nejm.org/doi/full/10....
Aldosterone synthase inhibitors - first one to finish the phase 3 line
#Lorundrostat #Hypertension
Lorundrostat Efficacy and Safety in Patients with Uncontrolled Hypertension | NEJM
Aldosterone dysregulation contributes to hypertension. Lorundrostat is an aldosterone synthase inhibitor, but data on its efficacy and safety in patients with hypertension are limited. In this mult...
www.nejm.org
April 23, 2025 at 10:01 PM
The ASIs have arrived
www.nejm.org/doi/full/10....
Aldosterone synthase inhibitors - first one to finish the phase 3 line
#Lorundrostat #Hypertension
www.nejm.org/doi/full/10....
Aldosterone synthase inhibitors - first one to finish the phase 3 line
#Lorundrostat #Hypertension
Reposted by Jonne Sikkens
Do not normalize children dying from measles. Measles was previously eliminated in the US, thanks to vaccines.
When children die from measles, it means that adults have catastrophically failed to protect them because they have rejected basic science.
When children die from measles, it means that adults have catastrophically failed to protect them because they have rejected basic science.
April 7, 2025 at 5:47 PM
Do not normalize children dying from measles. Measles was previously eliminated in the US, thanks to vaccines.
When children die from measles, it means that adults have catastrophically failed to protect them because they have rejected basic science.
When children die from measles, it means that adults have catastrophically failed to protect them because they have rejected basic science.
Reposted by Jonne Sikkens
a long time ago I used to knock normal saline for being hypertonic
I want to set the record straight on this, I was wrong
NS & LR are *functionally* isotonic
to affect sodium concentration, you'd need to give an impossibly massive volume
full discussion here: emcrit.org/ibcc/fluid/#...
I want to set the record straight on this, I was wrong
NS & LR are *functionally* isotonic
to affect sodium concentration, you'd need to give an impossibly massive volume
full discussion here: emcrit.org/ibcc/fluid/#...
April 8, 2025 at 1:42 AM
a long time ago I used to knock normal saline for being hypertonic
I want to set the record straight on this, I was wrong
NS & LR are *functionally* isotonic
to affect sodium concentration, you'd need to give an impossibly massive volume
full discussion here: emcrit.org/ibcc/fluid/#...
I want to set the record straight on this, I was wrong
NS & LR are *functionally* isotonic
to affect sodium concentration, you'd need to give an impossibly massive volume
full discussion here: emcrit.org/ibcc/fluid/#...
Reposted by Jonne Sikkens
Dropping The Kidney Roast Collection
A 90s retro-inspired cartoon project where the kidney finally gets to roast the other organs and specialties — sarcasm, dry humor all packed into vintage medical scenes.
1/4
#ArtCollection #RetroCartoon #MedicalArt #KidneyRoast #Illustration #90sVibe
A 90s retro-inspired cartoon project where the kidney finally gets to roast the other organs and specialties — sarcasm, dry humor all packed into vintage medical scenes.
1/4
#ArtCollection #RetroCartoon #MedicalArt #KidneyRoast #Illustration #90sVibe
March 30, 2025 at 4:51 AM
Dropping The Kidney Roast Collection
A 90s retro-inspired cartoon project where the kidney finally gets to roast the other organs and specialties — sarcasm, dry humor all packed into vintage medical scenes.
1/4
#ArtCollection #RetroCartoon #MedicalArt #KidneyRoast #Illustration #90sVibe
A 90s retro-inspired cartoon project where the kidney finally gets to roast the other organs and specialties — sarcasm, dry humor all packed into vintage medical scenes.
1/4
#ArtCollection #RetroCartoon #MedicalArt #KidneyRoast #Illustration #90sVibe
Reposted by Jonne Sikkens
Lariocidin hits drug-resistant bacteria where others fail- by hijacking the ribosome at a new site, bypassing defenses, and opening the door to a new generation of antibiotics.
The study has been published in Nature. YES, it is PEER-REVIEWED.
• www.nature.com/articles/s41...
The study has been published in Nature. YES, it is PEER-REVIEWED.
• www.nature.com/articles/s41...
March 31, 2025 at 4:01 PM
Lariocidin hits drug-resistant bacteria where others fail- by hijacking the ribosome at a new site, bypassing defenses, and opening the door to a new generation of antibiotics.
The study has been published in Nature. YES, it is PEER-REVIEWED.
• www.nature.com/articles/s41...
The study has been published in Nature. YES, it is PEER-REVIEWED.
• www.nature.com/articles/s41...
Reposted by Jonne Sikkens
I have a short lecture on bootstrapping.
friendly.github.io/6135/lecture...
friendly.github.io/6135/lecture...
April 1, 2025 at 2:40 AM
I have a short lecture on bootstrapping.
friendly.github.io/6135/lecture...
friendly.github.io/6135/lecture...
Reposted by Jonne Sikkens
De Nederlandse overheid moet per direct van sociale media platformen van Big Tech-bedrijven af. Dit roepen we samen met @waag.bsky.social, SETUP, PublicSpaces en De Goede Zaak op.
www.bitsoffreedom.nl/campagnes/op...
www.bitsoffreedom.nl/campagnes/op...
Oproep aan de Nederlandse overheid: vertrek van de sociale media van Big Tech!
Bits of Freedom komt op voor internetvrijheid door de online grondrechten op communicatievrijheid en privacy te beschermen.
www.bitsoffreedom.nl
January 10, 2025 at 3:59 PM
De Nederlandse overheid moet per direct van sociale media platformen van Big Tech-bedrijven af. Dit roepen we samen met @waag.bsky.social, SETUP, PublicSpaces en De Goede Zaak op.
www.bitsoffreedom.nl/campagnes/op...
www.bitsoffreedom.nl/campagnes/op...
Reposted by Jonne Sikkens
For Maths fans, 2025 is a square.
45² = 45 x 45 = 2025
Also,
9² x 5² = 2025
40² + 20² + 5² = 2025
My favourite?
1³+2³+3³+4³+5³+6³+7³+8³+9³ = 2025
#Mathematics #teaching #education
45² = 45 x 45 = 2025
Also,
9² x 5² = 2025
40² + 20² + 5² = 2025
My favourite?
1³+2³+3³+4³+5³+6³+7³+8³+9³ = 2025
#Mathematics #teaching #education
January 1, 2025 at 1:56 PM
For Maths fans, 2025 is a square.
45² = 45 x 45 = 2025
Also,
9² x 5² = 2025
40² + 20² + 5² = 2025
My favourite?
1³+2³+3³+4³+5³+6³+7³+8³+9³ = 2025
#Mathematics #teaching #education
45² = 45 x 45 = 2025
Also,
9² x 5² = 2025
40² + 20² + 5² = 2025
My favourite?
1³+2³+3³+4³+5³+6³+7³+8³+9³ = 2025
#Mathematics #teaching #education
Reposted by Jonne Sikkens
Researcher: "We let the data speak for itself."
Earlier that day:
Earlier that day:
January 2, 2025 at 3:31 PM
Researcher: "We let the data speak for itself."
Earlier that day:
Earlier that day:
Reposted by Jonne Sikkens
Reposted by Jonne Sikkens
There's a really interesting new paper out in Science for people who care about immunity to flu (which should be everyone because flu is a VERY big problem):
www.science.org/doi/10.1126/...
Here's my thread explaining this work🧵
www.science.org/doi/10.1126/...
Here's my thread explaining this work🧵
Coupling antigens from multiple subtypes of influenza can broaden antibody and T cell responses
The seasonal influenza vaccine contains strains of viruses from distinct subtypes that are grown independently and then combined. However, most individuals exhibit a more robust response to one of the...
www.science.org
December 20, 2024 at 4:57 PM
There's a really interesting new paper out in Science for people who care about immunity to flu (which should be everyone because flu is a VERY big problem):
www.science.org/doi/10.1126/...
Here's my thread explaining this work🧵
www.science.org/doi/10.1126/...
Here's my thread explaining this work🧵
Reposted by Jonne Sikkens
The n's justify the means
December 30, 2024 at 3:04 AM
The n's justify the means
Reposted by Jonne Sikkens
Among pts hospitalized with AKI, recommendations from a Kidney Action Team did not significantly prevent the composite outcome of worsening AKI stage, dialysis, or mortality, despite a higher rate of recommendation in the intervention group.
https://ja.ma/4iLsIRU
https://ja.ma/4iLsIRU
December 25, 2024 at 5:00 PM
Among pts hospitalized with AKI, recommendations from a Kidney Action Team did not significantly prevent the composite outcome of worsening AKI stage, dialysis, or mortality, despite a higher rate of recommendation in the intervention group.
https://ja.ma/4iLsIRU
https://ja.ma/4iLsIRU
Reposted by Jonne Sikkens
It's that time of year again. Here are my top 10 ID papers of 2024
1. My opinion
2. Practice changing, paradigm-shifting or dogma challenging
3. Not COVID
4. Alphabetical order by first author
5. CoI for 4 and 5 (I am an author)
Summary slide here, details in thread
#IDSky #Top10IDpapers
1. My opinion
2. Practice changing, paradigm-shifting or dogma challenging
3. Not COVID
4. Alphabetical order by first author
5. CoI for 4 and 5 (I am an author)
Summary slide here, details in thread
#IDSky #Top10IDpapers
December 23, 2024 at 2:42 AM
It's that time of year again. Here are my top 10 ID papers of 2024
1. My opinion
2. Practice changing, paradigm-shifting or dogma challenging
3. Not COVID
4. Alphabetical order by first author
5. CoI for 4 and 5 (I am an author)
Summary slide here, details in thread
#IDSky #Top10IDpapers
1. My opinion
2. Practice changing, paradigm-shifting or dogma challenging
3. Not COVID
4. Alphabetical order by first author
5. CoI for 4 and 5 (I am an author)
Summary slide here, details in thread
#IDSky #Top10IDpapers
Reposted by Jonne Sikkens
Can POCUS + Dimer exclude acute aortic dissection in the ED?
Or speed up the time to surgery?
broomedocs.com/2024/12/prof...
#medsky #emimcc #FOAMed
@emhighak.bsky.social @pulmcrit.bsky.social
@stemlyns.bsky.social
Or speed up the time to surgery?
broomedocs.com/2024/12/prof...
#medsky #emimcc #FOAMed
@emhighak.bsky.social @pulmcrit.bsky.social
@stemlyns.bsky.social
PROFUNDUS Trial Review - Broome Docs
The PROFUNDUS trial was published recently in the European Journal of Internal Medicine. THis is my review and critique of the trial. I have tried to
broomedocs.com
December 20, 2024 at 4:13 AM
Can POCUS + Dimer exclude acute aortic dissection in the ED?
Or speed up the time to surgery?
broomedocs.com/2024/12/prof...
#medsky #emimcc #FOAMed
@emhighak.bsky.social @pulmcrit.bsky.social
@stemlyns.bsky.social
Or speed up the time to surgery?
broomedocs.com/2024/12/prof...
#medsky #emimcc #FOAMed
@emhighak.bsky.social @pulmcrit.bsky.social
@stemlyns.bsky.social
Reposted by Jonne Sikkens
The field of "ultra-processed" food research & its media coverage are littered with poor definitions & comparisons, w misleading conclusions. This creates an illusion that UPFs provide new insights, but it's all slight-of-hand. @mbolotnikova.bsky.social takes a deep dive www.vox.com/future-perfe...
You’re being lied to about “ultra-processed” foods
Coverage of the latest nutrition buzzword is overly broad, arbitrary, and misleading. The problem goes deeper.
www.vox.com
December 19, 2024 at 5:46 PM
The field of "ultra-processed" food research & its media coverage are littered with poor definitions & comparisons, w misleading conclusions. This creates an illusion that UPFs provide new insights, but it's all slight-of-hand. @mbolotnikova.bsky.social takes a deep dive www.vox.com/future-perfe...
Reposted by Jonne Sikkens
Other gems from Ted Chiang: I don't call them language models because language is about communicating intent. Since the model does not have any intent, I prefer to call them large text models. #NeurIPS2024
December 17, 2024 at 1:37 PM
Other gems from Ted Chiang: I don't call them language models because language is about communicating intent. Since the model does not have any intent, I prefer to call them large text models. #NeurIPS2024
Reposted by Jonne Sikkens
Do you remember this study by Dr Raoult claiming that treatment with hydroxychloroquine reduced virus levels in COVID-19 patients, and that the drug was even more effective if used alongside azithromycin?
The study was retracted
www.science.org/content/arti...
The study was retracted
www.science.org/content/arti...
Infamous paper that popularized unproven COVID-19 treatment finally retracted
Study on hydroxychloroquine by Didier Raoult and colleagues gets pulled on ethical and scientific grounds
www.science.org
December 17, 2024 at 6:52 PM
Do you remember this study by Dr Raoult claiming that treatment with hydroxychloroquine reduced virus levels in COVID-19 patients, and that the drug was even more effective if used alongside azithromycin?
The study was retracted
www.science.org/content/arti...
The study was retracted
www.science.org/content/arti...
Reposted by Jonne Sikkens
Nieuw verhaal. Je zegt dat je nerveus bent en ik zie je handen trillen als de GGD-arts een infuus aanbrengt in je rechterhand. Als de klok op tien springt, weten we allemaal stilzwijgend dat je allerlaatste uur in is gegaan. Het is goed zo.
chrisklomp.nl/het-is-goed-...
chrisklomp.nl/het-is-goed-...
Het is goed zo - Chris Klomp
Het is 09.45 uur op vrijdag 13 december 2024. Op het aanrecht staat je laatste kop en schotel. De resten van een beschuitje en thee. Je zit in je blauwe stoel, een schim van wie je was. Je zegt dat je...
chrisklomp.nl
December 16, 2024 at 10:13 AM
Nieuw verhaal. Je zegt dat je nerveus bent en ik zie je handen trillen als de GGD-arts een infuus aanbrengt in je rechterhand. Als de klok op tien springt, weten we allemaal stilzwijgend dat je allerlaatste uur in is gegaan. Het is goed zo.
chrisklomp.nl/het-is-goed-...
chrisklomp.nl/het-is-goed-...
Reposted by Jonne Sikkens
1/
Time for another #POCUS pitfalls thread: the infamous IVC 🤩
I have MANY thoughts on the IVC 💭
When I first started teaching POCUS, I actually disliked the IVC because it was often poorly done or incorrectly interpreted ❌
I have now come to love the IVC, BUT you have to do it right!
#emimcc
Time for another #POCUS pitfalls thread: the infamous IVC 🤩
I have MANY thoughts on the IVC 💭
When I first started teaching POCUS, I actually disliked the IVC because it was often poorly done or incorrectly interpreted ❌
I have now come to love the IVC, BUT you have to do it right!
#emimcc
December 16, 2024 at 6:52 PM
Reposted by Jonne Sikkens
A new study this week showed how the most common blood test performed-—the CBC, complete blood count—contains a treasure chest of information that we are missing in reporting out to patients and doctors.
erictopol.substack.com/p/your-lab-t...
erictopol.substack.com/p/your-lab-t...
December 14, 2024 at 7:55 PM
A new study this week showed how the most common blood test performed-—the CBC, complete blood count—contains a treasure chest of information that we are missing in reporting out to patients and doctors.
erictopol.substack.com/p/your-lab-t...
erictopol.substack.com/p/your-lab-t...
Reposted by Jonne Sikkens
(it’s a fig tree)
December 15, 2024 at 4:54 PM
(it’s a fig tree)